Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 161525949

GI number: 161525949

Start: 3032655

End: 3034022

Strand: Direct

Name: accC [H]

Synonym: Bmul_2780

Alternate gene names: 161525949

Gene position: 3032655-3034022 (Clockwise)

Preceding gene: 161525948

Following gene: 161525950

Centisome position: 87.94

GC content: 64.55

Gene sequence:

>1368_bases
ATGTTTGAAAAAATCCTCATTGCCAACCGCGGTGAAATCGCGCTGCGCATTCAGCGCGCGTGCCGCGAGCTGGGCGTCAA
GACGGTGGTCGTCTACTCGGAAGCCGACAAGGAAGCCAAGTACGTGCGCCTCGCGGACGAGGCCGTCTGTATCGGCCCGG
CCCCGTCGAACCTGAGCTATCTGAACATGCCGGCGCTGATCAGCGCCGCGGAAGTCACCGACGCCGAAGCGATCCACCCC
GGCTACGGCTTCCTGTCCGAGAACGCCGACTTCGCCGAACGCGTCGAACAGTCGGGCTTCACGTTCATCGGCCCGCGTCC
CGAAACGATCCGCCTGATGGGCGACAAGGTCACCGCGAAGCAGACGATGATCAAGACCGGCGTGCCGTGCGTGCCGGGCT
CGGAAGGCGCGTTGCCGGAAGATCCGAAGGAGATCGTGAAGATTGCGCGCGCGATCGGCTATCCGGTGATCATCAAGGCC
GCAGGCGGCGGCGGCGGTCGCGGCATGCGCGTCGTGCACACCGAAGCCGCGCTCGTCAACGCGGTGAACATGACCCGCGA
GGAAGCCGGCCGTGCGTTCGGCAACCCGCAGGTCTACATGGAGAAGTTCCTCGAGAACCCGCGCCACATCGAGATCCAGG
TGCTGTCGGACGCGCACAAGAACGCGATCTGGCTCGGCGAGCGCGACTGCTCGATGCAGCGCCGCCACCAGAAGGTGATC
GAGGAAGCGCCGGCGCCCGGCATTCCGCGCCGCCTGATCGACCGCATCGGCGATCGCTGCGCCGACGCGTGCAAGAAGAT
GGGCTACCTCGGCGCCGGCACGTTCGAATTCCTGTACGAAAACGGCGAGTTCTACTTCATCGAAATGAACACGCGCGTGC
AGGTCGAGCACCCGGTCTCGGAGATGATCACCGGCGTCGACATCGTGCAGGAGCAGATCCGTATCGCGGCCGGCGAGAAG
CTCACGCTGCGCCAGCGCGACATCCAGTTCCGCGGCCACGCGATCGAATGCCGGATCAACGCCGAAGATCCGTTCAAATT
CACGCCGTCGCCGGGCCGGATCACGTCGTGGCATACGCCGGGCGGCCCCGGCGTGCGCGTCGATTCGCACGCCTACAATG
GCTATTTCGTGCCGCCGAACTACGATTCGATGATCGGCAAGCTGATCACCTACGGCGCGACGCGCGAGCAGGCGATCCGC
CGGATGCGCATCGCGCTGTCGGAGATGGTCGTCGAAGGCATCCAGACGAACATCCCGCTGCATCGCGAACTGATGATCGA
CTCGAAGTTCGTCGAAGGCGGCACGAGCATCCACTACCTCGAAAACCGGCTCGCGCAAAAGCAGGCCGTCGCACCGGAAG
AAGCGTAA

Upstream 100 bases:

>100_bases
TTTCGTGATCGGCTAAGCCCGCCGCGCGGCCATCCGGCCGCGCGCCGCCGATGCTCTCCAGGCGCCGTTCGCGCGCCCCT
CGAAGAGACGAATACTCGCT

Downstream 100 bases:

>100_bases
GCATGAGCTATCGCGAACTCGTCGTCGAACTGGCCCGCGAGCACGCGGAGGCGCTGTCCGACGCGCTGCTCGAACTCGGT
GCGCTGTCGGTATCGGTCGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAPSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPETIRLMGDKVTAKQTMIKTGVPCVPGSEGALPEDPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAHKNAIWLGERDCSMQRRHQKVI
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQVEHPVSEMITGVDIVQEQIRIAAGEK
LTLRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAIR
RMRIALSEMVVEGIQTNIPLHRELMIDSKFVEGGTSIHYLENRLAQKQAVAPEEA

Sequences:

>Translated_455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAPSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPETIRLMGDKVTAKQTMIKTGVPCVPGSEGALPEDPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAHKNAIWLGERDCSMQRRHQKVI
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQVEHPVSEMITGVDIVQEQIRIAAGEK
LTLRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAIR
RMRIALSEMVVEGIQTNIPLHRELMIDSKFVEGGTSIHYLENRLAQKQAVAPEEA
>Mature_455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAPSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPETIRLMGDKVTAKQTMIKTGVPCVPGSEGALPEDPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAHKNAIWLGERDCSMQRRHQKVI
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQVEHPVSEMITGVDIVQEQIRIAAGEK
LTLRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAIR
RMRIALSEMVVEGIQTNIPLHRELMIDSKFVEGGTSIHYLENRLAQKQAVAPEEA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=48.7640449438202, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=48.7640449438202, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=48.7640449438202, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI116805327, Length=457, Percent_Identity=47.2647702407002, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=44.3946188340807, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=44.3946188340807, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=44.3946188340807, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI38679960, Length=524, Percent_Identity=31.2977099236641, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI38679977, Length=524, Percent_Identity=31.2977099236641, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679967, Length=524, Percent_Identity=31.2977099236641, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679971, Length=524, Percent_Identity=31.2977099236641, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI38679974, Length=524, Percent_Identity=31.2977099236641, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI134142062, Length=524, Percent_Identity=30.9160305343511, Blast_Score=225, Evalue=6e-59,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=67.1875, Blast_Score=604, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.5011286681716, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=455, Percent_Identity=45.4945054945055, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=43.8478747203579, Blast_Score=347, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.6370967741936, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=515, Percent_Identity=27.9611650485437, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=27.9611650485437, Blast_Score=187, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=45.9821428571429, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6319685, Length=453, Percent_Identity=40.3973509933775, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=459, Percent_Identity=45.9694989106754, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=523, Percent_Identity=30.2103250478011, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=480, Percent_Identity=31.875, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24651757, Length=431, Percent_Identity=45.707656612529, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=45.7207207207207, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=394, Percent_Identity=44.6700507614213, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24586458, Length=518, Percent_Identity=29.3436293436293, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI161076409, Length=518, Percent_Identity=29.3436293436293, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI161076407, Length=511, Percent_Identity=29.3542074363992, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24586460, Length=511, Percent_Identity=29.3542074363992, Blast_Score=211, Evalue=9e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50437; Mature: 50437

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAPSNLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCCCCCCCE
LNMPALISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFTFIGPRPETIRLMGDKVTAK
ECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEEECCCHHHH
QTMIKTGVPCVPGSEGALPEDPKEIVKIARAIGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAHKNAIWLGERDCSMQRRHQKVI
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQVEHPVS
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDIVQEQIRIAAGEKLTLRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTP
HHHHHHHHHHHHHHHHCCCEEEEEECCEEECCEEEEEEECCCCCCEECCCCCCEEECCCC
GGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAIRRMRIALSEMVVEGIQTNIPL
CCCCEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HRELMIDSKFVEGGTSIHYLENRLAQKQAVAPEEA
HHHEEECCHHHCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAPSNLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCCCCCCCE
LNMPALISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFTFIGPRPETIRLMGDKVTAK
ECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEEECCCHHHH
QTMIKTGVPCVPGSEGALPEDPKEIVKIARAIGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAHKNAIWLGERDCSMQRRHQKVI
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENGEFYFIEMNTRVQVEHPVS
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDIVQEQIRIAAGEKLTLRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTP
HHHHHHHHHHHHHHHHCCCEEEEEECCEEECCEEEEEEECCCCCCEECCCCCCEEECCCC
GGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAIRRMRIALSEMVVEGIQTNIPL
CCCCEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HRELMIDSKFVEGGTSIHYLENRLAQKQAVAPEEA
HHHEEECCHHHCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]