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The map label for this gene is comEC [H]

Identifier: 162145890

GI number: 162145890

Start: 57935

End: 60058

Strand: Direct

Name: comEC [H]

Synonym: GDI_0051

Alternate gene names: 162145890

Gene position: 57935-60058 (Clockwise)

Preceding gene: 162145878

Following gene: 162145892

Centisome position: 1.47

GC content: 76.37

Gene sequence:

>2124_bases
ATGGCAGACGGACGACGCGAAGCGGACAGGGCAACGGTGGCGGACGCGCTGGCCGCGCGTCTGGCGCTGTGGCTGCCGGT
GGGGATCGGCCTCGGGATCGCCCTGTATTTCTCGCTGCGGCAGGAACCGGGCCGGGCGGCCATGCTGGCCGCCGCCGGCG
TGGTGGCGGCGGCGCTGGGCTGGATCGCGCGTCGCCCCTACGATCTGGTGCCCCGGGTGGCGGGCGGGGGGGCGGCGGCG
GTGGCCGTGGGGTTCGTGGTGGCATGCACGGCAACGCATCGCCAGCCGCCGCTGCCGGACCTGCCGCGCCGGGCCACCAT
CGTGACCGGCCAGGTCGTCGCGGTCGTGCTGCTGCCGCCCCGGCCGGGGGATGACGGCCCGGCCACCCGCAGGGTGGACC
TGGCCGGGGCGGTCCTGGACGATGCGATCGATGCCGGCATGCCGCCCCTGCGCCGCATCCTGCGCGTGCGCCTGCGGCCG
GACGATCCGGCGGTGCTGGTCCCGGGCATGACGGTCCGGGTTCGCGCCATGCTGCGGCCACCGGCCCCGCCCGCCTGGCC
CGGCGGCCCCGACCGGCAGCGCCGCGCCTGGTTCGACGGCACGGCGGGAACCGGCACCGCGCTGGGGCCGGTGCAGGCCG
CCGGTCCGCCCCCGCCGCCGCGTACTCTGGAAGGGCTGCGCGAACGGGTGGTGGCGCGCATCCTGCGCGTGCTGCCGGGC
GCGCCGGGCGGCGTGGCGGCGGCGGTCCTGACCGGCTCGGCCGCCACGATGCCGCAGGCCGACCGCGACGCGTTCGCCGA
TGCTGGGCTTGCCCATCTGCTGGCCGTCGCGGGGCTGCATCTGGGCATCGTCATGGGGTTGGTGATGGCGGCGGCGCGGC
TGCTGCTGGCCTGTTCCGAACGGGCGACGCTCTACTGGCCGTGCCGGCAGGTCGCGGCGCTGGCCGGGCTGGCGGCGGGC
ATCGTCTATGTGGTGCTGACCGGCGCGCACCTGCCCGCGCTGCGCAGCCTGACCATGGCCGCCCTGGTGGTGCTGGCCAT
CCTGACGGGCCGGCGGGCACTGTCGATGCGCGGGCTGGCGGTGGGGGCGACGCTGCTGCTGCTGACCGGCCCCGCCGACC
TGCTGGAGGCCCCGCTGCAGATGTCGCTGGCCGCCGTCATGGCCCTGGCGGCGGGGTTCGAGGCGACGCGGCCGGCCCTG
TCCCGCCTGAGGGAACAACCCGACTGGTGGCGGCGTCCCGCCCTGCACGTCGCCCATCTGGCGCTGGCCAGCCTGCTGGC
GGGGGGCGCCACCGTGCCGGTGGTGATGACGCATTTCGGCACGCTCCAGCCCTGGTTCGTACTGGCCAACCTGCTGGCCG
TGCCGCTGATGGCGCTGTGGATCCTGCCCTGGGGAGTGATCGCCCTGCTGCTGATGCCGTGGGGCGCGGACCCCGTGGCG
CTGGTGCCCATGGGCTGGGGTATCCGGCTGGTGCTGGGCCTGGCGCATGCGGTGTCCGGCTGGCCGGCGGCGCGGGTGAT
GGTGCCGGCCATGCCGTCCTGGGGACTCGCCGCGTGGATGCTGGGCCTGTGCTGGCTCTGTCTCTGGACCCGGCGCTGGC
GCTGGTGGGGCGTGGCCCCGATGGCCCTGGCGCTGGCGGCGCCCGTCCTGGTGGCGCGGCCGGATGTGCTGCTGTCCCCC
GACGGACGGGCGGTGGCGGTGCGTGACGGCGCCGTGCTGCGCATCGGCCCGCATCCGGGGGCCGACAAGGCGGTCGAATC
CGACTGGCAACAGGCCCTGGCTCTTCCGCTGGCCTCACTGCCGCAGGCGGACGGCCGCCTCGCCTGCCGTGACGAAGCCT
GCCGGATGGATGGCGGGCGGGTCCGCCTGCGCCTTTCCGCCGCCGCCCCGGCCGAGTGCGCGGGGGTTACCCTGCTGGTG
ACGCTGGTGCCGATGGATCAGGGCTGCCCCGCCGCCCGTACGCTCGACGGGCTGACCGTATGGCAAGGCGGCGCGCAGGC
GGTCTTCCTGCGCCCGGACGGGCCGCATGTGGTCTCGGATCGTGGGGTGCGCGGGGCCAGGCCGTGGGTGCTGGCGCCGG
GGCAGCATGGCATGCCGACCCTGCCGCTGGCCCAGCGGGAGTAA

