Click here to switch to the map view.

The map label for this gene is mutT [H]

Identifier: 161525993

GI number: 161525993

Start: 3075792

End: 3076253

Strand: Reverse

Name: mutT [H]

Synonym: Bmul_2824

Alternate gene names: 161525993

Gene position: 3076253-3075792 (Counterclockwise)

Preceding gene: 161525994

Following gene: 161525985

Centisome position: 89.21

GC content: 69.91

Gene sequence:

>462_bases
ATGAGCGGCGTCGATCGCGTGGCGTCCGCCGCGCACGCGCCCGACGGGCGCAAGGTGACCGAAGTCGCGGTCGGCGTGAT
GGTGCAGTCCGACGAAGCGACCGGCCGCAGCCGTTACCTACTCGCGCAGCGGCTGCAGGGCAAGCCGTACGAAGGCTACT
GGGAATTTCCGGGCGGCAAGCTCGAGGCCGGCGAGAGCGTCGAGGACGCGCTCGCGCGCGAACTGCACGAGGAACTCGGT
ATCGTCGTCACCGCGAGCCACCGCTGGCACACGCTCGAGCACGATTATCCGCACGCGTACGTGCGGCTGTATTTCTGCAA
GGTCACGGGCTGGACGGGCGAGCCGCACAGCAAGGAAGGACAGGCGTTCGTCTGGCAGCCGCTGCCGGTCGACGTCGCGC
CGCTGCTACCCGCGGCGCTGCCGGTGCTGGCGCTGCTCGAGCAGGAGGCGGCGTCACGCTGA

Upstream 100 bases:

>100_bases
CGCGCGGCGACGCGCTCGTGTGGGCGCTCGAGCGCGGCTCGCGCTCGGGGCGCGTCGCGTGGCAATTCGCGCGCGACTGG
TCGGGCCGCAAGGAGCAGGC

Downstream 100 bases:

>100_bases
CGTCGCCGCGGCCGGCCCGTGCGGCCGGTCGCTTCGCATACCCGGCGGCGTCGTGCGCCGCTCAGTTGTCGCGGCGTTCG
TCCGTGCCGTCCTCGTCGGA

Product: NUDIX hydrolase

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MSGVDRVASAAHAPDGRKVTEVAVGVMVQSDEATGRSRYLLAQRLQGKPYEGYWEFPGGKLEAGESVEDALARELHEELG
IVVTASHRWHTLEHDYPHAYVRLYFCKVTGWTGEPHSKEGQAFVWQPLPVDVAPLLPAALPVLALLEQEAASR

Sequences:

>Translated_153_residues
MSGVDRVASAAHAPDGRKVTEVAVGVMVQSDEATGRSRYLLAQRLQGKPYEGYWEFPGGKLEAGESVEDALARELHEELG
IVVTASHRWHTLEHDYPHAYVRLYFCKVTGWTGEPHSKEGQAFVWQPLPVDVAPLLPAALPVLALLEQEAASR
>Mature_152_residues
SGVDRVASAAHAPDGRKVTEVAVGVMVQSDEATGRSRYLLAQRLQGKPYEGYWEFPGGKLEAGESVEDALARELHEELGI
VVTASHRWHTLEHDYPHAYVRLYFCKVTGWTGEPHSKEGQAFVWQPLPVDVAPLLPAALPVLALLEQEAASR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=132, Percent_Identity=34.0909090909091, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI1788056, Length=127, Percent_Identity=36.2204724409449, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 16828; Mature: 16697

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVDRVASAAHAPDGRKVTEVAVGVMVQSDEATGRSRYLLAQRLQGKPYEGYWEFPGGK
CCCHHHHHHHHCCCCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCC
LEAGESVEDALARELHEELGIVVTASHRWHTLEHDYPHAYVRLYFCKVTGWTGEPHSKEG
CCCCCCHHHHHHHHHHHHCCEEEECCCCEEECCCCCCCEEEEEEEEEEECCCCCCCCCCC
QAFVWQPLPVDVAPLLPAALPVLALLEQEAASR
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGVDRVASAAHAPDGRKVTEVAVGVMVQSDEATGRSRYLLAQRLQGKPYEGYWEFPGGK
CCHHHHHHHHCCCCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCC
LEAGESVEDALARELHEELGIVVTASHRWHTLEHDYPHAYVRLYFCKVTGWTGEPHSKEG
CCCCCCHHHHHHHHHHHHCCEEEECCCCEEECCCCCCCEEEEEEEEEEECCCCCCCCCCC
QAFVWQPLPVDVAPLLPAALPVLALLEQEAASR
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]