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The map label for this gene is moeA [H]

Identifier: 162147708

GI number: 162147708

Start: 1958742

End: 1959947

Strand: Reverse

Name: moeA [H]

Synonym: GDI_1924

Alternate gene names: 162147708

Gene position: 1959947-1958742 (Counterclockwise)

Preceding gene: 162147710

Following gene: 162147707

Centisome position: 49.69

GC content: 71.56

Gene sequence:

>1206_bases
ATGCTGAGCGTGTCCGAGGCCCAGGAGCGAATCCTGGCGGAACTGATTCCCATGGGGCCGGAACTCGTGCCCCTGGCCGA
GGCCTGGGGGCGCGTCGCGGGGGCCGGCATTGCCGCGCGACTGGACAATCCGCCAGCCGATATTTCGGCCATGGACGGAT
ACGCGGTCCAGGCGGCGCACTGCCGGGCCGGTACGACCCTGCCGGTGATCGGCGAGAGCCCCGCCGGCCACCCCTTCCCC
GGCGTCGTCACCCCGGACGGGTGCGTGCGGATCTATACCGGCAGCGTGATGCCCAACGGGGCGGACAGCGTGCTGATCCA
GGAAAACGCGACCGAATCGGACGGGCGGATGACCGCGAGCGCGGACGCCCAGGCGGGCCGGCACATCCGGCGGCGCGGCC
AGGATTTCGCCCTGGGGCAGATCGTGGTGGCCCCCGGACGGCTGCTGCTGGCGCGCGAGGTCGGATTGATAGCGGCGGCC
AATCACGCATGGGTTCCCGTCCACCGGAAGCCGACCGTCGCGATCCTGGCGACGGGCGATGAAATCGCGCTGCCGGGAGA
GACGATCGCGCCGGGGGGAATCGCCAATTCCAACGCCCCGATGCTGGCGGCGCTGGTCCGGGCCTGTGGCGGAACGCCGG
TGATGCTGCCGATCGCGCGCGATGACGAAGCCGAGATCGCGCGGCTGGCCCAGGGCGTCGAGAGTGCGGACCTGCTGCTG
ACCGTGGGGGGGGCGAGCGTCGGCCGCTATGATCTGGTGCAGCGGGCGCTGGAGCGGATCGGGCTGTCGGTCGATTTCTG
GAAGATCGCGATGCGTCCGGGCAAGCCGCTGATGCATGGCCGAATCGGCCGGGTGCCGGTGCTGGGCCTGCCGGGCAATC
CGGTGGCGGCCATGATCTGCGCCATCGTTTTCGCCATGCCGGCAATCCGGGTACTGGCGGGCCGCAGCGACCCGATGGTG
GCGTACGACCTGGCGACACTGGGGGGCGACCTGCCGGCGAACGACCATCGGGCGGACCATCTGCGTGCCCGGCTGGACCG
GGCGGCGGACGGCAGCCTGCTCGCCACCGCGTTCCCGCGACAGGATTCGGCCATGCTGCGCACCCTGGCGGACAGCCAGG
CGTTGATCCTGCGCGCCCCCCACGCCCCTGCGGCCCGGACGGGCGAGCCGTGCCGGATCATCCGCCTGGATACGCTGTCC
ATCTGA

Upstream 100 bases:

>100_bases
TCGGCGGAAAATGCGCATACACAGCCCCGAGGTCAAGCGTTAGTCGCACCGATCGTCCAGATATGTGTGATTCGCGCCAA
AACGGGGGAGAACGGGACCA

Downstream 100 bases:

>100_bases
GATGGCTGACCGGAAATGCGCGCTGCGCGGCACTCTCGCCCACCAGCCCACATTTCCGGGCAGCCTCCGAGGGCTGTTGA
CGGCGCAGGGGGAACCAATA

Product: molybdopterin biosynthesis protein moeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLSVSEAQERILAELIPMGPELVPLAEAWGRVAGAGIAARLDNPPADISAMDGYAVQAAHCRAGTTLPVIGESPAGHPFP
GVVTPDGCVRIYTGSVMPNGADSVLIQENATESDGRMTASADAQAGRHIRRRGQDFALGQIVVAPGRLLLAREVGLIAAA
NHAWVPVHRKPTVAILATGDEIALPGETIAPGGIANSNAPMLAALVRACGGTPVMLPIARDDEAEIARLAQGVESADLLL
TVGGASVGRYDLVQRALERIGLSVDFWKIAMRPGKPLMHGRIGRVPVLGLPGNPVAAMICAIVFAMPAIRVLAGRSDPMV
AYDLATLGGDLPANDHRADHLRARLDRAADGSLLATAFPRQDSAMLRTLADSQALILRAPHAPAARTGEPCRIIRLDTLS
I

Sequences:

>Translated_401_residues
MLSVSEAQERILAELIPMGPELVPLAEAWGRVAGAGIAARLDNPPADISAMDGYAVQAAHCRAGTTLPVIGESPAGHPFP
GVVTPDGCVRIYTGSVMPNGADSVLIQENATESDGRMTASADAQAGRHIRRRGQDFALGQIVVAPGRLLLAREVGLIAAA
NHAWVPVHRKPTVAILATGDEIALPGETIAPGGIANSNAPMLAALVRACGGTPVMLPIARDDEAEIARLAQGVESADLLL
TVGGASVGRYDLVQRALERIGLSVDFWKIAMRPGKPLMHGRIGRVPVLGLPGNPVAAMICAIVFAMPAIRVLAGRSDPMV
AYDLATLGGDLPANDHRADHLRARLDRAADGSLLATAFPRQDSAMLRTLADSQALILRAPHAPAARTGEPCRIIRLDTLS
I
>Mature_401_residues
MLSVSEAQERILAELIPMGPELVPLAEAWGRVAGAGIAARLDNPPADISAMDGYAVQAAHCRAGTTLPVIGESPAGHPFP
GVVTPDGCVRIYTGSVMPNGADSVLIQENATESDGRMTASADAQAGRHIRRRGQDFALGQIVVAPGRLLLAREVGLIAAA
NHAWVPVHRKPTVAILATGDEIALPGETIAPGGIANSNAPMLAALVRACGGTPVMLPIARDDEAEIARLAQGVESADLLL
TVGGASVGRYDLVQRALERIGLSVDFWKIAMRPGKPLMHGRIGRVPVLGLPGNPVAAMICAIVFAMPAIRVLAGRSDPMV
AYDLATLGGDLPANDHRADHLRARLDRAADGSLLATAFPRQDSAMLRTLADSQALILRAPHAPAARTGEPCRIIRLDTLS
I

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=385, Percent_Identity=30.3896103896104, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI10880983, Length=383, Percent_Identity=30.5483028720627, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1787049, Length=380, Percent_Identity=34.2105263157895, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25147659, Length=368, Percent_Identity=30.1630434782609, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=358, Percent_Identity=24.0223463687151, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136978, Length=379, Percent_Identity=28.7598944591029, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24638841, Length=379, Percent_Identity=28.7598944591029, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41804; Mature: 41804

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVSEAQERILAELIPMGPELVPLAEAWGRVAGAGIAARLDNPPADISAMDGYAVQAAH
CCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEC
CRAGTTLPVIGESPAGHPFPGVVTPDGCVRIYTGSVMPNGADSVLIQENATESDGRMTAS
CCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCEEEC
ADAQAGRHIRRRGQDFALGQIVVAPGRLLLAREVGLIAAANHAWVPVHRKPTVAILATGD
CCHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCEEEECCCCEEEECCCCCEEEEECCC
EIALPGETIAPGGIANSNAPMLAALVRACGGTPVMLPIARDDEAEIARLAQGVESADLLL
CEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCEEEE
TVGGASVGRYDLVQRALERIGLSVDFWKIAMRPGKPLMHGRIGRVPVLGLPGNPVAAMIC
EECCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCHHCCCCCCCEEEECCCCHHHHHHH
AIVFAMPAIRVLAGRSDPMVAYDLATLGGDLPANDHRADHLRARLDRAADGSLLATAFPR
HHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCC
QDSAMLRTLADSQALILRAPHAPAARTGEPCRIIRLDTLSI
CHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MLSVSEAQERILAELIPMGPELVPLAEAWGRVAGAGIAARLDNPPADISAMDGYAVQAAH
CCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEC
CRAGTTLPVIGESPAGHPFPGVVTPDGCVRIYTGSVMPNGADSVLIQENATESDGRMTAS
CCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCEEEC
ADAQAGRHIRRRGQDFALGQIVVAPGRLLLAREVGLIAAANHAWVPVHRKPTVAILATGD
CCHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCEEEECCCCEEEECCCCCEEEEECCC
EIALPGETIAPGGIANSNAPMLAALVRACGGTPVMLPIARDDEAEIARLAQGVESADLLL
CEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCEEEE
TVGGASVGRYDLVQRALERIGLSVDFWKIAMRPGKPLMHGRIGRVPVLGLPGNPVAAMIC
EECCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCHHCCCCCCCEEEECCCCHHHHHHH
AIVFAMPAIRVLAGRSDPMVAYDLATLGGDLPANDHRADHLRARLDRAADGSLLATAFPR
HHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCC
QDSAMLRTLADSQALILRAPHAPAARTGEPCRIIRLDTLSI
CHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]