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The map label for this gene is macA [H]

Identifier: 161869478

GI number: 161869478

Start: 509500

End: 510678

Strand: Direct

Name: macA [H]

Synonym: NMCC_0490

Alternate gene names: 161869478

Gene position: 509500-510678 (Clockwise)

Preceding gene: 161869474

Following gene: 161869479

Centisome position: 23.66

GC content: 55.3

Gene sequence:

>1179_bases
ATGGCAAAAATGATGAAATGGGCGGCTGTTGCGGCGGTCGCGGCGGCAGCGGTTTGGGGCGGATGGTCTTATCTGAAGCC
CGAGCCGCAGGCTGCTTATATTACGGAAACGGTCAGGCGCGGCGACATCAGCCGGACGGTTTCTGCAACAGGGGAGATTT
CGCCGTCCAACCTGGTATCGGTCGGCGCGCAGGCATCGGGGCAGATTAAGAAACTTTATGTCAAACTCGGGCAACAGGTT
AAAAAGGGCGATTTGATTGCGGAAATCAATTCGACCTCGCAGACCAATACGCTCAATACGGAAAAATCCAAATTGGAAAC
GTATCAGGCGAAGCTGGTGTCGGCACAGATTGCATTGGGCAGCGCGGAGAAGAAATATAAGCGTCAGGCGGCGTTATGGA
AGGAAAACGCGACTTCCAAAGAGGATTTGGAAAGCGCGCAGGATGCGTTTGCCGCCGCCAAAGCCAATGTTGCCGAGCTG
AAGGCTTTAATCAGACAGAGCAAAATTTCCATCAATACCGCCGAGTCGGAATTGGGCTACACGCGCATTACCGCAACGAT
GGACGGCACGGTGGTGGCGATTCTCGTGGAAGAGGGGCAGACTGTGAACGCGGCGCAGTCTACGCCGACGATTGTCCAAT
TGGCGAATCTGGATATGATGTTGAACAAAATGCAGATTGCCGAGGGCGATATTACCAAGGTGAAGGCGGGGCAGGATATT
TCGTTTACGATTTTGTCCGAACCGGATACGCCGATTAAGGCGAAGCTCGACAGCGTCGACCCCGGGCTGACCACGATGTC
GTCGGGCGGTTACAACAGCAGTACGGATACGGCTTCCAATGCGGTCTACTATTATGCCCGTTCGTTTGTGCCGAATCCGG
ACGGCAAACTCGCCACGGGGATGACGACGCAGAATACGGTTGAAATCGACGGCGTGAAAAATGTGCTGATTATTCCGTCG
CTGACCGTGAAAAATCGCGGCGGCAAGGCGTTTGTGCGCGTGTTGGGTGCGGACGGCAAGGCGGCGGAACGCGAAATCCG
GACCGGTATGAGAGACAGTATGAATACCGAAGTAAAAAGCGGGTTGAAAGAGGGGGACAAAGTGGTCATCTCCGAAATAA
CCGCCGCCGAGCAACAGGAAAGCGGCGAACGCGCCCTAGGCGGCCCGCCGCGCCGATAA

Upstream 100 bases:

>100_bases
TATTTTTATTGTCGGCAGTTTGCCGCCTTGGATGGGGCAGGGACTTGCGGTAGAATCCGCTTCCGATTTATGGGATTGAC
GCATACAGAGAATTGAAAAC

Downstream 100 bases:

>100_bases
ACGAATATGCCGTCTGAACACGGAAACGGTTTCAGACGGCATTTGTTATTGATTTACGGAATATTATGAGCTTGATCGAA
TGTAAAAACATCAACCGCTA

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAKMMKWAAVAAVAAAAVWGGWSYLKPEPQAAYITETVRRGDISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQV
KKGDLIAEINSTSQTNTLNTEKSKLETYQAKLVSAQIALGSAEKKYKRQAALWKENATSKEDLESAQDAFAAAKANVAEL
KALIRQSKISINTAESELGYTRITATMDGTVVAILVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDI
SFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLIIPS
LTVKNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGGPPRR

Sequences:

>Translated_392_residues
MAKMMKWAAVAAVAAAAVWGGWSYLKPEPQAAYITETVRRGDISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQV
KKGDLIAEINSTSQTNTLNTEKSKLETYQAKLVSAQIALGSAEKKYKRQAALWKENATSKEDLESAQDAFAAAKANVAEL
KALIRQSKISINTAESELGYTRITATMDGTVVAILVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDI
SFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLIIPS
LTVKNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGGPPRR
>Mature_391_residues
AKMMKWAAVAAVAAAAVWGGWSYLKPEPQAAYITETVRRGDISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQVK
KGDLIAEINSTSQTNTLNTEKSKLETYQAKLVSAQIALGSAEKKYKRQAALWKENATSKEDLESAQDAFAAAKANVAELK
ALIRQSKISINTAESELGYTRITATMDGTVVAILVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDIS
FTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLIIPSL
TVKNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGGPPRR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=368, Percent_Identity=35.054347826087, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87082036, Length=359, Percent_Identity=25.3481894150418, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789929, Length=345, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41759; Mature: 41628

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKMMKWAAVAAVAAAAVWGGWSYLKPEPQAAYITETVRRGDISRTVSATGEISPSNLVS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHEECCCCCCCHHHHHE
VGAQASGQIKKLYVKLGQQVKKGDLIAEINSTSQTNTLNTEKSKLETYQAKLVSAQIALG
ECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
SAEKKYKRQAALWKENATSKEDLESAQDAFAAAKANVAELKALIRQSKISINTAESELGY
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEECCHHHCCE
TRITATMDGTVVAILVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDI
EEEEEEECCEEEEEEEECCCEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEECCCCE
SFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAVYYYARSFVPNPDGKLATG
EEEEECCCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEC
MTTQNTVEIDGVKNVLIIPSLTVKNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKS
CCCCCEEEECCCCCEEEECCEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHH
GLKEGDKVVISEITAAEQQESGERALGGPPRR
HHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AKMMKWAAVAAVAAAAVWGGWSYLKPEPQAAYITETVRRGDISRTVSATGEISPSNLVS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHEECCCCCCCHHHHHE
VGAQASGQIKKLYVKLGQQVKKGDLIAEINSTSQTNTLNTEKSKLETYQAKLVSAQIALG
ECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
SAEKKYKRQAALWKENATSKEDLESAQDAFAAAKANVAELKALIRQSKISINTAESELGY
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEECCHHHCCE
TRITATMDGTVVAILVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDI
EEEEEEECCEEEEEEEECCCEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEECCCCE
SFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAVYYYARSFVPNPDGKLATG
EEEEECCCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEC
MTTQNTVEIDGVKNVLIIPSLTVKNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKS
CCCCCEEEECCCCCEEEECCEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHH
GLKEGDKVVISEITAAEQQESGERALGGPPRR
HHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]