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The map label for this gene is serS [H]

Identifier: 161870532

GI number: 161870532

Start: 1626834

End: 1628129

Strand: Direct

Name: serS [H]

Synonym: NMCC_1597

Alternate gene names: 161870532

Gene position: 1626834-1628129 (Clockwise)

Preceding gene: 161870529

Following gene: 161870541

Centisome position: 75.55

GC content: 54.09

Gene sequence:

>1296_bases
ATGTTAGATATCCAATTGCTCCGCAGCAACACCGCCGCTGTGGCGGAACGCTTGGCGGCGCGCGGTTACGAGTTTGATGC
CGCGCGTTTCAATGCGCTGGAAGAACAACGCAAAGCCGTCCAAGTGAAAACCGAAGAACTACAAGCCTCGCGTAACAGCA
TTTCCAAGCAAATCGGCGCACTGAAAGGTCAGGGCAAACACGAAGAGGCGCAGGCGGCCATGGATCAAGTCGCCCAAATC
AAAACCGATTTGGAACAGGCTGCCGCCGATTTGGATGCCGTTCAAAAAGAATTGGACGCATGGTTGTTGAGCATACCTAA
CCTGCCGCACGAAAGCGTACCTGCCGGTAAAGACGAAACCGAAAACGTCGAAGTCCGCAAAGTCGGCACCCCGCGCGAAT
TTGACTTTGAAATCAAAGACCATGTCGATTTGGGCGAACCTTTGGGTTTGGATTTTGAAGGCGGTGCAAAACTCTCCGGC
GCACGATTTACCGTGATGCGCGGACAAATCGCCCGTCTGCACCGCGCCTTGGCACAGTTCATGCTGGATACGCACACGCT
GCAACACGGCTACACCGAGCATTACACGCCTTATATCGTTGACGATACGACGCTGCAAGGTACGGGCCAACTACCAAAAT
TTGCGGAAGATCTGTTCCACGTTACCCGTGGCGGCGACGAAACCAAAACCACCCAATACCTGATTCCGACAGCCGAAGTT
ACCCTGACCAATACCGTTGCCGACAGCATTATCCCGTCCGAACAACTGCCGCTGAAGCTGACCGCGCATTCGCCCTGTTT
CCGCAGCGAGGCGGGTTCGTACGGCAAAGACACGCGCGGTCTGATTCGCCAGCACCAGTTCGACAAAGTGGAAATGGTTC
AAATCGTTCATCCCGAAAAATCATACGAAACGCTGGAAGAAATGGTCGGCCATGCCGAAAACATCCTGAAGGCTTTGGAA
CTGCCCTACCGCGTGATTACCCTGTGTACCGGCGACATGGGCTTCGGCGCGGCAAAAACGTATGACTTGGAAGTTTGGGT
GCCGGCGCAAAATACCTACCGCGAAATCTCAAGCTGCTCCAACTGCGAAGATTTCCAAGCCCGTCGCATGAAGGCGCGTT
TCAAAGACGAAAACGGCAAAAACCGCTTGGTACATACTTTGAACGGCTCCGGTTTGGCAGTCGGCAGAACCTTGGTCGCC
GTGTTGGAAAACCATCAAAACGCCGACGGCAGCATCAACATCCCTGCCGCACTGCAACCGTATATGGGCGGCGTTGCCAA
GTTGGAAGTGAAATAA

Upstream 100 bases:

>100_bases
AGACGGCATGGTTCAAGCATGTCGAAACACAGACGGACTCGGGAAAATATCTTAAATTTGGTTTACAATAATGTGTTTCA
AATTATTCGGGAATCAGACC

Downstream 100 bases:

>100_bases
GCCTTAACCCTGAACATAAATGCCGTCTGAAACTTGGTTCAGACGGCATTTCCTTTAAACTTTTAAAACACGTCAGCCGT
CGGCACGAACCGCATTGCCG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLDIQLLRSNTAAVAERLAARGYEFDAARFNALEEQRKAVQVKTEELQASRNSISKQIGALKGQGKHEEAQAAMDQVAQI
KTDLEQAAADLDAVQKELDAWLLSIPNLPHESVPAGKDETENVEVRKVGTPREFDFEIKDHVDLGEPLGLDFEGGAKLSG
ARFTVMRGQIARLHRALAQFMLDTHTLQHGYTEHYTPYIVDDTTLQGTGQLPKFAEDLFHVTRGGDETKTTQYLIPTAEV
TLTNTVADSIIPSEQLPLKLTAHSPCFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVHPEKSYETLEEMVGHAENILKALE
LPYRVITLCTGDMGFGAAKTYDLEVWVPAQNTYREISSCSNCEDFQARRMKARFKDENGKNRLVHTLNGSGLAVGRTLVA
VLENHQNADGSINIPAALQPYMGGVAKLEVK

Sequences:

>Translated_431_residues
MLDIQLLRSNTAAVAERLAARGYEFDAARFNALEEQRKAVQVKTEELQASRNSISKQIGALKGQGKHEEAQAAMDQVAQI
KTDLEQAAADLDAVQKELDAWLLSIPNLPHESVPAGKDETENVEVRKVGTPREFDFEIKDHVDLGEPLGLDFEGGAKLSG
ARFTVMRGQIARLHRALAQFMLDTHTLQHGYTEHYTPYIVDDTTLQGTGQLPKFAEDLFHVTRGGDETKTTQYLIPTAEV
TLTNTVADSIIPSEQLPLKLTAHSPCFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVHPEKSYETLEEMVGHAENILKALE
LPYRVITLCTGDMGFGAAKTYDLEVWVPAQNTYREISSCSNCEDFQARRMKARFKDENGKNRLVHTLNGSGLAVGRTLVA
VLENHQNADGSINIPAALQPYMGGVAKLEVK
>Mature_431_residues
MLDIQLLRSNTAAVAERLAARGYEFDAARFNALEEQRKAVQVKTEELQASRNSISKQIGALKGQGKHEEAQAAMDQVAQI
KTDLEQAAADLDAVQKELDAWLLSIPNLPHESVPAGKDETENVEVRKVGTPREFDFEIKDHVDLGEPLGLDFEGGAKLSG
ARFTVMRGQIARLHRALAQFMLDTHTLQHGYTEHYTPYIVDDTTLQGTGQLPKFAEDLFHVTRGGDETKTTQYLIPTAEV
TLTNTVADSIIPSEQLPLKLTAHSPCFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVHPEKSYETLEEMVGHAENILKALE
LPYRVITLCTGDMGFGAAKTYDLEVWVPAQNTYREISSCSNCEDFQARRMKARFKDENGKNRLVHTLNGSGLAVGRTLVA
VLENHQNADGSINIPAALQPYMGGVAKLEVK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=373, Percent_Identity=35.3887399463807, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=31.75, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI225579074, Length=326, Percent_Identity=33.7423312883436, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=64.2523364485981, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17539260, Length=421, Percent_Identity=33.9667458432304, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=306, Percent_Identity=31.0457516339869, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=399, Percent_Identity=33.5839598997494, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=409, Percent_Identity=30.3178484107579, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24581334, Length=368, Percent_Identity=36.6847826086957, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17737985, Length=336, Percent_Identity=31.8452380952381, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47726; Mature: 47726

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRSNTAAVAERLAARGYEFDAARFNALEEQRKAVQVKTEELQASRNSISKQIGA
CCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGQGKHEEAQAAMDQVAQIKTDLEQAAADLDAVQKELDAWLLSIPNLPHESVPAGKDET
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ENVEVRKVGTPREFDFEIKDHVDLGEPLGLDFEGGAKLSGARFTVMRGQIARLHRALAQF
CCEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
MLDTHTLQHGYTEHYTPYIVDDTTLQGTGQLPKFAEDLFHVTRGGDETKTTQYLIPTAEV
HHHHHHHHCCCCCCCCCEEEECCEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCE
TLTNTVADSIIPSEQLPLKLTAHSPCFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVHPEK
EEEHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECCCH
SYETLEEMVGHAENILKALELPYRVITLCTGDMGFGAAKTYDLEVWVPAQNTYREISSCS
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCC
NCEDFQARRMKARFKDENGKNRLVHTLNGSGLAVGRTLVAVLENHQNADGSINIPAALQP
CCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEECCCHHHH
YMGGVAKLEVK
HHCCCEEEEEC
>Mature Secondary Structure
MLDIQLLRSNTAAVAERLAARGYEFDAARFNALEEQRKAVQVKTEELQASRNSISKQIGA
CCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGQGKHEEAQAAMDQVAQIKTDLEQAAADLDAVQKELDAWLLSIPNLPHESVPAGKDET
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ENVEVRKVGTPREFDFEIKDHVDLGEPLGLDFEGGAKLSGARFTVMRGQIARLHRALAQF
CCEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
MLDTHTLQHGYTEHYTPYIVDDTTLQGTGQLPKFAEDLFHVTRGGDETKTTQYLIPTAEV
HHHHHHHHCCCCCCCCCEEEECCEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCE
TLTNTVADSIIPSEQLPLKLTAHSPCFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVHPEK
EEEHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECCCH
SYETLEEMVGHAENILKALELPYRVITLCTGDMGFGAAKTYDLEVWVPAQNTYREISSCS
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCC
NCEDFQARRMKARFKDENGKNRLVHTLNGSGLAVGRTLVAVLENHQNADGSINIPAALQP
CCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEECCCHHHH
YMGGVAKLEVK
HHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA