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The map label for this gene is argH [H]

Identifier: 161869570

GI number: 161869570

Start: 609323

End: 610699

Strand: Reverse

Name: argH [H]

Synonym: NMCC_0585

Alternate gene names: 161869570

Gene position: 610699-609323 (Counterclockwise)

Preceding gene: 161869571

Following gene: 161869569

Centisome position: 28.36

GC content: 57.88

Gene sequence:

>1377_bases
ATGCACGACAAAACCTGGTCCGGACGTTTCAACGAACCCGTTTCCGAACTCGTCAAACAATACACCGCCTCCATCGGTTT
CGACCGACGGCTTGCCGAATGGGACATCCAAGGCTCGCTGGCACACGCGCAAATGCTGAAAGAAACCGGCGTGTTGGACG
AAGGCGATTTGGCGGACATCCGCCGGGGTATGGCGGAAATCCTCGAAGAAATCCGCAGCGGCAAAATCGAATGGTCGTCC
GATTTGGAAGATGTCCATATGAACATCGAACGCCGCCTGACCGACAAAATCGGCGACGCGGGCAAACGCCTGCACACCGG
CCGCAGCCGCAACGACCAAGTCGCCACCGACATCCGCCTGTGGCTGCGCGACCAGATTACCGTTATACAAAGCCTGATTC
AAAGCCTTCAGACGGCATTGCTGGATTTGGCGGAACAAAACGCCGAAACCGTCATGCCAGGCTTTACCCACCTGCAAGTC
GCCCAGCCCGTCAGCTTCGGACACCATATGCTCGCCTACGTCGAAATGCTCGGACGCGATAACGAACGGATGGCGGACTG
CCGCTGCCGCGTCAACCGTATGCCGCTCGGCGCAGCCGCCCTTGCCGGGACGACCTACCCGATTCAGCGCGAAATCACCG
CCGAGCTATTGGGCTTTGAACAAATCTGCCAGAACTCGCTCGATGCCGTATCCGACCGCGATTTCGCCATTGAGTTCACA
GCCGCCGCCTCGCTGGTTATGGTTCACCTGAGCCGCCTGTCTGAAGAATTGATTTTGTGGATGAGCCCGCGTTTCGGCTT
TATCGACATCGCCGACCGTTTCTGCACAGGTTCGTCCATCATGCCGCAGAAGAAAAACCCCGACGTGCCCGAACTCGTGC
GCGGCAAATCCGGCCGCGTCATCGGACACCTTATCGGTCTGATTACCCTGATGAAATCCCAACCCTTGGCGTACAACAAA
GACAATCAGGAAGACAAAGAACCCTTGTTCGACACCGCCGACACGCTTATCGACACGTTGCGGATTTACGCCGATATGAT
GCGCGGCGTAACCGTCAAACCCGACAATATGCGCGCCGCCGTGATGCAGGGCTTCGCTACCGCCACCGACTTGGCGGATT
ATCTGGTCAAAAAAGGCATGCCTTTCCGCGATGCCCACGAAGTCGTCGCCCAAGCCGTGCGCCACGCCGACCAAGCGGGC
GTCGATTTGAGCGAACTGCCGCTCGAAGTCTTACAAGGTTTCAGCGATTTGATTGCCGACGACGTTTACGGCGTGCTGAC
ACCCGAAGGCAGCTTAAACGCCCGCAACCACTTGGGCGGTACCGCGCCGGAACAAGTCCGCTTCCAAGTGAAACGCTGGC
GGGAAATGTTGGCTTAA

Upstream 100 bases:

>100_bases
AGCCACCGTCGCCTACGGTCTGAAACATCCCGAAACCGGCGAACCCTTCCGCCGGCTTTTGGAAAAATACCGCACCGAAT
AACCCCATCAAGGAATCCTT

Downstream 100 bases:

>100_bases
CCCCCGATGCCGTCTGAAGCCGTTCAGACGGCATTTTTAAAAGACAAGAACACCATGACCGATACGGATACCCAAGCCGA
CCGCTTCGAACAGATGATGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MHDKTWSGRFNEPVSELVKQYTASIGFDRRLAEWDIQGSLAHAQMLKETGVLDEGDLADIRRGMAEILEEIRSGKIEWSS
DLEDVHMNIERRLTDKIGDAGKRLHTGRSRNDQVATDIRLWLRDQITVIQSLIQSLQTALLDLAEQNAETVMPGFTHLQV
AQPVSFGHHMLAYVEMLGRDNERMADCRCRVNRMPLGAAALAGTTYPIQREITAELLGFEQICQNSLDAVSDRDFAIEFT
AAASLVMVHLSRLSEELILWMSPRFGFIDIADRFCTGSSIMPQKKNPDVPELVRGKSGRVIGHLIGLITLMKSQPLAYNK
DNQEDKEPLFDTADTLIDTLRIYADMMRGVTVKPDNMRAAVMQGFATATDLADYLVKKGMPFRDAHEVVAQAVRHADQAG
VDLSELPLEVLQGFSDLIADDVYGVLTPEGSLNARNHLGGTAPEQVRFQVKRWREMLA

Sequences:

>Translated_458_residues
MHDKTWSGRFNEPVSELVKQYTASIGFDRRLAEWDIQGSLAHAQMLKETGVLDEGDLADIRRGMAEILEEIRSGKIEWSS
DLEDVHMNIERRLTDKIGDAGKRLHTGRSRNDQVATDIRLWLRDQITVIQSLIQSLQTALLDLAEQNAETVMPGFTHLQV
AQPVSFGHHMLAYVEMLGRDNERMADCRCRVNRMPLGAAALAGTTYPIQREITAELLGFEQICQNSLDAVSDRDFAIEFT
AAASLVMVHLSRLSEELILWMSPRFGFIDIADRFCTGSSIMPQKKNPDVPELVRGKSGRVIGHLIGLITLMKSQPLAYNK
DNQEDKEPLFDTADTLIDTLRIYADMMRGVTVKPDNMRAAVMQGFATATDLADYLVKKGMPFRDAHEVVAQAVRHADQAG
VDLSELPLEVLQGFSDLIADDVYGVLTPEGSLNARNHLGGTAPEQVRFQVKRWREMLA
>Mature_458_residues
MHDKTWSGRFNEPVSELVKQYTASIGFDRRLAEWDIQGSLAHAQMLKETGVLDEGDLADIRRGMAEILEEIRSGKIEWSS
DLEDVHMNIERRLTDKIGDAGKRLHTGRSRNDQVATDIRLWLRDQITVIQSLIQSLQTALLDLAEQNAETVMPGFTHLQV
AQPVSFGHHMLAYVEMLGRDNERMADCRCRVNRMPLGAAALAGTTYPIQREITAELLGFEQICQNSLDAVSDRDFAIEFT
AAASLVMVHLSRLSEELILWMSPRFGFIDIADRFCTGSSIMPQKKNPDVPELVRGKSGRVIGHLIGLITLMKSQPLAYNK
DNQEDKEPLFDTADTLIDTLRIYADMMRGVTVKPDNMRAAVMQGFATATDLADYLVKKGMPFRDAHEVVAQAVRHADQAG
VDLSELPLEVLQGFSDLIADDVYGVLTPEGSLNARNHLGGTAPEQVRFQVKRWREMLA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=42.9515418502203, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=42.9515418502203, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=40.9691629955947, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=40.5286343612335, Blast_Score=342, Evalue=5e-94,
Organism=Escherichia coli, GI1790398, Length=442, Percent_Identity=49.3212669683258, Blast_Score=431, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321806, Length=457, Percent_Identity=41.1378555798687, Blast_Score=346, Evalue=4e-96,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=39.6061269146608, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=39.6061269146608, Blast_Score=330, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51245; Mature: 51245

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKTWSGRFNEPVSELVKQYTASIGFDRRLAEWDIQGSLAHAQMLKETGVLDEGDLADI
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHH
RRGMAEILEEIRSGKIEWSSDLEDVHMNIERRLTDKIGDAGKRLHTGRSRNDQVATDIRL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
WLRDQITVIQSLIQSLQTALLDLAEQNAETVMPGFTHLQVAQPVSFGHHMLAYVEMLGRD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCC
NERMADCRCRVNRMPLGAAALAGTTYPIQREITAELLGFEQICQNSLDAVSDRDFAIEFT
CCHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
AAASLVMVHLSRLSEELILWMSPRFGFIDIADRFCTGSSIMPQKKNPDVPELVRGKSGRV
HHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCH
IGHLIGLITLMKSQPLAYNKDNQEDKEPLFDTADTLIDTLRIYADMMRGVTVKPDNMRAA
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VMQGFATATDLADYLVKKGMPFRDAHEVVAQAVRHADQAGVDLSELPLEVLQGFSDLIAD
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DVYGVLTPEGSLNARNHLGGTAPEQVRFQVKRWREMLA
HHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHDKTWSGRFNEPVSELVKQYTASIGFDRRLAEWDIQGSLAHAQMLKETGVLDEGDLADI
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHH
RRGMAEILEEIRSGKIEWSSDLEDVHMNIERRLTDKIGDAGKRLHTGRSRNDQVATDIRL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
WLRDQITVIQSLIQSLQTALLDLAEQNAETVMPGFTHLQVAQPVSFGHHMLAYVEMLGRD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCC
NERMADCRCRVNRMPLGAAALAGTTYPIQREITAELLGFEQICQNSLDAVSDRDFAIEFT
CCHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
AAASLVMVHLSRLSEELILWMSPRFGFIDIADRFCTGSSIMPQKKNPDVPELVRGKSGRV
HHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCH
IGHLIGLITLMKSQPLAYNKDNQEDKEPLFDTADTLIDTLRIYADMMRGVTVKPDNMRAA
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VMQGFATATDLADYLVKKGMPFRDAHEVVAQAVRHADQAGVDLSELPLEVLQGFSDLIAD
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DVYGVLTPEGSLNARNHLGGTAPEQVRFQVKRWREMLA
HHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA