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The map label for this gene is ghrA [H]

Identifier: 162146241

GI number: 162146241

Start: 413206

End: 414132

Strand: Reverse

Name: ghrA [H]

Synonym: GDI_0416

Alternate gene names: 162146241

Gene position: 414132-413206 (Counterclockwise)

Preceding gene: 162146242

Following gene: 162146235

Centisome position: 10.5

GC content: 68.39

Gene sequence:

>927_bases
ATGTCCTTCGTCATCAAATCCACCCCGGAACGCGCCGCCATCTGGTCCGCCCTGTTCGCGGCCCACATGCCCGACCAGAA
GATCGAGATCTGGCCCGATATCGCCGATCCACATTCCGTCGAATTCCTGGCCGCCTGGGTACCGCCCCGGGACCTGGAGC
AGACATTTCCCAACCTGAAGGTGCTGTTTTCGGTCGGCGCGGGGGTGGACCAGTTGGACCTGTCCGCCGTGCCGGCCCAT
GTGCAGGTCGTGCGCATGATCGAATCCGGCCTGACCGACGGCATGGTGGATTACGTGCGGTTCTCGGTCCTCGCCCTGCA
TCGGGGCATGCTGCGCTACGTGGCGCAGCAGCGCGAGCAGGTGTGGAAAGCGCACCCCTATGTGCCGGCGTCGGCGCTGA
CCGTGGGCGTGATGGGGCTGGGGCAACTCGGCCTGCCGGTCGTCGAGGCCGTACGGGCGCTGGGCTATGGCTGCCGGGGC
TGGGCGCGGAGCCGGCGCGACATCGACGGCATTCCGACCTTCGCCGGGCAGGAGGAACTGGATGCGTTCCTGGGCGGGAC
GGACATCCTGGTCTGCCTTCTGCCGCTGACCGCCGAGACGACGGGACTTCTGGCCCGGCCGCTTTTCTCGCGCCTGCCGC
GCGGCGCGGGGCTGGTCCATTGCGGGCGGGGCAAGCAACTGGTGCTGGACGACCTGATGGCCGCGCTGGATGCCGGGGAA
CTGGGCGGCGCCGTCGTCGACGTCACCGACCCCGAGCCGCTGCCGCCCGGCCACGCCCTGTGGAACCGGGCGGATGTCCT
GATCACCCCCCACACGGCCAGCATCACCCAGGCGGAAACGGGCGGGAAATCCATCCTGGAAAACCTGCAACGCTACCGAA
AGGGCGAACCCCTCAAGGGCCTGGTGGACAGGACCATCGGGTACTGA

Upstream 100 bases:

>100_bases
CTGTTCGGGAGCCTTGTGCCGGGTACATGCGACGGCCCAAAACGGATAAAAGCCTTTTTGCTTCTTTTTCTTCAGAAAAA
GAAGAAATCAGGAAACTTTC

Downstream 100 bases:

>100_bases
CCCGTCATCGGGGCCAGGGCCACAGGCCCTGGCGGGTTCGCGTTACGGGGCCGAGGGCGCTTCGTTCTTCGCAGCTGACA
ATGCCACGGATGCCTCGGTC

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSFVIKSTPERAAIWSALFAAHMPDQKIEIWPDIADPHSVEFLAAWVPPRDLEQTFPNLKVLFSVGAGVDQLDLSAVPAH
VQVVRMIESGLTDGMVDYVRFSVLALHRGMLRYVAQQREQVWKAHPYVPASALTVGVMGLGQLGLPVVEAVRALGYGCRG
WARSRRDIDGIPTFAGQEELDAFLGGTDILVCLLPLTAETTGLLARPLFSRLPRGAGLVHCGRGKQLVLDDLMAALDAGE
LGGAVVDVTDPEPLPPGHALWNRADVLITPHTASITQAETGGKSILENLQRYRKGEPLKGLVDRTIGY

