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The map label for this gene is pepA [H]

Identifier: 161870425

GI number: 161870425

Start: 1497927

End: 1499333

Strand: Reverse

Name: pepA [H]

Synonym: NMCC_1473

Alternate gene names: 161870425

Gene position: 1499333-1497927 (Counterclockwise)

Preceding gene: 161870429

Following gene: 161870423

Centisome position: 69.63

GC content: 56.36

Gene sequence:

>1407_bases
GTGGAATTTAGCACAAAAACCGAAATCTTGCAGGAACAGCAGGCAGGCGCACAGTTATTTGTCTGCACCGAAGAGGCGCA
ATTAAACCATCCGACCGCCCTTGCCCTTTTGTCTTCGCTTGAAGAAGGTCAAAATTTTGCCGACACAAAAATCCCGACAG
GCAACGGTTTGCAGGCTGTTGCCGTATGCTGTCTGAAAAGCACCGGCCGCGCCGCATTGAACAAGGCCGCCGCCGAAGCC
GCCAAATGGGCGCAAAATCAGGAAACGGTCAATGTGGACATCCATGCCTTCGATGAAGCGCAAGCCGCCGCCGTAGCCGA
AGCGTTTGCGATTGCGTTCGGCAACGCCGCCTACCGTTTCGACCGCTACAAAAAAGAAGCCAAGCCCGCCAAATTTGAAA
CCGCCGTGTTCCACAGCGCACACGAAGCCGTCGTTAAAGAAGCCTTGCGCGTCGCCGAAGCGCAAGTTTACGGACAAAGC
CTCTGCCGCGACTTGGGCAACGCCGCGCCCAACGAATGCACGCCCGAATTTTTAGCGCGCACCGCCAAAGCCGAAGCCGA
AAAACTGGGCGCGCACGCCAAAATCATCGAAAAAGACTACATCAAAGAAAACATGGGTTCGTTTTGGTCGGTCGCCAAAG
GCAGCGCGGAAGCCCCCTATTTGGTCGAACTGAGCTATTTCGGTGCAGCCGACAAAGAAGCCGCCCCCGTCGTCTTGGTC
GGCAAAGGCATTACCTTCGACACCGGCGGCATTTCCCTCAAACCCGGTCTGAACATGGACGAAATGAAGTTTGATATGTG
CGGCGCGGCAACCGTCATCAGCACCTTCTGCGCCGCCGTCAAACTGCAACTGCCGATCAACCTGATTGCCATCGTCGCCA
CTTGTGAAAATATGCCTTCCGGCGCGGCCAACAAACCGGGCGACGTCGTAAAAAGCATGAAAGGCCTGACCATCGAAGTG
TTGAACACCGATGCTGAAGGCCGTCTGATTTTGTGTGACGCGCTCACTTACGCCGAACAATTCAAACCTAAAGCCGTCAT
CGACGTCGCCACCCTGACCGGTGCATGCATCGTCGCCTTGGGGCACGATGTCAGCGGCGTGATGGGCAACAATCAGGATT
TGATCAACAGCCTGCTCGCCGCCTCCCGCAACGTGGACGACAAAGCGTGGCAACTGCCGCTTTTCGAGACCTACAAAGAC
CAGCTCAAGTCCAATTTTGCCGACATCCCCAACATCGGCACGCCCGGCGCGGGCACGATTACCGCCGCAACATTCCTGTC
TTACTTCACCGAAGGCTACCCGTGGGCGCACCTTGACATCGCGGGTACGGCGTGGAAATCCGGAGCGGAAAAAGGTGCGA
CTGGCCGTCCCGTTCCCTTGCTGCTGAACTATCTGCGGAATCTTTAA

Upstream 100 bases:

>100_bases
CTTCAAATGGGGTACAATCGTGCCAGCCGTCTTCAGACGGTCTTTTGAGCGAAAGGCCGTCCGAAAACTACCGACAACCG
TCTCAATCAGGAGAATAAAC

Downstream 100 bases:

>100_bases
CCCCGTAATCATGCCGTCTGAAACAGTGTACCGCACCGTTCAGACGGCATCGTCCTGCCAAATGTTCAAACAATATGCCG
AAAGCCACCTTTTACACGCA

Product: aminopeptidase A

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MEFSTKTEILQEQQAGAQLFVCTEEAQLNHPTALALLSSLEEGQNFADTKIPTGNGLQAVAVCCLKSTGRAALNKAAAEA
AKWAQNQETVNVDIHAFDEAQAAAVAEAFAIAFGNAAYRFDRYKKEAKPAKFETAVFHSAHEAVVKEALRVAEAQVYGQS
LCRDLGNAAPNECTPEFLARTAKAEAEKLGAHAKIIEKDYIKENMGSFWSVAKGSAEAPYLVELSYFGAADKEAAPVVLV
GKGITFDTGGISLKPGLNMDEMKFDMCGAATVISTFCAAVKLQLPINLIAIVATCENMPSGAANKPGDVVKSMKGLTIEV
LNTDAEGRLILCDALTYAEQFKPKAVIDVATLTGACIVALGHDVSGVMGNNQDLINSLLAASRNVDDKAWQLPLFETYKD
QLKSNFADIPNIGTPGAGTITAATFLSYFTEGYPWAHLDIAGTAWKSGAEKGATGRPVPLLLNYLRNL

Sequences:

>Translated_468_residues
MEFSTKTEILQEQQAGAQLFVCTEEAQLNHPTALALLSSLEEGQNFADTKIPTGNGLQAVAVCCLKSTGRAALNKAAAEA
AKWAQNQETVNVDIHAFDEAQAAAVAEAFAIAFGNAAYRFDRYKKEAKPAKFETAVFHSAHEAVVKEALRVAEAQVYGQS
LCRDLGNAAPNECTPEFLARTAKAEAEKLGAHAKIIEKDYIKENMGSFWSVAKGSAEAPYLVELSYFGAADKEAAPVVLV
GKGITFDTGGISLKPGLNMDEMKFDMCGAATVISTFCAAVKLQLPINLIAIVATCENMPSGAANKPGDVVKSMKGLTIEV
LNTDAEGRLILCDALTYAEQFKPKAVIDVATLTGACIVALGHDVSGVMGNNQDLINSLLAASRNVDDKAWQLPLFETYKD
QLKSNFADIPNIGTPGAGTITAATFLSYFTEGYPWAHLDIAGTAWKSGAEKGATGRPVPLLLNYLRNL
>Mature_468_residues
MEFSTKTEILQEQQAGAQLFVCTEEAQLNHPTALALLSSLEEGQNFADTKIPTGNGLQAVAVCCLKSTGRAALNKAAAEA
AKWAQNQETVNVDIHAFDEAQAAAVAEAFAIAFGNAAYRFDRYKKEAKPAKFETAVFHSAHEAVVKEALRVAEAQVYGQS
LCRDLGNAAPNECTPEFLARTAKAEAEKLGAHAKIIEKDYIKENMGSFWSVAKGSAEAPYLVELSYFGAADKEAAPVVLV
GKGITFDTGGISLKPGLNMDEMKFDMCGAATVISTFCAAVKLQLPINLIAIVATCENMPSGAANKPGDVVKSMKGLTIEV
LNTDAEGRLILCDALTYAEQFKPKAVIDVATLTGACIVALGHDVSGVMGNNQDLINSLLAASRNVDDKAWQLPLFETYKD
QLKSNFADIPNIGTPGAGTITAATFLSYFTEGYPWAHLDIAGTAWKSGAEKGATGRPVPLLLNYLRNL

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=408, Percent_Identity=43.1372549019608, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI47155554, Length=301, Percent_Identity=34.21926910299, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1790710, Length=307, Percent_Identity=55.0488599348534, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=40.5660377358491, Blast_Score=188, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=284, Percent_Identity=35.5633802816901, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=253, Percent_Identity=28.4584980237154, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI20129969, Length=405, Percent_Identity=33.0864197530864, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24661038, Length=404, Percent_Identity=31.1881188118812, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21355725, Length=406, Percent_Identity=31.2807881773399, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI161077148, Length=488, Percent_Identity=30.327868852459, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI20130057, Length=488, Percent_Identity=30.327868852459, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI21355645, Length=428, Percent_Identity=30.3738317757009, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24662223, Length=428, Percent_Identity=30.3738317757009, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19922386, Length=474, Percent_Identity=29.3248945147679, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24662227, Length=413, Percent_Identity=30.7506053268765, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI20129963, Length=404, Percent_Identity=30.1980198019802, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI221379063, Length=304, Percent_Identity=33.5526315789474, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221379062, Length=304, Percent_Identity=33.5526315789474, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357381, Length=304, Percent_Identity=33.5526315789474, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646701, Length=353, Percent_Identity=27.1954674220963, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646703, Length=353, Percent_Identity=27.1954674220963, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358201, Length=353, Percent_Identity=27.1954674220963, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49809; Mature: 49809

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSTKTEILQEQQAGAQLFVCTEEAQLNHPTALALLSSLEEGQNFADTKIPTGNGLQAV
CCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
AVCCLKSTGRAALNKAAAEAAKWAQNQETVNVDIHAFDEAQAAAVAEAFAIAFGNAAYRF
HHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCHHHHH
DRYKKEAKPAKFETAVFHSAHEAVVKEALRVAEAQVYGQSLCRDLGNAAPNECTPEFLAR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TAKAEAEKLGAHAKIIEKDYIKENMGSFWSVAKGSAEAPYLVELSYFGAADKEAAPVVLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEEE
GKGITFDTGGISLKPGLNMDEMKFDMCGAATVISTFCAAVKLQLPINLIAIVATCENMPS
ECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
GAANKPGDVVKSMKGLTIEVLNTDAEGRLILCDALTYAEQFKPKAVIDVATLTGACIVAL
CCCCCCHHHHHHHCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCCEEEHHHHHCEEEEEE
GHDVSGVMGNNQDLINSLLAASRNVDDKAWQLPLFETYKDQLKSNFADIPNIGTPGAGTI
CCCCCCCCCCCHHHHHHHHHHCCCCCCHHEECCHHHHHHHHHHHHHCCCCCCCCCCCCHH
TAATFLSYFTEGYPWAHLDIAGTAWKSGAEKGATGRPVPLLLNYLRNL
HHHHHHHHHHCCCCEEEEEECCHHHHCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEFSTKTEILQEQQAGAQLFVCTEEAQLNHPTALALLSSLEEGQNFADTKIPTGNGLQAV
CCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
AVCCLKSTGRAALNKAAAEAAKWAQNQETVNVDIHAFDEAQAAAVAEAFAIAFGNAAYRF
HHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCHHHHH
DRYKKEAKPAKFETAVFHSAHEAVVKEALRVAEAQVYGQSLCRDLGNAAPNECTPEFLAR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TAKAEAEKLGAHAKIIEKDYIKENMGSFWSVAKGSAEAPYLVELSYFGAADKEAAPVVLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEEE
GKGITFDTGGISLKPGLNMDEMKFDMCGAATVISTFCAAVKLQLPINLIAIVATCENMPS
ECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
GAANKPGDVVKSMKGLTIEVLNTDAEGRLILCDALTYAEQFKPKAVIDVATLTGACIVAL
CCCCCCHHHHHHHCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCCEEEHHHHHCEEEEEE
GHDVSGVMGNNQDLINSLLAASRNVDDKAWQLPLFETYKDQLKSNFADIPNIGTPGAGTI
CCCCCCCCCCCHHHHHHHHHHCCCCCCHHEECCHHHHHHHHHHHHHCCCCCCCCCCCCHH
TAATFLSYFTEGYPWAHLDIAGTAWKSGAEKGATGRPVPLLLNYLRNL
HHHHHHHHHHCCCCEEEEEECCHHHHCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]