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The map label for this gene is shc [H]

Identifier: 162147405

GI number: 162147405

Start: 1629496

End: 1631487

Strand: Reverse

Name: shc [H]

Synonym: GDI_1620

Alternate gene names: 162147405

Gene position: 1631487-1629496 (Counterclockwise)

Preceding gene: 162147406

Following gene: 162147404

Centisome position: 41.36

GC content: 68.12

Gene sequence:

>1992_bases
ATGATGGCGAACGCGACCGATACAATCGAACTCCCCCCGTCCCGCGCGGCGGACCGGATCGTGCCGATGACCGACATCGA
CCAGGCGGTCGATGCGGCGCATGCGGCACTCGGCCGCCGGCAGCAGGATGACGGGCACTGGGTGTTCGAGCTGGAGGCCG
ATGCCACCATCCCGGCGGAATATGTCTTGCTGGAACATTACCTGGACCGGATCGACCCGGCGCTGGAGGAGCGGATCGGC
GTCTATCTGCGCCGCATCCAGGGCGACCATGGCGGCTGGCCGCTCTATCACGGCGGCAAGTTCGACGTCTCGGCCACGGT
CAAGGCCTATTTCGCGCTGAAGGCGATCGGCGACGATATCGACGCCCCGCACATGGCGCGCGCCCGCGCGGCGATCCTGG
ATCATGGCGGGGCCGAGCGCAGCAACGTCTTCACCCGCTTCCAGCTTGCCCTGTTCGGCGAGGTCCCGTGGCATGCGACG
CCGGTGATGCCGGTGGAACTGATGCTGCTGCCGCGCAAGGCGCTGTTTTCGGTCTGGAACATGTCCTACTGGTCGCGGAC
GGTCATCGCGCCGCTGCTGGTGCTGGCCGCGCTGCGCCCGCGCGCGATCAATCCGCGCGACGTGCATGTGCCCGAACTGT
TCGTCACCCCGCCGGACCAGGTGCGGGACTGGATTCGCGGCCCCTACCGGTCGCAGCTTGGGCGCCTGTTCAAATATGTG
GACATCGCCCTGCGCCCGGCCGAACGGCTGATCCCCGACGCCACGCGGCAGCGCGCGATCAAGGCGGCGGTCGATTTCAT
CGAACCCCGCCTGAATGGCGAGGACGGGCTGGGCGCGATCTATCCCGCCATGGCCAACACGGTGATGATGTATCGCGCCC
TGGGCGTGCCCGACAGCGACCCGCGCGCCGCCACGGCGTGGGAGGCCGTGCGCAGGCTGCTGGTCGAACTGGACGGCGAG
GCCTATTGCCAGCCCTGCGTCTCGCCGATCTGGGACACCGGCCTGGCCGGCCATGCGATGATCGAGGCCGCGTCCGGCCC
CAAGGGCATCCGCCCCGAGGACACGAAGAAGAAGCTGGCCGCCGCCGCCGAATGGCTGCGCGAGCGCCAGATCCTGAACG
GGGAAGGGCGACTGGGCGATCAACTGCCCCGACGTGCCCCCCGGCGGCTGGGCCTTCCAGTACAACAACGATTACTACCC
CGACGTGGACGACACGGCAGTGGTCGGCATGTGCTGCACCGCGAGGGCGACCCCGCGAATGACGAGGCGCTGGAGCGCGC
GCGCCAGTGGATCATCGGGATGCAGAGCAGCAATGGCGGCTGGGGCGCGTTCGATATCGACAACAACCTCGATTTCCTGA
ACCATATTCCCTTCGCCGACCACGGTGCGCTGCTGGACCCGCCGACGGCCGACGTGACGGCGCGCTGCATCTCGTTCCTG
GCGCAGCTCGGCCATCCCGAGGACCGGCCGGTGATCGAACGCGGCATCGCCTACCTGCGCACGGACCAGGAACGGGAAGG
GTGCTGGTTCGGCCGCTGGGGCACCAATTACATCTACGGCACCTGGTCGGTGCTGTGCGCCTATAACGCCGCCGGCGTGG
CGCATGACGACCCGTCGGTCGTGCGCGCGGTGGACTGGCTGCGTTCGGTCCAGCGCGAGGATGGCGGCTGGGGCGAGGAT
TGCGCGTCGTACGAAGGCGCCACGCCGGGCATCTATACCGAAAGCCTGCCGTCGCAGACCGCCTGGGCGGTGCTGGGCCT
GATGGCGGTGGGCCTGCGCGACGACCCGGCGGTGATGCGCGGCATGGCCTACCTGACCCGCACGCAGAAGGATGACGGCG
AATGGGACGAAGAACCCTATAACGCCGTCGGTTTCCCCAAGGTCTTCTACCTGCGCTATCACGGATACCGTCAGTTCTTT
CCGCTGCTGGCCCTGTCGCGCTACCGCAACCTGGCGTCCAGCAACAGCCGCCACGTCGCGTTCGGCTTCTGA

Upstream 100 bases:

>100_bases
CGCGCGACATGGCGGGGATGCCGGCGGGGTGATCGCGCCGGGTGCGAAACATCCGTATACAGGAATTTTTGGACAGGTCC
CGCCCGGCGGGGAACAGGAA

Downstream 100 bases:

>100_bases
AGGACAGGCGGATGGCACCCGACGGTTCGGCACCCGCGCAGGCGCGCCTCTCCCCCTCCGGCGCGCCCTTGGCGGGCACG
CTGGGCGTCGTGGTCGGGAT

Product: squalene--hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MMANATDTIELPPSRAADRIVPMTDIDQAVDAAHAALGRRQQDDGHWVFELEADATIPAEYVLLEHYLDRIDPALEERIG
VYLRRIQGDHGGWPLYHGGKFDVSATVKAYFALKAIGDDIDAPHMARARAAILDHGGAERSNVFTRFQLALFGEVPWHAT
PVMPVELMLLPRKALFSVWNMSYWSRTVIAPLLVLAALRPRAINPRDVHVPELFVTPPDQVRDWIRGPYRSQLGRLFKYV
DIALRPAERLIPDATRQRAIKAAVDFIEPRLNGEDGLGAIYPAMANTVMMYRALGVPDSDPRAATAWEAVRRLLVELDGE
AYCQPCVSPIWDTGLAGHAMIEAASGPKGIRPEDTKKKLAAAAEWLRERQILNGEGRLGDQLPRRAPRRLGLPVQQRLLP
RRGRHGSGRHVLHREGDPANDEALERARQWIIGMQSSNGGWGAFDIDNNLDFLNHIPFADHGALLDPPTADVTARCISFL
AQLGHPEDRPVIERGIAYLRTDQEREGCWFGRWGTNYIYGTWSVLCAYNAAGVAHDDPSVVRAVDWLRSVQREDGGWGED
CASYEGATPGIYTESLPSQTAWAVLGLMAVGLRDDPAVMRGMAYLTRTQKDDGEWDEEPYNAVGFPKVFYLRYHGYRQFF
PLLALSRYRNLASSNSRHVAFGF

Sequences:

>Translated_663_residues
MMANATDTIELPPSRAADRIVPMTDIDQAVDAAHAALGRRQQDDGHWVFELEADATIPAEYVLLEHYLDRIDPALEERIG
VYLRRIQGDHGGWPLYHGGKFDVSATVKAYFALKAIGDDIDAPHMARARAAILDHGGAERSNVFTRFQLALFGEVPWHAT
PVMPVELMLLPRKALFSVWNMSYWSRTVIAPLLVLAALRPRAINPRDVHVPELFVTPPDQVRDWIRGPYRSQLGRLFKYV
DIALRPAERLIPDATRQRAIKAAVDFIEPRLNGEDGLGAIYPAMANTVMMYRALGVPDSDPRAATAWEAVRRLLVELDGE
AYCQPCVSPIWDTGLAGHAMIEAASGPKGIRPEDTKKKLAAAAEWLRERQILNGEGRLGDQLPRRAPRRLGLPVQQRLLP
RRGRHGSGRHVLHREGDPANDEALERARQWIIGMQSSNGGWGAFDIDNNLDFLNHIPFADHGALLDPPTADVTARCISFL
AQLGHPEDRPVIERGIAYLRTDQEREGCWFGRWGTNYIYGTWSVLCAYNAAGVAHDDPSVVRAVDWLRSVQREDGGWGED
CASYEGATPGIYTESLPSQTAWAVLGLMAVGLRDDPAVMRGMAYLTRTQKDDGEWDEEPYNAVGFPKVFYLRYHGYRQFF
PLLALSRYRNLASSNSRHVAFGF
>Mature_663_residues
MMANATDTIELPPSRAADRIVPMTDIDQAVDAAHAALGRRQQDDGHWVFELEADATIPAEYVLLEHYLDRIDPALEERIG
VYLRRIQGDHGGWPLYHGGKFDVSATVKAYFALKAIGDDIDAPHMARARAAILDHGGAERSNVFTRFQLALFGEVPWHAT
PVMPVELMLLPRKALFSVWNMSYWSRTVIAPLLVLAALRPRAINPRDVHVPELFVTPPDQVRDWIRGPYRSQLGRLFKYV
DIALRPAERLIPDATRQRAIKAAVDFIEPRLNGEDGLGAIYPAMANTVMMYRALGVPDSDPRAATAWEAVRRLLVELDGE
AYCQPCVSPIWDTGLAGHAMIEAASGPKGIRPEDTKKKLAAAAEWLRERQILNGEGRLGDQLPRRAPRRLGLPVQQRLLP
RRGRHGSGRHVLHREGDPANDEALERARQWIIGMQSSNGGWGAFDIDNNLDFLNHIPFADHGALLDPPTADVTARCISFL
AQLGHPEDRPVIERGIAYLRTDQEREGCWFGRWGTNYIYGTWSVLCAYNAAGVAHDDPSVVRAVDWLRSVQREDGGWGED
CASYEGATPGIYTESLPSQTAWAVLGLMAVGLRDDPAVMRGMAYLTRTQKDDGEWDEEPYNAVGFPKVFYLRYHGYRQFF
PLLALSRYRNLASSNSRHVAFGF

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=655, Percent_Identity=27.7862595419847, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI47933397, Length=655, Percent_Identity=27.7862595419847, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI224177558, Length=655, Percent_Identity=27.7862595419847, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI224177556, Length=655, Percent_Identity=27.175572519084, Blast_Score=138, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321863, Length=163, Percent_Identity=33.7423312883436, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 74115; Mature: 74115

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMANATDTIELPPSRAADRIVPMTDIDQAVDAAHAALGRRQQDDGHWVFELEADATIPAE
CCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHH
YVLLEHYLDRIDPALEERIGVYLRRIQGDHGGWPLYHGGKFDVSATVKAYFALKAIGDDI
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHHCCCC
DAPHMARARAAILDHGGAERSNVFTRFQLALFGEVPWHATPVMPVELMLLPRKALFSVWN
CCCHHHHHHHHHHHCCCCCHHHHHHHEEHHHCCCCCCCCCCCCCHHHEECCHHHHHHHHH
MSYWSRTVIAPLLVLAALRPRAINPRDVHVPELFVTPPDQVRDWIRGPYRSQLGRLFKYV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHH
DIALRPAERLIPDATRQRAIKAAVDFIEPRLNGEDGLGAIYPAMANTVMMYRALGVPDSD
HHHHCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
PRAATAWEAVRRLLVELDGEAYCQPCVSPIWDTGLAGHAMIEAASGPKGIRPEDTKKKLA
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCHHHHHHH
AAAEWLRERQILNGEGRLGDQLPRRAPRRLGLPVQQRLLPRRGRHGSGRHVLHREGDPAN
HHHHHHHHHHHCCCCCCCCHHHHHHCHHHCCCCHHHHHHHCCCCCCCCCEEEECCCCCCC
DEALERARQWIIGMQSSNGGWGAFDIDNNLDFLNHIPFADHGALLDPPTADVTARCISFL
HHHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
AQLGHPEDRPVIERGIAYLRTDQEREGCWFGRWGTNYIYGTWSVLCAYNAAGVAHDDPSV
HHHCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEHHHHHHHHCCCCCCCCCHHH
VRAVDWLRSVQREDGGWGEDCASYEGATPGIYTESLPSQTAWAVLGLMAVGLRDDPAVMR
HHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
GMAYLTRTQKDDGEWDEEPYNAVGFPKVFYLRYHGYRQFFPLLALSRYRNLASSNSRHVA
HHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEE
FGF
ECC
>Mature Secondary Structure
MMANATDTIELPPSRAADRIVPMTDIDQAVDAAHAALGRRQQDDGHWVFELEADATIPAE
CCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHH
YVLLEHYLDRIDPALEERIGVYLRRIQGDHGGWPLYHGGKFDVSATVKAYFALKAIGDDI
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHHCCCC
DAPHMARARAAILDHGGAERSNVFTRFQLALFGEVPWHATPVMPVELMLLPRKALFSVWN
CCCHHHHHHHHHHHCCCCCHHHHHHHEEHHHCCCCCCCCCCCCCHHHEECCHHHHHHHHH
MSYWSRTVIAPLLVLAALRPRAINPRDVHVPELFVTPPDQVRDWIRGPYRSQLGRLFKYV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHH
DIALRPAERLIPDATRQRAIKAAVDFIEPRLNGEDGLGAIYPAMANTVMMYRALGVPDSD
HHHHCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
PRAATAWEAVRRLLVELDGEAYCQPCVSPIWDTGLAGHAMIEAASGPKGIRPEDTKKKLA
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCHHHHHHH
AAAEWLRERQILNGEGRLGDQLPRRAPRRLGLPVQQRLLPRRGRHGSGRHVLHREGDPAN
HHHHHHHHHHHCCCCCCCCHHHHHHCHHHCCCCHHHHHHHCCCCCCCCCEEEECCCCCCC
DEALERARQWIIGMQSSNGGWGAFDIDNNLDFLNHIPFADHGALLDPPTADVTARCISFL
HHHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
AQLGHPEDRPVIERGIAYLRTDQEREGCWFGRWGTNYIYGTWSVLCAYNAAGVAHDDPSV
HHHCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEHHHHHHHHCCCCCCCCCHHH
VRAVDWLRSVQREDGGWGEDCASYEGATPGIYTESLPSQTAWAVLGLMAVGLRDDPAVMR
HHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
GMAYLTRTQKDDGEWDEEPYNAVGFPKVFYLRYHGYRQFFPLLALSRYRNLASSNSRHVA
HHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEE
FGF
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]