Sequences:

>Translated_308_residues
MSFVIKSTPERAAIWSALFAAHMPDQKIEIWPDIADPHSVEFLAAWVPPRDLEQTFPNLKVLFSVGAGVDQLDLSAVPAH
VQVVRMIESGLTDGMVDYVRFSVLALHRGMLRYVAQQREQVWKAHPYVPASALTVGVMGLGQLGLPVVEAVRALGYGCRG
WARSRRDIDGIPTFAGQEELDAFLGGTDILVCLLPLTAETTGLLARPLFSRLPRGAGLVHCGRGKQLVLDDLMAALDAGE
LGGAVVDVTDPEPLPPGHALWNRADVLITPHTASITQAETGGKSILENLQRYRKGEPLKGLVDRTIGY
>Mature_307_residues
SFVIKSTPERAAIWSALFAAHMPDQKIEIWPDIADPHSVEFLAAWVPPRDLEQTFPNLKVLFSVGAGVDQLDLSAVPAHV
QVVRMIESGLTDGMVDYVRFSVLALHRGMLRYVAQQREQVWKAHPYVPASALTVGVMGLGQLGLPVVEAVRALGYGCRGW
ARSRRDIDGIPTFAGQEELDAFLGGTDILVCLLPLTAETTGLLARPLFSRLPRGAGLVHCGRGKQLVLDDLMAALDAGEL
GGAVVDVTDPEPLPPGHALWNRADVLITPHTASITQAETGGKSILENLQRYRKGEPLKGLVDRTIGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=271, Percent_Identity=27.6752767527675, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI23308577, Length=281, Percent_Identity=25.2669039145907, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87081824, Length=301, Percent_Identity=35.8803986710963, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082289, Length=261, Percent_Identity=25.6704980842912, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=256, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574286, Length=305, Percent_Identity=27.8688524590164, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=27.6923076923077, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=27.6923076923077, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=27.6923076923077, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=27.6923076923077, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=27.6923076923077, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33350; Mature: 33219

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVIKSTPERAAIWSALFAAHMPDQKIEIWPDIADPHSVEFLAAWVPPRDLEQTFPNLK
CCEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEECCCCHHHHHHCCCCE
VLFSVGAGVDQLDLSAVPAHVQVVRMIESGLTDGMVDYVRFSVLALHRGMLRYVAQQREQ
EEEECCCCCCHHCHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWKAHPYVPASALTVGVMGLGQLGLPVVEAVRALGYGCRGWARSRRDIDGIPTFAGQEEL
HHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCHHHH
DAFLGGTDILVCLLPLTAETTGLLARPLFSRLPRGAGLVHCGRGKQLVLDDLMAALDAGE
HHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCHH
LGGAVVDVTDPEPLPPGHALWNRADVLITPHTASITQAETGGKSILENLQRYRKGEPLKG
CCCEEEECCCCCCCCCCHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
LVDRTIGY
HHHHHCCC
>Mature Secondary Structure 
SFVIKSTPERAAIWSALFAAHMPDQKIEIWPDIADPHSVEFLAAWVPPRDLEQTFPNLK
CEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEECCCCHHHHHHCCCCE
VLFSVGAGVDQLDLSAVPAHVQVVRMIESGLTDGMVDYVRFSVLALHRGMLRYVAQQREQ
EEEECCCCCCHHCHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWKAHPYVPASALTVGVMGLGQLGLPVVEAVRALGYGCRGWARSRRDIDGIPTFAGQEEL
HHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCHHHH
DAFLGGTDILVCLLPLTAETTGLLARPLFSRLPRGAGLVHCGRGKQLVLDDLMAALDAGE
HHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCHH
LGGAVVDVTDPEPLPPGHALWNRADVLITPHTASITQAETGGKSILENLQRYRKGEPLKG
CCCEEEECCCCCCCCCCHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
LVDRTIGY
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA