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The map label for this gene is aroE [H]

Identifier: 162145857

GI number: 162145857

Start: 14515

End: 15372

Strand: Direct

Name: aroE [H]

Synonym: GDI_0015

Alternate gene names: 162145857

Gene position: 14515-15372 (Clockwise)

Preceding gene: 162145854

Following gene: 162145858

Centisome position: 0.37

GC content: 65.5

Gene sequence:

>858_bases
ATGACCGACAAGAGCTTCCTGAGTATCCTGACGGGATCTTTCTCCACGCCGTGTGCCGACAACCCGACGGTCGCCATGAT
CGAGGCGGCCTATCGCCATCACGATATCGACGCGCGCTACATCAACTGCGATGTGAAACCCGACAATCTGGCCGATGCCG
TTCGCGGCGCGAAGGCGATGGAATGGGTGGGATTCAATTGCTCGCTGCCGCATAAGGTCGCGGTGATCCAGCACCTGGAC
GCATTGTCCGAGGCCGCGCGGATTATCGGGGCGGTCAACTGCGTGACGATCCGCGACGGCAAGCTGACCGGCGACAACAC
GGACGGCAAGGGCTTCCTGGCCTCGCTGAAGGACGTCACCGACCCGCGCGGCAAGAAGATCCTGCTGCTGGGCGCGGGCG
GCGCCGCCCGGGCGATTGCCGTGGAACTGGGACTGGCCGGCACGGCCCATATCACCGTCATCAACCGCGACCCGGCGAAG
GCCGAAACCATCGCGGCGCTGGTGCGCGACAATACCCGAAGCGACGCGACCGCGAAGCCATGGGACGGCGAGGCGCGCGT
CCCGGACGACGTCGATATCGTCATCAACGCCACCTCGATCGGCCTGGGCGACAAGGAGGCCATTCCGCCCATCGCGCTGG
ACAGCCTGAAGAAAGGGCACATCGTCGCCGACGTGATCCCGAATCCCCCCAGGACACACCTGCTCCGCGAGGCCAAGGCG
CGGGGCTGCACGCCGCTCGACGGGCTGGGCATGCTCGTCAATCAGGGCGTGATCGGCGTGGAATTGTGGCTGGGCAAGAC
GCTGGATGCCGGCGTCATGAAGCGCGCGCTCCAGGACATTTTCGGTTCGTCCGACTGA

Upstream 100 bases:

>100_bases
TCACGGCTTTAACTTTGCGTCATGTCCCAACCTTGGACATACCGATACCATTGTGCATAGCTATGCAAGACAGCCGCAAC
CCTAGTTTCCGGAGCGCCGC

Downstream 100 bases:

>100_bases
TGTGAACGACGGCAGCGCCCGATCGCGAAGGGACCCGGGGAATGGCAAGCTCAAGCACGGCCGACATTGCGCGTGACACC
GAAAACAGCGAAAGGCACCG

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTDKSFLSILTGSFSTPCADNPTVAMIEAAYRHHDIDARYINCDVKPDNLADAVRGAKAMEWVGFNCSLPHKVAVIQHLD
ALSEAARIIGAVNCVTIRDGKLTGDNTDGKGFLASLKDVTDPRGKKILLLGAGGAARAIAVELGLAGTAHITVINRDPAK
AETIAALVRDNTRSDATAKPWDGEARVPDDVDIVINATSIGLGDKEAIPPIALDSLKKGHIVADVIPNPPRTHLLREAKA
RGCTPLDGLGMLVNQGVIGVELWLGKTLDAGVMKRALQDIFGSSD

Sequences:

>Translated_285_residues
MTDKSFLSILTGSFSTPCADNPTVAMIEAAYRHHDIDARYINCDVKPDNLADAVRGAKAMEWVGFNCSLPHKVAVIQHLD
ALSEAARIIGAVNCVTIRDGKLTGDNTDGKGFLASLKDVTDPRGKKILLLGAGGAARAIAVELGLAGTAHITVINRDPAK
AETIAALVRDNTRSDATAKPWDGEARVPDDVDIVINATSIGLGDKEAIPPIALDSLKKGHIVADVIPNPPRTHLLREAKA
RGCTPLDGLGMLVNQGVIGVELWLGKTLDAGVMKRALQDIFGSSD
>Mature_284_residues
TDKSFLSILTGSFSTPCADNPTVAMIEAAYRHHDIDARYINCDVKPDNLADAVRGAKAMEWVGFNCSLPHKVAVIQHLDA
LSEAARIIGAVNCVTIRDGKLTGDNTDGKGFLASLKDVTDPRGKKILLLGAGGAARAIAVELGLAGTAHITVINRDPAKA
ETIAALVRDNTRSDATAKPWDGEARVPDDVDIVINATSIGLGDKEAIPPIALDSLKKGHIVADVIPNPPRTHLLREAKAR
GCTPLDGLGMLVNQGVIGVELWLGKTLDAGVMKRALQDIFGSSD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=278, Percent_Identity=31.294964028777, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789675, Length=271, Percent_Identity=30.6273062730627, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 30065; Mature: 29934

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKSFLSILTGSFSTPCADNPTVAMIEAAYRHHDIDARYINCDVKPDNLADAVRGAKAM
CCCHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHCCCCCEEEEECCCCCHHHHHHHCCHHH
EWVGFNCSLPHKVAVIQHLDALSEAARIIGAVNCVTIRDGKLTGDNTDGKGFLASLKDVT
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCEECCCCCCCCHHHHHHHHCC
DPRGKKILLLGAGGAARAIAVELGLAGTAHITVINRDPAKAETIAALVRDNTRSDATAKP
CCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCC
WDGEARVPDDVDIVINATSIGLGDKEAIPPIALDSLKKGHIVADVIPNPPRTHLLREAKA
CCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
RGCTPLDGLGMLVNQGVIGVELWLGKTLDAGVMKRALQDIFGSSD
CCCCCCHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDKSFLSILTGSFSTPCADNPTVAMIEAAYRHHDIDARYINCDVKPDNLADAVRGAKAM
CCHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHCCCCCEEEEECCCCCHHHHHHHCCHHH
EWVGFNCSLPHKVAVIQHLDALSEAARIIGAVNCVTIRDGKLTGDNTDGKGFLASLKDVT
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCEECCCCCCCCHHHHHHHHCC
DPRGKKILLLGAGGAARAIAVELGLAGTAHITVINRDPAKAETIAALVRDNTRSDATAKP
CCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCC
WDGEARVPDDVDIVINATSIGLGDKEAIPPIALDSLKKGHIVADVIPNPPRTHLLREAKA
CCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
RGCTPLDGLGMLVNQGVIGVELWLGKTLDAGVMKRALQDIFGSSD
CCCCCCHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]