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The map label for this gene is msrA [H]

Identifier: 162147548

GI number: 162147548

Start: 1790319

End: 1790897

Strand: Direct

Name: msrA [H]

Synonym: GDI_1764

Alternate gene names: 162147548

Gene position: 1790319-1790897 (Clockwise)

Preceding gene: 162147547

Following gene: 162147553

Centisome position: 45.39

GC content: 65.11

Gene sequence:

>579_bases
GTGGAAGGAAGGCGGATAATGGATGACATGACGCGAGCCCCCCGGACGGAGGTCGCCTATCTGGGCGGAGGCTGTTTCTG
GTGCGTCGAGGCGATGCTGCGGGAACTGGCTGGGATCACGGACGTGGCGCCGGGCTATGCCGGCGGCACGCTGGCGGCCC
CGACATACGAACAGGTCTGCAGCGGGCGGACCGGCCATGCCGAGATCGTGCGCGTCACGTTCGACCCCGCGATCCTGTCC
TATGCCGACCTGGTGCGGATTTTCTTCACGATCCACGACCCTACCACCCTGAATCGGCAGGGGCCGGATTCCGGCACCCA
GTACCGGTCGGTCATCTTCACCGCGACACCGGAACAGGCGGCCACCGCCCGCGCGGTCCGCGATGAAATCGCCGCGTCGA
AACTCTGGGCCGACCCGATCGTCACCGAGATCCTGCCCCTGGAGCAGTTCTACGAGGCCGAAGATTATCACCACAATTAT
TTCGCGAAGCATCCCGAACGGGGATATTGCGCGGCGGTGATCTCACCCAAGGTGTCGAAGGTGCGACGGTCGTTCCAGGA
CCGGCTGGCGCTGGGGTAG

Upstream 100 bases:

>100_bases
GGTTGGCCTGATCCACGCGCCCCCATCACCATCCCTTCTCTTTTAATCGGGTGGCGGGCGTCACATCTTGCAGGGAACGA
ACGCCCCCGGAGCGTGAGGG

Downstream 100 bases:

>100_bases
GAAAGTATATCGGCCGATCACTCCATCTCGTCATCCAGGAACAACTGGTCCGCTTCCTCGTCGAAATCGAACAGTTCGGC
GTAGCGGGCCCAGCCGATCA

Product: peptide methionine sulfoxide reductase msrA

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MEGRRIMDDMTRAPRTEVAYLGGGCFWCVEAMLRELAGITDVAPGYAGGTLAAPTYEQVCSGRTGHAEIVRVTFDPAILS
YADLVRIFFTIHDPTTLNRQGPDSGTQYRSVIFTATPEQAATARAVRDEIAASKLWADPIVTEILPLEQFYEAEDYHHNY
FAKHPERGYCAAVISPKVSKVRRSFQDRLALG

Sequences:

>Translated_192_residues
MEGRRIMDDMTRAPRTEVAYLGGGCFWCVEAMLRELAGITDVAPGYAGGTLAAPTYEQVCSGRTGHAEIVRVTFDPAILS
YADLVRIFFTIHDPTTLNRQGPDSGTQYRSVIFTATPEQAATARAVRDEIAASKLWADPIVTEILPLEQFYEAEDYHHNY
FAKHPERGYCAAVISPKVSKVRRSFQDRLALG
>Mature_192_residues
MEGRRIMDDMTRAPRTEVAYLGGGCFWCVEAMLRELAGITDVAPGYAGGTLAAPTYEQVCSGRTGHAEIVRVTFDPAILS
YADLVRIFFTIHDPTTLNRQGPDSGTQYRSVIFTATPEQAATARAVRDEIAASKLWADPIVTEILPLEQFYEAEDYHHNY
FAKHPERGYCAAVISPKVSKVRRSFQDRLALG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=158, Percent_Identity=42.4050632911392, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=42.4050632911392, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=42.3423423423423, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1790665, Length=160, Percent_Identity=48.125, Blast_Score=147, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=34.4827586206897, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=36.5853658536585, Blast_Score=120, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24664627, Length=164, Percent_Identity=30.4878048780488, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45553131, Length=158, Percent_Identity=30.379746835443, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664631, Length=164, Percent_Identity=29.8780487804878, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 21290; Mature: 21290

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGRRIMDDMTRAPRTEVAYLGGGCFWCVEAMLRELAGITDVAPGYAGGTLAAPTYEQVC
CCCCHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
SGRTGHAEIVRVTFDPAILSYADLVRIFFTIHDPTTLNRQGPDSGTQYRSVIFTATPEQA
CCCCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCHHH
ATARAVRDEIAASKLWADPIVTEILPLEQFYEAEDYHHNYFAKHPERGYCAAVISPKVSK
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHCCCCCCCEEEEECCHHHHH
VRRSFQDRLALG
HHHHHHHHHCCC
>Mature Secondary Structure
MEGRRIMDDMTRAPRTEVAYLGGGCFWCVEAMLRELAGITDVAPGYAGGTLAAPTYEQVC
CCCCHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
SGRTGHAEIVRVTFDPAILSYADLVRIFFTIHDPTTLNRQGPDSGTQYRSVIFTATPEQA
CCCCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCHHH
ATARAVRDEIAASKLWADPIVTEILPLEQFYEAEDYHHNYFAKHPERGYCAAVISPKVSK
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHCCCCCCCEEEEECCHHHHH
VRRSFQDRLALG
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA