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The map label for this gene is frmA [H]

Identifier: 162147636

GI number: 162147636

Start: 1890469

End: 1891584

Strand: Direct

Name: frmA [H]

Synonym: GDI_1852

Alternate gene names: 162147636

Gene position: 1890469-1891584 (Clockwise)

Preceding gene: 162147633

Following gene: 162147637

Centisome position: 47.93

GC content: 66.22

Gene sequence:

>1116_bases
ATGGATGTCAGAGCGGCTGTCGCCTTCGAGGCAGGCAAACCCCTTGAAATCGAAACCGTCCAGCTCGAAGGCCCCCGCGC
GGGCGAGGTCCTGGTCGAGATCAGGGCCACGGGCCTGTGCCATACCGACAAGTTCACCCTGTCCGGCGCGGACCCCGAGG
GGCTGTTCCCCGCCATCCTGGGGCACGAGGGCGCCGGCGTGGTGGTCGAGGTCGGGCCGGGGGTGACGCACCTGAAGCCC
GGCGACCACGTGATCCCGCTCTACACCCCCGAATGCCGCGAATGTAAATCCTGCCTGTCGCGCAAGACCAACCTGTGTAC
CGCGATCCGCTCGACGCAGGGAAAGGGCCTGATGCCCGACGGCACGTCGCGCTTTTCCTACAAGGGGCGGCCGATCCGTC
ATTACATGGGCTGCTCGACCTTCGCGAACTACACGGTCCTGCCCGAGATCGCGCTGGCGAAAATCCGCCCCGACGCGCCG
TTCGACAAGGTCTGCTATATCGGCTGCGGCGTCACCACCGGCATCGGCGCGGTCCTGTTTACCGCCAAGGTGGAAACGGG
ATCGACCGTCGTGGTGTTCGGCCTGGGCGGGATCGGTCTGAACGTCATCCAGGGGGCCAGGATGGTGGGGGCCGACATGA
TCGTCGGCGTCGACATCAATCCGGCGCGCGAGGCGATGGCGCGCAAGTTCGGCATGACGCATTTCGTCAATCCGAAGGAC
CTGGGGCCCGACGGCGACATCGTCGGCCATCTGGTCGAACTGACGGGCGGCGGCGCGGATTATTCGTTCGAATGCGTGGG
CAACCCGACGCTGATGCGCCAGGCGCTGGAATGTTCCCATCGCGGCTGGGGTCTTTCGACCATCATCGGCGTGGCCGGTG
CGGGGCAGGAAATCAGCACCCGCCCGTTCCAACTCGTCACCGGCCGGCGGTGGATCGGCTCGGCCTTCGGCGGCGCGCGC
GGGCGCACGGACGTGCCGAAGATCGTGGACTGGTACATGGAGGGCAAGATCAACATCGACGACCTGATCACCCACACGCT
GCCGCTGTCGCGCATCAACGAGGGATTCGACCTGATGGCGCGGGGCGAGAGCATCCGCACCGTCGTCGAATTCTGA

Upstream 100 bases:

>100_bases
GGCGCGGGGCACGGGCCCGATCCGCGCCATTGACCATGCCAATACCAGGGGGCTTTATGGCCCAGACGATTCCAGATCCG
ACACGGGGAGTATCGTAGTC

Downstream 100 bases:

>100_bases
TCCGATGCCGATTACCACCCGCGAGACGCATGCGTGCTGCGGCGGCACGGTCGGATATTACAGCCATCTGTCCGACAGCC
TGGGGCTGGAGGCGCGCTTC

Product: alcohol dehydrogenase class 3

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MDVRAAVAFEAGKPLEIETVQLEGPRAGEVLVEIRATGLCHTDKFTLSGADPEGLFPAILGHEGAGVVVEVGPGVTHLKP
GDHVIPLYTPECRECKSCLSRKTNLCTAIRSTQGKGLMPDGTSRFSYKGRPIRHYMGCSTFANYTVLPEIALAKIRPDAP
FDKVCYIGCGVTTGIGAVLFTAKVETGSTVVVFGLGGIGLNVIQGARMVGADMIVGVDINPAREAMARKFGMTHFVNPKD
LGPDGDIVGHLVELTGGGADYSFECVGNPTLMRQALECSHRGWGLSTIIGVAGAGQEISTRPFQLVTGRRWIGSAFGGAR
GRTDVPKIVDWYMEGKINIDDLITHTLPLSRINEGFDLMARGESIRTVVEF

Sequences:

>Translated_371_residues
MDVRAAVAFEAGKPLEIETVQLEGPRAGEVLVEIRATGLCHTDKFTLSGADPEGLFPAILGHEGAGVVVEVGPGVTHLKP
GDHVIPLYTPECRECKSCLSRKTNLCTAIRSTQGKGLMPDGTSRFSYKGRPIRHYMGCSTFANYTVLPEIALAKIRPDAP
FDKVCYIGCGVTTGIGAVLFTAKVETGSTVVVFGLGGIGLNVIQGARMVGADMIVGVDINPAREAMARKFGMTHFVNPKD
LGPDGDIVGHLVELTGGGADYSFECVGNPTLMRQALECSHRGWGLSTIIGVAGAGQEISTRPFQLVTGRRWIGSAFGGAR
GRTDVPKIVDWYMEGKINIDDLITHTLPLSRINEGFDLMARGESIRTVVEF
>Mature_371_residues
MDVRAAVAFEAGKPLEIETVQLEGPRAGEVLVEIRATGLCHTDKFTLSGADPEGLFPAILGHEGAGVVVEVGPGVTHLKP
GDHVIPLYTPECRECKSCLSRKTNLCTAIRSTQGKGLMPDGTSRFSYKGRPIRHYMGCSTFANYTVLPEIALAKIRPDAP
FDKVCYIGCGVTTGIGAVLFTAKVETGSTVVVFGLGGIGLNVIQGARMVGADMIVGVDINPAREAMARKFGMTHFVNPKD
LGPDGDIVGHLVELTGGGADYSFECVGNPTLMRQALECSHRGWGLSTIIGVAGAGQEISTRPFQLVTGRRWIGSAFGGAR
GRTDVPKIVDWYMEGKINIDDLITHTLPLSRINEGFDLMARGESIRTVVEF

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=59.0296495956873, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=47.7453580901857, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=46.0916442048518, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=45.822102425876, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI262073058, Length=373, Percent_Identity=45.0402144772118, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI71743840, Length=373, Percent_Identity=45.0402144772118, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=45.5525606469003, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=43.7158469945355, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=43.8888888888889, Blast_Score=310, Evalue=1e-84,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=61.1859838274933, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI87082125, Length=384, Percent_Identity=27.0833333333333, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790045, Length=357, Percent_Identity=27.7310924369748, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=25.1412429378531, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=397, Percent_Identity=26.448362720403, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI226510992, Length=366, Percent_Identity=25.9562841530055, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081918, Length=354, Percent_Identity=27.4011299435028, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=359, Percent_Identity=24.5125348189415, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788407, Length=227, Percent_Identity=28.6343612334802, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=367, Percent_Identity=25.6130790190736, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=55.4959785522788, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=55.2, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=55.3935860058309, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562584, Length=375, Percent_Identity=29.0666666666667, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=26.4150943396226, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=381, Percent_Identity=27.0341207349081, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=55.1630434782609, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319621, Length=374, Percent_Identity=29.4117647058824, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324486, Length=375, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=391, Percent_Identity=27.3657289002558, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=358, Percent_Identity=27.9329608938547, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=358, Percent_Identity=27.9329608938547, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=368, Percent_Identity=26.3586956521739, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=376, Percent_Identity=26.063829787234, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=341, Percent_Identity=25.8064516129032, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=60.8695652173913, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI17137530, Length=343, Percent_Identity=27.6967930029155, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39575; Mature: 39575

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRAAVAFEAGKPLEIETVQLEGPRAGEVLVEIRATGLCHTDKFTLSGADPEGLFPAIL
CCCEEEEEECCCCCEEEEEEEECCCCCCEEEEEEEECCCEECCEEEECCCCCCCCCHHHH
GHEGAGVVVEVGPGVTHLKPGDHVIPLYTPECRECKSCLSRKTNLCTAIRSTQGKGLMPD
CCCCCEEEEECCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GTSRFSYKGRPIRHYMGCSTFANYTVLPEIALAKIRPDAPFDKVCYIGCGVTTGIGAVLF
CCCCCCCCCCCHHHHHCCHHHCCCEECCCHHEEEECCCCCCCCEEEEECCHHHCCCEEEE
TAKVETGSTVVVFGLGGIGLNVIQGARMVGADMIVGVDINPAREAMARKFGMTHFVNPKD
EEEECCCCEEEEEECCCCCHHHHHCCEEECCEEEEEECCCHHHHHHHHHHCCCCCCCCCC
LGPDGDIVGHLVELTGGGADYSFECVGNPTLMRQALECSHRGWGLSTIIGVAGAGQEIST
CCCCCHHHEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCC
RPFQLVTGRRWIGSAFGGARGRTDVPKIVDWYMEGKINIDDLITHTLPLSRINEGFDLMA
CCEEEEECCHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCEEEE
RGESIRTVVEF
CCCCHHHEECC
>Mature Secondary Structure
MDVRAAVAFEAGKPLEIETVQLEGPRAGEVLVEIRATGLCHTDKFTLSGADPEGLFPAIL
CCCEEEEEECCCCCEEEEEEEECCCCCCEEEEEEEECCCEECCEEEECCCCCCCCCHHHH
GHEGAGVVVEVGPGVTHLKPGDHVIPLYTPECRECKSCLSRKTNLCTAIRSTQGKGLMPD
CCCCCEEEEECCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GTSRFSYKGRPIRHYMGCSTFANYTVLPEIALAKIRPDAPFDKVCYIGCGVTTGIGAVLF
CCCCCCCCCCCHHHHHCCHHHCCCEECCCHHEEEECCCCCCCCEEEEECCHHHCCCEEEE
TAKVETGSTVVVFGLGGIGLNVIQGARMVGADMIVGVDINPAREAMARKFGMTHFVNPKD
EEEECCCCEEEEEECCCCCHHHHHCCEEECCEEEEEECCCHHHHHHHHHHCCCCCCCCCC
LGPDGDIVGHLVELTGGGADYSFECVGNPTLMRQALECSHRGWGLSTIIGVAGAGQEIST
CCCCCHHHEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCC
RPFQLVTGRRWIGSAFGGARGRTDVPKIVDWYMEGKINIDDLITHTLPLSRINEGFDLMA
CCEEEEECCHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCEEEE
RGESIRTVVEF
CCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]