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The map label for this gene is ilvC

Identifier: 162145866

GI number: 162145866

Start: 24420

End: 25439

Strand: Direct

Name: ilvC

Synonym: GDI_0024

Alternate gene names: 162145866

Gene position: 24420-25439 (Clockwise)

Preceding gene: 162145865

Following gene: 162145867

Centisome position: 0.62

GC content: 65.0

Gene sequence:

>1020_bases
ATGCGCGTGTATTACGATCGCGACGCCGACGTGAACCTGATCAAGTCCAAGAAGGTCGCGATCATCGGCTACGGCAGCCA
GGGCCACGCCCATGCCAACAACCTGAAGGACAGCGGCGTCACCGACATGGTGATCGGCCTGCGTCCGGGTTCGTCCGCGG
TGGCCAAGGCCGAGGCCGCGGGCTTCAAGGTGATGGGCCCGTCCGAGGCCGCCGCCTGGGCCGACGTCGTCATGGTCCTG
ACCCCGGACGAGGGCCAGGGCGCGCTGTACAAGGAGCATCTGGAGGCCAACCTGAAGCAGGGCGCCGCCCTGGCCTTCGC
GCACGGCCTGTCGATCCATTTCCGCATCATCGAGGCCCGTCCCGACCTGGACGTGTTCCTGATCGCGCCCAAGGGCCCGG
GCCACACCGTGCGCTCCGAATACCAGCGTGGCGGCGGCGTGCCCTCGCTGGTCGCGGTGGCGCAGAACGCGTCGGGCAAT
GCGCTGGAAATCGCGCTGTCCTATGCCTCGGCCAACGGCGGCGGCCGCGCCGGCATCATCGAGACGAGCTTCAAGGAAGA
GGTCGAAACCGACCTGTTCGGCGAACAGGCGGTGCTGTGCGGCGGCCTGGTCGAACTGATCCGCGCCGGGTTCGAAACGC
TGGTCGAGGCCGGCTACGCCCCCGAGATGGCGTATTTCGAGTGCCTGCACGAAACCAAGCTGATCGTCGACCTGATCTAC
GAGGGCGGCATCGCGAACATGAACTACTCGATCTCGAACACCGCCGAATACGGTGAATACGCCACCGGCCCGCGCATCGT
GACGCCGGAAACCAAGGCCGAGATGAAGCGCGTCCTGACCGATATCCAGGACGGCACGTTCGTGCGCAATTTCATCCTGG
AAAACCAGTCGGGCAATGTCGGCTTCAAGGCGATCCGCGCGCGCAACAACGCGCATCAGATCGAACAGGTCGGCGAGAAG
CTGCGCGGCATGATGCCGTGGATCGGCAAGAACAAGCTGGTGGACAAGACGCGGAATTAA

Upstream 100 bases:

>100_bases
GGCCGAGGTCTCCCGCACCGGAGTGGCCGCGATCATCCGGGGCCCCCGGACGATCTGACCACGGGTCTTTCCTTCCATCT
GTCTCAACAGGAGTCTTCCC

Downstream 100 bases:

>100_bases
AGTTCTTTTTTGAAAAAAAGAACCAAAAAACTTTGATTCGTCTGGGAAACATGTGCCGTGTGCATACGAGGACCTAAAAC
GAATCAAAGTCTTTTTGCTT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADVNLIKSKKVAIIGYGSQGHAHANNLKDSGVTDMVIGLRPGSSAVAKAEAAGFKVMGPSEAAAWADVVMVL
TPDEGQGALYKEHLEANLKQGAALAFAHGLSIHFRIIEARPDLDVFLIAPKGPGHTVRSEYQRGGGVPSLVAVAQNASGN
ALEIALSYASANGGGRAGIIETSFKEEVETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHETKLIVDLIY
EGGIANMNYSISNTAEYGEYATGPRIVTPETKAEMKRVLTDIQDGTFVRNFILENQSGNVGFKAIRARNNAHQIEQVGEK
LRGMMPWIGKNKLVDKTRN

Sequences:

>Translated_339_residues
MRVYYDRDADVNLIKSKKVAIIGYGSQGHAHANNLKDSGVTDMVIGLRPGSSAVAKAEAAGFKVMGPSEAAAWADVVMVL
TPDEGQGALYKEHLEANLKQGAALAFAHGLSIHFRIIEARPDLDVFLIAPKGPGHTVRSEYQRGGGVPSLVAVAQNASGN
ALEIALSYASANGGGRAGIIETSFKEEVETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHETKLIVDLIY
EGGIANMNYSISNTAEYGEYATGPRIVTPETKAEMKRVLTDIQDGTFVRNFILENQSGNVGFKAIRARNNAHQIEQVGEK
LRGMMPWIGKNKLVDKTRN
>Mature_339_residues
MRVYYDRDADVNLIKSKKVAIIGYGSQGHAHANNLKDSGVTDMVIGLRPGSSAVAKAEAAGFKVMGPSEAAAWADVVMVL
TPDEGQGALYKEHLEANLKQGAALAFAHGLSIHFRIIEARPDLDVFLIAPKGPGHTVRSEYQRGGGVPSLVAVAQNASGN
ALEIALSYASANGGGRAGIIETSFKEEVETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHETKLIVDLIY
EGGIANMNYSISNTAEYGEYATGPRIVTPETKAEMKRVLTDIQDGTFVRNFILENQSGNVGFKAIRARNNAHQIEQVGEK
LRGMMPWIGKNKLVDKTRN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=279, Percent_Identity=37.2759856630824, Blast_Score=144, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=335, Percent_Identity=30.4477611940298, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_GLUDA (A9GZJ4)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001600324.1
- RefSeq:   YP_002276159.1
- ProteinModelPortal:   A9GZJ4
- SMR:   A9GZJ4
- GeneID:   5791965
- GeneID:   6975202
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_1781
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36488; Mature: 36488

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADVNLIKSKKVAIIGYGSQGHAHANNLKDSGVTDMVIGLRPGSSAVAKAEAA
CEEEECCCCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHC
GFKVMGPSEAAAWADVVMVLTPDEGQGALYKEHLEANLKQGAALAFAHGLSIHFRIIEAR
CEEEECCCCHHCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCEEEEEEEEEC
PDLDVFLIAPKGPGHTVRSEYQRGGGVPSLVAVAQNASGNALEIALSYASANGGGRAGII
CCCEEEEEECCCCCCHHHHHHHHCCCCCHHHHEECCCCCCEEEEEEEEECCCCCCCEEEE
ETSFKEEVETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHETKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYATGPRIVTPETKAEMKRVLTDIQDGTFVRNFILENQSGNV
CCCCCCCCEEECCCHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEHEEECCCCCC
GFKAIRARNNAHQIEQVGEKLRGMMPWIGKNKLVDKTRN
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVYYDRDADVNLIKSKKVAIIGYGSQGHAHANNLKDSGVTDMVIGLRPGSSAVAKAEAA
CEEEECCCCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHC
GFKVMGPSEAAAWADVVMVLTPDEGQGALYKEHLEANLKQGAALAFAHGLSIHFRIIEAR
CEEEECCCCHHCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCEEEEEEEEEC
PDLDVFLIAPKGPGHTVRSEYQRGGGVPSLVAVAQNASGNALEIALSYASANGGGRAGII
CCCEEEEEECCCCCCHHHHHHHHCCCCCHHHHEECCCCCCEEEEEEEEECCCCCCCEEEE
ETSFKEEVETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHETKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYATGPRIVTPETKAEMKRVLTDIQDGTFVRNFILENQSGNV
CCCCCCCCEEECCCHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEHEEECCCCCC
GFKAIRARNNAHQIEQVGEKLRGMMPWIGKNKLVDKTRN
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA