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The map label for this gene is pyrE [H]

Identifier: 161869341

GI number: 161869341

Start: 348199

End: 348840

Strand: Reverse

Name: pyrE [H]

Synonym: NMCC_0347

Alternate gene names: 161869341

Gene position: 348840-348199 (Counterclockwise)

Preceding gene: 161869342

Following gene: 161869340

Centisome position: 16.2

GC content: 55.61

Gene sequence:

>642_bases
ATGACTGATTTCCGCCAAGATTTCCTCAAATTCTCCCTCGCCCAAAACGTCTTAAAATTCGGCGAATTTACCACCAAGGC
AGGACGGCGGTCGCCTTACTTCTTCAATGCCGGCCTCTTCAACGACGGCGCGTCCACGCTGCAACTGGCAAAATTTTACG
CACAATCCATCATTGAAAGCGGCATCCGATTCGATATGCTGTTCGGCCCCGCATACAAAGGCATTATTTTGGCGGCGGCA
ACCGCGATGATGCTGGCGGAAAAAGGCGTGAACGTCCCGTTTGCCTACAACCGCAAAGAAGCCAAAGACCACGGCGAAGG
CGGCGTGTTGGTCGGTGCGCCGCTTAAAGGGCGCGTGCTGATTATCGACGACGTGATTTCCGCCGGCACATCCGTACGCG
AATCAATCAAACTGATTGAAGCGGAGGGTGCAACCCCCGCCGGCGTCGCCATCGCGCTCGACCGCATGGAAAAAGGCACC
GGCGAATTGAGCGCGGTTCAGGAAGTGGAAAAACAATACGGCCTGCCCGTCGCCCCCATCGCCAGCCTGAACGATTTGTT
TATTCTGTTGCAAAACAACCCCGAATTCGGACAGTTCCTCGAACCCGTCCGAGCCTACCGTCGGCAGTACGGCGTAGAAT
AA

Upstream 100 bases:

>100_bases
AAACAGTTGAAACGCGCCTTGCAGGCAGGCGGCAGTTGAAGTGCGCCGCACGGGGCGGTAGAATCGCAACTGCGTCCCAA
TATCTGACAGAAAGCACAAA

Downstream 100 bases:

>100_bases
AAACAAAGCATATGCCGTCCGAACCGCCTTACGCCTCAGACGGCATCAAACCTGACACACACGAGGAAATACCATGCCCG
CCTGTTTCTGCCCCCACTGC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MTDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGASTLQLAKFYAQSIIESGIRFDMLFGPAYKGIILAAA
TAMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKGRVLIIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGT
GELSAVQEVEKQYGLPVAPIASLNDLFILLQNNPEFGQFLEPVRAYRRQYGVE

Sequences:

>Translated_213_residues
MTDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGASTLQLAKFYAQSIIESGIRFDMLFGPAYKGIILAAA
TAMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKGRVLIIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGT
GELSAVQEVEKQYGLPVAPIASLNDLFILLQNNPEFGQFLEPVRAYRRQYGVE
>Mature_212_residues
TDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGASTLQLAKFYAQSIIESGIRFDMLFGPAYKGIILAAAT
AMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKGRVLIIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTG
ELSAVQEVEKQYGLPVAPIASLNDLFILLQNNPEFGQFLEPVRAYRRQYGVE

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=177, Percent_Identity=27.683615819209, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790073, Length=213, Percent_Identity=55.868544600939, Blast_Score=257, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17508631, Length=160, Percent_Identity=28.125, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323530, Length=200, Percent_Identity=47.5, Blast_Score=181, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6323927, Length=223, Percent_Identity=43.0493273542601, Blast_Score=172, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 23220; Mature: 23089

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGASTLQLAKFYAQSIIES
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHC
GIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKGRVL
CCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEECCCCCCCEE
IIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTGELSAVQEVEKQYGLPVAPI
EEECHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
ASLNDLFILLQNNPEFGQFLEPVRAYRRQYGVE
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGASTLQLAKFYAQSIIES
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHC
GIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKGRVL
CCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEECCCCCCCEE
IIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTGELSAVQEVEKQYGLPVAPI
EEECHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
ASLNDLFILLQNNPEFGQFLEPVRAYRRQYGVE
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA