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The map label for this gene is ilvA [H]

Identifier: 161869811

GI number: 161869811

Start: 842260

End: 843786

Strand: Direct

Name: ilvA [H]

Synonym: NMCC_0840

Alternate gene names: 161869811

Gene position: 842260-843786 (Clockwise)

Preceding gene: 161869809

Following gene: 161869815

Centisome position: 39.11

GC content: 53.18

Gene sequence:

>1527_bases
ATGAACACGCCCCTTCCTTATTCCGATTACCTCATCCGCATCCTGACGGCATCTGTCTATGATGTCGCGGTCGAAACGCC
TTTGGAACCGGCACGCAGCCTTTCTGTACGTTTGAAAAACAACATCCTTTTGAAACGCGAAGATTTGCAGCCGGTTTTTT
CGTTCAAAATACGCGGCGCGTACAACAAAATGTCCAAGTTGCCGAAAGATGCGCTCGCTTGCGGCGTGATTGCGGCAAGC
GCGGGCAATCACGCACAAGGCGTGGCATTGTCCGCACAGCGTTTGGGTTGCCGTGCCGTTATCGTCATGCCGGAGACTAC
GCCGAAAATCAAAGTGGATGCGGTCAAAAGCCGTGGCGGCGAGGTGGTTTTGCGCGGTGTTTCATACAACGATGCTTACG
ATTATGCGATGGAGCTGGCGGAACAGGAAGGGCTGACCTATATCGCACCGTTTGACGATCCTGATGTGATTGCAGGACAA
GGGACGGTAGGGATGGAAATTGTCAGCCAGCATCCCGATCCAATCCGCGCCGTATTCGTACCGATAGGGGGGGGCGGTTT
GGCGGCGGGCGTGGCGGCATTTATCAAGCAGGTCCGTCCCGAAATCAAAGTTATCGGCGTTCAGACCAACGATTCCTGCT
GTATGAAGCAGTCGGTCGAAGCGGGTGAAATCGTCCATTTGAAAGATGTCGGGCTGTTTTCAGACGGCACTGCGGTCAAA
GTTGTCGGAGACGAAACCTTCCGCCTCTGCAAAGAACTTTTGGATGAAATCATTACAGTCGATACCGATGCGGTTTGCGG
CGCGGTCAAGGATATTTTCGATGACACGCGCAGCATTACCGAGCCGGCGGGCGCGTTGGCGTTGGCGGGTCTGAAAGCCT
ATATCGCCCGAGAAGGCGCGGAAAACCAAACCCTGATTGCCGTTACCAGCGGTGCGAATATGAATTTTCACCGTTTGCGC
CATGTGTCGGAGCGTAGTGAATTGGGCGAGGGCAACGAAGGTATTTTTGCCGTTACCATCCCCGAAGAACGCGGCAGCTT
CCTTAAGTTTGTCAATATATTGGGAAATAGGAATATTACCGAGTTCAACTACCGCTACGGAGACGATGAAAAAGCGCATA
TCTTTGTCGGACTTCAAGCGGCAGGCCCGCAGGATTTGGCGGTTATCGGCAGCCGGTTGGATGAGGCGGGATTGCCCAAT
GTCGACCTGACTGATGATGAGATTGCCAAAATCCATATCCGTTATATGGTTGGAGGGCGGACGGACAAAGTAGAAAACGA
GCGTTTGGTCAGTTTTGAGTTTCCGGAGCGTCCGGGGGCATTGGCACGCTTTTTGAACCATATGCAGGGAGGGTGGAATA
TTACGCTTTTCCATTACCGCAACCACGGTGCGGATTACGGGCGGATTTTGGTCGGTATCGATGTGCCGCCGCACGATGCC
GCCGCATTTGACGGTTTCTTGGAAAGTCTGGGATACAGCTATCATGAGGAAACGCAAAATGCCGCGTACAAGCTGTTTCT
TGCCTGA

Upstream 100 bases:

>100_bases
AGGGTGTCTGATCGGGCGGATTTTTCTTGATTTCGCGCCGTCTTGGGCGTATGGTTTTGGGTTTTGCGATTTTAATAAAC
CGATTATCCCATATTGAATT

Downstream 100 bases:

>100_bases
CGCTTGAAAGCACAATGCCGTCTGAAAGCCTTTCAGACGGCATTGCGCTTTCATGGTTAAATCGAATATTCAATCAGCTC
GTTTTGAGAAAAGACATAAA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MNTPLPYSDYLIRILTASVYDVAVETPLEPARSLSVRLKNNILLKREDLQPVFSFKIRGAYNKMSKLPKDALACGVIAAS
AGNHAQGVALSAQRLGCRAVIVMPETTPKIKVDAVKSRGGEVVLRGVSYNDAYDYAMELAEQEGLTYIAPFDDPDVIAGQ
GTVGMEIVSQHPDPIRAVFVPIGGGGLAAGVAAFIKQVRPEIKVIGVQTNDSCCMKQSVEAGEIVHLKDVGLFSDGTAVK
VVGDETFRLCKELLDEIITVDTDAVCGAVKDIFDDTRSITEPAGALALAGLKAYIAREGAENQTLIAVTSGANMNFHRLR
HVSERSELGEGNEGIFAVTIPEERGSFLKFVNILGNRNITEFNYRYGDDEKAHIFVGLQAAGPQDLAVIGSRLDEAGLPN
VDLTDDEIAKIHIRYMVGGRTDKVENERLVSFEFPERPGALARFLNHMQGGWNITLFHYRNHGADYGRILVGIDVPPHDA
AAFDGFLESLGYSYHEETQNAAYKLFLA

Sequences:

>Translated_508_residues
MNTPLPYSDYLIRILTASVYDVAVETPLEPARSLSVRLKNNILLKREDLQPVFSFKIRGAYNKMSKLPKDALACGVIAAS
AGNHAQGVALSAQRLGCRAVIVMPETTPKIKVDAVKSRGGEVVLRGVSYNDAYDYAMELAEQEGLTYIAPFDDPDVIAGQ
GTVGMEIVSQHPDPIRAVFVPIGGGGLAAGVAAFIKQVRPEIKVIGVQTNDSCCMKQSVEAGEIVHLKDVGLFSDGTAVK
VVGDETFRLCKELLDEIITVDTDAVCGAVKDIFDDTRSITEPAGALALAGLKAYIAREGAENQTLIAVTSGANMNFHRLR
HVSERSELGEGNEGIFAVTIPEERGSFLKFVNILGNRNITEFNYRYGDDEKAHIFVGLQAAGPQDLAVIGSRLDEAGLPN
VDLTDDEIAKIHIRYMVGGRTDKVENERLVSFEFPERPGALARFLNHMQGGWNITLFHYRNHGADYGRILVGIDVPPHDA
AAFDGFLESLGYSYHEETQNAAYKLFLA
>Mature_508_residues
MNTPLPYSDYLIRILTASVYDVAVETPLEPARSLSVRLKNNILLKREDLQPVFSFKIRGAYNKMSKLPKDALACGVIAAS
AGNHAQGVALSAQRLGCRAVIVMPETTPKIKVDAVKSRGGEVVLRGVSYNDAYDYAMELAEQEGLTYIAPFDDPDVIAGQ
GTVGMEIVSQHPDPIRAVFVPIGGGGLAAGVAAFIKQVRPEIKVIGVQTNDSCCMKQSVEAGEIVHLKDVGLFSDGTAVK
VVGDETFRLCKELLDEIITVDTDAVCGAVKDIFDDTRSITEPAGALALAGLKAYIAREGAENQTLIAVTSGANMNFHRLR
HVSERSELGEGNEGIFAVTIPEERGSFLKFVNILGNRNITEFNYRYGDDEKAHIFVGLQAAGPQDLAVIGSRLDEAGLPN
VDLTDDEIAKIHIRYMVGGRTDKVENERLVSFEFPERPGALARFLNHMQGGWNITLFHYRNHGADYGRILVGIDVPPHDA
AAFDGFLESLGYSYHEETQNAAYKLFLA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=296, Percent_Identity=30.0675675675676, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=30.5295950155763, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI19923959, Length=319, Percent_Identity=31.974921630094, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1790207, Length=502, Percent_Identity=55.9760956175299, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1789505, Length=299, Percent_Identity=41.1371237458194, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI1789235, Length=236, Percent_Identity=29.2372881355932, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=300, Percent_Identity=33.6666666666667, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17537387, Length=336, Percent_Identity=30.6547619047619, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=256, Percent_Identity=31.640625, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=521, Percent_Identity=50.4798464491363, Blast_Score=493, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322631, Length=294, Percent_Identity=35.7142857142857, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319788, Length=265, Percent_Identity=27.1698113207547, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21355833, Length=240, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24645328, Length=179, Percent_Identity=31.8435754189944, Blast_Score=86, Evalue=9e-17,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55215; Mature: 55215

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPLPYSDYLIRILTASVYDVAVETPLEPARSLSVRLKNNILLKREDLQPVFSFKIRGA
CCCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHEEEEEECCEEEEECCCCCEEEEEECCH
YNKMSKLPKDALACGVIAASAGNHAQGVALSAQRLGCRAVIVMPETTPKIKVDAVKSRGG
HHHHHHCCHHHHHHHHEEECCCCCCCCEEEEHHHCCCEEEEEECCCCCCEEEEEECCCCC
EVVLRGVSYNDAYDYAMELAEQEGLTYIAPFDDPDVIAGQGTVGMEIVSQHPDPIRAVFV
EEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCHHHHHCCCCCEEEEEE
PIGGGGLAAGVAAFIKQVRPEIKVIGVQTNDSCCMKQSVEAGEIVHLKDVGLFSDGTAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCCCCEEEEEECCEECCCCEEE
VVGDETFRLCKELLDEIITVDTDAVCGAVKDIFDDTRSITEPAGALALAGLKAYIAREGA
EECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
ENQTLIAVTSGANMNFHRLRHVSERSELGEGNEGIFAVTIPEERGSFLKFVNILGNRNIT
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECHHCCCHHHHHHHHCCCCEE
EFNYRYGDDEKAHIFVGLQAAGPQDLAVIGSRLDEAGLPNVDLTDDEIAKIHIRYMVGGR
EEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCC
TDKVENERLVSFEFPERPGALARFLNHMQGGWNITLFHYRNHGADYGRILVGIDVPPHDA
CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEEECCCCCCH
AAFDGFLESLGYSYHEETQNAAYKLFLA
HHHHHHHHHHCCCHHHHCCCCEEEEEEC
>Mature Secondary Structure
MNTPLPYSDYLIRILTASVYDVAVETPLEPARSLSVRLKNNILLKREDLQPVFSFKIRGA
CCCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHEEEEEECCEEEEECCCCCEEEEEECCH
YNKMSKLPKDALACGVIAASAGNHAQGVALSAQRLGCRAVIVMPETTPKIKVDAVKSRGG
HHHHHHCCHHHHHHHHEEECCCCCCCCEEEEHHHCCCEEEEEECCCCCCEEEEEECCCCC
EVVLRGVSYNDAYDYAMELAEQEGLTYIAPFDDPDVIAGQGTVGMEIVSQHPDPIRAVFV
EEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCHHHHHCCCCCEEEEEE
PIGGGGLAAGVAAFIKQVRPEIKVIGVQTNDSCCMKQSVEAGEIVHLKDVGLFSDGTAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCCCCEEEEEECCEECCCCEEE
VVGDETFRLCKELLDEIITVDTDAVCGAVKDIFDDTRSITEPAGALALAGLKAYIAREGA
EECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
ENQTLIAVTSGANMNFHRLRHVSERSELGEGNEGIFAVTIPEERGSFLKFVNILGNRNIT
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECHHCCCHHHHHHHHCCCCEE
EFNYRYGDDEKAHIFVGLQAAGPQDLAVIGSRLDEAGLPNVDLTDDEIAKIHIRYMVGGR
EEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCC
TDKVENERLVSFEFPERPGALARFLNHMQGGWNITLFHYRNHGADYGRILVGIDVPPHDA
CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEEECCCCCCH
AAFDGFLESLGYSYHEETQNAAYKLFLA
HHHHHHHHHHCCCHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA