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The map label for this gene is fur [H]

Identifier: 162147193

GI number: 162147193

Start: 1400273

End: 1400770

Strand: Direct

Name: fur [H]

Synonym: GDI_1398

Alternate gene names: 162147193

Gene position: 1400273-1400770 (Clockwise)

Preceding gene: 162147192

Following gene: 162147194

Centisome position: 35.5

GC content: 67.27

Gene sequence:

>498_bases
ATGGTAGCGGCAGGCGAGGCTATGGAATCGCGCATCGGGCGCATGTGTATCGAGCGCGGCCTGAAGATGACGGGCCAGCG
GCGGGTGATCGCGCGCGTCCTGTCCGAGGCCGAGGACCATCCCGACGTGGAGGAACTCTACCGCCGCGCCGCCGCCCTGG
ATTCGCGGATTTCGGTCGCGACCGTGTACCGCACCGTGCGCCTGCTGGAAGAGAAGGGCATTCTCGAGCGGCGTGATTTC
GGTGGCGGCCGCGCGCGCTACGAGGCGACCGAGGACGGCGACCATTATCACCTGATCGATGTCGACACCGGCAAGGTCGT
CGAATTCGAGGACGCCGAACACACTGCCCTGATGCGGCGGATAGCCGACCGGCTGGGATTCGAGCTCGTATCCCATCGCA
TGGAACTGTTCGCGCGCAGGAAGCCGGCGACGCCGGTCGCGTCAGATGGGGCGGCCGCGCAGCGCGCCGCGGCAAGCAAG
GATGAATCACGGCGGTGA

Upstream 100 bases:

>100_bases
CGAGGAATGAATGTGGCGTGCCGCGCGGCGGCACGGCCCGATCAAGGGGAGGCGACGCTTCGTTGGACCACACGTCTGAT
GTTCGGGTTGGGCCGTCGAC

Downstream 100 bases:

>100_bases
GCATCGAGAAACCGACTCAATCCCTGTCGACCCTGGAACTCGACCGTGACGGCTTTCCCGAATTGCGGGGGGGCAACCTG
GGGGTGCGCATCGCGGCCAA

Product: ferric uptake regulation protein

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MVAAGEAMESRIGRMCIERGLKMTGQRRVIARVLSEAEDHPDVEELYRRAAALDSRISVATVYRTVRLLEEKGILERRDF
GGGRARYEATEDGDHYHLIDVDTGKVVEFEDAEHTALMRRIADRLGFELVSHRMELFARRKPATPVASDGAAAQRAAASK
DESRR

Sequences:

>Translated_165_residues
MVAAGEAMESRIGRMCIERGLKMTGQRRVIARVLSEAEDHPDVEELYRRAAALDSRISVATVYRTVRLLEEKGILERRDF
GGGRARYEATEDGDHYHLIDVDTGKVVEFEDAEHTALMRRIADRLGFELVSHRMELFARRKPATPVASDGAAAQRAAASK
DESRR
>Mature_165_residues
MVAAGEAMESRIGRMCIERGLKMTGQRRVIARVLSEAEDHPDVEELYRRAAALDSRISVATVYRTVRLLEEKGILERRDF
GGGRARYEATEDGDHYHLIDVDTGKVVEFEDAEHTALMRRIADRLGFELVSHRMELFARRKPATPVASDGAAAQRAAASK
DESRR

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=121, Percent_Identity=38.8429752066116, Blast_Score=87, Evalue=7e-19,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 18541; Mature: 18541

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAAGEAMESRIGRMCIERGLKMTGQRRVIARVLSEAEDHPDVEELYRRAAALDSRISVA
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
TVYRTVRLLEEKGILERRDFGGGRARYEATEDGDHYHLIDVDTGKVVEFEDAEHTALMRR
HHHHHHHHHHHCCCHHHHCCCCCCEECCCCCCCCEEEEEECCCCCEEEECCCHHHHHHHH
IADRLGFELVSHRMELFARRKPATPVASDGAAAQRAAASKDESRR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVAAGEAMESRIGRMCIERGLKMTGQRRVIARVLSEAEDHPDVEELYRRAAALDSRISVA
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
TVYRTVRLLEEKGILERRDFGGGRARYEATEDGDHYHLIDVDTGKVVEFEDAEHTALMRR
HHHHHHHHHHHCCCHHHHCCCCCCEECCCCCCCCEEEEEECCCCCEEEECCCHHHHHHHH
IADRLGFELVSHRMELFARRKPATPVASDGAAAQRAAASKDESRR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9835040 [H]