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The map label for this gene is cbh [H]

Identifier: 162146045

GI number: 162146045

Start: 229892

End: 230917

Strand: Reverse

Name: cbh [H]

Synonym: GDI_0213

Alternate gene names: 162146045

Gene position: 230917-229892 (Counterclockwise)

Preceding gene: 162146046

Following gene: 162146044

Centisome position: 5.85

GC content: 60.72

Gene sequence:

>1026_bases
ATGGTCATGTCGACGAACCTTCTGGGCCACCCGGCGGCCGACGCCTGCACGCGCCTCGTCTATCATGGCGCGCATGACGA
GGTCATCACGGCACGTTCCATGGACTGGAAGACCGATGTCGGAACCAACCTCTGGGTCTTCCCCCGCGGCATGAAGCGTT
CGGGGGAAGCGGGGCCGAACTCGGTCCGATGGACGTCGAAATACGGCAGCGTCATTGCCTCGGGCTATGACATTTCCACC
ACCGACGGCATGAACGAAGCAGGACTTGTCGCCAACGTGCTGTGGCTGGTCGAATCGTCCTATCCGAAATATGACGGCAG
GACCCCAGGCCTGTCGCTCGCGGCCTGGGCGCAATATGTGCTGGATAATTTCGCCACCGTGCAGGAAGCGGTCGATGCGC
TGGCAAGGCAGCCCTTCACGATCGTCACCGCCACCGTACCGGGTGAAGGCAGGCTCGCCACCCTGCACCTCTCGCTCTCG
GATGCGTCCGGCGACAGCGCAATCATCGAATATATCGACGGCAAGCAGGTCATCCACCACAGCCGCGCCTATCAGGTGAT
GACCAACTCCCCGACCTTCGAAAAGCAGCTCGCGCTGAACGAATACTGGACGCAGATCGGCGGCACCGTCATGCTGCCCG
GCACCAATCGCGCCTCGGACCGGTTTGCACGCGCTGCCTTCTATGTGAACGCGATCCCGAAGACCGAAAGTCCGGTCGAT
GCCATCGCCAGCGTCTTCAGCGTGATCCGCAATGTCTCCGTTCCCTTTGGAATCACCACGCCCGATCAGCCCAATATCTC
CTCGACGCGCTGGCGCACGGTCGCCGACCAGAAGCGCAAGCTCTATTTCTTCGAATCGGCACTCACGCCCAACGTCTTCT
GGGTCGACCTGAAGAAACTGGATTTCTCGGAAGGAACCGGGAAGGTGATGAAACTCGATCTCGGCCCCGATCAGACGCAT
ATCTATTCCGGCATGGCCAACGACCGGTTCGTTGAAACCAGGCCTTTCAGGTTCCTCGGGCTCTGA

Upstream 100 bases:

>100_bases
AAATCACGCCGCATGGTATTGCTGTGACCTGCCGGTATAATTGAGTGGAATAAAGCCCATGATGCCGAAGAAGCGTTCTT
TCGCGACTGCGTGCGCGGCC

Downstream 100 bases:

>100_bases
GCGCGGCACGGCACAGGTGCCCCGTCCGGTTAGATCGAATATTTTATGTCTGACCAAGGAAATATATCGTTTTCCATCCC
ATATGACACCGCGTTATCGT

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MVMSTNLLGHPAADACTRLVYHGAHDEVITARSMDWKTDVGTNLWVFPRGMKRSGEAGPNSVRWTSKYGSVIASGYDIST
TDGMNEAGLVANVLWLVESSYPKYDGRTPGLSLAAWAQYVLDNFATVQEAVDALARQPFTIVTATVPGEGRLATLHLSLS
DASGDSAIIEYIDGKQVIHHSRAYQVMTNSPTFEKQLALNEYWTQIGGTVMLPGTNRASDRFARAAFYVNAIPKTESPVD
AIASVFSVIRNVSVPFGITTPDQPNISSTRWRTVADQKRKLYFFESALTPNVFWVDLKKLDFSEGTGKVMKLDLGPDQTH
IYSGMANDRFVETRPFRFLGL

Sequences:

>Translated_341_residues
MVMSTNLLGHPAADACTRLVYHGAHDEVITARSMDWKTDVGTNLWVFPRGMKRSGEAGPNSVRWTSKYGSVIASGYDIST
TDGMNEAGLVANVLWLVESSYPKYDGRTPGLSLAAWAQYVLDNFATVQEAVDALARQPFTIVTATVPGEGRLATLHLSLS
DASGDSAIIEYIDGKQVIHHSRAYQVMTNSPTFEKQLALNEYWTQIGGTVMLPGTNRASDRFARAAFYVNAIPKTESPVD
AIASVFSVIRNVSVPFGITTPDQPNISSTRWRTVADQKRKLYFFESALTPNVFWVDLKKLDFSEGTGKVMKLDLGPDQTH
IYSGMANDRFVETRPFRFLGL
>Mature_341_residues
MVMSTNLLGHPAADACTRLVYHGAHDEVITARSMDWKTDVGTNLWVFPRGMKRSGEAGPNSVRWTSKYGSVIASGYDIST
TDGMNEAGLVANVLWLVESSYPKYDGRTPGLSLAAWAQYVLDNFATVQEAVDALARQPFTIVTATVPGEGRLATLHLSLS
DASGDSAIIEYIDGKQVIHHSRAYQVMTNSPTFEKQLALNEYWTQIGGTVMLPGTNRASDRFARAAFYVNAIPKTESPVD
AIASVFSVIRNVSVPFGITTPDQPNISSTRWRTVADQKRKLYFFESALTPNVFWVDLKKLDFSEGTGKVMKLDLGPDQTH
IYSGMANDRFVETRPFRFLGL

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 37574; Mature: 37574

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMSTNLLGHPAADACTRLVYHGAHDEVITARSMDWKTDVGTNLWVFPRGMKRSGEAGPN
CEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCC
SVRWTSKYGSVIASGYDISTTDGMNEAGLVANVLWLVESSYPKYDGRTPGLSLAAWAQYV
CEEEEHHHCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LDNFATVQEAVDALARQPFTIVTATVPGEGRLATLHLSLSDASGDSAIIEYIDGKQVIHH
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHH
SRAYQVMTNSPTFEKQLALNEYWTQIGGTVMLPGTNRASDRFARAAFYVNAIPKTESPVD
CCEEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHEEEEECCCCCCCHHH
AIASVFSVIRNVSVPFGITTPDQPNISSTRWRTVADQKRKLYFFESALTPNVFWVDLKKL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCEEEEEEEEE
DFSEGTGKVMKLDLGPDQTHIYSGMANDRFVETRPFRFLGL
CCCCCCCCEEEEECCCCHHHEECCCCCCCEEECCCEEEECC
>Mature Secondary Structure
MVMSTNLLGHPAADACTRLVYHGAHDEVITARSMDWKTDVGTNLWVFPRGMKRSGEAGPN
CEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCC
SVRWTSKYGSVIASGYDISTTDGMNEAGLVANVLWLVESSYPKYDGRTPGLSLAAWAQYV
CEEEEHHHCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LDNFATVQEAVDALARQPFTIVTATVPGEGRLATLHLSLSDASGDSAIIEYIDGKQVIHH
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHH
SRAYQVMTNSPTFEKQLALNEYWTQIGGTVMLPGTNRASDRFARAAFYVNAIPKTESPVD
CCEEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHEEEEECCCCCCCHHH
AIASVFSVIRNVSVPFGITTPDQPNISSTRWRTVADQKRKLYFFESALTPNVFWVDLKKL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCEEEEEEEEE
DFSEGTGKVMKLDLGPDQTHIYSGMANDRFVETRPFRFLGL
CCCCCCCCEEEEECCCCHHHEECCCCCCCEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]