Upstream 100 bases:

>100_bases
GGAACGAATAAAAGTCTTTTTGCCGCTTTTTCTTCAGAAAAAGAGGCGGGGCCGCTCCCTTCAACTTGCAGCGACCGGCG
TCTAGTCTGCCCCCGTGGGC

Downstream 100 bases:

>100_bases
CTGTTACCGGGCCGGCGCCACCAGCACCTTGGCCGTGTACTGGCACGGTTCCTGTGCCGGGCACCGCCAGCATTCCGGCC
GCCGGGCCTTGCAGACATAG

Product: DNA uptake protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 707; Mature: 706

Protein sequence:

>707_residues
MADGRREADRATVADALAARLALWLPVGIGLGIALYFSLRQEPGRAAMLAAAGVVAAALGWIARRPYDLVPRVAGGGAAA
VAVGFVVACTATHRQPPLPDLPRRATIVTGQVVAVVLLPPRPGDDGPATRRVDLAGAVLDDAIDAGMPPLRRILRVRLRP
DDPAVLVPGMTVRVRAMLRPPAPPAWPGGPDRQRRAWFDGTAGTGTALGPVQAAGPPPPPRTLEGLRERVVARILRVLPG
APGGVAAAVLTGSAATMPQADRDAFADAGLAHLLAVAGLHLGIVMGLVMAAARLLLACSERATLYWPCRQVAALAGLAAG
IVYVVLTGAHLPALRSLTMAALVVLAILTGRRALSMRGLAVGATLLLLTGPADLLEAPLQMSLAAVMALAAGFEATRPAL
SRLREQPDWWRRPALHVAHLALASLLAGGATVPVVMTHFGTLQPWFVLANLLAVPLMALWILPWGVIALLLMPWGADPVA
LVPMGWGIRLVLGLAHAVSGWPAARVMVPAMPSWGLAAWMLGLCWLCLWTRRWRWWGVAPMALALAAPVLVARPDVLLSP
DGRAVAVRDGAVLRIGPHPGADKAVESDWQQALALPLASLPQADGRLACRDEACRMDGGRVRLRLSAAAPAECAGVTLLV
TLVPMDQGCPAARTLDGLTVWQGGAQAVFLRPDGPHVVSDRGVRGARPWVLAPGQHGMPTLPLAQRE

Sequences:

>Translated_707_residues
MADGRREADRATVADALAARLALWLPVGIGLGIALYFSLRQEPGRAAMLAAAGVVAAALGWIARRPYDLVPRVAGGGAAA
VAVGFVVACTATHRQPPLPDLPRRATIVTGQVVAVVLLPPRPGDDGPATRRVDLAGAVLDDAIDAGMPPLRRILRVRLRP
DDPAVLVPGMTVRVRAMLRPPAPPAWPGGPDRQRRAWFDGTAGTGTALGPVQAAGPPPPPRTLEGLRERVVARILRVLPG
APGGVAAAVLTGSAATMPQADRDAFADAGLAHLLAVAGLHLGIVMGLVMAAARLLLACSERATLYWPCRQVAALAGLAAG
IVYVVLTGAHLPALRSLTMAALVVLAILTGRRALSMRGLAVGATLLLLTGPADLLEAPLQMSLAAVMALAAGFEATRPAL
SRLREQPDWWRRPALHVAHLALASLLAGGATVPVVMTHFGTLQPWFVLANLLAVPLMALWILPWGVIALLLMPWGADPVA
LVPMGWGIRLVLGLAHAVSGWPAARVMVPAMPSWGLAAWMLGLCWLCLWTRRWRWWGVAPMALALAAPVLVARPDVLLSP
DGRAVAVRDGAVLRIGPHPGADKAVESDWQQALALPLASLPQADGRLACRDEACRMDGGRVRLRLSAAAPAECAGVTLLV
TLVPMDQGCPAARTLDGLTVWQGGAQAVFLRPDGPHVVSDRGVRGARPWVLAPGQHGMPTLPLAQRE
>Mature_706_residues
ADGRREADRATVADALAARLALWLPVGIGLGIALYFSLRQEPGRAAMLAAAGVVAAALGWIARRPYDLVPRVAGGGAAAV
AVGFVVACTATHRQPPLPDLPRRATIVTGQVVAVVLLPPRPGDDGPATRRVDLAGAVLDDAIDAGMPPLRRILRVRLRPD
DPAVLVPGMTVRVRAMLRPPAPPAWPGGPDRQRRAWFDGTAGTGTALGPVQAAGPPPPPRTLEGLRERVVARILRVLPGA
PGGVAAAVLTGSAATMPQADRDAFADAGLAHLLAVAGLHLGIVMGLVMAAARLLLACSERATLYWPCRQVAALAGLAAGI
VYVVLTGAHLPALRSLTMAALVVLAILTGRRALSMRGLAVGATLLLLTGPADLLEAPLQMSLAAVMALAAGFEATRPALS
RLREQPDWWRRPALHVAHLALASLLAGGATVPVVMTHFGTLQPWFVLANLLAVPLMALWILPWGVIALLLMPWGADPVAL
VPMGWGIRLVLGLAHAVSGWPAARVMVPAMPSWGLAAWMLGLCWLCLWTRRWRWWGVAPMALALAAPVLVARPDVLLSPD
GRAVAVRDGAVLRIGPHPGADKAVESDWQQALALPLASLPQADGRLACRDEACRMDGGRVRLRLSAAAPAECAGVTLLVT
LVPMDQGCPAARTLDGLTVWQGGAQAVFLRPDGPHVVSDRGVRGARPWVLAPGQHGMPTLPLAQRE

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 73921; Mature: 73790

Theoretical pI: Translated: 11.53; Mature: 11.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGRREADRATVADALAARLALWLPVGIGLGIALYFSLRQEPGRAAMLAAAGVVAAALG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
WIARRPYDLVPRVAGGGAAAVAVGFVVACTATHRQPPLPDLPRRATIVTGQVVAVVLLPP
HHHCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCEEEEEEECC
RPGDDGPATRRVDLAGAVLDDAIDAGMPPLRRILRVRLRPDDPAVLVPGMTVRVRAMLRP
CCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCEEEECCCEEEEEEEECC
PAPPAWPGGPDRQRRAWFDGTAGTGTALGPVQAAGPPPPPRTLEGLRERVVARILRVLPG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
APGGVAAAVLTGSAATMPQADRDAFADAGLAHLLAVAGLHLGIVMGLVMAAARLLLACSE
CCCCHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RATLYWPCRQVAALAGLAAGIVYVVLTGAHLPALRSLTMAALVVLAILTGRRALSMRGLA
CCEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHH
VGATLLLLTGPADLLEAPLQMSLAAVMALAAGFEATRPALSRLREQPDWWRRPALHVAHL
HCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCHHHHHHHH
ALASLLAGGATVPVVMTHFGTLQPWFVLANLLAVPLMALWILPWGVIALLLMPWGADPVA
HHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LVPMGWGIRLVLGLAHAVSGWPAARVMVPAMPSWGLAAWMLGLCWLCLWTRRWRWWGVAP
EEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
MALALAAPVLVARPDVLLSPDGRAVAVRDGAVLRIGPHPGADKAVESDWQQALALPLASL
HHHHHHCCHHEECCCEEECCCCCEEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
PQADGRLACRDEACRMDGGRVRLRLSAAAPAECAGVTLLVTLVPMDQGCPAARTLDGLTV
CCCCCCEEECCHHHCCCCCEEEEEEECCCCCHHCCEEEEEEEEECCCCCCHHHHCCCCEE
WQGGAQAVFLRPDGPHVVSDRGVRGARPWVLAPGQHGMPTLPLAQRE
ECCCCCEEEECCCCCCEECCCCCCCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADGRREADRATVADALAARLALWLPVGIGLGIALYFSLRQEPGRAAMLAAAGVVAAALG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
WIARRPYDLVPRVAGGGAAAVAVGFVVACTATHRQPPLPDLPRRATIVTGQVVAVVLLPP
HHHCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCEEEEEEECC
RPGDDGPATRRVDLAGAVLDDAIDAGMPPLRRILRVRLRPDDPAVLVPGMTVRVRAMLRP
CCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCEEEECCCEEEEEEEECC
PAPPAWPGGPDRQRRAWFDGTAGTGTALGPVQAAGPPPPPRTLEGLRERVVARILRVLPG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
APGGVAAAVLTGSAATMPQADRDAFADAGLAHLLAVAGLHLGIVMGLVMAAARLLLACSE
CCCCHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RATLYWPCRQVAALAGLAAGIVYVVLTGAHLPALRSLTMAALVVLAILTGRRALSMRGLA
CCEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHH
VGATLLLLTGPADLLEAPLQMSLAAVMALAAGFEATRPALSRLREQPDWWRRPALHVAHL
HCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCHHHHHHHH
ALASLLAGGATVPVVMTHFGTLQPWFVLANLLAVPLMALWILPWGVIALLLMPWGADPVA
HHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LVPMGWGIRLVLGLAHAVSGWPAARVMVPAMPSWGLAAWMLGLCWLCLWTRRWRWWGVAP
EEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
MALALAAPVLVARPDVLLSPDGRAVAVRDGAVLRIGPHPGADKAVESDWQQALALPLASL
HHHHHHCCHHEECCCEEECCCCCEEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
PQADGRLACRDEACRMDGGRVRLRLSAAAPAECAGVTLLVTLVPMDQGCPAARTLDGLTV
CCCCCCEEECCHHHCCCCCEEEEEEECCCCCHHCCEEEEEEEEECCCCCCHHHHCCCCEE
WQGGAQAVFLRPDGPHVVSDRGVRGARPWVLAPGQHGMPTLPLAQRE
ECCCCCEEEECCCCCCEECCCCCCCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]