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The map label for this gene is hemC [H]

Identifier: 161869466

GI number: 161869466

Start: 497279

End: 498229

Strand: Direct

Name: hemC [H]

Synonym: NMCC_0478

Alternate gene names: 161869466

Gene position: 497279-498229 (Clockwise)

Preceding gene: 161869464

Following gene: 161869468

Centisome position: 23.09

GC content: 55.63

Gene sequence:

>951_bases
TTGAACGCATTGAACATGAACCCGAAAAAACTCGTCATCGCCAGCCGCGAAAGCCTGCTTGCTATGTGGCAGGCAAAGCA
TATCCAAGGCCGTCTGAAGGCTCTGTATCCCGATTGCGAAGTCGAGATTTTGGGCATGACCACGCGCGGCGATCAGATTT
TGGACAAAACTTTGTCAAAAGTCGGCGGTAAAGGCTTGTTTGTCAAAGAGTTGGAACAGGCTTTATATGACGGGCGCGCC
GATTTGGCGGTGCATTCGATTAAAGACGTACCGATGGATTTGCCTGAAGGTTTCGCGCTTGCGACCATCGGCGAACGCGC
CAATCCGTTTGACGCATTTGTGTCCAACCAATACACGCGTTTGGAAGAAATGCCCGAAGGCGCGGTTGTCGGCACATCCA
GCCTGCGCCGCGAAGCCCAGTTGCGTGCGCGCTATCCGCATTTGCTTATCAAACCTTTGCGCGGCAATGTGCAAACCCGT
TTGTCCAAACTCGATAACGGCGAATACGACGCAATTATCTTGGCTGCCGCCGGTTTGCAGCGTCTGAAATTGGACGGACG
CATCCGCATGATTTTGTCGGAATCCGACAGCCTGCCTGCCGCCGGACAAGGCGCATTGGGTATCGAAATTGCCGCGCACC
GCGAAGATTTGTATGAAGTTTTGAAACCCTTGAACCACGGCGTTACCAATGCCTGCGTTACCGCCGAACGCGCCCTCGCA
CGCGCTTTGGGCGGAAGCTGCCAAGTGCCTTTGGCCGCATATTGCACGGAAGAAAACGGCTTGCTGACCTTGCGCGGCTT
GGTCGGACACCCCGACGGTTCGGTTGTGTTGCGGGCGGACGCGCAAGCCCCTGCCGAATATGCCGACGCGCTCGGACGCG
CAGTCGCTAAGAAATTGGCGGACGACGGTGCGCAGGAATTGATTGGGGCGGTATTGAATACGGAAAATTGA

Upstream 100 bases:

>100_bases
GGCGGGTTTCGTGTTTTGTGGGCGTAAATATAACATAGACCACGGCATACCGTCTGAAGAAACGTTCAAAATATGATAGA
CTTTACGCCGTTTCCATTCT

Downstream 100 bases:

>100_bases
TTTTATCGAAAATTTAAAGAAAATGATATAAGTTATTGTTTTTAATTAATTTGTTTCATCAGTTTTACTCGCCTTATTTC
GTCATTCCCGCGCAGGCAGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNALNMNPKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLFVKELEQALYDGRA
DLAVHSIKDVPMDLPEGFALATIGERANPFDAFVSNQYTRLEEMPEGAVVGTSSLRREAQLRARYPHLLIKPLRGNVQTR
LSKLDNGEYDAIILAAAGLQRLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALA
RALGGSCQVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGAQELIGAVLNTEN

Sequences:

>Translated_316_residues
MNALNMNPKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLFVKELEQALYDGRA
DLAVHSIKDVPMDLPEGFALATIGERANPFDAFVSNQYTRLEEMPEGAVVGTSSLRREAQLRARYPHLLIKPLRGNVQTR
LSKLDNGEYDAIILAAAGLQRLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALA
RALGGSCQVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGAQELIGAVLNTEN
>Mature_316_residues
MNALNMNPKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLFVKELEQALYDGRA
DLAVHSIKDVPMDLPEGFALATIGERANPFDAFVSNQYTRLEEMPEGAVVGTSSLRREAQLRARYPHLLIKPLRGNVQTR
LSKLDNGEYDAIILAAAGLQRLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALA
RALGGSCQVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGAQELIGAVLNTEN

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=293, Percent_Identity=45.3924914675768, Blast_Score=226, Evalue=1e-59,
Organism=Homo sapiens, GI66933009, Length=285, Percent_Identity=45.2631578947368, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=54.1254125412541, Blast_Score=312, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=38.6292834890966, Blast_Score=212, Evalue=5e-56,
Organism=Drosophila melanogaster, GI20130425, Length=285, Percent_Identity=41.0526315789474, Blast_Score=204, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34025; Mature: 34025

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALNMNPKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSK
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
VGGKGLFVKELEQALYDGRADLAVHSIKDVPMDLPEGFALATIGERANPFDAFVSNQYTR
HCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHCCHHHH
LEEMPEGAVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLDNGEYDAIILAAAGLQ
HHHCCCCCEECHHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHCCCCCCCEEEEEECCHH
RLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALA
HEECCCEEEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RALGGSCQVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLA
HHHCCCCCCCCEEEEECCCCEEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
DDGAQELIGAVLNTEN
CCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNALNMNPKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSK
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
VGGKGLFVKELEQALYDGRADLAVHSIKDVPMDLPEGFALATIGERANPFDAFVSNQYTR
HCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHCCHHHH
LEEMPEGAVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLDNGEYDAIILAAAGLQ
HHHCCCCCEECHHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHCCCCCCCEEEEEECCHH
RLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALA
HEECCCEEEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RALGGSCQVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLA
HHHCCCCCCCCEEEEECCCCEEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
DDGAQELIGAVLNTEN
CCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]