Click here to switch to the map view.

The map label for this gene is mutY [H]

Identifier: 162147119

GI number: 162147119

Start: 1324548

End: 1325612

Strand: Reverse

Name: mutY [H]

Synonym: GDI_1324

Alternate gene names: 162147119

Gene position: 1325612-1324548 (Counterclockwise)

Preceding gene: 162147123

Following gene: 162147118

Centisome position: 33.61

GC content: 73.15

Gene sequence:

>1065_bases
GTGCCCCCTTCATCCGCCGACCTGCTGCATTGGTACGACCGCCACCGGCGAACCCTGCCCTGGCGGGCCCTGCCCGGCCA
CAGCGCCGATCCCTACCATGTCTGGCTGAGCGAAATCATGCTGCAGCAGACGACGGTCACGGCGGTCATCCCCTATTATC
GCCGATTCCTGGACCGGTTTCCCACCGTCATGGACCTGGCACGCGCCGAATCCGACACCGTCATGGCCGCCTGGGCCGGT
CTGGGCTATTACGCCCGGGCACGCAACCTGCATGACTGCGCGCGGGTGGTGGCGGCGGCCGGCCGCTTTCCCGACGACAT
GCCGGGGTTGCTGGCCCTGCCGGGGGTGGGGGCCTATACCGCCGCCGCCATCGCCGCCATCGCCTTCGGCCGGCCGGTGG
TCCCGGTGGACGGCAATGTGGAGCGCGTGACCAGCCGGCTGTTCGCCCTGTCCGACCCGCTGCCGGCCGCCCGCAAATCC
ATCGCCCGCCAGGCGGCCACCCTGAACCAGTCCGCCGAGGCGCAGGCGCGGCCGTCCGACTTCGCGCAGGCGCTGTTCGA
CCTGGGCGCCGGGGTCTGCACGCCGCGAAGCCCGGCCTGCGCCCTGTGTCCATGGCGGGAGGCCTGCGCCGGGTTCCGCC
AGGGCATCGCGGCGAACCTGCCCGTCAAGGCGCCCCGCGCGACGAAGCCGGTGCGCTACGGCGCGCATTTCCACGTCACC
GACGCGGCCGGCCAGATCCTGCTGCGCCGCCGGGCGGCGAAGGGATTGCTGGGCGGCATGCTGGAACTGCCGGGGACCGA
CTGGCGCGCCGCCCCCTGGACGCCGGCCGAGGCCCTGGCCCATGCCCCCCTGGCGGCATCCTGGCAGGCGGCCGGGCGGG
TGACGCATGTCTTCACCCATTTCACCCTGCATGTGGACCTGTATGACGCGGCGGTGGGGCACTTCCCCAACAGCGCGGCG
CGGGCGGGCGGCCTGGCCTTCGCCGGGCAGGCCCTGGACGGGCTGGCCCTGCCGTCGCTGATGCGCAAATGCCTGGCCGC
GATCCGTCCCGCCATGACGGCATGA

Upstream 100 bases:

>100_bases
GGCAGAAGGCGGGGCGGGTGACGGCCGGCATCAGCGCCCCCAGGCTGCGCATCCACAGGGCGCGCTTGCCGTCGGTTCCA
TCCTTCGTCATAAGCGGCCC

Downstream 100 bases:

>100_bases
CAGGCCGGGTTCCATCATCATTCTGTCATTTTTTCGTTGACGCGGGCCGAACCGGCGCGGTTGAGTGACTGCAACGGCCT
GGATGACCGACCGTAGGGTC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPPSSADLLHWYDRHRRTLPWRALPGHSADPYHVWLSEIMLQQTTVTAVIPYYRRFLDRFPTVMDLARAESDTVMAAWAG
LGYYARARNLHDCARVVAAAGRFPDDMPGLLALPGVGAYTAAAIAAIAFGRPVVPVDGNVERVTSRLFALSDPLPAARKS
IARQAATLNQSAEAQARPSDFAQALFDLGAGVCTPRSPACALCPWREACAGFRQGIAANLPVKAPRATKPVRYGAHFHVT
DAAGQILLRRRAAKGLLGGMLELPGTDWRAAPWTPAEALAHAPLAASWQAAGRVTHVFTHFTLHVDLYDAAVGHFPNSAA
RAGGLAFAGQALDGLALPSLMRKCLAAIRPAMTA

Sequences:

>Translated_354_residues
MPPSSADLLHWYDRHRRTLPWRALPGHSADPYHVWLSEIMLQQTTVTAVIPYYRRFLDRFPTVMDLARAESDTVMAAWAG
LGYYARARNLHDCARVVAAAGRFPDDMPGLLALPGVGAYTAAAIAAIAFGRPVVPVDGNVERVTSRLFALSDPLPAARKS
IARQAATLNQSAEAQARPSDFAQALFDLGAGVCTPRSPACALCPWREACAGFRQGIAANLPVKAPRATKPVRYGAHFHVT
DAAGQILLRRRAAKGLLGGMLELPGTDWRAAPWTPAEALAHAPLAASWQAAGRVTHVFTHFTLHVDLYDAAVGHFPNSAA
RAGGLAFAGQALDGLALPSLMRKCLAAIRPAMTA
>Mature_353_residues
PPSSADLLHWYDRHRRTLPWRALPGHSADPYHVWLSEIMLQQTTVTAVIPYYRRFLDRFPTVMDLARAESDTVMAAWAGL
GYYARARNLHDCARVVAAAGRFPDDMPGLLALPGVGAYTAAAIAAIAFGRPVVPVDGNVERVTSRLFALSDPLPAARKSI
ARQAATLNQSAEAQARPSDFAQALFDLGAGVCTPRSPACALCPWREACAGFRQGIAANLPVKAPRATKPVRYGAHFHVTD
AAGQILLRRRAAKGLLGGMLELPGTDWRAAPWTPAEALAHAPLAASWQAAGRVTHVFTHFTLHVDLYDAAVGHFPNSAAR
AGGLAFAGQALDGLALPSLMRKCLAAIRPAMTA

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=400, Percent_Identity=34.5, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI115298654, Length=402, Percent_Identity=34.3283582089552, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI115298652, Length=402, Percent_Identity=34.3283582089552, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI115298650, Length=402, Percent_Identity=34.3283582089552, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI190358497, Length=399, Percent_Identity=34.5864661654135, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI115298648, Length=402, Percent_Identity=34.3283582089552, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1789331, Length=310, Percent_Identity=40.6451612903226, Blast_Score=210, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 37919; Mature: 37788

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSSADLLHWYDRHRRTLPWRALPGHSADPYHVWLSEIMLQQTTVTAVIPYYRRFLDRF
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PTVMDLARAESDTVMAAWAGLGYYARARNLHDCARVVAAAGRFPDDMPGLLALPGVGAYT
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEECCCCCHHH
AAAIAAIAFGRPVVPVDGNVERVTSRLFALSDPLPAARKSIARQAATLNQSAEAQARPSD
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHH
FAQALFDLGAGVCTPRSPACALCPWREACAGFRQGIAANLPVKAPRATKPVRYGAHFHVT
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCEEEEE
DAAGQILLRRRAAKGLLGGMLELPGTDWRAAPWTPAEALAHAPLAASWQAAGRVTHVFTH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHHHHCHHEEEEEE
FTLHVDLYDAAVGHFPNSAARAGGLAFAGQALDGLALPSLMRKCLAAIRPAMTA
EEEEEEHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PPSSADLLHWYDRHRRTLPWRALPGHSADPYHVWLSEIMLQQTTVTAVIPYYRRFLDRF
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PTVMDLARAESDTVMAAWAGLGYYARARNLHDCARVVAAAGRFPDDMPGLLALPGVGAYT
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEECCCCCHHH
AAAIAAIAFGRPVVPVDGNVERVTSRLFALSDPLPAARKSIARQAATLNQSAEAQARPSD
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHH
FAQALFDLGAGVCTPRSPACALCPWREACAGFRQGIAANLPVKAPRATKPVRYGAHFHVT
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCEEEEE
DAAGQILLRRRAAKGLLGGMLELPGTDWRAAPWTPAEALAHAPLAASWQAAGRVTHVFTH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHHHHCHHEEEEEE
FTLHVDLYDAAVGHFPNSAARAGGLAFAGQALDGLALPSLMRKCLAAIRPAMTA
EEEEEEHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]