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The map label for this gene is copR [H]

Identifier: 162146495

GI number: 162146495

Start: 679099

End: 679743

Strand: Direct

Name: copR [H]

Synonym: GDI_0671

Alternate gene names: 162146495

Gene position: 679099-679743 (Clockwise)

Preceding gene: 162146494

Following gene: 162146496

Centisome position: 17.22

GC content: 66.05

Gene sequence:

>645_bases
ATGACCCATGTTCCTTCCCCTGTCCGGTTGCTCCTGGTCGAAGACGATCCTCATACGGCCGCCTATGTTCGCGATGGCCT
GGCGCGGGACGGGATCGGCGTGACGTGGGTCGCCAACGGTACCGACGGGCTGTCGGCGGCCCTGGGCCGGCACTGGGACG
TCATCGTGCTGGACCGGATGCTGCCGGGCCTGGATGGCATGGCGATTCTGAAGCGCGTGCGCGAGGTCGGAATTCGCATC
CCCGTCCTGTTCCTGACCACGATGGACGGGGTCAACAGCCGCGTCGGCGGCCTGCGGGGCGGGGCGGACGATTACCTGGT
CAAGCCGTTCGCGGTGCGCGAACTGGCGGCCCGGGTTGCGGTCCTGCTGCGCCGGATGGGCCTGGCGCGGGACGCCACCG
TCCTGCGGGCGGCGGGCATCACGCTGGACCTGCTGACGCGCGAGGTCACGCGTCATGGGGAAAAGCTGTTCCTGCAGCCG
CAGGAGGTCAGGATCCTGGAATATTTCATGCGCAATCCAGGGACGATCCTGTCGCGGCGGATGCTGCTGCACGCCTGGAA
CGTGGATTTTCCGGTGCACACGAATCTCGTCGAAACCCATCTCATACCAACTCCGGTCCGCCCTGACTCATATGTGATTG
CCTGA

Upstream 100 bases:

>100_bases
GTCGTCCGCAAGCACCTGATCCGGCCTATCTTAAAAAATCCCAATCTACCGTGGACGCCCTTTACGAGGGGGAGGGCGGC
TTTATCCTCGGCGGGGCCCC

Downstream 100 bases:

>100_bases
CGGTATCGTTCTGGAACGAGCTGTGATTCACAGGATGCCGAACCGGGCGGGAGGCATCCGAATGGGCGGGGCGTTAGCGT
TGCGTGAGGATTATGATGCG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MTHVPSPVRLLLVEDDPHTAAYVRDGLARDGIGVTWVANGTDGLSAALGRHWDVIVLDRMLPGLDGMAILKRVREVGIRI
PVLFLTTMDGVNSRVGGLRGGADDYLVKPFAVRELAARVAVLLRRMGLARDATVLRAAGITLDLLTREVTRHGEKLFLQP
QEVRILEYFMRNPGTILSRRMLLHAWNVDFPVHTNLVETHLIPTPVRPDSYVIA

Sequences:

>Translated_214_residues
MTHVPSPVRLLLVEDDPHTAAYVRDGLARDGIGVTWVANGTDGLSAALGRHWDVIVLDRMLPGLDGMAILKRVREVGIRI
PVLFLTTMDGVNSRVGGLRGGADDYLVKPFAVRELAARVAVLLRRMGLARDATVLRAAGITLDLLTREVTRHGEKLFLQP
QEVRILEYFMRNPGTILSRRMLLHAWNVDFPVHTNLVETHLIPTPVRPDSYVIA
>Mature_213_residues
THVPSPVRLLLVEDDPHTAAYVRDGLARDGIGVTWVANGTDGLSAALGRHWDVIVLDRMLPGLDGMAILKRVREVGIRIP
VLFLTTMDGVNSRVGGLRGGADDYLVKPFAVRELAARVAVLLRRMGLARDATVLRAAGITLDLLTREVTRHGEKLFLQPQ
EVRILEYFMRNPGTILSRRMLLHAWNVDFPVHTNLVETHLIPTPVRPDSYVIA

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=197, Percent_Identity=43.1472081218274, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1786784, Length=192, Percent_Identity=38.5416666666667, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI87082012, Length=192, Percent_Identity=36.4583333333333, Blast_Score=116, Evalue=9e-28,
Organism=Escherichia coli, GI1790552, Length=200, Percent_Identity=35.5, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1786599, Length=197, Percent_Identity=35.5329949238579, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786911, Length=213, Percent_Identity=32.3943661971831, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1788394, Length=206, Percent_Identity=32.0388349514563, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=183, Percent_Identity=34.4262295081967, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1789809, Length=182, Percent_Identity=32.967032967033, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790860, Length=192, Percent_Identity=31.25, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787375, Length=178, Percent_Identity=30.8988764044944, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790863, Length=218, Percent_Identity=29.3577981651376, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788550, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=134, Percent_Identity=29.1044776119403, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI2367329, Length=181, Percent_Identity=31.4917127071823, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 23734; Mature: 23603

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHVPSPVRLLLVEDDPHTAAYVRDGLARDGIGVTWVANGTDGLSAALGRHWDVIVLDRM
CCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCCCCEEEEHHH
LPGLDGMAILKRVREVGIRIPVLFLTTMDGVNSRVGGLRGGADDYLVKPFAVRELAARVA
CCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHCCCCCCCCCCHHCCHHHHHHHHHHHH
VLLRRMGLARDATVLRAAGITLDLLTREVTRHGEKLFLQPQEVRILEYFMRNPGTILSRR
HHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCCCHHHHHH
MLLHAWNVDFPVHTNLVETHLIPTPVRPDSYVIA
HHHHHCCCCCCCCCCHHHHCCCCCCCCCCCEEEC
>Mature Secondary Structure 
THVPSPVRLLLVEDDPHTAAYVRDGLARDGIGVTWVANGTDGLSAALGRHWDVIVLDRM
CCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCCCCEEEEHHH
LPGLDGMAILKRVREVGIRIPVLFLTTMDGVNSRVGGLRGGADDYLVKPFAVRELAARVA
CCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHCCCCCCCCCCHHCCHHHHHHHHHHHH
VLLRRMGLARDATVLRAAGITLDLLTREVTRHGEKLFLQPQEVRILEYFMRNPGTILSRR
HHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCCCHHHHHH
MLLHAWNVDFPVHTNLVETHLIPTPVRPDSYVIA
HHHHHCCCCCCCCCCHHHHCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]