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The map label for this gene is ndh [H]

Identifier: 162146140

GI number: 162146140

Start: 321948

End: 323231

Strand: Direct

Name: ndh [H]

Synonym: GDI_0312

Alternate gene names: 162146140

Gene position: 321948-323231 (Clockwise)

Preceding gene: 162146139

Following gene: 162146142

Centisome position: 8.16

GC content: 65.42

Gene sequence:

>1284_bases
ATGGTGTCCAGATCCGAAATCCTGATTGTCGGCGGTGGTGTGGCCGGACTTGCCCTGGCGACGCGGCTTGGCGGGACACT
GGGGAAGCAGGGCAGCGCGCGCATCACGCTTATCGATAAAAGCTTCTCGCACGTCTGGAAGCCGATGCTGCACTGCTTCG
CTGCCGGCACCGCGCAGAACGAGAACGACCGCATCAGCTTCATGTCGCAGGCCGGCGCCCATCATTTCGAGTTCTGGCCG
GGCGAGGTGATTTCCCTGGATCGCGCGAAGCGGGAGGTCGTGCTTGGCCCGCTGCGGGCCTCGGACGGCAGCACCGTCCT
GGAAAGCCGCACCGTGACCTATGACGCGCTGGTGCTGTCGATCGGCAGTTGCGCCAACGATTTCCGGACCCCGGGCGTCG
CGGAACATTGCCTGTTCATCGACAATCTGGTGGAAGCGAACGGATTCAACGAAAAATTCCGCATGGAACTCCTGCGGGCC
TATGCGACGAATGCCGAGCTGGACATCGCCATCGTCGGCGGCGGCGCCACCGGAACGCAGTTGGCCGCCGAACTGCACAA
GGCGCTCGACATCGTCGGGCTGCATGCGTTCGGCCCGACGCCGCCCAGGCTCCGGATCACCCTGCTGGAGGCCGGACCGC
GCGTACTGCCCGCTTTTCCGGAGGCGGTGTCCGCCGCGGCGCAGCAGGAACTGGAGCGGATCGGCGTTTCGGTGCGCACC
TCGGCCATGGTTTCGGGCGCCGACGAGACGGGATTCAGCCTGAAGGACGGCACGCATATTCCGGCCACGCTGCGCGTCTG
GGCCGCGGGCGTGAAGGCGCCGGACGTGACGAAATCCTATGGCGGCCTGTCCCTGAGCCGTTCGGGGCAGATCCTGGTCA
AGCCCAATCTGCTTTCCGTCGATGACGACCGGATTTTCGCGCTGGGGGATTGTTCGTTCATCGTCGACGACCCGCTGCCG
CCCACGGCACAGGTGGCCCGGCAGCAGGCGCACCATCTGGCCCGCCATCTGTCCGCGTGGATACGCGACGGGCAGGACGT
CCCCGCCTGCGTGTTCCGCAACAAGGGCGCGATCGTGGCCCTGGGCAATTATAACGGCTGGGGTACGCTGCCCGGTGGAA
GCGTCTTCGGTGGCGGCGTGCTGAAGGGCCTGACGGCACGGGTGGGCCATCTGATGCTCTATCGTCAGCATCAGGTCGAA
CTGTACGGTTTCTTTCGCGGCCTGATGTCCTGTGTCGCGGACTGGATCGACACTATGGTGCGGCCGTCAGTTCGTCTGGA
CTGA

Upstream 100 bases:

>100_bases
AGCTCGGATTCTTCTGAGGTTTTTTCTCCTGAGCTTTCGGGGCGGGGCCTGCTATGCTGCGCCCCGTTTTCCATTCTGCT
GGTATGGAATTTGAAAATCG

Downstream 100 bases:

>100_bases
TCCAGTCCAGATCGGCCGGGGCCAGCATCGCGGCCTGCAGTCGCATGATCCGGCGCAGGATCGGAACCAGGCGGCTGCGC
CCCTTCAGCCTGATCCATTC

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MVSRSEILIVGGGVAGLALATRLGGTLGKQGSARITLIDKSFSHVWKPMLHCFAAGTAQNENDRISFMSQAGAHHFEFWP
GEVISLDRAKREVVLGPLRASDGSTVLESRTVTYDALVLSIGSCANDFRTPGVAEHCLFIDNLVEANGFNEKFRMELLRA
YATNAELDIAIVGGGATGTQLAAELHKALDIVGLHAFGPTPPRLRITLLEAGPRVLPAFPEAVSAAAQQELERIGVSVRT
SAMVSGADETGFSLKDGTHIPATLRVWAAGVKAPDVTKSYGGLSLSRSGQILVKPNLLSVDDDRIFALGDCSFIVDDPLP
PTAQVARQQAHHLARHLSAWIRDGQDVPACVFRNKGAIVALGNYNGWGTLPGGSVFGGGVLKGLTARVGHLMLYRQHQVE
LYGFFRGLMSCVADWIDTMVRPSVRLD

Sequences:

>Translated_427_residues
MVSRSEILIVGGGVAGLALATRLGGTLGKQGSARITLIDKSFSHVWKPMLHCFAAGTAQNENDRISFMSQAGAHHFEFWP
GEVISLDRAKREVVLGPLRASDGSTVLESRTVTYDALVLSIGSCANDFRTPGVAEHCLFIDNLVEANGFNEKFRMELLRA
YATNAELDIAIVGGGATGTQLAAELHKALDIVGLHAFGPTPPRLRITLLEAGPRVLPAFPEAVSAAAQQELERIGVSVRT
SAMVSGADETGFSLKDGTHIPATLRVWAAGVKAPDVTKSYGGLSLSRSGQILVKPNLLSVDDDRIFALGDCSFIVDDPLP
PTAQVARQQAHHLARHLSAWIRDGQDVPACVFRNKGAIVALGNYNGWGTLPGGSVFGGGVLKGLTARVGHLMLYRQHQVE
LYGFFRGLMSCVADWIDTMVRPSVRLD
>Mature_427_residues
MVSRSEILIVGGGVAGLALATRLGGTLGKQGSARITLIDKSFSHVWKPMLHCFAAGTAQNENDRISFMSQAGAHHFEFWP
GEVISLDRAKREVVLGPLRASDGSTVLESRTVTYDALVLSIGSCANDFRTPGVAEHCLFIDNLVEANGFNEKFRMELLRA
YATNAELDIAIVGGGATGTQLAAELHKALDIVGLHAFGPTPPRLRITLLEAGPRVLPAFPEAVSAAAQQELERIGVSVRT
SAMVSGADETGFSLKDGTHIPATLRVWAAGVKAPDVTKSYGGLSLSRSGQILVKPNLLSVDDDRIFALGDCSFIVDDPLP
PTAQVARQQAHHLARHLSAWIRDGQDVPACVFRNKGAIVALGNYNGWGTLPGGSVFGGGVLKGLTARVGHLMLYRQHQVE
LYGFFRGLMSCVADWIDTMVRPSVRLD

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=432, Percent_Identity=41.4351851851852, Blast_Score=326, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6323794, Length=356, Percent_Identity=27.5280898876405, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323515, Length=473, Percent_Identity=24.5243128964059, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320118, Length=368, Percent_Identity=23.6413043478261, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 45642; Mature: 45642

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRSEILIVGGGVAGLALATRLGGTLGKQGSARITLIDKSFSHVWKPMLHCFAAGTAQN
CCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCC
ENDRISFMSQAGAHHFEFWPGEVISLDRAKREVVLGPLRASDGSTVLESRTVTYDALVLS
CCCHHHHHHHCCCCCEECCCCCEEEHHHHCCEEEEECEECCCCCEEHHCCCEEHHHHHHH
IGSCANDFRTPGVAEHCLFIDNLVEANGFNEKFRMELLRAYATNAELDIAIVGGGATGTQ
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHH
LAAELHKALDIVGLHAFGPTPPRLRITLLEAGPRVLPAFPEAVSAAAQQELERIGVSVRT
HHHHHHHHHHHEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEE
SAMVSGADETGFSLKDGTHIPATLRVWAAGVKAPDVTKSYGGLSLSRSGQILVKPNLLSV
HHEECCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCEEECCCCEEEECCCEEEE
DDDRIFALGDCSFIVDDPLPPTAQVARQQAHHLARHLSAWIRDGQDVPACVFRNKGAIVA
CCCCEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEE
LGNYNGWGTLPGGSVFGGGVLKGLTARVGHLMLYRQHQVELYGFFRGLMSCVADWIDTMV
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPSVRLD
CCCCCCC
>Mature Secondary Structure
MVSRSEILIVGGGVAGLALATRLGGTLGKQGSARITLIDKSFSHVWKPMLHCFAAGTAQN
CCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCC
ENDRISFMSQAGAHHFEFWPGEVISLDRAKREVVLGPLRASDGSTVLESRTVTYDALVLS
CCCHHHHHHHCCCCCEECCCCCEEEHHHHCCEEEEECEECCCCCEEHHCCCEEHHHHHHH
IGSCANDFRTPGVAEHCLFIDNLVEANGFNEKFRMELLRAYATNAELDIAIVGGGATGTQ
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHH
LAAELHKALDIVGLHAFGPTPPRLRITLLEAGPRVLPAFPEAVSAAAQQELERIGVSVRT
HHHHHHHHHHHEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEE
SAMVSGADETGFSLKDGTHIPATLRVWAAGVKAPDVTKSYGGLSLSRSGQILVKPNLLSV
HHEECCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCEEECCCCEEEECCCEEEE
DDDRIFALGDCSFIVDDPLPPTAQVARQQAHHLARHLSAWIRDGQDVPACVFRNKGAIVA
CCCCEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEE
LGNYNGWGTLPGGSVFGGGVLKGLTARVGHLMLYRQHQVELYGFFRGLMSCVADWIDTMV
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPSVRLD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]