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The map label for this gene is mutM

Identifier: 162147553

GI number: 162147553

Start: 1796591

End: 1797451

Strand: Direct

Name: mutM

Synonym: GDI_1769

Alternate gene names: 162147553

Gene position: 1796591-1797451 (Clockwise)

Preceding gene: 162147548

Following gene: 162147554

Centisome position: 45.55

GC content: 69.11

Gene sequence:

>861_bases
ATGCCGGAACTCCCTGAAGTCGAAACAGTGATGCGCGGGATGCGATTGCATCTCGACGGGAAGACGATCGCGCGGGTCGC
GGTGCGTCGCGCCGACCTGCGTTTCCCCTTTCCCGCGGACCTGGTGGCCCGGCTGGAGGGCGCCACGATCACCGGTTTCG
CCCGACGGGCGAAATATATCCTGATCCGGCTGGATACGGGCGATACCCTGCTGCTGCACCTGGGCATGTCGGGGCGGGTC
CTGCTGTCATTGCCCGGCGACGCCCCCGTGCCCGACCGGCACGAGCATTTCTTCTTCGAGACCACGGACGGGACGCGGTG
CGGCCTGATCGACCCCAGGCGCTTCGGCGCGGTCGACCTGATGCCGACGGCGGAGGAGCGAGCACATCGGCTGCTGGCCC
GACTCGGTCCCGAACCGCTGGGCAACCAGTTCTCGCAACACTGGCTGCAGGAAGTACTGGCCCGGCGGCGGACCTCCATC
AAGGCGGCGCTGCTGGACCAGACGGTGGTGGCGGGCCTGGGCAATATCTATGTGTCCGAGGCGCTGTTCCGCGCCGGCAT
CCATCCGGCACGCCTGGCCTGCACCCTGGACGCGGCCGAGGACGCGCGCCTGGTCCAGGCGATCCGCGCCGTGCTGCGCG
AAGCGATCGCAGCGGGCGGGTCCAGCCTGCGCGACTATGTCCAGCCGGATGGGGAACTGGGTTATTTCCAGCACGCGTGG
CGTGTCTACGGCCGTGCGGGGCAGGGATGCCCGGATTGTCCCGGTCCCCCCGCATGCCATGGTGTGGAGCGGCTGGAACA
GGCCGGACGCTCCAGCTTCTTCTGCCCCCTGTGCCAGCCCCCGCCGGGCAAGGTCTCGTGA

Upstream 100 bases:

>100_bases
GTCCCCGTTCCAGTGGCATCGGGGCCGGCGGGATGGGGCGCGAACGGAGAGGGGGTGGGATTGTCGGTCATGTCCCAGGG
ATATAACCTCAGATCCGCTC

Downstream 100 bases:

>100_bases
GAATGGATGCTCCGCGAAGACTTGTCTTGACGGGGGACAAGGGCATGGACTAGATCGCCAGCCTGATCTGGATGTCCGCG
CATATCAGGGGCGGACCTCG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPELPEVETVMRGMRLHLDGKTIARVAVRRADLRFPFPADLVARLEGATITGFARRAKYILIRLDTGDTLLLHLGMSGRV
LLSLPGDAPVPDRHEHFFFETTDGTRCGLIDPRRFGAVDLMPTAEERAHRLLARLGPEPLGNQFSQHWLQEVLARRRTSI
KAALLDQTVVAGLGNIYVSEALFRAGIHPARLACTLDAAEDARLVQAIRAVLREAIAAGGSSLRDYVQPDGELGYFQHAW
RVYGRAGQGCPDCPGPPACHGVERLEQAGRSSFFCPLCQPPPGKVS

Sequences:

>Translated_286_residues
MPELPEVETVMRGMRLHLDGKTIARVAVRRADLRFPFPADLVARLEGATITGFARRAKYILIRLDTGDTLLLHLGMSGRV
LLSLPGDAPVPDRHEHFFFETTDGTRCGLIDPRRFGAVDLMPTAEERAHRLLARLGPEPLGNQFSQHWLQEVLARRRTSI
KAALLDQTVVAGLGNIYVSEALFRAGIHPARLACTLDAAEDARLVQAIRAVLREAIAAGGSSLRDYVQPDGELGYFQHAW
RVYGRAGQGCPDCPGPPACHGVERLEQAGRSSFFCPLCQPPPGKVS
>Mature_285_residues
PELPEVETVMRGMRLHLDGKTIARVAVRRADLRFPFPADLVARLEGATITGFARRAKYILIRLDTGDTLLLHLGMSGRVL
LSLPGDAPVPDRHEHFFFETTDGTRCGLIDPRRFGAVDLMPTAEERAHRLLARLGPEPLGNQFSQHWLQEVLARRRTSIK
AALLDQTVVAGLGNIYVSEALFRAGIHPARLACTLDAAEDARLVQAIRAVLREAIAAGGSSLRDYVQPDGELGYFQHAWR
VYGRAGQGCPDCPGPPACHGVERLEQAGRSSFFCPLCQPPPGKVS

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=279, Percent_Identity=43.010752688172, Blast_Score=216, Evalue=1e-57,
Organism=Escherichia coli, GI1786932, Length=282, Percent_Identity=25.531914893617, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_GLUDA (A9HI30)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602014.1
- RefSeq:   YP_002277888.1
- ProteinModelPortal:   A9HI30
- SMR:   A9HI30
- GeneID:   5790022
- GeneID:   6977003
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_3550
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK01103
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31344; Mature: 31212

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 270-270 BINDING 94-94 BINDING 113-113 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVMRGMRLHLDGKTIARVAVRRADLRFPFPADLVARLEGATITGFARRAKYI
CCCCCHHHHHHCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEHHHHHCCEEE
LIRLDTGDTLLLHLGMSGRVLLSLPGDAPVPDRHEHFFFETTDGTRCGLIDPRRFGAVDL
EEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCEECCCCCHHCCCEEC
MPTAEERAHRLLARLGPEPLGNQFSQHWLQEVLARRRTSIKAALLDQTVVAGLGNIYVSE
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFRAGIHPARLACTLDAAEDARLVQAIRAVLREAIAAGGSSLRDYVQPDGELGYFQHAW
HHHHHCCCHHHEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHH
RVYGRAGQGCPDCPGPPACHGVERLEQAGRSSFFCPLCQPPPGKVS
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVMRGMRLHLDGKTIARVAVRRADLRFPFPADLVARLEGATITGFARRAKYI
CCCCHHHHHHCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEHHHHHCCEEE
LIRLDTGDTLLLHLGMSGRVLLSLPGDAPVPDRHEHFFFETTDGTRCGLIDPRRFGAVDL
EEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCEECCCCCHHCCCEEC
MPTAEERAHRLLARLGPEPLGNQFSQHWLQEVLARRRTSIKAALLDQTVVAGLGNIYVSE
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFRAGIHPARLACTLDAAEDARLVQAIRAVLREAIAAGGSSLRDYVQPDGELGYFQHAW
HHHHHCCCHHHEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHH
RVYGRAGQGCPDCPGPPACHGVERLEQAGRSSFFCPLCQPPPGKVS
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA