Click here to switch to the map view.

The map label for this gene is apt [H]

Identifier: 161870509

GI number: 161870509

Start: 1601171

End: 1601770

Strand: Direct

Name: apt [H]

Synonym: NMCC_1572

Alternate gene names: 161870509

Gene position: 1601171-1601770 (Clockwise)

Preceding gene: 161870505

Following gene: 161870511

Centisome position: 74.35

GC content: 53.83

Gene sequence:

>600_bases
ATGGCGTTAAAAACATCAAACTTGGAACACGCAATGCTGGTTCATCCCGAAGCTATGAGTGTCGGCGCGCTTGCCGACAA
AATCCGCAAAATCGAAAACTGGCCGCAAAAAGGCATCTTATTCCACGACATCACGCCCGTCCTGCAAAGCGCGGAATACT
TCCGCCTTTTGGTCGATTTATTGGTTTACCGCTATATGGATCAGAAAATCGACATCGTTGCCGGTTTGGACGCACGCGGC
TTCATTATCGGCGCGGCACTCGCCTACCAGCTCAATGTCGGTTTCGTCCCCATCCGCAAAAAAGGCAAGCTGCCTTTTGA
AACCGTATCGCAAAGCTACGCGCTCGAATACGGGGAAGCTGCGGTGGAAATCCACACCGATGCCGTCAAACCCGGTTCGC
GCGTGCTGCTGGTCGATGATTTGGTTGCCACGGGCGGCACGATGCTTGCCGGACTGGAGCTGATCCGCAAACTCGGCGGG
GAAATTGTCGAAGCTGCCGCCATTTTGGAATTTACCGACCTTCAAGGCGGCAAGAATATCCGTGCAAGCGGCGCGCCCTT
ATTTACCCTGCTTCAAAACGAAGGCTGTATGAAGGGCTGA

Upstream 100 bases:

>100_bases
ATTGTATCACAACGAACACCCGATTTCCTATTTGCCGATGCCCATATTTTGCCGCTATTGTTTTGATTGATTTGGCAAGC
GGCAGGCTGACGGCTACAAT

Downstream 100 bases:

>100_bases
AAACCGACCCTGCCGTCTGAAACCGGCAGGGTTGTTATTATGCGTTCAAATCACGCCCAAATCTTGCAAGCCCCTCAACA
CGCCGTCTTCATCAACGCTG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDLLVYRYMDQKIDIVAGLDARG
FIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEAAVEIHTDAVKPGSRVLLVDDLVATGGTMLAGLELIRKLGG
EIVEAAAILEFTDLQGGKNIRASGAPLFTLLQNEGCMKG

Sequences:

>Translated_199_residues
MALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDLLVYRYMDQKIDIVAGLDARG
FIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEAAVEIHTDAVKPGSRVLLVDDLVATGGTMLAGLELIRKLGG
EIVEAAAILEFTDLQGGKNIRASGAPLFTLLQNEGCMKG
>Mature_198_residues
ALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDLLVYRYMDQKIDIVAGLDARGF
IIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEAAVEIHTDAVKPGSRVLLVDDLVATGGTMLAGLELIRKLGGE
IVEAAAILEFTDLQGGKNIRASGAPLFTLLQNEGCMKG

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=45.9302325581395, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI71773201, Length=123, Percent_Identity=48.780487804878, Blast_Score=119, Evalue=1e-27,
Organism=Escherichia coli, GI1786675, Length=178, Percent_Identity=47.752808988764, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17509087, Length=151, Percent_Identity=46.3576158940397, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=190, Percent_Identity=38.4210526315789, Blast_Score=117, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=36.4705882352941, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17136334, Length=156, Percent_Identity=44.2307692307692, Blast_Score=126, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 21610; Mature: 21478

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDL
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHH
LVYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEA
HHHHHHCCCEEEEECCCCCCHHHHEEHEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCE
AVEIHTDAVKPGSRVLLVDDLVATGGTMLAGLELIRKLGGEIVEAAAILEFTDLQGGKNI
EEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEE
RASGAPLFTLLQNEGCMKG
ECCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
ALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDL
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHH
LVYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEA
HHHHHHCCCEEEEECCCCCCHHHHEEHEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCE
AVEIHTDAVKPGSRVLLVDDLVATGGTMLAGLELIRKLGGEIVEAAAILEFTDLQGGKNI
EEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEE
RASGAPLFTLLQNEGCMKG
ECCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA