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The map label for this gene is folP [H]

Identifier: 161870539

GI number: 161870539

Start: 1634767

End: 1635624

Strand: Reverse

Name: folP [H]

Synonym: NMCC_1604

Alternate gene names: 161870539

Gene position: 1635624-1634767 (Counterclockwise)

Preceding gene: 161870540

Following gene: 161870538

Centisome position: 75.95

GC content: 57.11

Gene sequence:

>858_bases
ATGGCACGACACGTTTGGCAGGCAGGACGGTTTGAAATCGGTTTGGACAAACCGAAAATCATGGGTATCGTGAATCTCAC
GCCCGATTCTTTTTCCGACGGCGGAGCGTATTCGCAAAACGCCCAAACAGCTTTGGCGCATGCCGAACGGCTTTTGAAAG
AGGGTGCGGACATTCTCGACATCGGCGGCGAATCGACGCGGCTGGGTGCGGATTATGTTTCGCCTGAAGAAGAATGGGCG
CGGGTTGAGCCTGTATTGGCAGAAGTGGCGGGGTGGGGCGTTCCCGTTAGTTTGGACACGCGCCGCACGGTGGTTATGGA
AAAAGCGTTGGCACTCGGCGGCATCGATATTATTAACGATGTGGCGGCGTTGACCGACGAAGGCGCGGTCGAATTGCTGG
CGCGTCAGGCGGACACGGGCATTTGCCTGATGCACATGCAGGGTTTGCCCAAAACCATGCAGATTAATCCGAAATATCAA
GATGTTGTCGGTGAAGTAGCGCGGTATTTGAAAGCGCGCTCAGCGGAATGTATCGCGGCAGGCATCGCACCGCAACGCAT
CATACTCGACCCCGGCTTCGGCTCCGGCTTCGGCAAAACCTTGCAACACAATATCGCGCTGATGCGGCATTTACCCGAAT
TGATGGCGGAAACAGGTTTTCCGCTGCTCATCGGCGTATCGCGCAAAAGCACGATAGGCGAGCTGACCGGCGAGGCAAAT
GCGGCGGAACGCGTACACGGCAGCGTGGCGGCAGCGTTGGCTTCCGTAGCGCGCGGCGCACAAATCGTGCGCGTGCATGA
TGTGAAGGCAACGGCGGATGCTTTGAAGGTGTGGGAAGCGTTGGGCATCAATCTGTAA

Upstream 100 bases:

>100_bases
GCAATTGAAAATTTTTTGGCGCATTTTTATGCGTCAAATTTCGTTAACAGACTATTTTTGCAAAGGTCTCAATCTGTTTT
TTATTTTGGGAGGAGTTCAG

Downstream 100 bases:

>100_bases
ACAGCGGTTCACATACTTCATGCCGTCTGAAAAGGACGGGGCGGCTTCAGACGGCATCAACGGTGCAGACAGCAAGGTAC
AAACAGACTGTATAATCTCG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRLGADYVSPEEEWA
RVEPVLAEVAGWGVPVSLDTRRTVVMEKALALGGIDIINDVAALTDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQ
DVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKTLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEAN
AAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL

Sequences:

>Translated_285_residues
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRLGADYVSPEEEWA
RVEPVLAEVAGWGVPVSLDTRRTVVMEKALALGGIDIINDVAALTDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQ
DVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKTLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEAN
AAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
>Mature_284_residues
ARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRLGADYVSPEEEWAR
VEPVLAEVAGWGVPVSLDTRRTVVMEKALALGGIDIINDVAALTDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQD
VVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKTLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANA
AERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=271, Percent_Identity=47.9704797047971, Blast_Score=228, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324073, Length=317, Percent_Identity=28.7066246056782, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30302; Mature: 30171

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGAYSQNAQTALAHAERLLKEGADILD
CCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
IGGESTRLGADYVSPEEEWARVEPVLAEVAGWGVPVSLDTRRTVVMEKALALGGIDIIND
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCHHHHHH
VAALTDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAA
HHHHCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCHHHEE
GIAPQRIILDPGFGSGFGKTLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEAN
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCC
AAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGAYSQNAQTALAHAERLLKEGADILD
CCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
IGGESTRLGADYVSPEEEWARVEPVLAEVAGWGVPVSLDTRRTVVMEKALALGGIDIIND
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCHHHHHH
VAALTDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAA
HHHHCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCHHHEE
GIAPQRIILDPGFGSGFGKTLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEAN
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCC
AAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400191; 7642493; 10710307 [H]