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The map label for this gene is trpF [H]

Identifier: 161869629

GI number: 161869629

Start: 656153

End: 656779

Strand: Reverse

Name: trpF [H]

Synonym: NMCC_0646

Alternate gene names: 161869629

Gene position: 656779-656153 (Counterclockwise)

Preceding gene: 161869630

Following gene: 161869628

Centisome position: 30.5

GC content: 61.24

Gene sequence:

>627_bases
ATGAGGAAAATCCGCACCAAAATCTGCGGCATCACCACACTGGAAGACGCAGCGGCCGCCGCAGCGGCAGGTGCGGATGC
CGTCGGGCTGGTCTTTTTCCAAGGCAGCAGCCGGGCCGTCGATATTGCCCGCGCCAAAAAAATCACCGCCGCACTGCCGC
CGTTTGTCAGCGTTGTCGCCCTTTTCGTCAACGAAAGCGCGCAAAACATCCGCCGCATCCTTGCCGAAGTGCCGATACAC
ATCATCCAATTCCACGGCGACGAAGACGACGCATTCTGCCGCCAGTTCGACCGCCCCTATATCAAGGCCATTCGTGTTCA
GACGGCATCAGACATCCGAAACGCCGCCGACCGCTTCCCCGACGCTCAGGCACTGCTGTTCGATGCCTACCACCCTTCGG
AATACGGCGGCACCGGACACCGCTTCGACTGGACGCTGCTGGCGGAATATTCGGGCAAACCGTGGGTGCTTGCCGGCGGG
CTGACCCCTGAAAACGTCGGCGAAGCCGTCCGCATCACCGGAGCGGAAGCGGTCGACGTATCCGGCGGCGTGGAAGCGTC
TAAAGGCAAAAAAGACCCAGCCAAAGTCGCCGCCTTTATCGCAACCGCCAACCGCCTATCCCGTTAA

Upstream 100 bases:

>100_bases
GAAATTGAAATCCTTTCTGTCGAATACATCAAAATCGACTGATCGGGAATGCCGTCTGAAACGGCACAAACGCATCGTTT
CCCAAATAAAGGAATACCGA

Downstream 100 bases:

>100_bases
AGCAACAAAAATTGCCGCTGGAATGACTTATAGTGGATTAACAAAAACCAGTACGGCGTTGCCTCGCCTTAGCTCAAAGA
GAACGATTCTCTAAGGTGCT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRKIRTKICGITTLEDAAAAAAAGADAVGLVFFQGSSRAVDIARAKKITAALPPFVSVVALFVNESAQNIRRILAEVPIH
IIQFHGDEDDAFCRQFDRPYIKAIRVQTASDIRNAADRFPDAQALLFDAYHPSEYGGTGHRFDWTLLAEYSGKPWVLAGG
LTPENVGEAVRITGAEAVDVSGGVEASKGKKDPAKVAAFIATANRLSR

Sequences:

>Translated_208_residues
MRKIRTKICGITTLEDAAAAAAAGADAVGLVFFQGSSRAVDIARAKKITAALPPFVSVVALFVNESAQNIRRILAEVPIH
IIQFHGDEDDAFCRQFDRPYIKAIRVQTASDIRNAADRFPDAQALLFDAYHPSEYGGTGHRFDWTLLAEYSGKPWVLAGG
LTPENVGEAVRITGAEAVDVSGGVEASKGKKDPAKVAAFIATANRLSR
>Mature_208_residues
MRKIRTKICGITTLEDAAAAAAAGADAVGLVFFQGSSRAVDIARAKKITAALPPFVSVVALFVNESAQNIRRILAEVPIH
IIQFHGDEDDAFCRQFDRPYIKAIRVQTASDIRNAADRFPDAQALLFDAYHPSEYGGTGHRFDWTLLAEYSGKPWVLAGG
LTPENVGEAVRITGAEAVDVSGGVEASKGKKDPAKVAAFIATANRLSR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=199, Percent_Identity=30.1507537688442, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320210, Length=216, Percent_Identity=33.7962962962963, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 22283; Mature: 22283

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIRTKICGITTLEDAAAAAAAGADAVGLVFFQGSSRAVDIARAKKITAALPPFVSVVA
CCCHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHHHHCCHHHHHHH
LFVNESAQNIRRILAEVPIHIIQFHGDEDDAFCRQFDRPYIKAIRVQTASDIRNAADRFP
HHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
DAQALLFDAYHPSEYGGTGHRFDWTLLAEYSGKPWVLAGGLTPENVGEAVRITGAEAVDV
CCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCHHCCCEEEECCCCEEEC
SGGVEASKGKKDPAKVAAFIATANRLSR
CCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKIRTKICGITTLEDAAAAAAAGADAVGLVFFQGSSRAVDIARAKKITAALPPFVSVVA
CCCHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHHHHCCHHHHHHH
LFVNESAQNIRRILAEVPIHIIQFHGDEDDAFCRQFDRPYIKAIRVQTASDIRNAADRFP
HHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
DAQALLFDAYHPSEYGGTGHRFDWTLLAEYSGKPWVLAGGLTPENVGEAVRITGAEAVDV
CCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCHHCCCEEEECCCCEEEC
SGGVEASKGKKDPAKVAAFIATANRLSR
CCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA