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The map label for this gene is ndk

Identifier: 162147798

GI number: 162147798

Start: 2054773

End: 2055195

Strand: Reverse

Name: ndk

Synonym: GDI_2014

Alternate gene names: 162147798

Gene position: 2055195-2054773 (Counterclockwise)

Preceding gene: 162147800

Following gene: 162147795

Centisome position: 52.11

GC content: 65.01

Gene sequence:

>423_bases
ATGGCGACCGAACGTACCCTGTCGATCATCAAGCCGGACGCGACCCGGCGCAACCTGACGGGCAAGATCAACGCGGTGTT
CGAGGATGCGGGCCTGCGCATCGTCGCGCAGAAGCGCGTGCAACTGAGCGAAGCCGAGGCCGGCGCGTTCTATGCCGTGC
ACAAGGACCGTCCGTTCTACGGCGAGCTGGTGTCGTTCATGGTGTCCGGCCCGGTCGTGCTGCAGGTGCTGGAAGGCGAG
AACGCCGTCCTGAAGCATCGCGACGTGATGGGCGCCACCGACCCGAAGAAGGCCGCGCCGGGCACCGTCCGCGCGCAGTT
CGCCGAGAGCATCGAGGCGAATTCGGTCCATGGTTCGGACAGCCTGGAAAACGCGAACACCGAAATCGCGTTCTTCTTCG
CCCAGACCGAAATCCTGCCCTGA

Upstream 100 bases:

>100_bases
CGGGGGAATATGCTCTAGATGGCGCGCGTAAGGGGCGCCGGTCCGCAAGGGCGCAAGGGGTCCTGGCCACGCATTTCGAG
CAATAAGAAGGAGCCATCCC

Downstream 100 bases:

>100_bases
TCACGCCGGACGGGCACCCGCCAGGGTGCCCGTCATGCCGACCGGGTTCCTACAGGAACAGCAGAGACCCGATATCCGGC
TGCGGCACGGCATCGGGCGT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MATERTLSIIKPDATRRNLTGKINAVFEDAGLRIVAQKRVQLSEAEAGAFYAVHKDRPFYGELVSFMVSGPVVLQVLEGE
NAVLKHRDVMGATDPKKAAPGTVRAQFAESIEANSVHGSDSLENANTEIAFFFAQTEILP

Sequences:

>Translated_140_residues
MATERTLSIIKPDATRRNLTGKINAVFEDAGLRIVAQKRVQLSEAEAGAFYAVHKDRPFYGELVSFMVSGPVVLQVLEGE
NAVLKHRDVMGATDPKKAAPGTVRAQFAESIEANSVHGSDSLENANTEIAFFFAQTEILP
>Mature_139_residues
ATERTLSIIKPDATRRNLTGKINAVFEDAGLRIVAQKRVQLSEAEAGAFYAVHKDRPFYGELVSFMVSGPVVLQVLEGEN
AVLKHRDVMGATDPKKAAPGTVRAQFAESIEANSVHGSDSLENANTEIAFFFAQTEILP

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=46.3768115942029, Blast_Score=126, Evalue=5e-30,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=43.7956204379562, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=43.7956204379562, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=43.3823529411765, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=43.3823529411765, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=43.3823529411765, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=43.3823529411765, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=43.3823529411765, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.1764705882353, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI30023828, Length=142, Percent_Identity=36.6197183098592, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=32.3308270676692, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=31.6176470588235, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=35.5072463768116, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4505413, Length=141, Percent_Identity=28.3687943262411, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=31.3868613138686, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788866, Length=140, Percent_Identity=53.5714285714286, Blast_Score=159, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=45.5882352941176, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=40.1459854014599, Blast_Score=115, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=42.6470588235294, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18860097, Length=133, Percent_Identity=34.5864661654135, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_GLUDA (A9HJV3)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602259.1
- RefSeq:   YP_002274649.1
- ProteinModelPortal:   A9HJV3
- SMR:   A9HJV3
- GeneID:   5789366
- GeneID:   6973629
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0237
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15203; Mature: 15072

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATERTLSIIKPDATRRNLTGKINAVFEDAGLRIVAQKRVQLSEAEAGAFYAVHKDRPFY
CCCCCEEEEECCCCCCCCCCCEEEEEEECCCEEEEEECCHHCCCCCCCEEEEEECCCCHH
GELVSFMVSGPVVLQVLEGENAVLKHRDVMGATDPKKAAPGTVRAQFAESIEANSVHGSD
HHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
SLENANTEIAFFFAQTEILP
CCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure 
ATERTLSIIKPDATRRNLTGKINAVFEDAGLRIVAQKRVQLSEAEAGAFYAVHKDRPFY
CCCCEEEEECCCCCCCCCCCEEEEEEECCCEEEEEECCHHCCCCCCCEEEEEECCCCHH
GELVSFMVSGPVVLQVLEGENAVLKHRDVMGATDPKKAAPGTVRAQFAESIEANSVHGSD
HHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
SLENANTEIAFFFAQTEILP
CCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA