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The map label for this gene is pyrC [H]

Identifier: 161869622

GI number: 161869622

Start: 650396

End: 651430

Strand: Direct

Name: pyrC [H]

Synonym: NMCC_0639

Alternate gene names: 161869622

Gene position: 650396-651430 (Clockwise)

Preceding gene: 161869621

Following gene: 161869625

Centisome position: 30.2

GC content: 59.03

Gene sequence:

>1035_bases
ATGCAAACCCTGACCATTATCCGCCCCGACGATATGCACCTGCACCTGCGCGACGGCGACGCGCTCAAAGCCGTTGTGCC
TTATACCGCCAGACAGATGGGGCGCGCCGTGATTATGCCCAATCTCAAACCGCCTGTCGTCAGCGTTGCCGACGCGCTTG
CCTACAAAGCGCGCATTATGGCGGCGTTGCCCGAAGGCAGCGCGTTTGAGCCGTTGATGACGCTTTATTTGACTGATAAC
GCCACGTCCGAACTTGTACGCGAAGCCAAAGCCGCCGGCATCGTCGCCTTCAAACTCTATCCTGCCGGCGCGACGACCAA
TTCCGATTCCGGCGTAACCGACCTGTTCAAACTCATCCCCGTTTTGGAAGAAATGGCAAAACAGGGCATTTTGTTCCTCG
TTCACGGCGAAGTAACCGACCCCGAAATCGACATCTTCGACCGCGAAGCCGCCTTTATCGGGCGCGTGATGAAACCCGTT
TTGGCGCAAGTGCCGAATCTTAAAGTCGTGTTCGAACACATCACCACCGCCGAAGCCGCCCGCCTGGTTTTGGAAGCAGG
CGACAACGTAGCCGCCACCGTTACCCCGCAACACCTCCTGCTCAACCGCAACGACCTCTTGGTCGGCGGCGTGCGCCCCC
ATCATTTCTGCCTGCCCGTACTCAAACGCGAAACCCACCGTCAGGCATTGGTTGCCGCCGTTACCGGCGAGAAGGCGCAC
AAATTCTTCCTCGGCACCGACTCCGCGCCGCACGCCAAGTCCGCCAAAGAAAACGCCTGCGGCTGCGCCGGTATGTTCAG
CGCGATGACCGCCGTCGAGCTTTACGCCGAAGTGTTTGAAAAAGCAGGCGCGTTGGACAAACTCGAAGCCTTTGCCTCGA
AAAATGGCGCAAGGTTTTACGGCATTCCGGAAAACGCCGGCACGATCACCCTCGTCAAACAAAGCCAAACCGTCCCCGCA
AGTGTTCCCTACGGCGACGGCGAACTTGTCCCGATGCGCGCGGGCGGCGAAATCGGCTGGACGGTACAGTATTGA

Upstream 100 bases:

>100_bases
CGCACCGTTCCCACAACGGGAAACCCCTAATTCTCCCCTAACTTCAGACGGCATAAAGTCGGCATGCCGTCTGAACATTC
AAATAAAACAAAGGAAAACC

Downstream 100 bases:

>100_bases
TTGAACGGTCAAGCAAAATGCCGTCTGAAAGGTTTTTCAGACGGCATTTATGTATTTTCCAATTCGGATTTTCCGGAGTG
TCAACGGCGTTTGGGCTCGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MQTLTIIRPDDMHLHLRDGDALKAVVPYTARQMGRAVIMPNLKPPVVSVADALAYKARIMAALPEGSAFEPLMTLYLTDN
ATSELVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIPVLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPV
LAQVPNLKVVFEHITTAEAARLVLEAGDNVAATVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAH
KFFLGTDSAPHAKSAKENACGCAGMFSAMTAVELYAEVFEKAGALDKLEAFASKNGARFYGIPENAGTITLVKQSQTVPA
SVPYGDGELVPMRAGGEIGWTVQY

Sequences:

>Translated_344_residues
MQTLTIIRPDDMHLHLRDGDALKAVVPYTARQMGRAVIMPNLKPPVVSVADALAYKARIMAALPEGSAFEPLMTLYLTDN
ATSELVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIPVLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPV
LAQVPNLKVVFEHITTAEAARLVLEAGDNVAATVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAH
KFFLGTDSAPHAKSAKENACGCAGMFSAMTAVELYAEVFEKAGALDKLEAFASKNGARFYGIPENAGTITLVKQSQTVPA
SVPYGDGELVPMRAGGEIGWTVQY
>Mature_344_residues
MQTLTIIRPDDMHLHLRDGDALKAVVPYTARQMGRAVIMPNLKPPVVSVADALAYKARIMAALPEGSAFEPLMTLYLTDN
ATSELVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIPVLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPV
LAQVPNLKVVFEHITTAEAARLVLEAGDNVAATVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAH
KFFLGTDSAPHAKSAKENACGCAGMFSAMTAVELYAEVFEKAGALDKLEAFASKNGARFYGIPENAGTITLVKQSQTVPA
SVPYGDGELVPMRAGGEIGWTVQY

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=343, Percent_Identity=55.3935860058309, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6323452, Length=359, Percent_Identity=33.7047353760446, Blast_Score=186, Evalue=7e-48,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37000; Mature: 37000

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLTIIRPDDMHLHLRDGDALKAVVPYTARQMGRAVIMPNLKPPVVSVADALAYKARIM
CCEEEEECCCCCEEEEECCCCEEEECCHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHE
AALPEGSAFEPLMTLYLTDNATSELVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIP
EECCCCCCCCCEEEEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHH
VLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPVLAQVPNLKVVFEHITTAEAA
HHHHHHHCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RLVLEAGDNVAATVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAH
HHHEECCCCEEEEECHHHEEECCCCEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCE
KFFLGTDSAPHAKSAKENACGCAGMFSAMTAVELYAEVFEKAGALDKLEAFASKNGARFY
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEE
GIPENAGTITLVKQSQTVPASVPYGDGELVPMRAGGEIGWTVQY
ECCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEC
>Mature Secondary Structure
MQTLTIIRPDDMHLHLRDGDALKAVVPYTARQMGRAVIMPNLKPPVVSVADALAYKARIM
CCEEEEECCCCCEEEEECCCCEEEECCHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHE
AALPEGSAFEPLMTLYLTDNATSELVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIP
EECCCCCCCCCEEEEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHH
VLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPVLAQVPNLKVVFEHITTAEAA
HHHHHHHCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RLVLEAGDNVAATVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAH
HHHEECCCCEEEEECHHHEEECCCCEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCE
KFFLGTDSAPHAKSAKENACGCAGMFSAMTAVELYAEVFEKAGALDKLEAFASKNGARFY
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEE
GIPENAGTITLVKQSQTVPASVPYGDGELVPMRAGGEIGWTVQY
ECCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA