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The map label for this gene is slt [C]

Identifier: 162146547

GI number: 162146547

Start: 742075

End: 744081

Strand: Reverse

Name: slt [C]

Synonym: GDI_0724

Alternate gene names: 162146547

Gene position: 744081-742075 (Counterclockwise)

Preceding gene: 162146549

Following gene: 162146544

Centisome position: 18.87

GC content: 72.4

Gene sequence:

>2007_bases
ATGCGAGGGACAACACACACACCCCCACAGATCGCGGTCCGGGCCTTTCTGGCCGGTGCCGCCCTTCTGGCAGGAGCGAC
GTTCACGCCGCTGCGTGTCCAGACCGCGAACGCCCGGAACACGGACGGACATCCGTCCGGCCCGGGCGAGCGGAACGAGG
AAACGGCCCTGGCCATGCCGCGGATCGCGCCGCCTGGTGGCGGAGCGGTCGGACTGGCCCAGCCGCTGAGCCCGGACGTC
GTCGCCCAGGTACGCCGGATCTTCAGCCTGCAGCGCGCGGGGGCGTTCGACGACGCCATCCGGGAGACCGCGCAATTGCG
CGACGACACTCTGCTGGGCGACATCCTGGCCGACCGCTACCTGAATCCCGCCTATCATCCCGCGCCGGGGCAGTTGCGGC
TGTGGCTGCGCACCTTTTCCACCCTGGCCGACGCCCCCGCCATCCACACGCTGCTGGCCGGCCTGTCGCCGCGCGGCGCC
AGCCTGCCGCCGCTGCCCGCGCAGATGGCGCTGGCGGCCGGCACCGGAGCGGCGGCCATGCGCCCGCCGGAAGAGGACGA
TCCCGCCGGCCGGGCCTTCGCCCGCAACCCGCTGCTGGACCGGACGGTGCGCGACCGGGCCGAGCAGGGGGTGAAGGGCG
CGCGCAGCGCGCTGCACCTGATCAAGATCACGCCGGGCATCGGCGACCTGTATGCCGCGCAGTTGCGCGCCGAGGTCGCG
ATGACGCTGTTCAGCGCGGGCGAAACCGCCCTGGCGCTGCGGACGGGGCAGGATGCCTTCATCCAGTCCGGCGGCCGGAT
CGGCCTGGCCGGCTATGTCGCCGGCCTGGCGGCCTGGCGCCGGGGACGGCCCGACATTGCCGAACCGCTGTTCGAAGGCG
CGTCGCGCGCCGAACTGACGGCAGCCGGCATCCGGGCCGGCGCCGCCTTCTGGGCGGCCCGGGCGCACCGCAATACCGGC
GACCTGGCGGCCTATCATCCCTGGCTGCATCGCGCCGCCGCCGCCCCGCACACGTTCTACGGCCTGCTGGCGGCCCAGTT
GCTGGGCCTGCGCCCGGCGAAGGGCCAGCACGCCGCGGACACGTCCCTTCCCGGTGAGCCCCTTTCCGGCGAACCCGCCG
CGCCGTCCGCCATGCCGGCGGAAGACCGGACGATGCTGCATGCCGGCGCGCCGGTCATGGGCGAAATCGACGTGGACGCC
GTGGCCGCGAAACCGGCCGGGCGGCGGGCCTTCGCCCTGTTGCAGGTCGGCGAGACGGCCCGGGCGGAAGCCGCCCTGCG
CCGCCTGTGGCCCGAGGTGCTGGGCGATGCCGCCCTGTGCCGCTCGATCCAGCTTGTGGCCGATGCCGCCGGGCTGACGG
GCCTGTCGGCGCAATTGTCGTCGCTGCTGGCATCACAGGGCGCGCCCCAGCCGGCCGTGCCCTCCCGCTTTCCGACGCCG
CGCCTGGCGCCCAGCCATGGGTTCAGGGTCGATCCGGCGCTGGTCTATGCCCTGACGCGCCTGGAATCGAATTTCGACAG
CGGGGCGATTTCCGGGTCCGGCGCGCATGGGCTGATGCAGATCATGCCGACGACCGCCAGCTTCGTGACCGGCAGGACCC
GGCGTTTCGAAGCGGCCCCGGCGCTGCTGCACAATGCGGCGACGAACCTGGATATCGGGCAGCTCTACGTCCTTTACCTG
GCGCACCTGAGCGAACAGCATGCTGGCGGCCGTCACCCGTCCGGCGGCGACCTGGTGCGGCTGCTGGCCAGCTACAATGC
CGGGCCGGGGGCGATTTCCCGACAGGAAGCCCTGAACGATTGCGGTGACGACCCGCTGCTGTTCATCGAAAGCCTGCCCA
GCGCCGAGACGCGGGATTACGTCCATCGCGCCCTGACCTATCTGTGGATCTATGCCGACCAGATGGGCCTGCCCACGCCG
TCGCTGGAAACCCTGGCGCGCAACGAATGGCCCGCCTTCGCCGCCGAGCAGGACCTGGCCGGCCGCCACTTCCACACCAT
ACACTGA

Upstream 100 bases:

>100_bases
TTTTTACTGCGGTTTGGCCATCTGTTCTGATGCCATACTGATTGCCCCGCACGCAAAAGGCTTGCCTTCCGGGGAATAAC
CCCTTAGACGCCCCTCGGCC

Downstream 100 bases:

>100_bases
AGGTCGGCCCGGAAGGGCGGCCTGGACCCGGGCGGTTCAGTCCGCCAGCGCCTGACGGCTGGCCCGGACCTTCACGACCC
GCCGCTGGTCGGTCTCCAGG

Product: lytic transglycosylase, catalytic

Products: 1,6-Anhydrobond [C]

Alternate protein names: Soluble Lytic Murein Transglycosylase; Lytic Transglycosylase; Transglycosylase; Soluble Lytic Transglycosylase; Slt Family Transglycosylase; Transglycosylase SLT Domain Protein; Lytic Murein Transglycosylase; Lytic Murein Transglycosylase Soluble; SLT Domain-Containing Protein; Transglycosylase SLT Family Protein; Transglycosylase Slt Family; Transglycosylase SLT Domain-Containing Protein; Peptidoglycan N-Acetylmuramoylhydrolase; Soulbe Lytic Murein Transglycosylase; Lytic Murein Transglycosylase Family Protein

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MRGTTHTPPQIAVRAFLAGAALLAGATFTPLRVQTANARNTDGHPSGPGERNEETALAMPRIAPPGGGAVGLAQPLSPDV
VAQVRRIFSLQRAGAFDDAIRETAQLRDDTLLGDILADRYLNPAYHPAPGQLRLWLRTFSTLADAPAIHTLLAGLSPRGA
SLPPLPAQMALAAGTGAAAMRPPEEDDPAGRAFARNPLLDRTVRDRAEQGVKGARSALHLIKITPGIGDLYAAQLRAEVA
MTLFSAGETALALRTGQDAFIQSGGRIGLAGYVAGLAAWRRGRPDIAEPLFEGASRAELTAAGIRAGAAFWAARAHRNTG
DLAAYHPWLHRAAAAPHTFYGLLAAQLLGLRPAKGQHAADTSLPGEPLSGEPAAPSAMPAEDRTMLHAGAPVMGEIDVDA
VAAKPAGRRAFALLQVGETARAEAALRRLWPEVLGDAALCRSIQLVADAAGLTGLSAQLSSLLASQGAPQPAVPSRFPTP
RLAPSHGFRVDPALVYALTRLESNFDSGAISGSGAHGLMQIMPTTASFVTGRTRRFEAAPALLHNAATNLDIGQLYVLYL
AHLSEQHAGGRHPSGGDLVRLLASYNAGPGAISRQEALNDCGDDPLLFIESLPSAETRDYVHRALTYLWIYADQMGLPTP
SLETLARNEWPAFAAEQDLAGRHFHTIH

Sequences:

>Translated_668_residues
MRGTTHTPPQIAVRAFLAGAALLAGATFTPLRVQTANARNTDGHPSGPGERNEETALAMPRIAPPGGGAVGLAQPLSPDV
VAQVRRIFSLQRAGAFDDAIRETAQLRDDTLLGDILADRYLNPAYHPAPGQLRLWLRTFSTLADAPAIHTLLAGLSPRGA
SLPPLPAQMALAAGTGAAAMRPPEEDDPAGRAFARNPLLDRTVRDRAEQGVKGARSALHLIKITPGIGDLYAAQLRAEVA
MTLFSAGETALALRTGQDAFIQSGGRIGLAGYVAGLAAWRRGRPDIAEPLFEGASRAELTAAGIRAGAAFWAARAHRNTG
DLAAYHPWLHRAAAAPHTFYGLLAAQLLGLRPAKGQHAADTSLPGEPLSGEPAAPSAMPAEDRTMLHAGAPVMGEIDVDA
VAAKPAGRRAFALLQVGETARAEAALRRLWPEVLGDAALCRSIQLVADAAGLTGLSAQLSSLLASQGAPQPAVPSRFPTP
RLAPSHGFRVDPALVYALTRLESNFDSGAISGSGAHGLMQIMPTTASFVTGRTRRFEAAPALLHNAATNLDIGQLYVLYL
AHLSEQHAGGRHPSGGDLVRLLASYNAGPGAISRQEALNDCGDDPLLFIESLPSAETRDYVHRALTYLWIYADQMGLPTP
SLETLARNEWPAFAAEQDLAGRHFHTIH
>Mature_668_residues
MRGTTHTPPQIAVRAFLAGAALLAGATFTPLRVQTANARNTDGHPSGPGERNEETALAMPRIAPPGGGAVGLAQPLSPDV
VAQVRRIFSLQRAGAFDDAIRETAQLRDDTLLGDILADRYLNPAYHPAPGQLRLWLRTFSTLADAPAIHTLLAGLSPRGA
SLPPLPAQMALAAGTGAAAMRPPEEDDPAGRAFARNPLLDRTVRDRAEQGVKGARSALHLIKITPGIGDLYAAQLRAEVA
MTLFSAGETALALRTGQDAFIQSGGRIGLAGYVAGLAAWRRGRPDIAEPLFEGASRAELTAAGIRAGAAFWAARAHRNTG
DLAAYHPWLHRAAAAPHTFYGLLAAQLLGLRPAKGQHAADTSLPGEPLSGEPAAPSAMPAEDRTMLHAGAPVMGEIDVDA
VAAKPAGRRAFALLQVGETARAEAALRRLWPEVLGDAALCRSIQLVADAAGLTGLSAQLSSLLASQGAPQPAVPSRFPTP
RLAPSHGFRVDPALVYALTRLESNFDSGAISGSGAHGLMQIMPTTASFVTGRTRRFEAAPALLHNAATNLDIGQLYVLYL
AHLSEQHAGGRHPSGGDLVRLLASYNAGPGAISRQEALNDCGDDPLLFIESLPSAETRDYVHRALTYLWIYADQMGLPTP
SLETLARNEWPAFAAEQDLAGRHFHTIH

Specific function: Murein-Degrading Enzyme. Catalyzes The Cleavage Of The Glycosidic Bonds Between N-Acetylmuramic Acid And N- Acetylglucosamine Residues In Peptidoglycan. May Play A Role In Recycling Of Muropeptides During Cell Elongation And/Or Cell Division. [C]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Periplasmic Protein. Tightly Associated With The Murein Sacculus [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082441, Length=254, Percent_Identity=29.5275590551181, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 70253; Mature: 70253

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGTTHTPPQIAVRAFLAGAALLAGATFTPLRVQTANARNTDGHPSGPGERNEETALAMP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHEECC
RIAPPGGGAVGLAQPLSPDVVAQVRRIFSLQRAGAFDDAIRETAQLRDDTLLGDILADRY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LNPAYHPAPGQLRLWLRTFSTLADAPAIHTLLAGLSPRGASLPPLPAQMALAAGTGAAAM
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCC
RPPEEDDPAGRAFARNPLLDRTVRDRAEQGVKGARSALHLIKITPGIGDLYAAQLRAEVA
CCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHH
MTLFSAGETALALRTGQDAFIQSGGRIGLAGYVAGLAAWRRGRPDIAEPLFEGASRAELT
HHHHHCCCEEEEEECCCHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHH
AAGIRAGAAFWAARAHRNTGDLAAYHPWLHRAAAAPHTFYGLLAAQLLGLRPAKGQHAAD
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC
TSLPGEPLSGEPAAPSAMPAEDRTMLHAGAPVMGEIDVDAVAAKPAGRRAFALLQVGETA
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCHHHCCCCCCCCEEEEEECCCHH
RAEAALRRLWPEVLGDAALCRSIQLVADAAGLTGLSAQLSSLLASQGAPQPAVPSRFPTP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
RLAPSHGFRVDPALVYALTRLESNFDSGAISGSGAHGLMQIMPTTASFVTGRTRRFEAAP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHCCCCHHHHHHH
ALLHNAATNLDIGQLYVLYLAHLSEQHAGGRHPSGGDLVRLLASYNAGPGAISRQEALND
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
CGDDPLLFIESLPSAETRDYVHRALTYLWIYADQMGLPTPSLETLARNEWPAFAAEQDLA
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCC
GRHFHTIH
CCCCCCCC
>Mature Secondary Structure
MRGTTHTPPQIAVRAFLAGAALLAGATFTPLRVQTANARNTDGHPSGPGERNEETALAMP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHEECC
RIAPPGGGAVGLAQPLSPDVVAQVRRIFSLQRAGAFDDAIRETAQLRDDTLLGDILADRY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LNPAYHPAPGQLRLWLRTFSTLADAPAIHTLLAGLSPRGASLPPLPAQMALAAGTGAAAM
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCC
RPPEEDDPAGRAFARNPLLDRTVRDRAEQGVKGARSALHLIKITPGIGDLYAAQLRAEVA
CCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHH
MTLFSAGETALALRTGQDAFIQSGGRIGLAGYVAGLAAWRRGRPDIAEPLFEGASRAELT
HHHHHCCCEEEEEECCCHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHH
AAGIRAGAAFWAARAHRNTGDLAAYHPWLHRAAAAPHTFYGLLAAQLLGLRPAKGQHAAD
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC
TSLPGEPLSGEPAAPSAMPAEDRTMLHAGAPVMGEIDVDAVAAKPAGRRAFALLQVGETA
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCHHHCCCCCCCCEEEEEECCCHH
RAEAALRRLWPEVLGDAALCRSIQLVADAAGLTGLSAQLSSLLASQGAPQPAVPSRFPTP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
RLAPSHGFRVDPALVYALTRLESNFDSGAISGSGAHGLMQIMPTTASFVTGRTRRFEAAP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHCCCCHHHHHHH
ALLHNAATNLDIGQLYVLYLAHLSEQHAGGRHPSGGDLVRLLASYNAGPGAISRQEALND
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
CGDDPLLFIESLPSAETRDYVHRALTYLWIYADQMGLPTPSLETLARNEWPAFAAEQDLA
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCC
GRHFHTIH
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA