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The map label for this gene is degP [H]

Identifier: 161869459

GI number: 161869459

Start: 489495

End: 490994

Strand: Reverse

Name: degP [H]

Synonym: NMCC_0471

Alternate gene names: 161869459

Gene position: 490994-489495 (Counterclockwise)

Preceding gene: 161869460

Following gene: 161869458

Centisome position: 22.8

GC content: 56.93

Gene sequence:

>1500_bases
GTGTTCAAAAAATACCAATACCTCGCTTTGGCAGCACTGTGTGCCGCCTCGCTGGCAGGCTGCGACAAAGCCGGCAGCTT
TTTCGGTGCGGACAAAAAAGAAGCATCCTTCGTAGAACGCATCGAACACACCAAAGACGACGGCAGCGTCAGTATGCTGC
TGCCCGACTTTGTCCAACTGGTTCAAAGCGAAGGTCCGGCAGTCGTCAATATTCAGGCAGCCCCCGCCCCGCGCACCCAA
AACGGCAGCGGCAATGCCGAAACCGATTCCGACCCGCTTGCCGACAGCGACCCGTTCTACGAATTTTTCAAACGCCTCGT
CCCGAACATGCCCGAAATCCCCCAAGAAGAAGCAGATGACGGCGGATTGAACTTCGGTTCGGGCTTCATCATCAGCAAAG
ACGGCTATATTCTGACCAATACGCACGTCGTTACCGGCATGGGCAGTATCAAAGTCCTGCTCAACGACAAGCGCGAATAT
ACCGCCAAACTCATCGGTTCGGATGTCCAATCCGATGTCGCCCTTCTGAAAATCGACGCAACGGAAGAGCTGCCCGTCGT
CAAAATCGGCAATCCCAAAGATTTGAAACCGGGCGAATGGGTCGCCGCCATCGGCGCGCCCTTCGGCTTCGACAACAGCG
TGACCGCCGGCATCGTGTCCGCCAAAGGCAGAAGCCTGCCCAACGAAAGCTACACACCCTTCATCCAAACCGACGTTGCC
ATCAATCCGGGCAACTCCGGCGGCCCGCTGTTCAACTTAAAAGGACAGGTCGTCGGCATCAACTCGCAAATATACAGCCG
CAGCGGCGGATTCATGGGCATTTCCTTCGCCATCCCGATTGACGTTGCCATGAATGTCGCCGAACAGCTGAAAAACACCG
GCAAAGTCCAACGCGGACAACTGGGCGTGATTATTCAAGAAGTATCCTACGGTTTGGCACAATCGTTCGGTTTGGACAAA
GCCGGCGGCGCACTGATTGCCAAAATCCTGCCCGGCAGCCCCGCAGAACGTGCCGGCCTGCAGGCGGGCGACATCGTCCT
CAGCCTCGACGGCGGAGAAATACGTTCTTCCGGCGACCTTCCCGTTATGGTCGGCGCCATTACGCCGGGAAAAGAAGTCA
GCCTCGGCGTATGGCGCAAAGGCGAAGAAATCACAATCAAAGTCAAGCTGGGCAACGCCGCCGAGCATATCGGCGCATCA
TCCAAAACAGATGAAGCCCCCTACACCGAACAGCAATCCGGTACGTTCTCGGTCGAATCCGCAGGCATTACCCTTCAGAC
ACATACCGACAGCAGCGGCGGACACCTCGTCGTCGTACGGGTTTCCGACGCGGCAGAACGCGCAGGCTTGAGGCGCGGCG
ACGAAATTCTTGCCGTCGGGCAAGTCCCCGTCAATGACGAAGCCGGTTTCCGCAAAGCTATGGACAAGGCAGGCAAAAAC
GTCCCCCTGCTGGTCATGCGCCGTGGCAACACGCTGTTTATCGCATTAAACCTGCAATAA

Upstream 100 bases:

>100_bases
GGACGGACGTTGTAGAATTTCAACCTATGCCGTCTGAAGCCGACAAAATGCGCTTCAGACGGCATTAAAGCCGGTACCGG
CATCCGACAAAGGACAAAAC

Downstream 100 bases:

>100_bases
CCCACATAATTTAACCAAAATATTTTTTAAATGATAAAATGCCCGTCAATACCGATTAACGGGCATTTTACAAAAATCAG
TTGGTTGATTTTAAACAAAT

Product: periplasmic serine protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MFKKYQYLALAALCAASLAGCDKAGSFFGADKKEASFVERIEHTKDDGSVSMLLPDFVQLVQSEGPAVVNIQAAPAPRTQ
NGSGNAETDSDPLADSDPFYEFFKRLVPNMPEIPQEEADDGGLNFGSGFIISKDGYILTNTHVVTGMGSIKVLLNDKREY
TAKLIGSDVQSDVALLKIDATEELPVVKIGNPKDLKPGEWVAAIGAPFGFDNSVTAGIVSAKGRSLPNESYTPFIQTDVA
INPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQLGVIIQEVSYGLAQSFGLDK
AGGALIAKILPGSPAERAGLQAGDIVLSLDGGEIRSSGDLPVMVGAITPGKEVSLGVWRKGEEITIKVKLGNAAEHIGAS
SKTDEAPYTEQQSGTFSVESAGITLQTHTDSSGGHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN
VPLLVMRRGNTLFIALNLQ

Sequences:

>Translated_499_residues
MFKKYQYLALAALCAASLAGCDKAGSFFGADKKEASFVERIEHTKDDGSVSMLLPDFVQLVQSEGPAVVNIQAAPAPRTQ
NGSGNAETDSDPLADSDPFYEFFKRLVPNMPEIPQEEADDGGLNFGSGFIISKDGYILTNTHVVTGMGSIKVLLNDKREY
TAKLIGSDVQSDVALLKIDATEELPVVKIGNPKDLKPGEWVAAIGAPFGFDNSVTAGIVSAKGRSLPNESYTPFIQTDVA
INPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQLGVIIQEVSYGLAQSFGLDK
AGGALIAKILPGSPAERAGLQAGDIVLSLDGGEIRSSGDLPVMVGAITPGKEVSLGVWRKGEEITIKVKLGNAAEHIGAS
SKTDEAPYTEQQSGTFSVESAGITLQTHTDSSGGHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN
VPLLVMRRGNTLFIALNLQ
>Mature_499_residues
MFKKYQYLALAALCAASLAGCDKAGSFFGADKKEASFVERIEHTKDDGSVSMLLPDFVQLVQSEGPAVVNIQAAPAPRTQ
NGSGNAETDSDPLADSDPFYEFFKRLVPNMPEIPQEEADDGGLNFGSGFIISKDGYILTNTHVVTGMGSIKVLLNDKREY
TAKLIGSDVQSDVALLKIDATEELPVVKIGNPKDLKPGEWVAAIGAPFGFDNSVTAGIVSAKGRSLPNESYTPFIQTDVA
INPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQLGVIIQEVSYGLAQSFGLDK
AGGALIAKILPGSPAERAGLQAGDIVLSLDGGEIRSSGDLPVMVGAITPGKEVSLGVWRKGEEITIKVKLGNAAEHIGAS
SKTDEAPYTEQQSGTFSVESAGITLQTHTDSSGGHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN
VPLLVMRRGNTLFIALNLQ

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=304, Percent_Identity=36.8421052631579, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=37.6, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI22129776, Length=256, Percent_Identity=38.28125, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI7019477, Length=280, Percent_Identity=35, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1786356, Length=383, Percent_Identity=36.5535248041775, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1789629, Length=406, Percent_Identity=37.4384236453202, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1789630, Length=270, Percent_Identity=37.037037037037, Blast_Score=165, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24646839, Length=258, Percent_Identity=37.5968992248062, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 52493; Mature: 52493

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKYQYLALAALCAASLAGCDKAGSFFGADKKEASFVERIEHTKDDGSVSMLLPDFVQL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHH
VQSEGPAVVNIQAAPAPRTQNGSGNAETDSDPLADSDPFYEFFKRLVPNMPEIPQEEADD
HHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
GGLNFGSGFIISKDGYILTNTHVVTGMGSIKVLLNDKREYTAKLIGSDVQSDVALLKIDA
CCCCCCCCEEEECCCEEEECCEEEECCCEEEEEEECCHHHHHHHHCCCCCCCEEEEEECC
TEELPVVKIGNPKDLKPGEWVAAIGAPFGFDNSVTAGIVSAKGRSLPNESYTPFIQTDVA
CCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEE
INPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQ
ECCCCCCCCEEEECCEEEEECHHEEECCCCEEEEEEEECHHHHHHHHHHHHHCCCCCCCC
LGVIIQEVSYGLAQSFGLDKAGGALIAKILPGSPAERAGLQAGDIVLSLDGGEIRSSGDL
EEEEEEHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCCCC
PVMVGAITPGKEVSLGVWRKGEEITIKVKLGNAAEHIGASSKTDEAPYTEQQSGTFSVES
EEEEEECCCCCCEEEEEEECCCEEEEEEEECCHHHHCCCCCCCCCCCCCCCCCCEEEEEC
AGITLQTHTDSSGGHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN
CCEEEEEECCCCCCEEEEEEECCCHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCC
VPLLVMRRGNTLFIALNLQ
CCEEEEECCCEEEEEEECC
>Mature Secondary Structure
MFKKYQYLALAALCAASLAGCDKAGSFFGADKKEASFVERIEHTKDDGSVSMLLPDFVQL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHH
VQSEGPAVVNIQAAPAPRTQNGSGNAETDSDPLADSDPFYEFFKRLVPNMPEIPQEEADD
HHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
GGLNFGSGFIISKDGYILTNTHVVTGMGSIKVLLNDKREYTAKLIGSDVQSDVALLKIDA
CCCCCCCCEEEECCCEEEECCEEEECCCEEEEEEECCHHHHHHHHCCCCCCCEEEEEECC
TEELPVVKIGNPKDLKPGEWVAAIGAPFGFDNSVTAGIVSAKGRSLPNESYTPFIQTDVA
CCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEE
INPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQ
ECCCCCCCCEEEECCEEEEECHHEEECCCCEEEEEEEECHHHHHHHHHHHHHCCCCCCCC
LGVIIQEVSYGLAQSFGLDKAGGALIAKILPGSPAERAGLQAGDIVLSLDGGEIRSSGDL
EEEEEEHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCCCC
PVMVGAITPGKEVSLGVWRKGEEITIKVKLGNAAEHIGASSKTDEAPYTEQQSGTFSVES
EEEEEECCCCCCEEEEEEECCCEEEEEEEECCHHHHCCCCCCCCCCCCCCCCCCEEEEEC
AGITLQTHTDSSGGHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN
CCEEEEEECCCCCCEEEEEEECCCHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCC
VPLLVMRRGNTLFIALNLQ
CCEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]