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The map label for this gene is groEL

Identifier: 162147833

GI number: 162147833

Start: 2096311

End: 2097954

Strand: Reverse

Name: groEL

Synonym: GDI_2049

Alternate gene names: 162147833

Gene position: 2097954-2096311 (Counterclockwise)

Preceding gene: 162147834

Following gene: 162147832

Centisome position: 53.19

GC content: 65.57

Gene sequence:

>1644_bases
ATGGCAGCCAAGGACGTAAAGTTCGGTGGTGACGCACGCCAGCGCATGCTGCGGGGCGTGGACATTCTGGCCGACGCGGT
GAAGGTGACCCTGGGCCCGAAGGGCCGGAACGTCGTGCTCGACAAGAGCTTCGGCGCGCCGCGCATCACCAAGGACGGCG
TTTCCGTCGCCAAGGAAATCGAACTGGCCGACAAGTTCGAGAACATGGGCGCCCAGATGGTGCGCGAAGTGGCGTCGAAG
ACCAACGACGTCGCCGGTGACGGCACCACGACCGCGACCGTTCTGGCCCAGGCCATCGTCCGCGAGGGTGCCAAGGCCGT
TGCGGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCCGTCATCGCGGTCGTCGAGGAGTTGAAGAAGA
ACACCAAGAAGATCACGACCCCGGCCGAAACGGCGCAGGTCGGCACGATCTCGGCCAACGGCGAGCATGAGATCGGCGAG
ATGATCTCGCAGGCCATGCAGAAGGTCGGCAGCGAAGGCGTCATCACGGTGGAAGAGGCCAAGGGCCTGCACACCGAACT
GGACGTCGTCGAGGGCATGCAGTTCGATCGCGGCTATATCTCCCCGTATTTCATCACGAACGCGGAGAAGATGGTTGCCG
ACCTGGACAACCCCTACATCCTGATCCACGAAAAGAAGCTGTCGTCGCTGCAGCCGATGCTGCCGCTGCTGGAGAGCGTC
GTGCAGTCCGGCCGTCCGCTGCTGATCATCGCCGAGGACGTCGATGGCGAGGCGCTGGCGACCCTGGTCGTCAACAAGCT
GCGTGGTGGCCTGAAGATCGCCGCCGTCAAGGCGCCGGGCTTCGGTGATCGTCGCAAGGCGATGCTGGAAGACATCGCGA
TCCTGACCGGTGGACAGGTCATCAGCGAAGATCTGGGCATCAAGCTGGAGACCGTGACCCTGGCGATGCTGGGCCGTGCG
AAGAAGGTCCGCATCGAGAAGGAAAACACCACGATCGTCGAGGGCGCCGGCGCGTCCGACGACATCAAGGGCCGTTGCGG
CCAGATCCGCGCGCAGATCGAGGAGACCACCTCGGACTACGATCGCGAGAAGCTGCAGGAGCGTCTGGCGAAGCTGGCGG
GCGGCGTCGCCGTCATCCGCGTCGGCGGCTCGACCGAGGTCGAGGTGAAGGAGCGCAAGGACCGCGTCGACGACGCGCTG
CATGCGACCCGCGCCGCGGTCGAGGAAGGCATCGTCCCCGGCGGCGGCACGGCGCTGGCGCGTGCGTCCACCGCCCTGGG
CAACCTGCATTTCCACAATGACGACCAGCGCGTCGGCGCGGAAATCATCCGCAAGGCCCTGCAGGCTCCGCTGCGCCAGA
TCGCCCACAACGCGGGCGAAGACGGTGCGGTCATCGCCGGCAAGGTGCTGGAAAGCAACGACTACAACTACGGCTTCGAC
GCCCAGATCGGCGATTACAAGGATCTGGTGGCTGCCGGTATCATCGACCCGACCAAGGTCGTGCGGACCGCGCTGCAGGA
CGCGTCGTCGGTTGCCGGCCTGCTGATCACCACCGAGGCGATGGTGGCCGAGAAGCCGGAAAAGAAGGCCCCGGCCATGC
CCGCCGGTGGCGGCATGGGCGGCATGGGCGACATGGATTTCTAA

Upstream 100 bases:

>100_bases
GCTGCTGATCATGAAGGAAAGCGACATCATGGGCGTGATCGCCTGAGGTCTCCCCTCCTTTTCCCTCTGATCGACAAGAT
TCCTACAGGAGAATTCTGAT

Downstream 100 bases:

>100_bases
GATCCATGAAACCGGTCCGGTGGCGGAATGCCGCCGGATCGGCGTCCGGTTACTCGGAAAAGAAGGCCGTCCGGTTTCGG
GCGGCCTTTTTTTACGTTTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVKFGGDARQRMLRGVDILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVSVAKEIELADKFENMGAQMVREVASK
TNDVAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDKAVIAVVEELKKNTKKITTPAETAQVGTISANGEHEIGE
MISQAMQKVGSEGVITVEEAKGLHTELDVVEGMQFDRGYISPYFITNAEKMVADLDNPYILIHEKKLSSLQPMLPLLESV
VQSGRPLLIIAEDVDGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLETVTLAMLGRA
KKVRIEKENTTIVEGAGASDDIKGRCGQIRAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDAL
HATRAAVEEGIVPGGGTALARASTALGNLHFHNDDQRVGAEIIRKALQAPLRQIAHNAGEDGAVIAGKVLESNDYNYGFD
AQIGDYKDLVAAGIIDPTKVVRTALQDASSVAGLLITTEAMVAEKPEKKAPAMPAGGGMGGMGDMDF

Sequences:

>Translated_547_residues
MAAKDVKFGGDARQRMLRGVDILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVSVAKEIELADKFENMGAQMVREVASK
TNDVAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDKAVIAVVEELKKNTKKITTPAETAQVGTISANGEHEIGE
MISQAMQKVGSEGVITVEEAKGLHTELDVVEGMQFDRGYISPYFITNAEKMVADLDNPYILIHEKKLSSLQPMLPLLESV
VQSGRPLLIIAEDVDGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLETVTLAMLGRA
KKVRIEKENTTIVEGAGASDDIKGRCGQIRAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDAL
HATRAAVEEGIVPGGGTALARASTALGNLHFHNDDQRVGAEIIRKALQAPLRQIAHNAGEDGAVIAGKVLESNDYNYGFD
AQIGDYKDLVAAGIIDPTKVVRTALQDASSVAGLLITTEAMVAEKPEKKAPAMPAGGGMGGMGDMDF
>Mature_546_residues
AAKDVKFGGDARQRMLRGVDILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVSVAKEIELADKFENMGAQMVREVASKT
NDVAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDKAVIAVVEELKKNTKKITTPAETAQVGTISANGEHEIGEM
ISQAMQKVGSEGVITVEEAKGLHTELDVVEGMQFDRGYISPYFITNAEKMVADLDNPYILIHEKKLSSLQPMLPLLESVV
QSGRPLLIIAEDVDGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLETVTLAMLGRAK
KVRIEKENTTIVEGAGASDDIKGRCGQIRAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDALH
ATRAAVEEGIVPGGGTALARASTALGNLHFHNDDQRVGAEIIRKALQAPLRQIAHNAGEDGAVIAGKVLESNDYNYGFDA
QIGDYKDLVAAGIIDPTKVVRTALQDASSVAGLLITTEAMVAEKPEKKAPAMPAGGGMGGMGDMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=55.1789077212806, Blast_Score=569, Evalue=1e-162,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=55.1789077212806, Blast_Score=569, Evalue=1e-162,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=66.9811320754717, Blast_Score=702, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=55.0094517958412, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI193210679, Length=240, Percent_Identity=50.8333333333333, Blast_Score=221, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=57.4427480916031, Blast_Score=590, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6322524, Length=526, Percent_Identity=23.0038022813688, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=56.9259962049336, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=56.9259962049336, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=52.7619047619048, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=52.7619047619048, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=52.7619047619048, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI17864606, Length=546, Percent_Identity=45.4212454212454, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=36.8224299065421, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=36.8224299065421, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI18858175, Length=556, Percent_Identity=22.4820143884892, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28571140, Length=556, Percent_Identity=22.4820143884892, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_GLUDA (A9HK37)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602294.1
- RefSeq:   YP_002274683.1
- ProteinModelPortal:   A9HK37
- SMR:   A9HK37
- GeneID:   5792406
- GeneID:   6973663
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0271
- HOGENOM:   HBG625289
- OMA:   DDIKGRC
- ProtClustDB:   PRK00013
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57918; Mature: 57787

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGGDARQRMLRGVDILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELADKFENMGAQMVREVASKTNDVAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
DKAVIAVVEELKKNTKKITTPAETAQVGTISANGEHEIGEMISQAMQKVGSEGVITVEEA
HHHHHHHHHHHHHHHHCCCCCCHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCC
KGLHTELDVVEGMQFDRGYISPYFITNAEKMVADLDNPYILIHEKKLSSLQPMLPLLESV
CCCCHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHH
VQSGRPLLIIAEDVDGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLETVTLAMLGRAKKVRIEKENTTIVEGAGASDDIKGRCGQIRAQIEETTSDY
HHHCCCCEEHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDALHATRAAVEEGIVPGGGTALA
HHHHHHHHHHHHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RASTALGNLHFHNDDQRVGAEIIRKALQAPLRQIAHNAGEDGAVIAGKVLESNDYNYGFD
HHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCC
AQIGDYKDLVAAGIIDPTKVVRTALQDASSVAGLLITTEAMVAEKPEKKAPAMPAGGGMG
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEHHHHHHCCCHHCCCCCCCCCCCC
GMGDMDF
CCCCCCC
>Mature Secondary Structure 
AAKDVKFGGDARQRMLRGVDILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELADKFENMGAQMVREVASKTNDVAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
DKAVIAVVEELKKNTKKITTPAETAQVGTISANGEHEIGEMISQAMQKVGSEGVITVEEA
HHHHHHHHHHHHHHHHCCCCCCHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCC
KGLHTELDVVEGMQFDRGYISPYFITNAEKMVADLDNPYILIHEKKLSSLQPMLPLLESV
CCCCHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHH
VQSGRPLLIIAEDVDGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLETVTLAMLGRAKKVRIEKENTTIVEGAGASDDIKGRCGQIRAQIEETTSDY
HHHCCCCEEHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDALHATRAAVEEGIVPGGGTALA
HHHHHHHHHHHHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RASTALGNLHFHNDDQRVGAEIIRKALQAPLRQIAHNAGEDGAVIAGKVLESNDYNYGFD
HHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCC
AQIGDYKDLVAAGIIDPTKVVRTALQDASSVAGLLITTEAMVAEKPEKKAPAMPAGGGMG
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEHHHHHHCCCHHCCCCCCCCCCCC
GMGDMDF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA