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The map label for this gene is icd [H]

Identifier: 162146726

GI number: 162146726

Start: 918839

End: 920053

Strand: Direct

Name: icd [H]

Synonym: GDI_0904

Alternate gene names: 162146726

Gene position: 918839-920053 (Clockwise)

Preceding gene: 162146722

Following gene: 162146729

Centisome position: 23.3

GC content: 62.96

Gene sequence:

>1215_bases
ATGGCCAAGATCAAGGTCAAGGAGCCGGTCGTCGAACTGGACGGCGACGAGATGACGCGGATCATCTGGAGCTTCATCAA
GCAGAAGCTGATCCTTCCCTACCTCGATATCGACCTGAAATATTACGATCTGGGGATCGAACATCGCGACGCCACCGACG
ACCGGGTCACGGTCGAGGCGGCCGAGGCGATCAAGAAGTACCGCGTCGGCGTCAAGTGCGCGACGATCACCCCCGACGAG
GCCCGGGTGACGGAATTCGGGCTGAAGAAGATGTGGCGGTCGCCCAATGGCACGATCCGCAACATCCTGGACGGCACCAT
CTTTCGCGAGCCGATCGTCTGTTCCAACGTGCCCCGCCTGGTGCCGCACTGGACCCAGCCGATCGTCATCGGCCGCCATG
CCTATGGTGACATCTATCGCGCGGCGGAAACCCGGATTCCGGGGCCGGGCAAGGTCAGCCTGACCTACACCCCCGCCGAC
GGCGGCGCGCCGATCGAACTGGAGGTGCATGATTTCAAGGGCCCGGGCGTGGCGCTGGGCATGCACAACACCTTGGCCTC
GATCGAAGGCTTCGCCCGCGCGTCGCTGACTTATGGCCGCGACCGTAAGCTGCCGGTCTATCTGTCGACCAAGAACACGA
TCCTGAAAGCCTATGACGGCATGTTCAAGGACGTGTTCCAGAAGGTCTTCGAGACCGAGTTCAAGGTCGATTTCGACCGG
CTGGGCCTGACCTACGAACACCGGTTGATCGACGACATGGTGGCGTCCGCCCTGAAATGGAGCGGCGGCTATGTCTGGGC
GTGCAAGAACTATGATGGCGATGTGGAAAGCGACATCGTGGCCCAGGGCTTCGGCAGCCTGGGACTGATGACCTCGGTGC
TGCTGAACCCGACCGGCGATGTGGTGGAATCCGAGGCCGCGCATGGCACCGTGACCCGCCATTACCGCGAACACCAGAAG
GGCCGGCCGACCAGCACGAACCCGATCGCGTCGATCTTCGCCTGGACGCGCGGCCTGGCCTATCGCGGACGGTTCGACAA
CACGCCGGACGTTACCCATTTCGCCGAAACGCTGGAACGCGTCTGCGTGGAAACGGTCGAAGCCGGCCAGATGACCAAGG
ACCTCGCCCTGCTGATCGGGCCCGAGGCCAAATGGCTGACGACCGAGGACTTCCTGGCGGCGCTGGATACCAACCTCCGC
AAGGCCATCTCCTGA

Upstream 100 bases:

>100_bases
CGCGTCGTCCCCTGCCGACGGGCCGTGGATCTGTCCCATCCCTCGGACCTAATAAGCGTCCGGCCACAGGCCGGCGAGAT
AACACAAGAGGAAGAGCCGT

Downstream 100 bases:

>100_bases
CACGTCTGCCCGGAAACGCGCGCCGGTAGCGATCCGGCGCGTGTTTCCTCTGCCCCGATGCTATCGGCCCGGACGGTCGG
GATTCTGTCCGTTGCCGCTA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVKEPVVELDGDEMTRIIWSFIKQKLILPYLDIDLKYYDLGIEHRDATDDRVTVEAAEAIKKYRVGVKCATITPDE
ARVTEFGLKKMWRSPNGTIRNILDGTIFREPIVCSNVPRLVPHWTQPIVIGRHAYGDIYRAAETRIPGPGKVSLTYTPAD
GGAPIELEVHDFKGPGVALGMHNTLASIEGFARASLTYGRDRKLPVYLSTKNTILKAYDGMFKDVFQKVFETEFKVDFDR
LGLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVESDIVAQGFGSLGLMTSVLLNPTGDVVESEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLAYRGRFDNTPDVTHFAETLERVCVETVEAGQMTKDLALLIGPEAKWLTTEDFLAALDTNLR
KAIS

Sequences:

>Translated_404_residues
MAKIKVKEPVVELDGDEMTRIIWSFIKQKLILPYLDIDLKYYDLGIEHRDATDDRVTVEAAEAIKKYRVGVKCATITPDE
ARVTEFGLKKMWRSPNGTIRNILDGTIFREPIVCSNVPRLVPHWTQPIVIGRHAYGDIYRAAETRIPGPGKVSLTYTPAD
GGAPIELEVHDFKGPGVALGMHNTLASIEGFARASLTYGRDRKLPVYLSTKNTILKAYDGMFKDVFQKVFETEFKVDFDR
LGLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVESDIVAQGFGSLGLMTSVLLNPTGDVVESEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLAYRGRFDNTPDVTHFAETLERVCVETVEAGQMTKDLALLIGPEAKWLTTEDFLAALDTNLR
KAIS
>Mature_403_residues
AKIKVKEPVVELDGDEMTRIIWSFIKQKLILPYLDIDLKYYDLGIEHRDATDDRVTVEAAEAIKKYRVGVKCATITPDEA
RVTEFGLKKMWRSPNGTIRNILDGTIFREPIVCSNVPRLVPHWTQPIVIGRHAYGDIYRAAETRIPGPGKVSLTYTPADG
GAPIELEVHDFKGPGVALGMHNTLASIEGFARASLTYGRDRKLPVYLSTKNTILKAYDGMFKDVFQKVFETEFKVDFDRL
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVESDIVAQGFGSLGLMTSVLLNPTGDVVESEAAHGTVTRHYREHQKG
RPTSTNPIASIFAWTRGLAYRGRFDNTPDVTHFAETLERVCVETVEAGQMTKDLALLIGPEAKWLTTEDFLAALDTNLRK
AIS

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=64.1277641277641, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI28178825, Length=397, Percent_Identity=62.4685138539043, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17550822, Length=404, Percent_Identity=62.8712871287129, Blast_Score=532, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17540874, Length=399, Percent_Identity=62.65664160401, Blast_Score=521, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320137, Length=408, Percent_Identity=64.7058823529412, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6323203, Length=405, Percent_Identity=61.9753086419753, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=58.968058968059, Blast_Score=512, Evalue=1e-146,
Organism=Drosophila melanogaster, GI21356561, Length=402, Percent_Identity=62.4378109452736, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24660856, Length=402, Percent_Identity=62.4378109452736, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221330987, Length=402, Percent_Identity=62.4378109452736, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221330985, Length=402, Percent_Identity=62.4378109452736, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI28574947, Length=402, Percent_Identity=62.4378109452736, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24660849, Length=402, Percent_Identity=62.4378109452736, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221330983, Length=402, Percent_Identity=62.4378109452736, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24660868, Length=402, Percent_Identity=62.4378109452736, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24660860, Length=402, Percent_Identity=62.4378109452736, Blast_Score=527, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45133; Mature: 45002

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVKEPVVELDGDEMTRIIWSFIKQKLILPYLDIDLKYYDLGIEHRDATDDRVTVEA
CCCEEECCCCEECCCHHHHHHHHHHHHHHHCCCEEECEEEEEEECCCCCCCCCCEEEHHH
AEAIKKYRVGVKCATITPDEARVTEFGLKKMWRSPNGTIRNILDGTIFREPIVCSNVPRL
HHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCCCHHCCCCCC
VPHWTQPIVIGRHAYGDIYRAAETRIPGPGKVSLTYTPADGGAPIELEVHDFKGPGVALG
CCCCCCCEEEECCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCEEEE
MHNTLASIEGFARASLTYGRDRKLPVYLSTKNTILKAYDGMFKDVFQKVFETEFKVDFDR
CHHHHHHHHHHHHHHEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCEEHHH
LGLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVESDIVAQGFGSLGLMTSVLLNPTGD
HCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCC
VVESEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLAYRGRFDNTPDVTHFAETLER
HHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHH
VCVETVEAGQMTKDLALLIGPEAKWLTTEDFLAALDTNLRKAIS
HHHHHHHHCCHHHCEEEEECCCCCEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVKEPVVELDGDEMTRIIWSFIKQKLILPYLDIDLKYYDLGIEHRDATDDRVTVEA
CCEEECCCCEECCCHHHHHHHHHHHHHHHCCCEEECEEEEEEECCCCCCCCCCEEEHHH
AEAIKKYRVGVKCATITPDEARVTEFGLKKMWRSPNGTIRNILDGTIFREPIVCSNVPRL
HHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCCCHHCCCCCC
VPHWTQPIVIGRHAYGDIYRAAETRIPGPGKVSLTYTPADGGAPIELEVHDFKGPGVALG
CCCCCCCEEEECCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCEEEE
MHNTLASIEGFARASLTYGRDRKLPVYLSTKNTILKAYDGMFKDVFQKVFETEFKVDFDR
CHHHHHHHHHHHHHHEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCEEHHH
LGLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVESDIVAQGFGSLGLMTSVLLNPTGD
HCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCC
VVESEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLAYRGRFDNTPDVTHFAETLER
HHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHH
VCVETVEAGQMTKDLALLIGPEAKWLTTEDFLAALDTNLRKAIS
HHHHHHHHCCHHHCEEEEECCCCCEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]