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The map label for this gene is cynR [H]

Identifier: 162145879

GI number: 162145879

Start: 42702

End: 43607

Strand: Reverse

Name: cynR [H]

Synonym: GDI_0040

Alternate gene names: 162145879

Gene position: 43607-42702 (Counterclockwise)

Preceding gene: 162145880

Following gene: 162145877

Centisome position: 1.11

GC content: 68.43

Gene sequence:

>906_bases
ATGTTCCTGCGTCAACTGACCTATCTGATCGCCCTCGACCAGTTCCGGCACTTTTCCCGCGCCGCCGAAAGCTGCGGCGT
TTCGCAGCCGGCCCTTTCCGCCGGCATCCGGCAGTTGGAAAACGAGCTGGGCGTTGCGATCATCCACCGCAATCGCCGCT
TCCACGGGCTGACCGACGAAGGACGGCGCGTGCTGGTCTGGGCGAAGCAGACCCTGGCCGCGCTGGACGGGCTGCGGCAG
GAAGCCGCCTTCGCGCGGGATGTCTGCGGCGGTTCCCTGTCGATCGGCGTCATGTCGCCGGCCCTGCAGACCGTTCCGCT
GCTGCTGGAAATCTTCCGCGACGCCATTCCGGGCCTGCACCTGGAAGTCCTGTCCGGCACCGCCGCCGACATCGCGCACC
GGCTGCGCGAACAGCACCTGCATCTGGGGGTCATGTACCTGGACCAGATCCCGGCGGACGGCCCGTTCGATACGCTACCG
CTTTATACCGAGCAATATGTGCTGGCGGGGAGCGCGTCGGCCCGGATGCCGGCCGGACCGTCCTGCGGCTGGGCCGATGC
CGCGGACCTGCCGCTGTGCCTGTTCAGCCGCACCATGCGCAGCCGACAGATCGTCGATGCCGGCTTCCTTGAGGCCGGGG
TCAGGCCGAGCATCATACTGGAAACGGATTCGATCAGCGTCCTGCATTCCGAACTGCGGGCGGGGCGGCTGTGCAGCATC
CTGCCGGTGGCGGCCCTGCCGGAAACGGTGGGGGATGCCGGCCTGCGCACCATCCCGATCATGCCCTGCGTCGCGCCGCA
GGTCGGCATCGTGAAGCTGCGCCAGCCGGTCATGTCGCCCGTCCTGTCGCGCATATGGGACGTCTGCGGCCGCCTGCAGG
CCGGCGACGTCTTCGCGGCCGTCTGA

Upstream 100 bases:

>100_bases
CACCCGCTGGTGGCAACCGGCCCCAACACCCGCGAACCGCAGAACCGGCGGGTCGAGATCATCCTGCACTGACCGGGGCA
GGAGGGCCCGCACCGCCTTC

Downstream 100 bases:

>100_bases
ACACACGCCGCCTGTCGCCCGGTCCGGGAATGACGCACGCCCCCGCGATCAGACGAACCGTTCCCGCCGCATCCAGCTTT
CGGCCATCGCCGGCCATTCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MFLRQLTYLIALDQFRHFSRAAESCGVSQPALSAGIRQLENELGVAIIHRNRRFHGLTDEGRRVLVWAKQTLAALDGLRQ
EAAFARDVCGGSLSIGVMSPALQTVPLLLEIFRDAIPGLHLEVLSGTAADIAHRLREQHLHLGVMYLDQIPADGPFDTLP
LYTEQYVLAGSASARMPAGPSCGWADAADLPLCLFSRTMRSRQIVDAGFLEAGVRPSIILETDSISVLHSELRAGRLCSI
LPVAALPETVGDAGLRTIPIMPCVAPQVGIVKLRQPVMSPVLSRIWDVCGRLQAGDVFAAV

Sequences:

>Translated_301_residues
MFLRQLTYLIALDQFRHFSRAAESCGVSQPALSAGIRQLENELGVAIIHRNRRFHGLTDEGRRVLVWAKQTLAALDGLRQ
EAAFARDVCGGSLSIGVMSPALQTVPLLLEIFRDAIPGLHLEVLSGTAADIAHRLREQHLHLGVMYLDQIPADGPFDTLP
LYTEQYVLAGSASARMPAGPSCGWADAADLPLCLFSRTMRSRQIVDAGFLEAGVRPSIILETDSISVLHSELRAGRLCSI
LPVAALPETVGDAGLRTIPIMPCVAPQVGIVKLRQPVMSPVLSRIWDVCGRLQAGDVFAAV
>Mature_301_residues
MFLRQLTYLIALDQFRHFSRAAESCGVSQPALSAGIRQLENELGVAIIHRNRRFHGLTDEGRRVLVWAKQTLAALDGLRQ
EAAFARDVCGGSLSIGVMSPALQTVPLLLEIFRDAIPGLHLEVLSGTAADIAHRLREQHLHLGVMYLDQIPADGPFDTLP
LYTEQYVLAGSASARMPAGPSCGWADAADLPLCLFSRTMRSRQIVDAGFLEAGVRPSIILETDSISVLHSELRAGRLCSI
LPVAALPETVGDAGLRTIPIMPCVAPQVGIVKLRQPVMSPVLSRIWDVCGRLQAGDVFAAV

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=279, Percent_Identity=27.9569892473118, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790399, Length=270, Percent_Identity=27.7777777777778, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788748, Length=288, Percent_Identity=24.3055555555556, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788887, Length=172, Percent_Identity=33.1395348837209, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788296, Length=224, Percent_Identity=24.1071428571429, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787879, Length=151, Percent_Identity=31.1258278145695, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787530, Length=244, Percent_Identity=22.9508196721311, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI145693105, Length=299, Percent_Identity=20.066889632107, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32557; Mature: 32557

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLRQLTYLIALDQFRHFSRAAESCGVSQPALSAGIRQLENELGVAIIHRNRRFHGLTDE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCC
GRRVLVWAKQTLAALDGLRQEAAFARDVCGGSLSIGVMSPALQTVPLLLEIFRDAIPGLH
CCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCE
LEVLSGTAADIAHRLREQHLHLGVMYLDQIPADGPFDTLPLYTEQYVLAGSASARMPAGP
EEHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
SCGWADAADLPLCLFSRTMRSRQIVDAGFLEAGVRPSIILETDSISVLHSELRAGRLCSI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCHHHH
LPVAALPETVGDAGLRTIPIMPCVAPQVGIVKLRQPVMSPVLSRIWDVCGRLQAGDVFAA
HHHHHCCHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
V
C
>Mature Secondary Structure
MFLRQLTYLIALDQFRHFSRAAESCGVSQPALSAGIRQLENELGVAIIHRNRRFHGLTDE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCC
GRRVLVWAKQTLAALDGLRQEAAFARDVCGGSLSIGVMSPALQTVPLLLEIFRDAIPGLH
CCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCE
LEVLSGTAADIAHRLREQHLHLGVMYLDQIPADGPFDTLPLYTEQYVLAGSASARMPAGP
EEHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
SCGWADAADLPLCLFSRTMRSRQIVDAGFLEAGVRPSIILETDSISVLHSELRAGRLCSI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCHHHH
LPVAALPETVGDAGLRTIPIMPCVAPQVGIVKLRQPVMSPVLSRIWDVCGRLQAGDVFAA
HHHHHCCHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]