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The map label for this gene is kdtA [H]

Identifier: 161869033

GI number: 161869033

Start: 11660

End: 12931

Strand: Reverse

Name: kdtA [H]

Synonym: NMCC_0016

Alternate gene names: 161869033

Gene position: 12931-11660 (Counterclockwise)

Preceding gene: 161869034

Following gene: 161869032

Centisome position: 0.6

GC content: 59.51

Gene sequence:

>1272_bases
ATGTTCCAATGGCTTTATGATGTATTGTGGCTGCTTGCGCCGATATGGATACGGCGTTATTTGGACAAACGCTCCGGAAG
TGCCCCGGCATATCGGGCGCATCGGGACGAGCGTTTCGGCAAGCCGTATCCGAATCCCGTTACCGGCGCGGTTTGGATAC
ACGCCGTTTCGGTCGGAGAAACGCGTGCCGCCCAGCCCTTGATACGCGAGTTGCGGCAGCGTTTTCCCGATGCACCGCTG
CTGATGACGCAGATGACCCCGACGGGACGGGAAACCGCGCAAGTTCTGTTTCCCGATGCGCAATGCCGCTATCTTCCGTA
TGACAAAAAAACGTGGGTACGGCAGTTTTTGCGCGAACACCGCCCGATGTTCGGCATTTTGATGGAAACCGAAATCTGGC
CCAATCTGATGAAGGAATGCCGGCGCACGGGTGTGCCGCTGTTTTTGGCGAATGCGCGGCTGTCGGAAAAATCGCTGAAC
GGTTATCTGAAAGTCCGCCGCCTGATCCGTCCTGCCGCCGCTTCGCTGACGGGTTGTCTGGCGCAGACGGAGGCGGATGC
GGCGCGGTTGGCGAAATTGGGCGCGGCATCCGTGCAGGTGTGCGGCAATACCAAATACGACCTGATGCCGTCGGAACAGA
TGAAAACGCTGGCGGGGCAGTTTGAAAAACGCATCGGAGACCGGCAGGTTGCCGTGTGCGGCAGCACGCGCGTTTATCGG
GGTGAAGACGAGGCGGAAAAACTGCTGGCGGCGTGGCAACAATATCGCGGCGATGCGCTGCTGGTCGTCGTGCCGCGCCA
TCCCGAGCATTTTCAGACGGCATTTGAAACGGCAAAACGCTTCGGGTTTAAGGTTCAGCGGCGCAGCGACGGTTTGCCGG
TCGAACCCGATACGCAGGTGTGGATAGGCGACAGTATGGGCGAGCTGTATGCGTATTACCTGTGCGCCGATGTCGCTTTT
GTCGGCGGCAGTCTGGTCGATTCGGGTTGTCAGAACATCATCGAACCGCTTTCCTGCGGCGTTCCGACGATATTCGGCTT
TTCGACCTACAATTTTTCCGAAGCCTGCCGGCACGCCTTGGCATCGGGTGCGGCGGTTCAAGTCGAATCGGCGGACGCGT
GGCGGGAAGCCGTTGAAAAAACCTTATCTGCTGAGGGGGGCGGAATGCAGATGCAGGCGCGCGTGGACGGCTTTATCGCA
CAACATCGCGGAGCGGGCGCGAGAATCGCCGAGGCGGTACGGGAAGCGGTATGCGGACATCGGGGACGATAG

Upstream 100 bases:

>100_bases
AGGGCGGAGATACCGCTTCGACAACCTACGATATTTGATTCCGTTGCCGAAATGCCGTCTGAACCGTTCAGACGGCATTT
GTTTTGCAGGAAATAGAAAG

Downstream 100 bases:

>100_bases
TGATACAATCCGTATCCGAGTTTTCCGGTTGGAGTACCGTATGAGTATTTATGCCGTCGCGCACATCGTCCACCTGTATT
GCGCCATCGCCTTTGTCGGC

Product: 3-deoxy-D-manno-octulosonic-acid transferase

Products: NA

Alternate protein names: KDO transferase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MFQWLYDVLWLLAPIWIRRYLDKRSGSAPAYRAHRDERFGKPYPNPVTGAVWIHAVSVGETRAAQPLIRELRQRFPDAPL
LMTQMTPTGRETAQVLFPDAQCRYLPYDKKTWVRQFLREHRPMFGILMETEIWPNLMKECRRTGVPLFLANARLSEKSLN
GYLKVRRLIRPAAASLTGCLAQTEADAARLAKLGAASVQVCGNTKYDLMPSEQMKTLAGQFEKRIGDRQVAVCGSTRVYR
GEDEAEKLLAAWQQYRGDALLVVVPRHPEHFQTAFETAKRFGFKVQRRSDGLPVEPDTQVWIGDSMGELYAYYLCADVAF
VGGSLVDSGCQNIIEPLSCGVPTIFGFSTYNFSEACRHALASGAAVQVESADAWREAVEKTLSAEGGGMQMQARVDGFIA
QHRGAGARIAEAVREAVCGHRGR

Sequences:

>Translated_423_residues
MFQWLYDVLWLLAPIWIRRYLDKRSGSAPAYRAHRDERFGKPYPNPVTGAVWIHAVSVGETRAAQPLIRELRQRFPDAPL
LMTQMTPTGRETAQVLFPDAQCRYLPYDKKTWVRQFLREHRPMFGILMETEIWPNLMKECRRTGVPLFLANARLSEKSLN
GYLKVRRLIRPAAASLTGCLAQTEADAARLAKLGAASVQVCGNTKYDLMPSEQMKTLAGQFEKRIGDRQVAVCGSTRVYR
GEDEAEKLLAAWQQYRGDALLVVVPRHPEHFQTAFETAKRFGFKVQRRSDGLPVEPDTQVWIGDSMGELYAYYLCADVAF
VGGSLVDSGCQNIIEPLSCGVPTIFGFSTYNFSEACRHALASGAAVQVESADAWREAVEKTLSAEGGGMQMQARVDGFIA
QHRGAGARIAEAVREAVCGHRGR
>Mature_423_residues
MFQWLYDVLWLLAPIWIRRYLDKRSGSAPAYRAHRDERFGKPYPNPVTGAVWIHAVSVGETRAAQPLIRELRQRFPDAPL
LMTQMTPTGRETAQVLFPDAQCRYLPYDKKTWVRQFLREHRPMFGILMETEIWPNLMKECRRTGVPLFLANARLSEKSLN
GYLKVRRLIRPAAASLTGCLAQTEADAARLAKLGAASVQVCGNTKYDLMPSEQMKTLAGQFEKRIGDRQVAVCGSTRVYR
GEDEAEKLLAAWQQYRGDALLVVVPRHPEHFQTAFETAKRFGFKVQRRSDGLPVEPDTQVWIGDSMGELYAYYLCADVAF
VGGSLVDSGCQNIIEPLSCGVPTIFGFSTYNFSEACRHALASGAAVQVESADAWREAVEKTLSAEGGGMQMQARVDGFIA
QHRGAGARIAEAVREAVCGHRGR

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA [H]

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family [H]

Homologues:

Organism=Escherichia coli, GI1790064, Length=393, Percent_Identity=39.1857506361323, Blast_Score=248, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001296
- InterPro:   IPR007507 [H]

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N [H]

EC number: 2.-.-.-

Molecular weight: Translated: 47294; Mature: 47294

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00615 C_TYPE_LECTIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQWLYDVLWLLAPIWIRRYLDKRSGSAPAYRAHRDERFGKPYPNPVTGAVWIHAVSVGE
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEEECCC
TRAAQPLIRELRQRFPDAPLLMTQMTPTGRETAQVLFPDAQCRYLPYDKKTWVRQFLREH
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCCCEECCCCHHHHHHHHHHHC
RPMFGILMETEIWPNLMKECRRTGVPLFLANARLSEKSLNGYLKVRRLIRPAAASLTGCL
CCCEEEEEHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AQTEADAARLAKLGAASVQVCGNTKYDLMPSEQMKTLAGQFEKRIGDRQVAVCGSTRVYR
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEC
GEDEAEKLLAAWQQYRGDALLVVVPRHPEHFQTAFETAKRFGFKVQRRSDGLPVEPDTQV
CCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCE
WIGDSMGELYAYYLCADVAFVGGSLVDSGCQNIIEPLSCGVPTIFGFSTYNFSEACRHAL
EECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHH
ASGAAVQVESADAWREAVEKTLSAEGGGMQMQARVDGFIAQHRGAGARIAEAVREAVCGH
HCCCEEEEECHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
RGR
CCC
>Mature Secondary Structure
MFQWLYDVLWLLAPIWIRRYLDKRSGSAPAYRAHRDERFGKPYPNPVTGAVWIHAVSVGE
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEEECCC
TRAAQPLIRELRQRFPDAPLLMTQMTPTGRETAQVLFPDAQCRYLPYDKKTWVRQFLREH
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCCCEECCCCHHHHHHHHHHHC
RPMFGILMETEIWPNLMKECRRTGVPLFLANARLSEKSLNGYLKVRRLIRPAAASLTGCL
CCCEEEEEHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AQTEADAARLAKLGAASVQVCGNTKYDLMPSEQMKTLAGQFEKRIGDRQVAVCGSTRVYR
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEC
GEDEAEKLLAAWQQYRGDALLVVVPRHPEHFQTAFETAKRFGFKVQRRSDGLPVEPDTQV
CCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCE
WIGDSMGELYAYYLCADVAFVGGSLVDSGCQNIIEPLSCGVPTIFGFSTYNFSEACRHAL
EECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHH
ASGAAVQVESADAWREAVEKTLSAEGGGMQMQARVDGFIAQHRGAGARIAEAVREAVCGH
HCCCEEEEECHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
RGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]