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The map label for this gene is ggt [H]

Identifier: 162147780

GI number: 162147780

Start: 2030730

End: 2032292

Strand: Reverse

Name: ggt [H]

Synonym: GDI_1996

Alternate gene names: 162147780

Gene position: 2032292-2030730 (Counterclockwise)

Preceding gene: 162147781

Following gene: 162147779

Centisome position: 51.53

GC content: 72.1

Gene sequence:

>1563_bases
ATGGTGACGTCCCCGCATCATCTGGCCAGCCAGGCCGGACTGGACGTGCTGCGCGACGGCGGCACGGCAATCGAGGCGGT
GGTTGCGACCGCCGCCGCCCTGGCCGTCGTCTATCCCCACATGACCGGGATCGGCGGCGACGGGTTCTGGCTGGTCCTGT
GGCCCGACGGCCGGACCGAGACGATCGACGCCTGCGGCGCGGCGGCCCGGCGCGCCGACCTGGATTTCTATCGCGCGGCG
GGTCGGGACGCGATTCCGTGGCGCGGCCCGCTGGCCGCGAACACGGTCGCGGGCACGATCTCCGGCTGGGACCTCGCCCT
GTCCTGGAGCCACGCGCAGCAGCCGGGGCTGAGCCTGCACCGGCTGCTGCGCGATGCCATCTACTACGCCGAACAGGGCG
TGCCGGTGACCGAGGGCGGGGCCGCCCTGACCCAGGCGAAAATGGACGAACTGGCCGGCATTCCGGGCTTTCGCGATGTC
TTCCTGCCGAGGGGGCGTGCGCCCCGGGCGGGTGACATGCTGCATAACCCGGCGCTGTCCCAGACCCTTCGCCGGCTGGC
CTCGGACGGGCTGGATTCCTTCTATCGCGGCGCCCTGGCCCGCGACATGGCCCAGGACCTGCGCGTGCTGGGCAGCCCGC
TGGACCTGGCCGACCTGAACACCCACCAGGCCCGCGCCCGGCCGCCGCTGCATGTCGATGTCACGGGCGCGCGCCTGTTC
AACATGGCCCCGCCGACCCAGGGGGTCGCGTCGCTGCTGATCCTGGCCATCTTCGACCGGCTGCGCGCGGACCAGCCGGA
CGGGTTCGATCACGTCCACGGGCTGGTCGAAGCCACCAAGCAGGCCTTCCGCTATCGCGACGCCCATGTCGGCGATCCCG
CCTTCATGTCCGTGGACGCGCAGGCGGTGCTGGACGACACGCTGGCGCTGGACGGCATGGCGCTGGCGATCGACCCGGCC
CGGGCCGCGCCCTGGCCCCATCCGTCGCAGGCCGGCGATACGGTGTGGATGGGGGCAGTGGATGCCGACGGCGTGGCCGT
CAGCATGATCCAGAGCGTCTATTTCGAATACGGGTCCGGCGTGGTCCTGCCGCGCACCGGGGTGCTGTGGCAGAATCGCG
GCGCCAGCTTCCGCCTGGCGGAAGATGGCTGGAACGCGCTGCGCCCGGGGCGCAAGCCGTTCCATACGCTGAACCCCGCC
GCCGCCCGGTTCGATGACGGGCGCACCATGGTCTACGGCACCATGGGCGGCGAGGGCCAGCCCCAGACCCAGGCCGCGCT
GTTCACCCGCTATGCCCGCTACGGCATCGGGTTGCAGCAGGCGGTGACCGCCCCGCGCTGGCTGCTGGGCCGCACCTGGG
GCGAGGACAGCACCACCCTGAAATACGAGGACCGCTTCGCGCCGGAAGTCATCGCCCGGCTGGGCGAAGCCGGGCATGTG
CTGGAGGCCATGCCGGCCTTTACCTCCACCATGGGCCACGCGGGCGCGCTGGTGCTGCACCCGTCCGGCCTGATCGAGGG
CGCGACAGACCCGCGCAGCGACGGCATGGTGGCGGCATGGTAA

Upstream 100 bases:

>100_bases
TGCCGTGGCCGCGGCGCTGGAAGCCGCCGGCGTGGCCGGGAAGGTTCCGCTTCCGAAGGGACGATAGACCATGCTGCATA
CGCCACGTTCGCAGCGCGGG

Downstream 100 bases:

>100_bases
TTCCCCCGATGCGGGAGACGGCCTCCGGCATCCGCGCGGTCGTGCGGTGCGACGAACTGGGCACGGCCCCGTATTCGGAC
GACCCGGCGGGGCTTTTCCG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MVTSPHHLASQAGLDVLRDGGTAIEAVVATAAALAVVYPHMTGIGGDGFWLVLWPDGRTETIDACGAAARRADLDFYRAA
GRDAIPWRGPLAANTVAGTISGWDLALSWSHAQQPGLSLHRLLRDAIYYAEQGVPVTEGGAALTQAKMDELAGIPGFRDV
FLPRGRAPRAGDMLHNPALSQTLRRLASDGLDSFYRGALARDMAQDLRVLGSPLDLADLNTHQARARPPLHVDVTGARLF
NMAPPTQGVASLLILAIFDRLRADQPDGFDHVHGLVEATKQAFRYRDAHVGDPAFMSVDAQAVLDDTLALDGMALAIDPA
RAAPWPHPSQAGDTVWMGAVDADGVAVSMIQSVYFEYGSGVVLPRTGVLWQNRGASFRLAEDGWNALRPGRKPFHTLNPA
AARFDDGRTMVYGTMGGEGQPQTQAALFTRYARYGIGLQQAVTAPRWLLGRTWGEDSTTLKYEDRFAPEVIARLGEAGHV
LEAMPAFTSTMGHAGALVLHPSGLIEGATDPRSDGMVAAW

Sequences:

>Translated_520_residues
MVTSPHHLASQAGLDVLRDGGTAIEAVVATAAALAVVYPHMTGIGGDGFWLVLWPDGRTETIDACGAAARRADLDFYRAA
GRDAIPWRGPLAANTVAGTISGWDLALSWSHAQQPGLSLHRLLRDAIYYAEQGVPVTEGGAALTQAKMDELAGIPGFRDV
FLPRGRAPRAGDMLHNPALSQTLRRLASDGLDSFYRGALARDMAQDLRVLGSPLDLADLNTHQARARPPLHVDVTGARLF
NMAPPTQGVASLLILAIFDRLRADQPDGFDHVHGLVEATKQAFRYRDAHVGDPAFMSVDAQAVLDDTLALDGMALAIDPA
RAAPWPHPSQAGDTVWMGAVDADGVAVSMIQSVYFEYGSGVVLPRTGVLWQNRGASFRLAEDGWNALRPGRKPFHTLNPA
AARFDDGRTMVYGTMGGEGQPQTQAALFTRYARYGIGLQQAVTAPRWLLGRTWGEDSTTLKYEDRFAPEVIARLGEAGHV
LEAMPAFTSTMGHAGALVLHPSGLIEGATDPRSDGMVAAW
>Mature_520_residues
MVTSPHHLASQAGLDVLRDGGTAIEAVVATAAALAVVYPHMTGIGGDGFWLVLWPDGRTETIDACGAAARRADLDFYRAA
GRDAIPWRGPLAANTVAGTISGWDLALSWSHAQQPGLSLHRLLRDAIYYAEQGVPVTEGGAALTQAKMDELAGIPGFRDV
FLPRGRAPRAGDMLHNPALSQTLRRLASDGLDSFYRGALARDMAQDLRVLGSPLDLADLNTHQARARPPLHVDVTGARLF
NMAPPTQGVASLLILAIFDRLRADQPDGFDHVHGLVEATKQAFRYRDAHVGDPAFMSVDAQAVLDDTLALDGMALAIDPA
RAAPWPHPSQAGDTVWMGAVDADGVAVSMIQSVYFEYGSGVVLPRTGVLWQNRGASFRLAEDGWNALRPGRKPFHTLNPA
AARFDDGRTMVYGTMGGEGQPQTQAALFTRYARYGIGLQQAVTAPRWLLGRTWGEDSTTLKYEDRFAPEVIARLGEAGHV
LEAMPAFTSTMGHAGALVLHPSGLIEGATDPRSDGMVAAW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=467, Percent_Identity=28.9079229122056, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI73915090, Length=467, Percent_Identity=28.9079229122056, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI73915096, Length=467, Percent_Identity=28.9079229122056, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI73915094, Length=467, Percent_Identity=28.9079229122056, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI113429324, Length=467, Percent_Identity=28.9079229122056, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI113429326, Length=472, Percent_Identity=27.9661016949153, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI109148539, Length=380, Percent_Identity=25.7894736842105, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI153266901, Length=565, Percent_Identity=23.716814159292, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI153266885, Length=568, Percent_Identity=23.5915492957746, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI153266907, Length=557, Percent_Identity=23.6983842010772, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789856, Length=549, Percent_Identity=28.9617486338798, Blast_Score=194, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI193208247, Length=491, Percent_Identity=24.847250509165, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI193208245, Length=491, Percent_Identity=24.847250509165, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506189, Length=523, Percent_Identity=23.5181644359465, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18859893, Length=510, Percent_Identity=26.2745098039216, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI161077880, Length=524, Percent_Identity=24.618320610687, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24642670, Length=524, Percent_Identity=24.618320610687, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24642666, Length=524, Percent_Identity=24.618320610687, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161077878, Length=524, Percent_Identity=24.618320610687, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551474, Length=524, Percent_Identity=24.618320610687, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161077496, Length=469, Percent_Identity=21.9616204690832, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859741, Length=524, Percent_Identity=23.8549618320611, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55614; Mature: 55614

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSPHHLASQAGLDVLRDGGTAIEAVVATAAALAVVYPHMTGIGGDGFWLVLWPDGRTE
CCCCCHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCH
TIDACGAAARRADLDFYRAAGRDAIPWRGPLAANTVAGTISGWDLALSWSHAQQPGLSLH
HHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHEECCCCCEEEEEECCCCCCCHHHH
RLLRDAIYYAEQGVPVTEGGAALTQAKMDELAGIPGFRDVFLPRGRAPRAGDMLHNPALS
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHCCHHHH
QTLRRLASDGLDSFYRGALARDMAQDLRVLGSPLDLADLNTHQARARPPLHVDVTGARLF
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECHHEEE
NMAPPTQGVASLLILAIFDRLRADQPDGFDHVHGLVEATKQAFRYRDAHVGDPAFMSVDA
ECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCH
QAVLDDTLALDGMALAIDPARAAPWPHPSQAGDTVWMGAVDADGVAVSMIQSVYFEYGSG
HHHHHHHHHHCCEEEEECCHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCC
VVLPRTGVLWQNRGASFRLAEDGWNALRPGRKPFHTLNPAAARFDDGRTMVYGTMGGEGQ
EEECCCCCEECCCCCEEEECCCCCHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCC
PQTQAALFTRYARYGIGLQQAVTAPRWLLGRTWGEDSTTLKYEDRFAPEVIARLGEAGHV
CHHHHHHHHHHHHHCCCHHHHHCCCHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCHH
LEAMPAFTSTMGHAGALVLHPSGLIEGATDPRSDGMVAAW
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MVTSPHHLASQAGLDVLRDGGTAIEAVVATAAALAVVYPHMTGIGGDGFWLVLWPDGRTE
CCCCCHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCH
TIDACGAAARRADLDFYRAAGRDAIPWRGPLAANTVAGTISGWDLALSWSHAQQPGLSLH
HHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHEECCCCCEEEEEECCCCCCCHHHH
RLLRDAIYYAEQGVPVTEGGAALTQAKMDELAGIPGFRDVFLPRGRAPRAGDMLHNPALS
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHCCHHHH
QTLRRLASDGLDSFYRGALARDMAQDLRVLGSPLDLADLNTHQARARPPLHVDVTGARLF
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECHHEEE
NMAPPTQGVASLLILAIFDRLRADQPDGFDHVHGLVEATKQAFRYRDAHVGDPAFMSVDA
ECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCH
QAVLDDTLALDGMALAIDPARAAPWPHPSQAGDTVWMGAVDADGVAVSMIQSVYFEYGSG
HHHHHHHHHHCCEEEEECCHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCC
VVLPRTGVLWQNRGASFRLAEDGWNALRPGRKPFHTLNPAAARFDDGRTMVYGTMGGEGQ
EEECCCCCEECCCCCEEEECCCCCHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCC
PQTQAALFTRYARYGIGLQQAVTAPRWLLGRTWGEDSTTLKYEDRFAPEVIARLGEAGHV
CHHHHHHHHHHHHHCCCHHHHHCCCHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCHH
LEAMPAFTSTMGHAGALVLHPSGLIEGATDPRSDGMVAAW
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]