Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 162146853

GI number: 162146853

Start: 1051735

End: 1052409

Strand: Direct

Name: clpP [H]

Synonym: GDI_1036

Alternate gene names: 162146853

Gene position: 1051735-1052409 (Clockwise)

Preceding gene: 162146846

Following gene: 162146854

Centisome position: 26.67

GC content: 65.93

Gene sequence:

>675_bases
ATGAGCGGCATGCAGCCGAAAAACCGGATCCGCATGGATGACGAGGACCCGGATGGCCCCGACATCCCCGAGCCCCAGGG
CCCGGAACCCAAGGAACCCGGCGACAACAAGACCCTGTCCTCGCCGATCAACGAACTGGAAAGCCGGCTGTTCGACCAGC
GCAAGGTTCTGGTCTTCGGGGCGATCAACGACAAGCTGGCGCGTGACGTCACGGGCCGCCTGCTGGCGCTGGCCGGCGCG
TCCGACCACCCGATCGACGTCTATATCAACTCGCCCGGCGGCCATGTCGAAAGCGGCGACACGATCCACGACATGATCCG
CTTCGTCGACTCGGTGGCGCCGGTGAACGTCATCGGCACCGGCTGGGTGGCCTCGGCCGGGGCGCTGATCTTCGCCGCCG
GCAACGCGCAGCGCCGCTTCTGCCTGCCGAACACGCGCTTCCTGCTGCACCAGCCGATGGGCGGCGTGCGCGGACCCGCC
ACCGATATCGATATCGAGGCGCGGGAGATCGTGAAGATGCGCGAACGCCTGAACCGCCTGTTCGCGCGTGAAACCGGCCA
GTCGTACGAGAAGGTGTGCCGCGACACCGACCGCAATTACTGGATGTCGGCCGACGAAGCGATCGCCTACGGCCTGGTCA
CCCGGGTCATCAACACTCTTTCCGATATCCACTGA

Upstream 100 bases:

>100_bases
AGCGAGAGAGCGGCCGGGCAGGACGGGTCTTGGCACCGGCAAAAAGGCGGCGCAGGATAGACCGATAACGTAGACCAGTC
CTGGGTACAGGGAGACCACG

Downstream 100 bases:

>100_bases
TCGACGGGGCCTGCCCGTGCCGCCATCGCGCGGCACGGGGGCGCCCGCCAGGTATGCCGGTCCGGCCGCGCGGCCGCCGG
CGTCGTTCCTGTAAGCGAGC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSGMQPKNRIRMDDEDPDGPDIPEPQGPEPKEPGDNKTLSSPINELESRLFDQRKVLVFGAINDKLARDVTGRLLALAGA
SDHPIDVYINSPGGHVESGDTIHDMIRFVDSVAPVNVIGTGWVASAGALIFAAGNAQRRFCLPNTRFLLHQPMGGVRGPA
TDIDIEAREIVKMRERLNRLFARETGQSYEKVCRDTDRNYWMSADEAIAYGLVTRVINTLSDIH

Sequences:

>Translated_224_residues
MSGMQPKNRIRMDDEDPDGPDIPEPQGPEPKEPGDNKTLSSPINELESRLFDQRKVLVFGAINDKLARDVTGRLLALAGA
SDHPIDVYINSPGGHVESGDTIHDMIRFVDSVAPVNVIGTGWVASAGALIFAAGNAQRRFCLPNTRFLLHQPMGGVRGPA
TDIDIEAREIVKMRERLNRLFARETGQSYEKVCRDTDRNYWMSADEAIAYGLVTRVINTLSDIH
>Mature_223_residues
SGMQPKNRIRMDDEDPDGPDIPEPQGPEPKEPGDNKTLSSPINELESRLFDQRKVLVFGAINDKLARDVTGRLLALAGAS
DHPIDVYINSPGGHVESGDTIHDMIRFVDSVAPVNVIGTGWVASAGALIFAAGNAQRRFCLPNTRFLLHQPMGGVRGPAT
DIDIEAREIVKMRERLNRLFARETGQSYEKVCRDTDRNYWMSADEAIAYGLVTRVINTLSDIH

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=174, Percent_Identity=40.2298850574713, Blast_Score=134, Evalue=8e-32,
Organism=Escherichia coli, GI1786641, Length=175, Percent_Identity=42.2857142857143, Blast_Score=154, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17538017, Length=183, Percent_Identity=38.2513661202186, Blast_Score=133, Evalue=6e-32,
Organism=Drosophila melanogaster, GI20129427, Length=171, Percent_Identity=36.2573099415205, Blast_Score=126, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 24737; Mature: 24606

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGMQPKNRIRMDDEDPDGPDIPEPQGPEPKEPGDNKTLSSPINELESRLFDQRKVLVFG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEE
AINDKLARDVTGRLLALAGASDHPIDVYINSPGGHVESGDTIHDMIRFVDSVAPVNVIGT
CCCHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEC
GWVASAGALIFAAGNAQRRFCLPNTRFLLHQPMGGVRGPATDIDIEAREIVKMRERLNRL
CHHHHCCEEEEEECCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FARETGQSYEKVCRDTDRNYWMSADEAIAYGLVTRVINTLSDIH
HHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGMQPKNRIRMDDEDPDGPDIPEPQGPEPKEPGDNKTLSSPINELESRLFDQRKVLVFG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEE
AINDKLARDVTGRLLALAGASDHPIDVYINSPGGHVESGDTIHDMIRFVDSVAPVNVIGT
CCCHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEC
GWVASAGALIFAAGNAQRRFCLPNTRFLLHQPMGGVRGPATDIDIEAREIVKMRERLNRL
CHHHHCCEEEEEECCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FARETGQSYEKVCRDTDRNYWMSADEAIAYGLVTRVINTLSDIH
HHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA