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The map label for this gene is lctP [C]

Identifier: 161869472

GI number: 161869472

Start: 500893

End: 502479

Strand: Reverse

Name: lctP [C]

Synonym: NMCC_0484

Alternate gene names: 161869472

Gene position: 502479-500893 (Counterclockwise)

Preceding gene: 161869473

Following gene: 161869470

Centisome position: 23.33

GC content: 54.25

Gene sequence:

>1587_bases
ATGGCACTTTTCCTCAGCATATTCCCCATCGTCCTGCTGATTTGGCTGATGGTGAAAAAAAACAGTATGCCCTCCTACGT
CGCGCTGCCGATTACCGCAGTGCTGATTTACGCCATCAAACTTTTCTACTTCGACGATGCGGGCATGCTGCTCAACGCCA
CCGCCGCTTCCGGCCTCGTCAAAACGCTCACGCCGATTACCGTGATTTTCGGCGCGATTATGTTCAACCGTATGATGGAA
ACCACGGGCTGCATCGATGTCATCCGCAAATGGCTGGCGACCATCAGCCCCAACCCCGTAGCGCAACTGATGATTATCGG
CTGGGCTTTTGCCTTTATGATTGAAGGCGCATCCGGCTTCGGCACGCCTGCCGCGATTGCCGCGCCGATTCTGATGAGCT
TGGGCTTCAACCCGTTGAAAGTGGCGATTTTCACTTTGGTGATGAACTCCGTCCCCGTCTCTTTCGGCGCGGTCGGTACG
CCGACCTGGTTCGGTTTCGCACCGCTGAACCTGAGTGCCGAAGACATCCTCGCCATCGGCAGGCAGACCGGCGTAATGCA
CTTCTTCGCAGGTTTCGTCATCCCCGTCATCGGCTTGGGCTTCATCGTACCTTGGTCTGAAATCCGCAAAAACTTGGGCT
TCGTCGCCATTGCCGTCTTCTCCTGCACCATTCCTTATGTCGCATTGGCGATGGTCAACGAAGAATTCCCGTCGCTCGTC
GCCGGCGCGATCGGCCTGATGGTGTCCGTATTCGCCGCCAACCAAGGCTGGGGCTTGAGCAAGGACCACGCCAAAGACCC
GAATGCCGAAAAAGTGCCGTTCGCCCAAGTCGCCAAAGCACTCGCCCCTTTGGGTATGCTGATCGGCATGCTGGTGGTTA
CGCGCATCAAACAGCTCGGTATCAAAGGCATTTTGACCAGCAAAGAAGAATGGTTCAGCTTCCAACTGCCGTTTGATTTG
TCCAAAATCACCGTCAGCGACTCCCTGACGATTACCTTCGGCAATATTTTCGGACAAGATGTCAGCGCGTCTTACCAAAC
GCTGTACGTCCCGGCTTGGATTCCGTTTGTGCTGACCGTTTGGATTTGCATCCTGCTGTATAAAACCAAATTCAAAGATG
CCTGGACGATTTATGCCGTAACCTTCAATCAAACCAAAAAACCGCTGCTTGCCCTGATGGGCGCGCTGATTATGGTTCAG
CTGATGCTGGTCGGCGGCGACAATTCGATGGTGAAAATCATCGGTAAGGAATTTGCCGCAATGGCGGGCGAACACTGGGT
TTATTTCTCGCCGTATCTGGGCGCGATCGGTGCGTTCTTCTCCGGCTCCAACACCGTGTCCAACCTGACCTTCGGACCGA
TTCAGCAGCAAATCGCCTTGGATACCGGCCTGTCCGTTACCCTGATTCTGGCGTTGCAGTCCGTCGGCGGCGCGATGGGC
AATATGGTGTGCCTCAACAACATCATCGCCGTATGTACCGTATTGGATGTGAAAAATTCCGAAGGTGCGATTATCAAGAA
AACCGTTATCCCGATGGCGATTTACGGCGTGATTGCCGTCGTCGCGGCAATGATTTTCTTCCTCTAG

Upstream 100 bases:

>100_bases
ACCAATTTATCTTTTAACCAAAATATCGGGTGTACGGGATTTGAACGTCTTTCCAAACCTCGACGCGCCTTATGATGCAA
ATGCCTAAAAAGGATTCGTT

Downstream 100 bases:

>100_bases
GCGAAACGCCACCATCCATAGCGGCAGCACGCGGGGAACGGAAACCGCCGTTCCCCGTCTGGGCGGCGCGTCGGGCAGAA
TCCCGGTGCCGGAACAAGCC

Product: L-lactate permease, putative

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MALFLSIFPIVLLIWLMVKKNSMPSYVALPITAVLIYAIKLFYFDDAGMLLNATAASGLVKTLTPITVIFGAIMFNRMME
TTGCIDVIRKWLATISPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILMSLGFNPLKVAIFTLVMNSVPVSFGAVGT
PTWFGFAPLNLSAEDILAIGRQTGVMHFFAGFVIPVIGLGFIVPWSEIRKNLGFVAIAVFSCTIPYVALAMVNEEFPSLV
AGAIGLMVSVFAANQGWGLSKDHAKDPNAEKVPFAQVAKALAPLGMLIGMLVVTRIKQLGIKGILTSKEEWFSFQLPFDL
SKITVSDSLTITFGNIFGQDVSASYQTLYVPAWIPFVLTVWICILLYKTKFKDAWTIYAVTFNQTKKPLLALMGALIMVQ
LMLVGGDNSMVKIIGKEFAAMAGEHWVYFSPYLGAIGAFFSGSNTVSNLTFGPIQQQIALDTGLSVTLILALQSVGGAMG
NMVCLNNIIAVCTVLDVKNSEGAIIKKTVIPMAIYGVIAVVAAMIFFL

Sequences:

>Translated_528_residues
MALFLSIFPIVLLIWLMVKKNSMPSYVALPITAVLIYAIKLFYFDDAGMLLNATAASGLVKTLTPITVIFGAIMFNRMME
TTGCIDVIRKWLATISPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILMSLGFNPLKVAIFTLVMNSVPVSFGAVGT
PTWFGFAPLNLSAEDILAIGRQTGVMHFFAGFVIPVIGLGFIVPWSEIRKNLGFVAIAVFSCTIPYVALAMVNEEFPSLV
AGAIGLMVSVFAANQGWGLSKDHAKDPNAEKVPFAQVAKALAPLGMLIGMLVVTRIKQLGIKGILTSKEEWFSFQLPFDL
SKITVSDSLTITFGNIFGQDVSASYQTLYVPAWIPFVLTVWICILLYKTKFKDAWTIYAVTFNQTKKPLLALMGALIMVQ
LMLVGGDNSMVKIIGKEFAAMAGEHWVYFSPYLGAIGAFFSGSNTVSNLTFGPIQQQIALDTGLSVTLILALQSVGGAMG
NMVCLNNIIAVCTVLDVKNSEGAIIKKTVIPMAIYGVIAVVAAMIFFL
>Mature_527_residues
ALFLSIFPIVLLIWLMVKKNSMPSYVALPITAVLIYAIKLFYFDDAGMLLNATAASGLVKTLTPITVIFGAIMFNRMMET
TGCIDVIRKWLATISPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILMSLGFNPLKVAIFTLVMNSVPVSFGAVGTP
TWFGFAPLNLSAEDILAIGRQTGVMHFFAGFVIPVIGLGFIVPWSEIRKNLGFVAIAVFSCTIPYVALAMVNEEFPSLVA
GAIGLMVSVFAANQGWGLSKDHAKDPNAEKVPFAQVAKALAPLGMLIGMLVVTRIKQLGIKGILTSKEEWFSFQLPFDLS
KITVSDSLTITFGNIFGQDVSASYQTLYVPAWIPFVLTVWICILLYKTKFKDAWTIYAVTFNQTKKPLLALMGALIMVQL
MLVGGDNSMVKIIGKEFAAMAGEHWVYFSPYLGAIGAFFSGSNTVSNLTFGPIQQQIALDTGLSVTLILALQSVGGAMGN
MVCLNNIIAVCTVLDVKNSEGAIIKKTVIPMAIYGVIAVVAAMIFFL

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=540, Percent_Identity=24.6296296296296, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1789347, Length=535, Percent_Identity=24.4859813084112, Blast_Score=119, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 56808; Mature: 56677

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
ALFLSIFPIVLLIWLMVKKNSMPSYVALPITAVLIYAIKLFYFDDAGMLLNATAASGLV
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHH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CHHHHHHHHHHHHHEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]