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The map label for this gene is folP [H]

Identifier: 162146633

GI number: 162146633

Start: 829872

End: 830972

Strand: Direct

Name: folP [H]

Synonym: GDI_0811

Alternate gene names: 162146633

Gene position: 829872-830972 (Clockwise)

Preceding gene: 162146632

Following gene: 162146634

Centisome position: 21.04

GC content: 71.66

Gene sequence:

>1101_bases
TTGGGCGCAGGGAAACGGGAAGGCTGGATGGATTGTCTTCGGTTGATCGAACCCGTGGGGCTGGTCCTGGGGCGGCAGGC
GCATGTGGCCGTGGCGGCGGGACTGGCCCACTGGCTGGCCGGTGGGCCGGCGGCCTTTACCCTGGCTCGGCTGATCGACG
GGGACGATGTCCGCCTGGTCCGCGCGGGCGATATTCCGCCCGGCTGGCTGCCGGTCCTGGCCCGTGTGACGGCGCCGCTG
CCGTCGGCGGACCTGCCGGACGGGCCGCGGGTGATGGGCATCCTGAACGTGACGCCGGACAGCTTCAGCGACGGTGGCCG
CCATATGGGACCGGACGCCGCATTGCGTGCCGCGGCGGCCATGGTGGAAGCCGGTGCCGCGCTGCTGGATATCGGCGGCG
AGAGCACGCGGCCCGACGCCGCCGTGGTGACGCCGGACGAGGAATGGGCCCGCATCGCTCCGGTGCTGGCGGACCTGCAC
GGCCGGACCGGGGCCGTACTGTCGGTCGACACCCGCAACGCCCGTACCATGGCCTCCGCGCTGGGGCTGGGGGCGACGCT
GATCAACGATGTCTCGGCGCTGGCGCATGACCCGGATGCGCTGGGGGTGGTGGCGGATGCCGGGTGCCCCGTGGTGCTGA
TGCATATGCGCGGCACGCCGCAGACGATGTCGCGCCTTGCGACCTATGGCGACGTGGGCGCCGACGTGACGCGCGAACTC
GCCGCGCGAATCGACGCGGCCGTGGCCGCCGGTGTCGCGCGCCATCGCATCCTCGTCGATCCCGGCATCGGCTTCGCCAA
GACCACGGCGCAGAATGCCGCATTGCTGGGCCGGTTGCCGATCCTGGCGAACCTGGGGTGCCGTATCGTGCTGGGAACGT
CGCGCAAGCGCACGCTGGGGGAACTGGCCGGGGTGCAGGTGGCCGCCGACCGCGATCCGGGGACCGTGGCCAGCACCCTG
CCGGGCCTGGAACTCGGCAACACGATCCTGCGTGTACATAACGTGCCGGCCATGGTTCAGGCCCTGCGGGTCTGGCAGGG
CGTGTGGACCTGCGATAAGCCGGCATCAGGGCCCGCCATGGCAGGGCAGAACCAGGGATAG

Upstream 100 bases:

>100_bases
CGCCGGGCGGCGGGGGGCTGGATCCGGCGCCGCAGCCGGGCTAAGGCGCCGTCTATTCGAATAAACACGACAGGCGGGGG
TATCCCCCGCCTGTTTTCCG

Downstream 100 bases:

>100_bases
CCGGGAATGAGCAAGACCAGACATCTATTCGGCACCGACGGCATCCGCGGCCTCGCCAACCAGGACCCGATGACGGTGGA
AATCGCGCAGAAGCTGGGGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MGAGKREGWMDCLRLIEPVGLVLGRQAHVAVAAGLAHWLAGGPAAFTLARLIDGDDVRLVRAGDIPPGWLPVLARVTAPL
PSADLPDGPRVMGILNVTPDSFSDGGRHMGPDAALRAAAAMVEAGAALLDIGGESTRPDAAVVTPDEEWARIAPVLADLH
GRTGAVLSVDTRNARTMASALGLGATLINDVSALAHDPDALGVVADAGCPVVLMHMRGTPQTMSRLATYGDVGADVTREL
AARIDAAVAAGVARHRILVDPGIGFAKTTAQNAALLGRLPILANLGCRIVLGTSRKRTLGELAGVQVAADRDPGTVASTL
PGLELGNTILRVHNVPAMVQALRVWQGVWTCDKPASGPAMAGQNQG

Sequences:

>Translated_366_residues
MGAGKREGWMDCLRLIEPVGLVLGRQAHVAVAAGLAHWLAGGPAAFTLARLIDGDDVRLVRAGDIPPGWLPVLARVTAPL
PSADLPDGPRVMGILNVTPDSFSDGGRHMGPDAALRAAAAMVEAGAALLDIGGESTRPDAAVVTPDEEWARIAPVLADLH
GRTGAVLSVDTRNARTMASALGLGATLINDVSALAHDPDALGVVADAGCPVVLMHMRGTPQTMSRLATYGDVGADVTREL
AARIDAAVAAGVARHRILVDPGIGFAKTTAQNAALLGRLPILANLGCRIVLGTSRKRTLGELAGVQVAADRDPGTVASTL
PGLELGNTILRVHNVPAMVQALRVWQGVWTCDKPASGPAMAGQNQG
>Mature_365_residues
GAGKREGWMDCLRLIEPVGLVLGRQAHVAVAAGLAHWLAGGPAAFTLARLIDGDDVRLVRAGDIPPGWLPVLARVTAPLP
SADLPDGPRVMGILNVTPDSFSDGGRHMGPDAALRAAAAMVEAGAALLDIGGESTRPDAAVVTPDEEWARIAPVLADLHG
RTGAVLSVDTRNARTMASALGLGATLINDVSALAHDPDALGVVADAGCPVVLMHMRGTPQTMSRLATYGDVGADVTRELA
ARIDAAVAAGVARHRILVDPGIGFAKTTAQNAALLGRLPILANLGCRIVLGTSRKRTLGELAGVQVAADRDPGTVASTLP
GLELGNTILRVHNVPAMVQALRVWQGVWTCDKPASGPAMAGQNQG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=265, Percent_Identity=40.7547169811321, Blast_Score=202, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324073, Length=315, Percent_Identity=28.2539682539683, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 37566; Mature: 37435

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGKREGWMDCLRLIEPVGLVLGRQAHVAVAAGLAHWLAGGPAAFTLARLIDGDDVRLV
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEE
RAGDIPPGWLPVLARVTAPLPSADLPDGPRVMGILNVTPDSFSDGGRHMGPDAALRAAAA
EECCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
MVEAGAALLDIGGESTRPDAAVVTPDEEWARIAPVLADLHGRTGAVLSVDTRNARTMASA
HHHCCCEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
LGLGATLINDVSALAHDPDALGVVADAGCPVVLMHMRGTPQTMSRLATYGDVGADVTREL
HHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHH
AARIDAAVAAGVARHRILVDPGIGFAKTTAQNAALLGRLPILANLGCRIVLGTSRKRTLG
HHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHCCHHHHCCCCEEEECCCCHHHHH
ELAGVQVAADRDPGTVASTLPGLELGNTILRVHNVPAMVQALRVWQGVWTCDKPASGPAM
HHHCEEEEECCCCCCHHHHCCCCHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCC
AGQNQG
CCCCCC
>Mature Secondary Structure 
GAGKREGWMDCLRLIEPVGLVLGRQAHVAVAAGLAHWLAGGPAAFTLARLIDGDDVRLV
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEE
RAGDIPPGWLPVLARVTAPLPSADLPDGPRVMGILNVTPDSFSDGGRHMGPDAALRAAAA
EECCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
MVEAGAALLDIGGESTRPDAAVVTPDEEWARIAPVLADLHGRTGAVLSVDTRNARTMASA
HHHCCCEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
LGLGATLINDVSALAHDPDALGVVADAGCPVVLMHMRGTPQTMSRLATYGDVGADVTREL
HHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHH
AARIDAAVAAGVARHRILVDPGIGFAKTTAQNAALLGRLPILANLGCRIVLGTSRKRTLG
HHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHCCHHHHCCCCEEEECCCCHHHHH
ELAGVQVAADRDPGTVASTLPGLELGNTILRVHNVPAMVQALRVWQGVWTCDKPASGPAM
HHHCEEEEECCCCCCHHHHCCCCHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCC
AGQNQG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]