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The map label for this gene is moaA [H]

Identifier: 162147685

GI number: 162147685

Start: 1937212

End: 1938228

Strand: Direct

Name: moaA [H]

Synonym: GDI_1901

Alternate gene names: 162147685

Gene position: 1937212-1938228 (Clockwise)

Preceding gene: 162147684

Following gene: 162147687

Centisome position: 49.12

GC content: 66.27

Gene sequence:

>1017_bases
ATGGGTAAGCCTTTCGTCGATTCCTTCGGCCGGACAGTCTCTTATTTGCGGATCTCGGTAACGGACCGCTGCGACATGCG
ATGCGTCTATTGCATGTCGGAGGCCATGTCCTTCCTGCCCAAGGCCGAAATCCTGTCCTTCGAGGAGATGGAGCGACTCT
GCGCCGCCTTCATCCGCAACGGCGTGACGCGCATCCGCGTCACGGGCGGGGAGCCGCTGGTTCGCCGGGATATCGACGGG
TTCTTCGCGGCCCTGGGGACGTGGCTGCATCGGACGGATGGCGACGGCCATCTGGACGAACTGACATTGACCACCAACGG
ATCGCATCTGGCGACCCACGCCGACGCCCTGGCCCGCGCGGGGGTACGACGTGTGAATATCAGCCTGGACTCTCTTGATT
CTAAACGATTTCAGCGTATCACCCGGCGGGGTCGGCTGGAGCAGACCCTGGAAGGAATCCGCGCGGCACGGGCGGCCGGG
CTGGCCATTCGCATCAATACCGTCGCGATGGCCGGCGTGAATGACGACGAATTCGACACGCTGCTGGCGTGGTGTGGGGA
AATCGGCGCCGATCTCTGCCTGATCGAAACCATGCCGATGGGGGACACGGGCGAGGACCGGTCCGACCGTTACCTGCCGC
TGTCCACCGTCCGCGCGGACCTGGCGCGGCGCTGGACGCTGGAACCGCTGACGGTCCGGACGGGCGGGCCGGCGCGCTAC
CTGCGGGTGGGCGAGACCGGGTGCAAGCTCGGCCTGATCACGCCGATGACCCATAATTTCTGCGAAAGCTGCAACCGGGT
GCGGCTGTCCTGCACCGGCCAGCTTTATACCTGCCTGGGGCATGAAGGGGCCACCGACCTGCGCCAGCCGCTCCGCGAGG
GCGCCACCGATCCCGACCTGCTGCGCCTGGTCCAGGCGGCCATCCAGCGCAAGCCGAAAGGGCATGACTTCCTGATCGGG
CGCCACGCAGACGACCCCGCCGCCATCCGCAGGCACATGAGCGTCACCGGCGGGTAA

Upstream 100 bases:

>100_bases
GCCGTTGCCCATCGGGTGACGGTCAATTTCGAACATCAGGGCAAGATCCTGATCGATGCCTCGGTCATCATGCTGACCGT
CATTTCCTGAAGGCCGGATC

Downstream 100 bases:

>100_bases
AATAGACAGACAATATTGTATAATCAGTCTGTTATTATATTTTCTTGATCGCATCTTCCAACGACACGGTGAACTGGCCG
GGGCGTAGCGGCTGGGGCTG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MGKPFVDSFGRTVSYLRISVTDRCDMRCVYCMSEAMSFLPKAEILSFEEMERLCAAFIRNGVTRIRVTGGEPLVRRDIDG
FFAALGTWLHRTDGDGHLDELTLTTNGSHLATHADALARAGVRRVNISLDSLDSKRFQRITRRGRLEQTLEGIRAARAAG
LAIRINTVAMAGVNDDEFDTLLAWCGEIGADLCLIETMPMGDTGEDRSDRYLPLSTVRADLARRWTLEPLTVRTGGPARY
LRVGETGCKLGLITPMTHNFCESCNRVRLSCTGQLYTCLGHEGATDLRQPLREGATDPDLLRLVQAAIQRKPKGHDFLIG
RHADDPAAIRRHMSVTGG

Sequences:

>Translated_338_residues
MGKPFVDSFGRTVSYLRISVTDRCDMRCVYCMSEAMSFLPKAEILSFEEMERLCAAFIRNGVTRIRVTGGEPLVRRDIDG
FFAALGTWLHRTDGDGHLDELTLTTNGSHLATHADALARAGVRRVNISLDSLDSKRFQRITRRGRLEQTLEGIRAARAAG
LAIRINTVAMAGVNDDEFDTLLAWCGEIGADLCLIETMPMGDTGEDRSDRYLPLSTVRADLARRWTLEPLTVRTGGPARY
LRVGETGCKLGLITPMTHNFCESCNRVRLSCTGQLYTCLGHEGATDLRQPLREGATDPDLLRLVQAAIQRKPKGHDFLIG
RHADDPAAIRRHMSVTGG
>Mature_337_residues
GKPFVDSFGRTVSYLRISVTDRCDMRCVYCMSEAMSFLPKAEILSFEEMERLCAAFIRNGVTRIRVTGGEPLVRRDIDGF
FAALGTWLHRTDGDGHLDELTLTTNGSHLATHADALARAGVRRVNISLDSLDSKRFQRITRRGRLEQTLEGIRAARAAGL
AIRINTVAMAGVNDDEFDTLLAWCGEIGADLCLIETMPMGDTGEDRSDRYLPLSTVRADLARRWTLEPLTVRTGGPARYL
RVGETGCKLGLITPMTHNFCESCNRVRLSCTGQLYTCLGHEGATDLRQPLREGATDPDLLRLVQAAIQRKPKGHDFLIGR
HADDPAAIRRHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=35.1681957186544, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=35.1681957186544, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1786999, Length=341, Percent_Identity=33.7243401759531, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32566331, Length=327, Percent_Identity=30.8868501529052, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=315, Percent_Identity=31.4285714285714, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17561210, Length=315, Percent_Identity=31.1111111111111, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28574490, Length=315, Percent_Identity=36.1904761904762, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574488, Length=315, Percent_Identity=36.1904761904762, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37378; Mature: 37247

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKPFVDSFGRTVSYLRISVTDRCDMRCVYCMSEAMSFLPKAEILSFEEMERLCAAFIRN
CCCCCHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHC
GVTRIRVTGGEPLVRRDIDGFFAALGTWLHRTDGDGHLDELTLTTNGSHLATHADALARA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHC
GVRRVNISLDSLDSKRFQRITRRGRLEQTLEGIRAARAAGLAIRINTVAMAGVNDDEFDT
CCEEEEEEHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHH
LLAWCGEIGADLCLIETMPMGDTGEDRSDRYLPLSTVRADLARRWTLEPLTVRTGGPARY
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEEE
LRVGETGCKLGLITPMTHNFCESCNRVRLSCTGQLYTCLGHEGATDLRQPLREGATDPDL
EEECCCCCEEEEECCCHHHHHHCCCCEEEEECCEEEEECCCCCCHHHHHHHHCCCCCHHH
LRLVQAAIQRKPKGHDFLIGRHADDPAAIRRHMSVTGG
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
GKPFVDSFGRTVSYLRISVTDRCDMRCVYCMSEAMSFLPKAEILSFEEMERLCAAFIRN
CCCCHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHC
GVTRIRVTGGEPLVRRDIDGFFAALGTWLHRTDGDGHLDELTLTTNGSHLATHADALARA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHC
GVRRVNISLDSLDSKRFQRITRRGRLEQTLEGIRAARAAGLAIRINTVAMAGVNDDEFDT
CCEEEEEEHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHH
LLAWCGEIGADLCLIETMPMGDTGEDRSDRYLPLSTVRADLARRWTLEPLTVRTGGPARY
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEEE
LRVGETGCKLGLITPMTHNFCESCNRVRLSCTGQLYTCLGHEGATDLRQPLREGATDPDL
EEECCCCCEEEEECCCHHHHHHCCCCEEEEECCEEEEECCCCCCHHHHHHHHCCCCCHHH
LRLVQAAIQRKPKGHDFLIGRHADDPAAIRRHMSVTGG
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]