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The map label for this gene is hisD [H]

Identifier: 161870436

GI number: 161870436

Start: 1513117

End: 1514406

Strand: Direct

Name: hisD [H]

Synonym: NMCC_1485

Alternate gene names: 161870436

Gene position: 1513117-1514406 (Clockwise)

Preceding gene: 161870435

Following gene: 161870437

Centisome position: 70.27

GC content: 58.06

Gene sequence:

>1290_bases
ATGAAAAAACTCAACACCCAATCGCCCGATTTCCAAGCCGGACTCAAAGCCCTGCTGGCTTTTGAAACCGCGCAAAACCC
CGAAACCGAACGCATCGTCGCCGACATTTGCGCCGACGTGCAAAAGCGCGGCGATGCGGCTTTGATTGAATACACCAACA
AATTCGATCAGACAAACGCTAAAAGCATCGATGATTTAATACTTACGCAAGCCGATTTGAACGCGGCGTTCGAGCGCATT
CCGAACGACGTTCAGACGGCATTGCAGACCGCCGCCCTCCGTGTCGAAAGCTACCACCAACGCCAAAAAATGGAATCGTG
GAGCTACACCGATGAAGACGGCACGCTGTTGGGACAACAGATTACCCCGCTTGACCGCGTCGGCATTTACGTCCCCGGCG
GCAAGGCGGCATATCCGAGTTCCGTCATCATGAACGCCATGCCCGCCCACGTCGCAGGCGTGAAAGAAATTATTATGGTC
GTGCCGACACCGAAAGGCGAACGCAACGACATCGTGCTTGCCGCCGCATACGTCGCCGGCGTAACCAAAGTCTTCACCGT
CGGCGGCGCGCAGGCGGTTGCCGCCCTCGCCTACGGCACGGAAACCATCCCCCAAGTCGATAAAATCACCGGTCCGGGCA
ACGCCTTCGTCGCCGCCGCCAAACGCCGCGTGTTCGGCGTGGTCGGCATCGACATGGTGGCGGGGCCGTCTGAAATCTTG
GTCATCGCCGACGGCACGACACCTGCCGATTGGGTGGCGATGGATTTGTTCAGCCAGGCCGAACACGACGAAATTGCCCA
AGCCATCTTAATCGGCACGTCGCAAGCGTATCTCGACGAAGTAGAAGCCGCTATGGACAGGCTCATCGAAACCATGCCGC
GCCGCGACATCATCGAAGCCTCGCTCGGCAACAGGGGCGCGATGATACTCGCCAAAGACTTGGACGAAGCCTGCGAAATC
GCCAACTACATTTCCCCCGAACACTTGGAATTGTCAGTCGAAAATCCGCAGGAATGGGCGAAAAAAATCCGCCACGCCGG
CGCGATTTTCATGGGACGCTACACCGGCGAAAGCCTCGGCGACTACTGCGCCGGCCCAAACCATGTGTTGCCCACCAGCC
GAACCGCCCGCTTTTCCTCGCCTTTGGGGACATATGATTTCCAAAAACGCTCCAGCCTGATTCAGGTTTCGGAACAGGGC
GCGCAAAAATTAGGCGAAACCGCCAGCGTGCTGGCACACGGCGAAAGCCTGACCGCCCACGCCCGCGCGGCAGAGTTCCG
TATGAAATAA

Upstream 100 bases:

>100_bases
GAGAAAAAGCGTATATCAGACCCAAAACAGAGACAGAAACTGAACAAGAGAATATTCAGACGACCCCCAATCCAAAAATA
AAAAAGGAAAAAACCAAATC

Downstream 100 bases:

>100_bases
TGCCGAAACGGCGTACAGGCATATTCCAACCATTAAGGAAACACGATGAAATCCGTCCGCTCCTTCATCCGCGACGACAT
ACAAGCTATGTCGGCATATC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKKLNTQSPDFQAGLKALLAFETAQNPETERIVADICADVQKRGDAALIEYTNKFDQTNAKSIDDLILTQADLNAAFERI
PNDVQTALQTAALRVESYHQRQKMESWSYTDEDGTLLGQQITPLDRVGIYVPGGKAAYPSSVIMNAMPAHVAGVKEIIMV
VPTPKGERNDIVLAAAYVAGVTKVFTVGGAQAVAALAYGTETIPQVDKITGPGNAFVAAAKRRVFGVVGIDMVAGPSEIL
VIADGTTPADWVAMDLFSQAEHDEIAQAILIGTSQAYLDEVEAAMDRLIETMPRRDIIEASLGNRGAMILAKDLDEACEI
ANYISPEHLELSVENPQEWAKKIRHAGAIFMGRYTGESLGDYCAGPNHVLPTSRTARFSSPLGTYDFQKRSSLIQVSEQG
AQKLGETASVLAHGESLTAHARAAEFRMK

Sequences:

>Translated_429_residues
MKKLNTQSPDFQAGLKALLAFETAQNPETERIVADICADVQKRGDAALIEYTNKFDQTNAKSIDDLILTQADLNAAFERI
PNDVQTALQTAALRVESYHQRQKMESWSYTDEDGTLLGQQITPLDRVGIYVPGGKAAYPSSVIMNAMPAHVAGVKEIIMV
VPTPKGERNDIVLAAAYVAGVTKVFTVGGAQAVAALAYGTETIPQVDKITGPGNAFVAAAKRRVFGVVGIDMVAGPSEIL
VIADGTTPADWVAMDLFSQAEHDEIAQAILIGTSQAYLDEVEAAMDRLIETMPRRDIIEASLGNRGAMILAKDLDEACEI
ANYISPEHLELSVENPQEWAKKIRHAGAIFMGRYTGESLGDYCAGPNHVLPTSRTARFSSPLGTYDFQKRSSLIQVSEQG
AQKLGETASVLAHGESLTAHARAAEFRMK
>Mature_429_residues
MKKLNTQSPDFQAGLKALLAFETAQNPETERIVADICADVQKRGDAALIEYTNKFDQTNAKSIDDLILTQADLNAAFERI
PNDVQTALQTAALRVESYHQRQKMESWSYTDEDGTLLGQQITPLDRVGIYVPGGKAAYPSSVIMNAMPAHVAGVKEIIMV
VPTPKGERNDIVLAAAYVAGVTKVFTVGGAQAVAALAYGTETIPQVDKITGPGNAFVAAAKRRVFGVVGIDMVAGPSEIL
VIADGTTPADWVAMDLFSQAEHDEIAQAILIGTSQAYLDEVEAAMDRLIETMPRRDIIEASLGNRGAMILAKDLDEACEI
ANYISPEHLELSVENPQEWAKKIRHAGAIFMGRYTGESLGDYCAGPNHVLPTSRTARFSSPLGTYDFQKRSSLIQVSEQG
AQKLGETASVLAHGESLTAHARAAEFRMK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=403, Percent_Identity=42.6799007444169, Blast_Score=302, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=427, Percent_Identity=37.4707259953162, Blast_Score=269, Evalue=8e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46281; Mature: 46281

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLNTQSPDFQAGLKALLAFETAQNPETERIVADICADVQKRGDAALIEYTNKFDQTNA
CCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCC
KSIDDLILTQADLNAAFERIPNDVQTALQTAALRVESYHQRQKMESWSYTDEDGTLLGQQ
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCC
ITPLDRVGIYVPGGKAAYPSSVIMNAMPAHVAGVKEIIMVVPTPKGERNDIVLAAAYVAG
CCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCHHHEEEEECCCCCCCCCEEEEHHHHHH
VTKVFTVGGAQAVAALAYGTETIPQVDKITGPGNAFVAAAKRRVFGVVGIDMVAGPSEIL
HHHHHCCCCHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHHEEEEHHEECCCCEEE
VIADGTTPADWVAMDLFSQAEHDEIAQAILIGTSQAYLDEVEAAMDRLIETMPRRDIIEA
EEECCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
SLGNRGAMILAKDLDEACEIANYISPEHLELSVENPQEWAKKIRHAGAIFMGRYTGESLG
CCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEECCCCCHHH
DYCAGPNHVLPTSRTARFSSPLGTYDFQKRSSLIQVSEQGAQKLGETASVLAHGESLTAH
HHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHH
ARAAEFRMK
HHHHHHCCC
>Mature Secondary Structure
MKKLNTQSPDFQAGLKALLAFETAQNPETERIVADICADVQKRGDAALIEYTNKFDQTNA
CCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCC
KSIDDLILTQADLNAAFERIPNDVQTALQTAALRVESYHQRQKMESWSYTDEDGTLLGQQ
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCC
ITPLDRVGIYVPGGKAAYPSSVIMNAMPAHVAGVKEIIMVVPTPKGERNDIVLAAAYVAG
CCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCHHHEEEEECCCCCCCCCEEEEHHHHHH
VTKVFTVGGAQAVAALAYGTETIPQVDKITGPGNAFVAAAKRRVFGVVGIDMVAGPSEIL
HHHHHCCCCHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHHEEEEHHEECCCCEEE
VIADGTTPADWVAMDLFSQAEHDEIAQAILIGTSQAYLDEVEAAMDRLIETMPRRDIIEA
EEECCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
SLGNRGAMILAKDLDEACEIANYISPEHLELSVENPQEWAKKIRHAGAIFMGRYTGESLG
CCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEECCCCCHHH
DYCAGPNHVLPTSRTARFSSPLGTYDFQKRSSLIQVSEQGAQKLGETASVLAHGESLTAH
HHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHH
ARAAEFRMK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA