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The map label for this gene is hutH

Identifier: 162146375

GI number: 162146375

Start: 552156

End: 553703

Strand: Direct

Name: hutH

Synonym: GDI_0550

Alternate gene names: 162146375

Gene position: 552156-553703 (Clockwise)

Preceding gene: 162146373

Following gene: 162146379

Centisome position: 14.0

GC content: 71.06

Gene sequence:

>1548_bases
GTGATGACCGACTCCCTGATCCTGACCCCGGGTACGCTCTCCCTCGCGGATCTGCGGCGGCTCGCGTTCTCCGCGCCGTC
AGTCACGCTGGCGGCGGGGGTGCGTGACACCCTGGCGCAGGCCGCGCGCTCGGTCGACCGGATCGTGGCCGACGGCAGGC
CGGTCTATGGCGTCAATACCGGTTTCGGCAAGCTGGCGCGGACGCGCATCGCCGACGCCAACCTGCGCGACCTGCAACGC
AACCTGGTTCTCAGCCACGCCGCCGGGATCGGCGCGCCGATGGACGACCGCACGGTGCGGCTGATCCTGCTGCTGAAGGC
CAACGGCCTGGCGCGCGGCCATTCCGGCGTGCGGCCCGAAATCGTGGACCTGCTGCTGGAGATGGGCAATCGCGGCGTGC
TGCCCGTCATTCCGCAGAAGGGATCGGTGGGCGCGTCCGGCGACCTGGCGCCGCTGGCGCACATGACGGCGGTACTGATC
GGCGCGGGGCAGGCCAGGGTGGACGGGCGCGTCCTGCCGGGCGACCAGGCCCTGCGCGCGGTGGGCCTGGCGCCGGTGGA
ACTGGGGCCCAAGGAAGGGCTGGCCCTGCTGAACGGTACCCAGGCCTCGACCGCGCTGGCGCTGGTCGCCCTGTTCGACG
CCGAACGCGTGTTCCAGGCGGCGCTGGTGACGGGTGCGCTGACCCTGGACGCCGCCCGCGGCACCGACGCGCCGTTCGAC
CCGCGCCTGCACGCCCTGCGCGGGCAGAAGGGACAGATCGAATGCGCCGCCCTCTATCGCGCGCTGATGGCGGACTCGGC
CATTCGCGCCTCGCACCGCGAGGATGACGAACGCGTCCAGGACCCGTACTGCCTGCGCTGCCAGCCGCAGGTCATGGGGG
CCTGCCTGGACAGCCTGCGCCATGCGGCCTCGGTCCTGCTGATCGAAGCGAACGCCGTGTCCGACAACCCGATCCATTTC
GCGGAAACCGACGAAATGCTGTCGGGCGGCAACTTCCATGCCGAACCGGTGGCCATCGCCGCCGACCTGATGGCCATTGC
GGTGTCGGAAGTCGGGGCCATCGCGGAACGGCGCCTGGCGCTGCTGGTCGATGCGCAGATGAGCGGCCTGCCCCCCTTCC
TGGTCCGGGACAGCGGCGTCAATTCCGGGTTCATGATCGCGCAGGTCACGGCGGCGGCGCTGGCGTCGGAAAACAAGACC
CTGGCCCATCCGGCCAGCATCGACAGCCTGCCGACCTCGGCGAACCAGGAGGACCATGTCAGCATGGCCACCTTCGCCGC
GCGGCGCGTGGGCGACATCGTGGCCAATGTCCGCGACATCGTCGCCATCGAATATCTGGCGGCCGTGCAGGGGCTCGATT
TCCTGGCCCCGCTGCAGACGTCCCGCCCGCTGGCCGGCGCGGCGGCGGCCCTGCGCGCGCGGGTGCCGTTCTATGACCGC
GACCGGATCTTCACCCCGGATATCGAGGCCGCGCGGGACCTGATCGCCGATGGCGTGCCGACATTGCTGCCCGGGATTGC
CGACGTGCTGCCCCGGCTCGAAGTGTAA

Upstream 100 bases:

>100_bases
GTGGCGCAGTGGCCCATTGCATCCCTTGCCAGGGGATTTGACAAGAGCGGATCGCTGTCGCTATCGACCAATGTCTATAC
AAGTACAGGCAAGCCCCCCC

Downstream 100 bases:

>100_bases
GGGTCGTGTAGACCTTACCTGGCCTGTGCCGCCCGCTTCCGCCCCCGCACCACGGCCGTGTCCAGCGCCGAGAGAAATGT
CGAGCGATCCGCGCGGGTAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MMTDSLILTPGTLSLADLRRLAFSAPSVTLAAGVRDTLAQAARSVDRIVADGRPVYGVNTGFGKLARTRIADANLRDLQR
NLVLSHAAGIGAPMDDRTVRLILLLKANGLARGHSGVRPEIVDLLLEMGNRGVLPVIPQKGSVGASGDLAPLAHMTAVLI
GAGQARVDGRVLPGDQALRAVGLAPVELGPKEGLALLNGTQASTALALVALFDAERVFQAALVTGALTLDAARGTDAPFD
PRLHALRGQKGQIECAALYRALMADSAIRASHREDDERVQDPYCLRCQPQVMGACLDSLRHAASVLLIEANAVSDNPIHF
AETDEMLSGGNFHAEPVAIAADLMAIAVSEVGAIAERRLALLVDAQMSGLPPFLVRDSGVNSGFMIAQVTAAALASENKT
LAHPASIDSLPTSANQEDHVSMATFAARRVGDIVANVRDIVAIEYLAAVQGLDFLAPLQTSRPLAGAAAALRARVPFYDR
DRIFTPDIEAARDLIADGVPTLLPGIADVLPRLEV

Sequences:

>Translated_515_residues
MMTDSLILTPGTLSLADLRRLAFSAPSVTLAAGVRDTLAQAARSVDRIVADGRPVYGVNTGFGKLARTRIADANLRDLQR
NLVLSHAAGIGAPMDDRTVRLILLLKANGLARGHSGVRPEIVDLLLEMGNRGVLPVIPQKGSVGASGDLAPLAHMTAVLI
GAGQARVDGRVLPGDQALRAVGLAPVELGPKEGLALLNGTQASTALALVALFDAERVFQAALVTGALTLDAARGTDAPFD
PRLHALRGQKGQIECAALYRALMADSAIRASHREDDERVQDPYCLRCQPQVMGACLDSLRHAASVLLIEANAVSDNPIHF
AETDEMLSGGNFHAEPVAIAADLMAIAVSEVGAIAERRLALLVDAQMSGLPPFLVRDSGVNSGFMIAQVTAAALASENKT
LAHPASIDSLPTSANQEDHVSMATFAARRVGDIVANVRDIVAIEYLAAVQGLDFLAPLQTSRPLAGAAAALRARVPFYDR
DRIFTPDIEAARDLIADGVPTLLPGIADVLPRLEV
>Mature_515_residues
MMTDSLILTPGTLSLADLRRLAFSAPSVTLAAGVRDTLAQAARSVDRIVADGRPVYGVNTGFGKLARTRIADANLRDLQR
NLVLSHAAGIGAPMDDRTVRLILLLKANGLARGHSGVRPEIVDLLLEMGNRGVLPVIPQKGSVGASGDLAPLAHMTAVLI
GAGQARVDGRVLPGDQALRAVGLAPVELGPKEGLALLNGTQASTALALVALFDAERVFQAALVTGALTLDAARGTDAPFD
PRLHALRGQKGQIECAALYRALMADSAIRASHREDDERVQDPYCLRCQPQVMGACLDSLRHAASVLLIEANAVSDNPIHF
AETDEMLSGGNFHAEPVAIAADLMAIAVSEVGAIAERRLALLVDAQMSGLPPFLVRDSGVNSGFMIAQVTAAALASENKT
LAHPASIDSLPTSANQEDHVSMATFAARRVGDIVANVRDIVAIEYLAAVQGLDFLAPLQTSRPLAGAAAALRARVPFYDR
DRIFTPDIEAARDLIADGVPTLLPGIADVLPRLEV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=490, Percent_Identity=44.6938775510204, Blast_Score=400, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567831, Length=501, Percent_Identity=42.315369261477, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_GLUDA (A9H863)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001600834.1
- RefSeq:   YP_002275852.1
- ProteinModelPortal:   A9H863
- SMR:   A9H863
- GeneID:   5791307
- GeneID:   6974866
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_1458
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54015; Mature: 54015

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTDSLILTPGTLSLADLRRLAFSAPSVTLAAGVRDTLAQAARSVDRIVADGRPVYGVNT
CCCCCEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GFGKLARTRIADANLRDLQRNLVLSHAAGIGAPMDDRTVRLILLLKANGLARGHSGVRPE
CHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHH
IVDLLLEMGNRGVLPVIPQKGSVGASGDLAPLAHMTAVLIGAGQARVDGRVLPGDQALRA
HHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHH
VGLAPVELGPKEGLALLNGTQASTALALVALFDAERVFQAALVTGALTLDAARGTDAPFD
HCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCC
PRLHALRGQKGQIECAALYRALMADSAIRASHREDDERVQDPYCLRCQPQVMGACLDSLR
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEECCCHHHHHHHHHHHH
HAASVLLIEANAVSDNPIHFAETDEMLSGGNFHAEPVAIAADLMAIAVSEVGAIAERRLA
HHHEEEEEEECCCCCCCEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLVDAQMSGLPPFLVRDSGVNSGFMIAQVTAAALASENKTLAHPASIDSLPTSANQEDHV
EEEECHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SMATFAARRVGDIVANVRDIVAIEYLAAVQGLDFLAPLQTSRPLAGAAAALRARVPFYDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHCCCCCCC
DRIFTPDIEAARDLIADGVPTLLPGIADVLPRLEV
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMTDSLILTPGTLSLADLRRLAFSAPSVTLAAGVRDTLAQAARSVDRIVADGRPVYGVNT
CCCCCEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GFGKLARTRIADANLRDLQRNLVLSHAAGIGAPMDDRTVRLILLLKANGLARGHSGVRPE
CHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHH
IVDLLLEMGNRGVLPVIPQKGSVGASGDLAPLAHMTAVLIGAGQARVDGRVLPGDQALRA
HHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHH
VGLAPVELGPKEGLALLNGTQASTALALVALFDAERVFQAALVTGALTLDAARGTDAPFD
HCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCC
PRLHALRGQKGQIECAALYRALMADSAIRASHREDDERVQDPYCLRCQPQVMGACLDSLR
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEECCCHHHHHHHHHHHH
HAASVLLIEANAVSDNPIHFAETDEMLSGGNFHAEPVAIAADLMAIAVSEVGAIAERRLA
HHHEEEEEEECCCCCCCEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLVDAQMSGLPPFLVRDSGVNSGFMIAQVTAAALASENKTLAHPASIDSLPTSANQEDHV
EEEECHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SMATFAARRVGDIVANVRDIVAIEYLAAVQGLDFLAPLQTSRPLAGAAAALRARVPFYDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHCCCCCCC
DRIFTPDIEAARDLIADGVPTLLPGIADVLPRLEV
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA