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The map label for this gene is gyaR [H]

Identifier: 162146992

GI number: 162146992

Start: 1191129

End: 1192055

Strand: Reverse

Name: gyaR [H]

Synonym: GDI_1197

Alternate gene names: 162146992

Gene position: 1192055-1191129 (Counterclockwise)

Preceding gene: 162146993

Following gene: 162146991

Centisome position: 30.22

GC content: 68.72

Gene sequence:

>927_bases
ATGAAACCCGATATTCTTCTGATCGAGCCGATGATGCCGCAGATCGAGAAGGCCCTCGACGATGCCTATACCGTGCATCG
TTTCACCGACGTCGCGGCGCTGGCGGGCGTTGCCGGGTCGATCCGCGGCATCGCGACCGGCGGCGGCAGCGGCGTGCCGG
CCGATGTGATGGCGGCCCTGCCTGAACTGGGAATCATCGCGATCAACGGGATCGGGACCGACGCGGTGGATCTGAACGTG
GCGCGCCAGCGCGGCATCCGCGTCACGACGACGCCGGGCGTGCTGACCGCCGATGTCGCCGACATGGCGCTGGGCCTGAT
CCTGATGGCCTGCCGGGGCCTGGGCACCGGCGACCGCTATGTTCGCGCCGGATCGTGGGGCAAGGCCCCGATCGCGCTGG
GTCATACGGTGACGGGGCGGAAGCTGGGCATTCTCGGCCTAGGGCAGGTCGGGCGCGCGATCGCGGCCCGGGCGCGGGCG
TTCGACATGCCGATCGCCTATCACGATATCCGGGAAATTCCCGAGAGCGGCTATACCTATTTCGCCGACCTGACCGAGCT
GGCGCGGGACAGCGACGTGCTGGTCGTGGCGGCGTCCGGCGGCGCGCAGTCGCGCAATATCGTCGACAAGACGGTGCTGG
AGGCCCTGGGTCCCGACGGCGTGCTGATCAACGTCGCGCGCGGCACCGTGGTGGACGAGGACGCGCTGGTCGCGGCACTC
CAGGCCGGGACACTGGGCGGCGCCGGGCTGGACGTGTTCCAGCATGAACCCCATGTGCCCGATGCGCTGAAGACGATGGA
CAATGTCGCCTTGCAGCCCCATCGCGCCAGTGCCACGGTGGAAACCCGTCTGGCAATGGGCGACCTAGTCGTTCGCAACC
TCGCCGCCTGGTTCGCCGGGCAGTCGCTGCTGACCCCGGTGGTGTAG

Upstream 100 bases:

>100_bases
TCAGCGCGACATTCCCGCATCTGGGCACATTGTCGCTGACCTGCGGCTGAGTCCGCCTGCTCATTGGGGCCCATGGCGGG
CCCTGAACCGGAGAACATGA

Downstream 100 bases:

>100_bases
CATAACGTACCCGGTCCTGCTCCCGCCCCGGGGCCGCCGGGGCAGGAACGGGACAAGGTCCGTGGCCCATCATCCATCGC
CTGGCATGTCATCGCTCCCA

Product: D-2-hydroxyacid dehydrogensase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKPDILLIEPMMPQIEKALDDAYTVHRFTDVAALAGVAGSIRGIATGGGSGVPADVMAALPELGIIAINGIGTDAVDLNV
ARQRGIRVTTTPGVLTADVADMALGLILMACRGLGTGDRYVRAGSWGKAPIALGHTVTGRKLGILGLGQVGRAIAARARA
FDMPIAYHDIREIPESGYTYFADLTELARDSDVLVVAASGGAQSRNIVDKTVLEALGPDGVLINVARGTVVDEDALVAAL
QAGTLGGAGLDVFQHEPHVPDALKTMDNVALQPHRASATVETRLAMGDLVVRNLAAWFAGQSLLTPVV

Sequences:

>Translated_308_residues
MKPDILLIEPMMPQIEKALDDAYTVHRFTDVAALAGVAGSIRGIATGGGSGVPADVMAALPELGIIAINGIGTDAVDLNV
ARQRGIRVTTTPGVLTADVADMALGLILMACRGLGTGDRYVRAGSWGKAPIALGHTVTGRKLGILGLGQVGRAIAARARA
FDMPIAYHDIREIPESGYTYFADLTELARDSDVLVVAASGGAQSRNIVDKTVLEALGPDGVLINVARGTVVDEDALVAAL
QAGTLGGAGLDVFQHEPHVPDALKTMDNVALQPHRASATVETRLAMGDLVVRNLAAWFAGQSLLTPVV
>Mature_308_residues
MKPDILLIEPMMPQIEKALDDAYTVHRFTDVAALAGVAGSIRGIATGGGSGVPADVMAALPELGIIAINGIGTDAVDLNV
ARQRGIRVTTTPGVLTADVADMALGLILMACRGLGTGDRYVRAGSWGKAPIALGHTVTGRKLGILGLGQVGRAIAARARA
FDMPIAYHDIREIPESGYTYFADLTELARDSDVLVVAASGGAQSRNIVDKTVLEALGPDGVLINVARGTVVDEDALVAAL
QAGTLGGAGLDVFQHEPHVPDALKTMDNVALQPHRASATVETRLAMGDLVVRNLAAWFAGQSLLTPVV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=35.8870967741936, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI23308577, Length=266, Percent_Identity=30.0751879699248, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI61743967, Length=251, Percent_Identity=29.0836653386454, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4557497, Length=251, Percent_Identity=29.0836653386454, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI145580578, Length=238, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4557499, Length=238, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI145580575, Length=247, Percent_Identity=28.3400809716599, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI87082289, Length=306, Percent_Identity=33.0065359477124, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789279, Length=260, Percent_Identity=33.0769230769231, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787645, Length=274, Percent_Identity=23.7226277372263, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081824, Length=143, Percent_Identity=34.965034965035, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=262, Percent_Identity=29.0076335877863, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=235, Percent_Identity=30.2127659574468, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=245, Percent_Identity=33.8775510204082, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=310, Percent_Identity=27.741935483871, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=241, Percent_Identity=30.2904564315353, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=278, Percent_Identity=25.1798561151079, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=256, Percent_Identity=28.515625, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=310, Percent_Identity=23.8709677419355, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571528, Length=257, Percent_Identity=36.5758754863813, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45552429, Length=275, Percent_Identity=33.0909090909091, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24585514, Length=275, Percent_Identity=33.0909090909091, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574282, Length=275, Percent_Identity=33.0909090909091, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574284, Length=275, Percent_Identity=33.0909090909091, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI45551003, Length=275, Percent_Identity=33.0909090909091, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI28574286, Length=280, Percent_Identity=32.5, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24585516, Length=255, Percent_Identity=30.1960784313725, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646446, Length=233, Percent_Identity=30.4721030042918, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646448, Length=233, Percent_Identity=30.4721030042918, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646452, Length=233, Percent_Identity=30.4721030042918, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646450, Length=233, Percent_Identity=30.4721030042918, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI62472511, Length=227, Percent_Identity=31.2775330396476, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19921140, Length=242, Percent_Identity=27.6859504132231, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 31880; Mature: 31880

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDILLIEPMMPQIEKALDDAYTVHRFTDVAALAGVAGSIRGIATGGGSGVPADVMAAL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHC
PELGIIAINGIGTDAVDLNVARQRGIRVTTTPGVLTADVADMALGLILMACRGLGTGDRY
CCCCEEEEECCCCCCEEEHHHHHCCEEEEECCCEEEHHHHHHHHHHHHHHHCCCCCCCCE
VRAGSWGKAPIALGHTVTGRKLGILGLGQVGRAIAARARAFDMPIAYHDIREIPESGYTY
EECCCCCCCCEEECCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEE
FADLTELARDSDVLVVAASGGAQSRNIVDKTVLEALGPDGVLINVARGTVVDEDALVAAL
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEECHHHHHHHH
QAGTLGGAGLDVFQHEPHVPDALKTMDNVALQPHRASATVETRLAMGDLVVRNLAAWFAG
HHCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
QSLLTPVV
CHHHCCCC
>Mature Secondary Structure
MKPDILLIEPMMPQIEKALDDAYTVHRFTDVAALAGVAGSIRGIATGGGSGVPADVMAAL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHC
PELGIIAINGIGTDAVDLNVARQRGIRVTTTPGVLTADVADMALGLILMACRGLGTGDRY
CCCCEEEEECCCCCCEEEHHHHHCCEEEEECCCEEEHHHHHHHHHHHHHHHCCCCCCCCE
VRAGSWGKAPIALGHTVTGRKLGILGLGQVGRAIAARARAFDMPIAYHDIREIPESGYTY
EECCCCCCCCEEECCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEE
FADLTELARDSDVLVVAASGGAQSRNIVDKTVLEALGPDGVLINVARGTVVDEDALVAAL
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEECHHHHHHHH
QAGTLGGAGLDVFQHEPHVPDALKTMDNVALQPHRASATVETRLAMGDLVVRNLAAWFAG
HHCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
QSLLTPVV
CHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA