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The map label for this gene is pilE [H]

Identifier: 161869042

GI number: 161869042

Start: 19532

End: 20401

Strand: Reverse

Name: pilE [H]

Synonym: NMCC_0025

Alternate gene names: 161869042

Gene position: 20401-19532 (Counterclockwise)

Preceding gene: 161869043

Following gene: 161869041

Centisome position: 0.95

GC content: 52.07

Gene sequence:

>870_bases
TTGGCTGAAGGTCAAAAATCAGCCGTCACCGAGTATTACCTGAATCACGGCATATGGCCAAAAAACAATACTTCTGCCGG
CGTGGCATCCACCCCCTCCGACATCAAAGGCAAATATGTTCAGAAAGTTGAAGTCGCAAAAGGCGTCATTACCGCCACAA
TGCTTTCAAGCGGCGTAAACAAAGAAATCCAAGGCAAAGAACTCTCCCTGTGGGCCAAGCGTCAAGACGGTTCGGTAAAA
TGGTTCTGCGGACAGCCGGTTACGCGCAACGACACCGCCAAAGACGACGTTGCCGCCGACAACGACGCCACCAAGAAGAT
CGACACCAAGCACCTGCCGTCAACCTGCCGCGACGCAGCATCTGCCGTTTGCACAAAAACACCCGAGTATTACCTGAATC
ACGGCAAATGGCCTGACGGCAACAGTAATGCCGGCGTGGCATCTTCTTCAACAATCAAAGGCAAATATGTTGAGAAAGTT
GAAGTCGCAAAAGGCGTCATTACCGCCACAATGCTTTCAACCGGCGTAAACAACGAAATCAAAGACAAAAAACTCTCCCT
GTGGGCCAAGCGTCAAGACGGTTCGGTAAAATGGTTCTGCGGACAGCCGGTTACGCGCAACGCCAAAGCCGCCAACGCCG
ACGACGTCGCCGCCGACGACACCAACAAAATCGACACCAAGCACCTGCCGTCAACCTGCCGCGACGCATCATCTGCCAGC
CGTACAAAAACACCCGGTTTCGCTTTCAAATACTTCCAAAAAATCAGCCGTTACCGAGTATTGCCCGAATCACGGCAAAT
GACTAAAAAACTTCGTCATTCCCGCGCAGGCGGGAATCTAGGTTTGTCGGCGCAGAAACTTATCGGGTAA

Upstream 100 bases:

>100_bases
AGCGGTTTCTGTTGCTCCCGATAAATTCCTAAAACTCAAAATTTCATCATTCCCTCAAAGACAGAAAACCAAAATAAGAA
ACCTAAAATTCGTCATTCTT

Downstream 100 bases:

>100_bases
AAAGGTTTCTCCAGTCCTGAATCCTAGATTCCCACTTTCGTGGGAATGACGGGATTTAATGATGCCGCCGGCGTGGCATC
CTCCTCCGACATCAAAGGCA

Product: large pilS cassette

Products: NA

Alternate protein names: Pilin [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MAEGQKSAVTEYYLNHGIWPKNNTSAGVASTPSDIKGKYVQKVEVAKGVITATMLSSGVNKEIQGKELSLWAKRQDGSVK
WFCGQPVTRNDTAKDDVAADNDATKKIDTKHLPSTCRDAASAVCTKTPEYYLNHGKWPDGNSNAGVASSSTIKGKYVEKV
EVAKGVITATMLSTGVNNEIKDKKLSLWAKRQDGSVKWFCGQPVTRNAKAANADDVAADDTNKIDTKHLPSTCRDASSAS
RTKTPGFAFKYFQKISRYRVLPESRQMTKKLRHSRAGGNLGLSAQKLIG

Sequences:

>Translated_289_residues
MAEGQKSAVTEYYLNHGIWPKNNTSAGVASTPSDIKGKYVQKVEVAKGVITATMLSSGVNKEIQGKELSLWAKRQDGSVK
WFCGQPVTRNDTAKDDVAADNDATKKIDTKHLPSTCRDAASAVCTKTPEYYLNHGKWPDGNSNAGVASSSTIKGKYVEKV
EVAKGVITATMLSTGVNNEIKDKKLSLWAKRQDGSVKWFCGQPVTRNAKAANADDVAADDTNKIDTKHLPSTCRDASSAS
RTKTPGFAFKYFQKISRYRVLPESRQMTKKLRHSRAGGNLGLSAQKLIG
>Mature_288_residues
AEGQKSAVTEYYLNHGIWPKNNTSAGVASTPSDIKGKYVQKVEVAKGVITATMLSSGVNKEIQGKELSLWAKRQDGSVKW
FCGQPVTRNDTAKDDVAADNDATKKIDTKHLPSTCRDAASAVCTKTPEYYLNHGKWPDGNSNAGVASSSTIKGKYVEKVE
VAKGVITATMLSTGVNNEIKDKKLSLWAKRQDGSVKWFCGQPVTRNAKAANADDVAADDTNKIDTKHLPSTCRDASSASR
TKTPGFAFKYFQKISRYRVLPESRQMTKKLRHSRAGGNLGLSAQKLIG

Specific function: This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Fimbrium [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-Me-Phe pilin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001082
- InterPro:   IPR012902
- InterPro:   IPR001120 [H]

Pfam domain/function: PF07963 N_methyl; PF00114 Pilin [H]

EC number: NA

Molecular weight: Translated: 31376; Mature: 31244

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEGQKSAVTEYYLNHGIWPKNNTSAGVASTPSDIKGKYVQKVEVAKGVITATMLSSGVN
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCC
KEIQGKELSLWAKRQDGSVKWFCGQPVTRNDTAKDDVAADNDATKKIDTKHLPSTCRDAA
CCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHH
SAVCTKTPEYYLNHGKWPDGNSNAGVASSSTIKGKYVEKVEVAKGVITATMLSTGVNNEI
HHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
KDKKLSLWAKRQDGSVKWFCGQPVTRNAKAANADDVAADDTNKIDTKHLPSTCRDASSAS
HHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHCCC
RTKTPGFAFKYFQKISRYRVLPESRQMTKKLRHSRAGGNLGLSAQKLIG
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCC
>Mature Secondary Structure 
AEGQKSAVTEYYLNHGIWPKNNTSAGVASTPSDIKGKYVQKVEVAKGVITATMLSSGVN
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCC
KEIQGKELSLWAKRQDGSVKWFCGQPVTRNDTAKDDVAADNDATKKIDTKHLPSTCRDAA
CCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHH
SAVCTKTPEYYLNHGKWPDGNSNAGVASSSTIKGKYVEKVEVAKGVITATMLSTGVNNEI
HHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
KDKKLSLWAKRQDGSVKWFCGQPVTRNAKAANADDVAADDTNKIDTKHLPSTCRDASSAS
HHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHCCC
RTKTPGFAFKYFQKISRYRVLPESRQMTKKLRHSRAGGNLGLSAQKLIG
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919; 9515697 [H]