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The map label for this gene is gabP [H]

Identifier: 161526045

GI number: 161526045

Start: 3140648

End: 3142039

Strand: Reverse

Name: gabP [H]

Synonym: Bmul_2876

Alternate gene names: 161526045

Gene position: 3142039-3140648 (Counterclockwise)

Preceding gene: 161526046

Following gene: 161526042

Centisome position: 91.11

GC content: 65.45

Gene sequence:

>1392_bases
ATGAAGGAAAGCAAGACAGGCCTTGGCACCGGCCTGAAGCAGCGTCACGTGACGATGATGTCCATTGCGGGCGTGATCGG
CGCGGGCTTGTTCGTCGGTTCCGGCCACGCGATCGCGGAAGCCGGCCCGGCATCGATCCTCGCGTATGCGATCGCGGGCG
TGCTGGTCGTGCTCGTGATGCGCATGCTCGGCGAAATGGCCGTCGCGCATCCGGACAGCGGTTCGTTTTCCACCTATGCC
GACCGCGCGATCGGCCACTGGGCCGGCTTCACGATCGGCTGGCTGTACTGGTGGTTCTGGGTGCTCGTGATCCCGATCGA
GGCGACGGCCGCCGCGACCATCCTCAATGCGTGGTTCCCCGGCATCGCGACGTGGATGTTCGCGCTCGGCATCACGCTGC
TGCTGACCATCACGAATCTGTTCTCGGTCAAGAACTACGGTGAATTCGAATTCTGGTTCGCGCTGATCAAGGTCGTCGCG
ATCGTCGTGTTCCTGTGCGTCGGCGCGGCGGCGATCGTCGGCATCGTGCCGGCGCCGGCCGTGTCGGGCGTGTCGAACCT
GTTCGCGCATCACGGCTTCATGCCGAACGGCGCCGGCGCGGTGCTCGCGGCGATGTTGACGACGATGTTCTCGTTTCTCG
GCACTGAAATCGTGACGATCGCGGCCGCCGAATCCGACAACCCGCAACGCCAGATCGTGCGTGCGACGAATTCGGTGATC
TGGCGCATCACGCTGTTCTATCTCGGCTCGATCCTCGTCGTGGCGGCAATCGTGCCGTGGAACGACCCGCTGCTGCCGGC
GCACGGCTCGTATCAGCGTGCGATGGAGCTGATCGGCGTGCCGAACGCGAAGGCGATCATCGATGTGATCGTGCTCGTGT
CGGTCGCGAGCTGTCTGAATTCGGCGCTGTACACCGCGTCGCGGATGCTGTTCTCGCTGTCGAAGCGCAAGGATGCGCCC
GCGTTCCTGCATCGCACCGATGCGACCGGCACGCCGCGCGCGGCCGTGCTCGCATCGACCGCGTTCGGCTTCGTGACCGT
GATCGCGAACTACCTGATGCCCGAGCAGGTGTTCGGCTTCCTGCTCGCGACCTCGGGCGCGATCGCGCTGCTCGTGTATC
TCGTGATCGCGATCTCGCAACTGCGGATGCGCAGGACGCTCGAAGCGACCGGCGCGGATCTCCCGCTGCGGATGTGGATG
TTCCCGTGGCTCACGTGGGCCGTGATCCTGTTTATCTGCGGCACGCTGACCGTGATGCTCGTGAGCGAGGAACACCGGAT
GGAAGTCGGTGCGACGGCCGTGCTGGCGCTGCTCGTGCTGCTTGCGTCGTGGCTGAACAAGCGGGGTCGCGATGCGCGGG
TGGGGGAGGGGCGGCGCGTGTCGGCGACGTAA

Upstream 100 bases:

>100_bases
GCCGCGCGCACGTGGTTCCATCCCGGCTCAACAAAGACAATCCCCACGCCGCCTGCACGCGACACCCGGTCGTACCGGAC
CGTTTTTTGGAGAGAGACAG

Downstream 100 bases:

>100_bases
CTCGCGTGAACCGGACGGGCGCGGCTGCTGCGCCCGTTCGTGCTGTGCGGCGTAGGCGCGGTGGAATCGAGGCGTGGCGT
CGGGGAGGGCGGGCGTTGGC

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKESKTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGIATWMFALGITLLLTITNLFSVKNYGEFEFWFALIKVVA
IVVFLCVGAAAIVGIVPAPAVSGVSNLFAHHGFMPNGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPAHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSKRKDAP
AFLHRTDATGTPRAAVLASTAFGFVTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRRTLEATGADLPLRMWM
FPWLTWAVILFICGTLTVMLVSEEHRMEVGATAVLALLVLLASWLNKRGRDARVGEGRRVSAT

Sequences:

>Translated_463_residues
MKESKTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGIATWMFALGITLLLTITNLFSVKNYGEFEFWFALIKVVA
IVVFLCVGAAAIVGIVPAPAVSGVSNLFAHHGFMPNGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPAHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSKRKDAP
AFLHRTDATGTPRAAVLASTAFGFVTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRRTLEATGADLPLRMWM
FPWLTWAVILFICGTLTVMLVSEEHRMEVGATAVLALLVLLASWLNKRGRDARVGEGRRVSAT
>Mature_463_residues
MKESKTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGIATWMFALGITLLLTITNLFSVKNYGEFEFWFALIKVVA
IVVFLCVGAAAIVGIVPAPAVSGVSNLFAHHGFMPNGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPAHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSKRKDAP
AFLHRTDATGTPRAAVLASTAFGFVTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRRTLEATGADLPLRMWM
FPWLTWAVILFICGTLTVMLVSEEHRMEVGATAVLALLVLLASWLNKRGRDARVGEGRRVSAT

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=65.3488372093023, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1786302, Length=421, Percent_Identity=37.29216152019, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI48994972, Length=463, Percent_Identity=36.0691144708423, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1786789, Length=427, Percent_Identity=35.8313817330211, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788480, Length=420, Percent_Identity=36.6666666666667, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI87081708, Length=406, Percent_Identity=35.4679802955665, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI87081915, Length=460, Percent_Identity=33.0434782608696, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1790653, Length=459, Percent_Identity=31.3725490196078, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=33.1154684095861, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI87081869, Length=244, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=426, Percent_Identity=34.037558685446, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6322892, Length=433, Percent_Identity=34.1801385681293, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=31.7191283292978, Blast_Score=199, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6324061, Length=434, Percent_Identity=29.9539170506912, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=429, Percent_Identity=30.5361305361305, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=405, Percent_Identity=30.6172839506173, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=395, Percent_Identity=30.6329113924051, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=409, Percent_Identity=28.8508557457213, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321053, Length=414, Percent_Identity=28.9855072463768, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=412, Percent_Identity=30.8252427184466, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320251, Length=406, Percent_Identity=29.3103448275862, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=481, Percent_Identity=28.2744282744283, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6324924, Length=476, Percent_Identity=27.9411764705882, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=403, Percent_Identity=28.5359801488834, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=396, Percent_Identity=28.030303030303, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=29.7979797979798, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=418, Percent_Identity=26.555023923445, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320364, Length=475, Percent_Identity=23.3684210526316, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24668806, Length=409, Percent_Identity=23.2273838630807, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21356285, Length=409, Percent_Identity=23.2273838630807, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24668802, Length=409, Percent_Identity=23.2273838630807, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49660; Mature: 49660

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]