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The map label for this gene is pepE [H]

Identifier: 162147774

GI number: 162147774

Start: 2023299

End: 2025089

Strand: Direct

Name: pepE [H]

Synonym: GDI_1990

Alternate gene names: 162147774

Gene position: 2023299-2025089 (Clockwise)

Preceding gene: 162147773

Following gene: 162147775

Centisome position: 51.3

GC content: 70.41

Gene sequence:

>1791_bases
ATGACGGCGATCGCTTCCCGCCTCCCTGCCCTGCGGACCGTGCTGGGGCAGATGGACGTGGATGGTTTCATCCTGCTGCG
CGGTGACGAGCATCTGGGCGAATATGTCGCACCCTGTGCCGAGCGCCTGGCCTGGCTGACCGGGTTCACCGGCAGCGCCG
GCATGGCCGTGGTGCTGCGCGACGGGCCGGCGGCGGTGTTTTCCGACGGCCGCTATGTCACCCAGATGGACCAGCAGGTG
GACGGCGCGGCCTGGTCGCGCCTGCATCTGCGCGACACGCCGCCGGCCCGCTGGCTGGCATCCCATGCCGGGGCGGGCCA
GCGGATCGGCTACGACCCGCGGCTGGTCGGCGAGGCCGGGTTGCAGCCCTTCCTCGATTGCGGGCTGACCATGGTGCCGA
TGGCGGCCAACCCGGTGGACCGCATCTGGACCGACCGGCCGGCGGCACCCGCCACGGCCTGCATGCCGCAGCCCCTGGCC
TTCGCGGGCGAGGACAGCGCCGCCAAGCGGGCACGGATGGCCGCCATCCTGAAGGCGGACGGCCAGGATGCCGCCGTGCT
GGGCGACCCCACCGCCATTGCCTGGTTGCTGAACGTCAGGGGCCATGACGTTCAATACACCCCCGTCTGCCTGGCCTTCG
CCATCCTGCATGACGATGCGCGGGTGGACCTATTCATCGACCCCGCGCGCCTGCCGCAGGACACGGCGGCGTGGCTGGGC
CCCGAGGTGACGATCGTGGAGCCGGCGGGGCTGGAGGCGGCACTGGCGGCGCTGGCCGGACGGCGGGTGCGCGTCGATCC
GGTCGGGACCGCCATATGGTTCATCCAGATGCTGGAGGCGGCCGGGGCGACGGTGGCGCGCGGCGGCGACCCGTGCGTGC
TGCCCCGCGCCCGGAAGAACGATGTCGAGCAGGACGGCGCACGGCGGGCGCATCTGCTGGACGGGATCGCGCTCTGCCGT
TTCCTGCACTGGATGGATACCGAGGGCGTGGGCCCGGATAGCATAAGGCCGGGAGAACTGGACGCCGCGAACCGGCTGGA
CGCGTTCCGCGCCCTGTGCCCGGACTATCGCGAGGAAAGCTTTCCCGCGATTTCCGGGGCCGGCCCCAACGGCGCGGTCA
TCCATTATCGCGTGACCCCCGAAAGCAGCCGGACGATCGGGACGGACGAGGTCTATCTGATCGACAGCGGCGGGCAGTAT
CCGTTCGGCACCACCGACGTCACGCGCACGATCTGGACCGGCGCCGGCCGAGGGCCGGAGGATGTGCGCCACGCCTTCAC
CCGCGTGCTGAAGGGGCATATCGCCCTGGCGCGGGCCCGCTTTCCGGTGGGCACCACCGGGCACGCGCTGGACGGGCTGG
CGCGCTATGCGCTGTGGCAGGCGGGAATGGATTACGACCATGGAACCGGCCACGGCATCGGCAGCTATCTGTCGGTCCAT
GAGGGACCGTGTTCGATTTCGCCCGTCTATCGGCCCGTCGCGGTCGAGGCCGGCATGATCCTGTCCGACGAACCCGGATA
TTACCGGCCCGGCGCCTTCGGCATCCGGCTGGAAAATCTGCTGCTGGCCCGCCCGGCACCGGCCGAGCCCAACCGGTCGT
TCCTGGAGTTCGAGACGCTGACGCTGGCGCCGTTCGACCGGCGGCTGATCGACGCGTCCCTGCTGACGGCGGAGGAAACC
GCATGGATCGATGCGTACCATGCACGGGTTTGTGAAACGCTTGCCCCGCATCTGGAGGCTGCACCCACGGCATGGCTGCA
TGCCGCATGTGCCCCGATCGGCGCGGAATAG

Upstream 100 bases:

>100_bases
GGATGGTGCTGGCCGCCCACCGGCGCCAGGGCCTGGTACTGGAACGGCGCCTGACCGAAGGCGACTGGACGACCCTGGTG
CTGCGCAAGAGGACGACGAC

Downstream 100 bases:

>100_bases
CGCGGGATAGCGCCGGATAATGTGACCGGGAAAGCACCCGAGGCGGCGGGGAGTGGAATTGTCACCCGTCGGCCACGGGC
CTAGTCACTATGTCACGTGG

Product: peptidase M24

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MTAIASRLPALRTVLGQMDVDGFILLRGDEHLGEYVAPCAERLAWLTGFTGSAGMAVVLRDGPAAVFSDGRYVTQMDQQV
DGAAWSRLHLRDTPPARWLASHAGAGQRIGYDPRLVGEAGLQPFLDCGLTMVPMAANPVDRIWTDRPAAPATACMPQPLA
FAGEDSAAKRARMAAILKADGQDAAVLGDPTAIAWLLNVRGHDVQYTPVCLAFAILHDDARVDLFIDPARLPQDTAAWLG
PEVTIVEPAGLEAALAALAGRRVRVDPVGTAIWFIQMLEAAGATVARGGDPCVLPRARKNDVEQDGARRAHLLDGIALCR
FLHWMDTEGVGPDSIRPGELDAANRLDAFRALCPDYREESFPAISGAGPNGAVIHYRVTPESSRTIGTDEVYLIDSGGQY
PFGTTDVTRTIWTGAGRGPEDVRHAFTRVLKGHIALARARFPVGTTGHALDGLARYALWQAGMDYDHGTGHGIGSYLSVH
EGPCSISPVYRPVAVEAGMILSDEPGYYRPGAFGIRLENLLLARPAPAEPNRSFLEFETLTLAPFDRRLIDASLLTAEET
AWIDAYHARVCETLAPHLEAAPTAWLHAACAPIGAE

Sequences:

>Translated_596_residues
MTAIASRLPALRTVLGQMDVDGFILLRGDEHLGEYVAPCAERLAWLTGFTGSAGMAVVLRDGPAAVFSDGRYVTQMDQQV
DGAAWSRLHLRDTPPARWLASHAGAGQRIGYDPRLVGEAGLQPFLDCGLTMVPMAANPVDRIWTDRPAAPATACMPQPLA
FAGEDSAAKRARMAAILKADGQDAAVLGDPTAIAWLLNVRGHDVQYTPVCLAFAILHDDARVDLFIDPARLPQDTAAWLG
PEVTIVEPAGLEAALAALAGRRVRVDPVGTAIWFIQMLEAAGATVARGGDPCVLPRARKNDVEQDGARRAHLLDGIALCR
FLHWMDTEGVGPDSIRPGELDAANRLDAFRALCPDYREESFPAISGAGPNGAVIHYRVTPESSRTIGTDEVYLIDSGGQY
PFGTTDVTRTIWTGAGRGPEDVRHAFTRVLKGHIALARARFPVGTTGHALDGLARYALWQAGMDYDHGTGHGIGSYLSVH
EGPCSISPVYRPVAVEAGMILSDEPGYYRPGAFGIRLENLLLARPAPAEPNRSFLEFETLTLAPFDRRLIDASLLTAEET
AWIDAYHARVCETLAPHLEAAPTAWLHAACAPIGAE
>Mature_595_residues
TAIASRLPALRTVLGQMDVDGFILLRGDEHLGEYVAPCAERLAWLTGFTGSAGMAVVLRDGPAAVFSDGRYVTQMDQQVD
GAAWSRLHLRDTPPARWLASHAGAGQRIGYDPRLVGEAGLQPFLDCGLTMVPMAANPVDRIWTDRPAAPATACMPQPLAF
AGEDSAAKRARMAAILKADGQDAAVLGDPTAIAWLLNVRGHDVQYTPVCLAFAILHDDARVDLFIDPARLPQDTAAWLGP
EVTIVEPAGLEAALAALAGRRVRVDPVGTAIWFIQMLEAAGATVARGGDPCVLPRARKNDVEQDGARRAHLLDGIALCRF
LHWMDTEGVGPDSIRPGELDAANRLDAFRALCPDYREESFPAISGAGPNGAVIHYRVTPESSRTIGTDEVYLIDSGGQYP
FGTTDVTRTIWTGAGRGPEDVRHAFTRVLKGHIALARARFPVGTTGHALDGLARYALWQAGMDYDHGTGHGIGSYLSVHE
GPCSISPVYRPVAVEAGMILSDEPGYYRPGAFGIRLENLLLARPAPAEPNRSFLEFETLTLAPFDRRLIDASLLTAEETA
WIDAYHARVCETLAPHLEAAPTAWLHAACAPIGAE

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=609, Percent_Identity=38.0952380952381, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI264681565, Length=609, Percent_Identity=35.632183908046, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI93141226, Length=610, Percent_Identity=34.4262295081967, Blast_Score=330, Evalue=3e-90,
Organism=Escherichia coli, GI1788728, Length=175, Percent_Identity=34.2857142857143, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17509539, Length=602, Percent_Identity=35.3820598006645, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25149105, Length=621, Percent_Identity=29.14653784219, Blast_Score=244, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322999, Length=656, Percent_Identity=31.25, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI17137632, Length=622, Percent_Identity=34.4051446945338, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI161078230, Length=611, Percent_Identity=30.278232405892, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21357287, Length=611, Percent_Identity=30.278232405892, Blast_Score=241, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 63928; Mature: 63797

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIASRLPALRTVLGQMDVDGFILLRGDEHLGEYVAPCAERLAWLTGFTGSAGMAVVLR
CCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
DGPAAVFSDGRYVTQMDQQVDGAAWSRLHLRDTPPARWLASHAGAGQRIGYDPRLVGEAG
CCCCEEECCCEEEEHHHHHCCCCHHEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHHC
LQPFLDCGLTMVPMAANPVDRIWTDRPAAPATACMPQPLAFAGEDSAAKRARMAAILKAD
CCHHHHCCCEEEECCCCCHHHHHCCCCCCCCHHCCCCCCEECCCCHHHHHHHHHHHEECC
GQDAAVLGDPTAIAWLLNVRGHDVQYTPVCLAFAILHDDARVDLFIDPARLPQDTAAWLG
CCCCEEECCCCEEEEEEECCCCCEEECHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCC
PEVTIVEPAGLEAALAALAGRRVRVDPVGTAIWFIQMLEAAGATVARGGDPCVLPRARKN
CCEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCEEECCCCCEECCCHHCC
DVEQDGARRAHLLDGIALCRFLHWMDTEGVGPDSIRPGELDAANRLDAFRALCPDYREES
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
FPAISGAGPNGAVIHYRVTPESSRTIGTDEVYLIDSGGQYPFGTTDVTRTIWTGAGRGPE
CCEECCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCHH
DVRHAFTRVLKGHIALARARFPVGTTGHALDGLARYALWQAGMDYDHGTGHGIGSYLSVH
HHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEC
EGPCSISPVYRPVAVEAGMILSDEPGYYRPGAFGIRLENLLLARPAPAEPNRSFLEFETL
CCCCCCCCCCCCEEEECCEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEEE
TLAPFDRRLIDASLLTAEETAWIDAYHARVCETLAPHLEAAPTAWLHAACAPIGAE
EECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAIASRLPALRTVLGQMDVDGFILLRGDEHLGEYVAPCAERLAWLTGFTGSAGMAVVLR
CCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
DGPAAVFSDGRYVTQMDQQVDGAAWSRLHLRDTPPARWLASHAGAGQRIGYDPRLVGEAG
CCCCEEECCCEEEEHHHHHCCCCHHEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHHC
LQPFLDCGLTMVPMAANPVDRIWTDRPAAPATACMPQPLAFAGEDSAAKRARMAAILKAD
CCHHHHCCCEEEECCCCCHHHHHCCCCCCCCHHCCCCCCEECCCCHHHHHHHHHHHEECC
GQDAAVLGDPTAIAWLLNVRGHDVQYTPVCLAFAILHDDARVDLFIDPARLPQDTAAWLG
CCCCEEECCCCEEEEEEECCCCCEEECHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCC
PEVTIVEPAGLEAALAALAGRRVRVDPVGTAIWFIQMLEAAGATVARGGDPCVLPRARKN
CCEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCEEECCCCCEECCCHHCC
DVEQDGARRAHLLDGIALCRFLHWMDTEGVGPDSIRPGELDAANRLDAFRALCPDYREES
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
FPAISGAGPNGAVIHYRVTPESSRTIGTDEVYLIDSGGQYPFGTTDVTRTIWTGAGRGPE
CCEECCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCHH
DVRHAFTRVLKGHIALARARFPVGTTGHALDGLARYALWQAGMDYDHGTGHGIGSYLSVH
HHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEC
EGPCSISPVYRPVAVEAGMILSDEPGYYRPGAFGIRLENLLLARPAPAEPNRSFLEFETL
CCCCCCCCCCCCEEEECCEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEEE
TLAPFDRRLIDASLLTAEETAWIDAYHARVCETLAPHLEAAPTAWLHAACAPIGAE
EECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]