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The map label for this gene is hemE

Identifier: 162147010

GI number: 162147010

Start: 1205034

End: 1206095

Strand: Reverse

Name: hemE

Synonym: GDI_1215

Alternate gene names: 162147010

Gene position: 1206095-1205034 (Counterclockwise)

Preceding gene: 162147012

Following gene: 162147009

Centisome position: 30.58

GC content: 69.77

Gene sequence:

>1062_bases
ATGACGGATACAGGCAAACCCCTTCTGCGGGTCCTTCAGGGCGAGGCCGTATGGCCCCCGCCGATCTGGCTGATGCGTCA
GGCCGGACGGTACCTGCCGGAATTCCGTGCCCTGCGCGACCAGGCCGATTTCATCACCCGATGCATGACGCCCGACCTGG
CGACGGAAATCACGCTGCAACCGATCCGGCGCTACGCCATGGACGGGGCGATCCTGTTTTCCGACATTTTGATCCTGCCA
TGGGCGATGGGCCAGTCGCTGGATTTCGTGGCCGGCAAGGGACCCATCCTGGGCGCCATCCGCAGCGAGGCCGACCTGGC
GCGGCTGGACCCGAAGCGCGTGCCCGACGCGACGGCCCCGGTGATGGAAACCCTGAGCCGCCTGCGCGCGATTCTGGATG
GGCCCGATCCGATCGGCGCGGCCCAGGGCGGGCGCGTCACCCTGCTGGGCTTCGCAGGCGCGCCCTTCACCGTGGCGTGC
TACATGGTCGAGGGCCATGGCTCGCGTGAATTCGATGCCACGCGCGGCATGGCCTATTCCGATCCGCTGCTGTTCGACCG
GCTGATGGCGACGCTGACCCAGGCCACCGCCGACATGCTGGTCGCGCAGATCGACGCGGGGGCCGAGGCCGTGATGCTGT
TCGACAGCTGGTCCGGCCTGCTGCCGCCGGCGCAGTTCCGCCGCCACGTCATCGCCCCGACCCGCGCCATCGTGCAGGAG
ATCCAGGCCCGCCGCCCCGGCGTGCCGGTCATCGGCTTTCCGCGCCTGGCCGGGATCATGGCGGCGGAATATGCGCGCGA
GACCGGCCTGCGTGTCATGGCGCTGGATACCGGCGCCGACATGGCGGCGATGGCCGGCCTGCTGCCGCCCGGCATGACGG
TGCAGGGCAACCTGGACCCGCTGCTGCTGCTGGCGGGCGGCGATGCCATGGCGCAGGAAGCCCGCGCCATTCGCGATGCG
ATGAAAGGGCGGCCGCACGTCTTCAATCTCGGCCACGGCGTGGTGCCCCCGACGCCGCCCGAACATGTCGGTGATCTTGT
GCGCACCGTCAGGGAGGTCTGA

Upstream 100 bases:

>100_bases
CTTGGCGCGTGGTCCTGTCATCCTCGATGAAAGTACGGGATATTCCCGTGAGTGAACGGGATCGAACGACCATGGCTGAA
ACCACGATGACGGGCAGGCG

Downstream 100 bases:

>100_bases
GCATGGAGCCCGGAACATCATGGCCCGCGGCGACGCTGCCCCGGTCGGTCCGGCCGGACGGCCGGCTGCGGCTGGTCATC
TTCGATTGCGACGGCGTGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTDTGKPLLRVLQGEAVWPPPIWLMRQAGRYLPEFRALRDQADFITRCMTPDLATEITLQPIRRYAMDGAILFSDILILP
WAMGQSLDFVAGKGPILGAIRSEADLARLDPKRVPDATAPVMETLSRLRAILDGPDPIGAAQGGRVTLLGFAGAPFTVAC
YMVEGHGSREFDATRGMAYSDPLLFDRLMATLTQATADMLVAQIDAGAEAVMLFDSWSGLLPPAQFRRHVIAPTRAIVQE
IQARRPGVPVIGFPRLAGIMAAEYARETGLRVMALDTGADMAAMAGLLPPGMTVQGNLDPLLLLAGGDAMAQEARAIRDA
MKGRPHVFNLGHGVVPPTPPEHVGDLVRTVREV

Sequences:

>Translated_353_residues
MTDTGKPLLRVLQGEAVWPPPIWLMRQAGRYLPEFRALRDQADFITRCMTPDLATEITLQPIRRYAMDGAILFSDILILP
WAMGQSLDFVAGKGPILGAIRSEADLARLDPKRVPDATAPVMETLSRLRAILDGPDPIGAAQGGRVTLLGFAGAPFTVAC
YMVEGHGSREFDATRGMAYSDPLLFDRLMATLTQATADMLVAQIDAGAEAVMLFDSWSGLLPPAQFRRHVIAPTRAIVQE
IQARRPGVPVIGFPRLAGIMAAEYARETGLRVMALDTGADMAAMAGLLPPGMTVQGNLDPLLLLAGGDAMAQEARAIRDA
MKGRPHVFNLGHGVVPPTPPEHVGDLVRTVREV
>Mature_352_residues
TDTGKPLLRVLQGEAVWPPPIWLMRQAGRYLPEFRALRDQADFITRCMTPDLATEITLQPIRRYAMDGAILFSDILILPW
AMGQSLDFVAGKGPILGAIRSEADLARLDPKRVPDATAPVMETLSRLRAILDGPDPIGAAQGGRVTLLGFAGAPFTVACY
MVEGHGSREFDATRGMAYSDPLLFDRLMATLTQATADMLVAQIDAGAEAVMLFDSWSGLLPPAQFRRHVIAPTRAIVQEI
QARRPGVPVIGFPRLAGIMAAEYARETGLRVMALDTGADMAAMAGLLPPGMTVQGNLDPLLLLAGGDAMAQEARAIRDAM
KGRPHVFNLGHGVVPPTPPEHVGDLVRTVREV

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=38.3522727272727, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI2367337, Length=352, Percent_Identity=39.7727272727273, Blast_Score=220, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6320252, Length=359, Percent_Identity=31.7548746518106, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI19921920, Length=351, Percent_Identity=36.7521367521368, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI221330099, Length=351, Percent_Identity=36.7521367521368, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_GLUDA (A9HDX7)

Other databases:

- EMBL:   CP001189
- EMBL:   AM889285
- RefSeq:   YP_001601471.1
- RefSeq:   YP_002276302.1
- ProteinModelPortal:   A9HDX7
- SMR:   A9HDX7
- GeneID:   5788746
- GeneID:   6975351
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_1927
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38031; Mature: 37900

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 75-75 BINDING 161-161 BINDING 216-216 BINDING 332-332

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTGKPLLRVLQGEAVWPPPIWLMRQAGRYLPEFRALRDQADFITRCMTPDLATEITLQ
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PIRRYAMDGAILFSDILILPWAMGQSLDFVAGKGPILGAIRSEADLARLDPKRVPDATAP
HHHHHHHCCHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHCCCHHHHCCHHCCCCCHHH
VMETLSRLRAILDGPDPIGAAQGGRVTLLGFAGAPFTVACYMVEGHGSREFDATRGMAYS
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCHHHCCCCCC
DPLLFDRLMATLTQATADMLVAQIDAGAEAVMLFDSWSGLLPPAQFRRHVIAPTRAIVQE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHH
IQARRPGVPVIGFPRLAGIMAAEYARETGLRVMALDTGADMAAMAGLLPPGMTVQGNLDP
HHHCCCCCCEEECHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCCEEECCCCE
LLLLAGGDAMAQEARAIRDAMKGRPHVFNLGHGVVPPTPPEHVGDLVRTVREV
EEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDTGKPLLRVLQGEAVWPPPIWLMRQAGRYLPEFRALRDQADFITRCMTPDLATEITLQ
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PIRRYAMDGAILFSDILILPWAMGQSLDFVAGKGPILGAIRSEADLARLDPKRVPDATAP
HHHHHHHCCHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHCCCHHHHCCHHCCCCCHHH
VMETLSRLRAILDGPDPIGAAQGGRVTLLGFAGAPFTVACYMVEGHGSREFDATRGMAYS
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCHHHCCCCCC
DPLLFDRLMATLTQATADMLVAQIDAGAEAVMLFDSWSGLLPPAQFRRHVIAPTRAIVQE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHH
IQARRPGVPVIGFPRLAGIMAAEYARETGLRVMALDTGADMAAMAGLLPPGMTVQGNLDP
HHHCCCCCCEEECHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCCEEECCCCE
LLLLAGGDAMAQEARAIRDAMKGRPHVFNLGHGVVPPTPPEHVGDLVRTVREV
EEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA