Click here to switch to the map view.

The map label for this gene is trpA [H]

Identifier: 161869617

GI number: 161869617

Start: 647080

End: 647817

Strand: Direct

Name: trpA [H]

Synonym: NMCC_0634

Alternate gene names: 161869617

Gene position: 647080-647817 (Clockwise)

Preceding gene: 161869616

Following gene: 161869618

Centisome position: 30.05

GC content: 53.93

Gene sequence:

>738_bases
TTGATTCCCTATATTACGGTGGGCGACCCCGATATTCGGACAACTTTGGCATTGATGCATGGCATGGTTGCAAACGGTGC
GGATATTTTAGAGTTGGGCGTGCCGTTTTCCGATCCGATGGCGGACGGGCCGGTTATTCAGCGTGCGGCGGAGCGGGCGT
TGGCAAACGGGATTTCGCTGCGCGATGTCTTGGATGTCGTCAGAAAATTCCGTGAAACCGACACGCAAACGCCGGTTGTT
TTGATGGGATATTTGAACCCTGTACATAAGATGGGTTATCGGGAGTTTGCTCAGGAAGCCGCAAAGGCGGGTGTGGACGG
CGTGTTGACGGTGGATTCCCCTGTCGAAACCATCGATCCGCTCTATCGCGAGCTGAAGGATAACGGGGTCGACTGTATTT
TCCTGATTGCGCCGACGACGACGGAAGACCGTATTAAAACCATTGCCGAGCTGGCAGGCGGATTTGTCTATTATGTTTCG
CTCAAGGGCGTAACGGGCGCGGCAAGTTTGGATACGGATGAGGTTTCGCGTAAAATAGAGTATTTGCATCAGTATATCGA
TATTCCCATCGGTGTCGGTTTCGGCATCAGCAATGCGGAAAGCGCGCGCAAAATCGGCCGGGTTGCCGACGCGGTCATTG
TCGGCAGCCGGATTGTGAAAGAGATTGAAAACAATGCGGGCAACGAGGCTGCCGCCGTCGGTGCTTTGGTCAAAGAGTTG
AAGGATGCCGTGCGCTGA

Upstream 100 bases:

>100_bases
AATTTACTGATTGTGTTTTACGGCATATTTGCCGATAGGATGGAAGAGACAAATGAGCAGAATCCGGCAGGCTTTTGCCG
CTTTGGATGGCGGAAAGGCA

Downstream 100 bases:

>100_bases
TTCTGTCACGCATTCTAAATATTTTAGGAGTTGTCCATGAGCTGGTTAGATAAAATCCTGCCACCCAAAATCAAAAACCG
CAGCAAAGACGGTTCTTCCA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MIPYITVGDPDIRTTLALMHGMVANGADILELGVPFSDPMADGPVIQRAAERALANGISLRDVLDVVRKFRETDTQTPVV
LMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDPLYRELKDNGVDCIFLIAPTTTEDRIKTIAELAGGFVYYVS
LKGVTGAASLDTDEVSRKIEYLHQYIDIPIGVGFGISNAESARKIGRVADAVIVGSRIVKEIENNAGNEAAAVGALVKEL
KDAVR

Sequences:

>Translated_245_residues
MIPYITVGDPDIRTTLALMHGMVANGADILELGVPFSDPMADGPVIQRAAERALANGISLRDVLDVVRKFRETDTQTPVV
LMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDPLYRELKDNGVDCIFLIAPTTTEDRIKTIAELAGGFVYYVS
LKGVTGAASLDTDEVSRKIEYLHQYIDIPIGVGFGISNAESARKIGRVADAVIVGSRIVKEIENNAGNEAAAVGALVKEL
KDAVR
>Mature_245_residues
MIPYITVGDPDIRTTLALMHGMVANGADILELGVPFSDPMADGPVIQRAAERALANGISLRDVLDVVRKFRETDTQTPVV
LMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDPLYRELKDNGVDCIFLIAPTTTEDRIKTIAELAGGFVYYVS
LKGVTGAASLDTDEVSRKIEYLHQYIDIPIGVGFGISNAESARKIGRVADAVIVGSRIVKEIENNAGNEAAAVGALVKEL
KDAVR

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=249, Percent_Identity=35.3413654618474, Blast_Score=144, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6321412, Length=220, Percent_Identity=40.4545454545455, Blast_Score=179, Evalue=3e-46,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 26314; Mature: 26314

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPYITVGDPDIRTTLALMHGMVANGADILELGVPFSDPMADGPVIQRAAERALANGISL
CCCEEECCCCHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCCH
RDVLDVVRKFRETDTQTPVVLMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDP
HHHHHHHHHHHHCCCCCCEEEEHHHCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHH
LYRELKDNGVDCIFLIAPTTTEDRIKTIAELAGGFVYYVSLKGVTGAASLDTDEVSRKIE
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHH
YLHQYIDIPIGVGFGISNAESARKIGRVADAVIVGSRIVKEIENNAGNEAAAVGALVKEL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KDAVR
HHHCC
>Mature Secondary Structure
MIPYITVGDPDIRTTLALMHGMVANGADILELGVPFSDPMADGPVIQRAAERALANGISL
CCCEEECCCCHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCCH
RDVLDVVRKFRETDTQTPVVLMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDP
HHHHHHHHHHHHCCCCCCEEEEHHHCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHH
LYRELKDNGVDCIFLIAPTTTEDRIKTIAELAGGFVYYVSLKGVTGAASLDTDEVSRKIE
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHH
YLHQYIDIPIGVGFGISNAESARKIGRVADAVIVGSRIVKEIENNAGNEAAAVGALVKEL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KDAVR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA