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The map label for this gene is panE [C]

Identifier: 162146807

GI number: 162146807

Start: 1004278

End: 1005174

Strand: Direct

Name: panE [C]

Synonym: GDI_0989

Alternate gene names: 162146807

Gene position: 1004278-1005174 (Clockwise)

Preceding gene: 162146806

Following gene: 162146808

Centisome position: 25.46

GC content: 54.52

Gene sequence:

>897_bases
ATGGTTCAAGAGAAAATTGTGGTCATGGGAGCCGGCGCGGTCGGTTGCTATTATGGCGCCCTTCTCGCTTTGAACGGACA
TCAGGTCACCCTGATCGGCCGCCCGGGCTTGGTTGAGGCCGTTGCGAACAAGGGGCTACTCCTGGAACGGCAGAGTGGAA
TCGAGACGGTTGCTTTGGCCGCAAGCGAGTCTGTCGAAGCCGTGGCTGATGCCTCCATCGTCCTGCTTACGGTGAAATCG
GGTGACACGGAAAGTGCGGGGCGTGCTATTTCTCCCCTTCTCGCATCGAATAGCATTGTGCTCAGCATGCAGAATGGGAT
CGGCAACGCTGAACGACTTGCTGTGATACTCGGCCGGCCAGTCGTTCCGGTTGTCGTCTATATTGCGGCCGAGATGGCGG
GACCCGGCCATATGCGTCATCGCGGAAGAGGCGAACTGGTTTTCCCGGAAGGGCCCGACAGTTCCAGGCTCGCCTCTTTG
TTCAATGATGCGGGTGCTCCGGCCACGGTCTCCAACACAGCCGAGACGGCTATGTGGACGAAATTCGTCGTTAATTGCTG
TGTCAATGCGCTCTCCGCGCTGACCAATCAGACTTATGACCAGATAGCCATGCACGAGGGTGCTGAGCAATTAGTCAAAG
ATACAATGCACGAATGTGTTGCGGTCGCGAGTGCGAGTGGCGTCAGTCTTCCAGGCAACATTTGGGAAATCGTTTGGAAC
GTTTTCTCTAGCATGGTCGGTCAACGATCTTCGACGGCACAGGATCTGACTCGAGGCAGGAAAACTGAGATCGATCATTT
CAACGGGGAAATTGTGAGACTGGCTCAAAGATTCGAAATTGATGTCCCCGTTAATAATGCCTTGTGGACAATGGTAAGGA
TTGCTGAGAGCAAATAA

Upstream 100 bases:

>100_bases
TGCTCGACACGGTGTTGCGAAAGATCAGGCGCCGTAACGGCGCTTAGCCAGACCATCATCGACGATTCACCGGCCGCATC
AGGCCGAGGAGCAGAACATC

Downstream 100 bases:

>100_bases
AAACTCTTTCGGGAATAGTAATACCGGCGAATATGCCTTGAAAGTTCTCGCTATGAGCGGCGGTGCGGAACCCCCGTCGG
TTTGGCCGGCATCACTTCAG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MVQEKIVVMGAGAVGCYYGALLALNGHQVTLIGRPGLVEAVANKGLLLERQSGIETVALAASESVEAVADASIVLLTVKS
GDTESAGRAISPLLASNSIVLSMQNGIGNAERLAVILGRPVVPVVVYIAAEMAGPGHMRHRGRGELVFPEGPDSSRLASL
FNDAGAPATVSNTAETAMWTKFVVNCCVNALSALTNQTYDQIAMHEGAEQLVKDTMHECVAVASASGVSLPGNIWEIVWN
VFSSMVGQRSSTAQDLTRGRKTEIDHFNGEIVRLAQRFEIDVPVNNALWTMVRIAESK

Sequences:

>Translated_298_residues
MVQEKIVVMGAGAVGCYYGALLALNGHQVTLIGRPGLVEAVANKGLLLERQSGIETVALAASESVEAVADASIVLLTVKS
GDTESAGRAISPLLASNSIVLSMQNGIGNAERLAVILGRPVVPVVVYIAAEMAGPGHMRHRGRGELVFPEGPDSSRLASL
FNDAGAPATVSNTAETAMWTKFVVNCCVNALSALTNQTYDQIAMHEGAEQLVKDTMHECVAVASASGVSLPGNIWEIVWN
VFSSMVGQRSSTAQDLTRGRKTEIDHFNGEIVRLAQRFEIDVPVNNALWTMVRIAESK
>Mature_298_residues
MVQEKIVVMGAGAVGCYYGALLALNGHQVTLIGRPGLVEAVANKGLLLERQSGIETVALAASESVEAVADASIVLLTVKS
GDTESAGRAISPLLASNSIVLSMQNGIGNAERLAVILGRPVVPVVVYIAAEMAGPGHMRHRGRGELVFPEGPDSSRLASL
FNDAGAPATVSNTAETAMWTKFVVNCCVNALSALTNQTYDQIAMHEGAEQLVKDTMHECVAVASASGVSLPGNIWEIVWN
VFSSMVGQRSSTAQDLTRGRKTEIDHFNGEIVRLAQRFEIDVPVNNALWTMVRIAESK

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=307, Percent_Identity=26.0586319218241, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 31523; Mature: 31523

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQEKIVVMGAGAVGCYYGALLALNGHQVTLIGRPGLVEAVANKGLLLERQSGIETVALA
CCCCEEEEEECCHHHHHHHHHEEECCCEEEEEECCCHHHHHHCCCEEEECCCCCCEEEEE
ASESVEAVADASIVLLTVKSGDTESAGRAISPLLASNSIVLSMQNGIGNAERLAVILGRP
CCCCHHHHCCCEEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHEEEECCCC
VVPVVVYIAAEMAGPGHMRHRGRGELVFPEGPDSSRLASLFNDAGAPATVSNTAETAMWT
HHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
KFVVNCCVNALSALTNQTYDQIAMHEGAEQLVKDTMHECVAVASASGVSLPGNIWEIVWN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VFSSMVGQRSSTAQDLTRGRKTEIDHFNGEIVRLAQRFEIDVPVNNALWTMVRIAESK
HHHHHHCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCHHHHHHHHEECCC
>Mature Secondary Structure
MVQEKIVVMGAGAVGCYYGALLALNGHQVTLIGRPGLVEAVANKGLLLERQSGIETVALA
CCCCEEEEEECCHHHHHHHHHEEECCCEEEEEECCCHHHHHHCCCEEEECCCCCCEEEEE
ASESVEAVADASIVLLTVKSGDTESAGRAISPLLASNSIVLSMQNGIGNAERLAVILGRP
CCCCHHHHCCCEEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHEEEECCCC
VVPVVVYIAAEMAGPGHMRHRGRGELVFPEGPDSSRLASLFNDAGAPATVSNTAETAMWT
HHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
KFVVNCCVNALSALTNQTYDQIAMHEGAEQLVKDTMHECVAVASASGVSLPGNIWEIVWN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VFSSMVGQRSSTAQDLTRGRKTEIDHFNGEIVRLAQRFEIDVPVNNALWTMVRIAESK
HHHHHHCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]