Click here to switch to the map view.

The map label for this gene is tppB [H]

Identifier: 162146650

GI number: 162146650

Start: 846840

End: 848345

Strand: Direct

Name: tppB [H]

Synonym: GDI_0828

Alternate gene names: 162146650

Gene position: 846840-848345 (Clockwise)

Preceding gene: 162146649

Following gene: 162146652

Centisome position: 21.47

GC content: 67.99

Gene sequence:

>1506_bases
ATGAATTTCTCCCCCTCCGCCGGTGCCGCCCAGCCGTCCCGCGCGTCGTCCTTCGCGGTCGTGGTCGCCATCGAATTATG
GGAACGGTTCGGCTATTACGGCATGCAGGCCGTGCTGCTGCTGTTCATGGTGCAGCATATGGGCCTGGGCGACACGCAGG
CCAACCTGCTGATGGGCGCCTTCGCGGCCATGACCTATGCGCTGCCGGTGGTCGGCGGCTGGCTGGGCGATCGGGTGCTG
GGGTCGCGCCGGGCGATGCTGCTGGGGGCCGTGGGCATGATGTGCGGCTACGCCACCCTGGCGCTGGCGACGGTGCAGGT
GCAGTTCATGACGGTCGCGATGGGAATCATCGCGGTATCCAACGGCTTTTTCAAACCCAATGCCGCCAACCTGGTCCGCC
GTATCTATGACGACGACGATGCCGCGCTCGATTCCGCCTTCACGCTTTACTACATGGCGGTCAATGTCGGTTCGACGGCC
TCGACGCTGCTGACGCCGTGGCTGCAGAACCGGTTCGGTCCGGCGGTGGCGTTCGCCGCGTGTTCCGCCGGCCTGTTCGT
GGGGCTGTGCATGTACGTGGTCCGGCGGCGGCGGCTGGCACGGATCGGCTCGGTGCCCGATTTCGCGCCGCTTCCGCCCC
GGCACGCCGGGATGGTCCTGCTGGGGATCGGCGGGGTGATCGGCGCGCTGGACCTGGTGCTGGCGCGGCCCACGCTGGCA
CGGGACTGCGTCTGGCTGGCGGCGCTGCTTGTCCTGCTGTCCTGGGCCGTGATCTATCGCCGGGCCGCGGCGGCCCAGCG
GCCGGGGCTGCGCATGGCCTACATGCTGTCGATCCAGGGCATGCTCTATTTCATCTTCTACCAGCAGACGGTGACCTCGC
TGACCCTGTTCGCGCTGCGCGCCGTCCGAGGGCAGGTCGGGGTGGGTGGAGTGACGCTGTTCAGCATGTCGGCCGGTCAG
TTCCAGGCCCTGAATCCGATCTGGATCATGCTGGCCAGCCCCGCGCTGGCCTTTGCCTATCGGCGCCTGGCGCGGGCGGG
GCGAGACCTGTCGATCGCACAGAAATTCATGATCGGGTTCAGCCTGGTCTCGCTGTCCTTCGTGGTCTGGTGGCTGGGGG
CGCTTTCGGGCGGCACGGGGCGGGTCTCGCCCTGGATCATGATCTGGGCGTACGGCTTCCTGTCGGTGGGGGAATTGCTG
ATCGGCGGGCTGGGACTGGCGGTCATCGCACGCTATGTCCCGCCCGCCATGGGGGCATTCATGATGGGGTCGTACCTTCT
GGCGATGGGGGTTGCGATGTATCTCGGCAGCATGATCGCCAATCTGGCCGCCATCGACCATGGGGCGGGTGCTGCGGTCG
TGCCGGTCGGGGCAGGGGCCTATGCCGGCCTGTTCCTCGACCTGGCGGTCGGTGCTGCGGGGATCGTGGCGGTGGTCGCC
CTGCTGCTGCCGCTCGCCCGCCGGTGGGACCGCCAGCATATGGCGGCGAAGCCGGAAGCCCTCTAA

Upstream 100 bases:

>100_bases
GGCATCAAATGTCAGTTGCCGGTCTGTCCCGGCATTGTCGCGCGCCTGTCCTCTCTGTTAGGGCTCTCGCCTTCCGCGTT
GCCATGTCCTTGGGAATTTC

Downstream 100 bases:

>100_bases
TCGCCGTTTCGCGTCAGTTCGCCGTGGATATTCATCGGAATGACCGCGGTCAGCGTGCCGAGCGGACGGTCGCTGCGGAA
GACCGTGTCGCGCGGGTAAT

Product: tripeptide permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNFSPSAGAAQPSRASSFAVVVAIELWERFGYYGMQAVLLLFMVQHMGLGDTQANLLMGAFAAMTYALPVVGGWLGDRVL
GSRRAMLLGAVGMMCGYATLALATVQVQFMTVAMGIIAVSNGFFKPNAANLVRRIYDDDDAALDSAFTLYYMAVNVGSTA
STLLTPWLQNRFGPAVAFAACSAGLFVGLCMYVVRRRRLARIGSVPDFAPLPPRHAGMVLLGIGGVIGALDLVLARPTLA
RDCVWLAALLVLLSWAVIYRRAAAAQRPGLRMAYMLSIQGMLYFIFYQQTVTSLTLFALRAVRGQVGVGGVTLFSMSAGQ
FQALNPIWIMLASPALAFAYRRLARAGRDLSIAQKFMIGFSLVSLSFVVWWLGALSGGTGRVSPWIMIWAYGFLSVGELL
IGGLGLAVIARYVPPAMGAFMMGSYLLAMGVAMYLGSMIANLAAIDHGAGAAVVPVGAGAYAGLFLDLAVGAAGIVAVVA
LLLPLARRWDRQHMAAKPEAL

Sequences:

>Translated_501_residues
MNFSPSAGAAQPSRASSFAVVVAIELWERFGYYGMQAVLLLFMVQHMGLGDTQANLLMGAFAAMTYALPVVGGWLGDRVL
GSRRAMLLGAVGMMCGYATLALATVQVQFMTVAMGIIAVSNGFFKPNAANLVRRIYDDDDAALDSAFTLYYMAVNVGSTA
STLLTPWLQNRFGPAVAFAACSAGLFVGLCMYVVRRRRLARIGSVPDFAPLPPRHAGMVLLGIGGVIGALDLVLARPTLA
RDCVWLAALLVLLSWAVIYRRAAAAQRPGLRMAYMLSIQGMLYFIFYQQTVTSLTLFALRAVRGQVGVGGVTLFSMSAGQ
FQALNPIWIMLASPALAFAYRRLARAGRDLSIAQKFMIGFSLVSLSFVVWWLGALSGGTGRVSPWIMIWAYGFLSVGELL
IGGLGLAVIARYVPPAMGAFMMGSYLLAMGVAMYLGSMIANLAAIDHGAGAAVVPVGAGAYAGLFLDLAVGAAGIVAVVA
LLLPLARRWDRQHMAAKPEAL
>Mature_501_residues
MNFSPSAGAAQPSRASSFAVVVAIELWERFGYYGMQAVLLLFMVQHMGLGDTQANLLMGAFAAMTYALPVVGGWLGDRVL
GSRRAMLLGAVGMMCGYATLALATVQVQFMTVAMGIIAVSNGFFKPNAANLVRRIYDDDDAALDSAFTLYYMAVNVGSTA
STLLTPWLQNRFGPAVAFAACSAGLFVGLCMYVVRRRRLARIGSVPDFAPLPPRHAGMVLLGIGGVIGALDLVLARPTLA
RDCVWLAALLVLLSWAVIYRRAAAAQRPGLRMAYMLSIQGMLYFIFYQQTVTSLTLFALRAVRGQVGVGGVTLFSMSAGQ
FQALNPIWIMLASPALAFAYRRLARAGRDLSIAQKFMIGFSLVSLSFVVWWLGALSGGTGRVSPWIMIWAYGFLSVGELL
IGGLGLAVIARYVPPAMGAFMMGSYLLAMGVAMYLGSMIANLAAIDHGAGAAVVPVGAGAYAGLFLDLAVGAAGIVAVVA
LLLPLARRWDRQHMAAKPEAL

Specific function: Proton-dependent permease that transports di- and tripeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily [H]

Homologues:

Organism=Homo sapiens, GI226371746, Length=373, Percent_Identity=22.5201072386059, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI226371748, Length=365, Percent_Identity=22.4657534246575, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4827008, Length=380, Percent_Identity=22.6315789473684, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789911, Length=511, Percent_Identity=35.0293542074364, Blast_Score=289, Evalue=4e-79,
Organism=Escherichia coli, GI1787922, Length=481, Percent_Identity=34.5114345114345, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1786927, Length=509, Percent_Identity=28.2907662082515, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1790572, Length=484, Percent_Identity=28.9256198347107, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71987453, Length=167, Percent_Identity=26.9461077844311, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639585, Length=182, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571098, Length=179, Percent_Identity=28.4916201117318, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639583, Length=182, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639581, Length=182, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571102, Length=179, Percent_Identity=28.4916201117318, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571100, Length=179, Percent_Identity=28.4916201117318, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 53199; Mature: 53199

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA