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The map label for this gene is pyrC [H]

Identifier: 161525877

GI number: 161525877

Start: 2954381

End: 2955445

Strand: Reverse

Name: pyrC [H]

Synonym: Bmul_2708

Alternate gene names: 161525877

Gene position: 2955445-2954381 (Counterclockwise)

Preceding gene: 161525880

Following gene: 161525876

Centisome position: 85.7

GC content: 69.39

Gene sequence:

>1065_bases
ATGACTGCCTCGAACGCTTCCTCCCCGGCGACGCTGTCGCTCGCCCGTCCCGACGACATGCACCTGCACCTGCGCGACGG
CGAGATGCTGGCCGCCGTGCTGCCGCATACCGCCCGCCAGTTCGCGCGCGCGATCGTGATGCCGAACCTGAAACCGCCGG
TGACGACTACCGCGCACGCGCAGGCGTACCGCGACCGCATCCTCGCCGCGCTGCCGGCCGGCATGGCGTTCGAGCCGCTG
ATGACGCTGTACCTCACCGACAACACGTCGCCGGACGAGATCCGTCGCGCGCGCGAAAGCGGCTTCGTGCACGGCGTGAA
GCTGTATCCGGCCGGCGCGACGACGAACTCGGACCACGGCGTCACCGACCTTGCGAAGTGCGCGAAGACGCTCGAGGCGA
TGCAGGAAACCGGCATGCCGCTGCTCGTGCACGGCGAGGTGACCGATGCGTCGATCGACCTGTTCGATCGCGAGAAGGTG
TTCATCGATCGCGTGATGACGCCGCTGCGCCGCGATTTCCCGGGCCTGAAGGTCGTGTTCGAGCACATCACGACGAAGGA
CGCGGCCGATTACGTGCGCGACGCCGATGCGGCGCCCGGCCTGCTCGGCGCGACGATCACCGCGCATCACCTGCTGTACA
ACCGCAATGCGCTGTTCGTCGGCGGCATTCGTCCGCATTACTACTGCCTGCCGGTCCTGAAGCGCGAAACGCATCGCGTC
GCGCTCGTCGAAGCGGCGACGTCGGGCAATCCGCGCTTCTTCCTCGGCACCGACAGCGCGCCGCACGCGCGCGGCGCGAA
GGAAGCCGCGTGCGGCTGCGCCGGCTGCTACACGGCGCTGCACGCGCTCGAGCTGTATGCGGAGGCGTTCGACCAGGCCG
GCGCGCTCGACAAGCTCGAAGGCTTTGCGAGCTTCTACGGCGCCGATTTCTACGGGCTGCCGCGCAGCGCCGAGACGGTG
ACGCTGCGCCGCGAGACGTGGGAACTGCCGCGCGAGGTGCTGGCGGGCGACACGCCCGTCGTGCCGCTGCGCGCCGGCGA
GACGCTCGGCTGGAAACTCGCATGA

Upstream 100 bases:

>100_bases
CCGCCGGCCGAAGGCCCCGTGTTGCGGTTTGCCGTCAGTCGCGGGCCGCGCACGCGCGGTCCGGCCCCGCCGATGCCGGC
CCGTTCCTCACGAGCCCCCT

Downstream 100 bases:

>100_bases
CGCACGCGCCGCCGCGCGCGGCCGCCCAGGCGGGCGGCGACGGCGCGGCTGCGTTCGCGCGGATCGACTGGTCCGCGCCA
TGGCTCGCGCGCTTCGCGCA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTASNASSPATLSLARPDDMHLHLRDGEMLAAVLPHTARQFARAIVMPNLKPPVTTTAHAQAYRDRILAALPAGMAFEPL
MTLYLTDNTSPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKV
FIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRV
ALVEAATSGNPRFFLGTDSAPHARGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLEGFASFYGADFYGLPRSAETV
TLRRETWELPREVLAGDTPVVPLRAGETLGWKLA

Sequences:

>Translated_354_residues
MTASNASSPATLSLARPDDMHLHLRDGEMLAAVLPHTARQFARAIVMPNLKPPVTTTAHAQAYRDRILAALPAGMAFEPL
MTLYLTDNTSPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKV
FIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRV
ALVEAATSGNPRFFLGTDSAPHARGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLEGFASFYGADFYGLPRSAETV
TLRRETWELPREVLAGDTPVVPLRAGETLGWKLA
>Mature_353_residues
TASNASSPATLSLARPDDMHLHLRDGEMLAAVLPHTARQFARAIVMPNLKPPVTTTAHAQAYRDRILAALPAGMAFEPLM
TLYLTDNTSPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKVF
IDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRVA
LVEAATSGNPRFFLGTDSAPHARGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLEGFASFYGADFYGLPRSAETVT
LRRETWELPREVLAGDTPVVPLRAGETLGWKLA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=343, Percent_Identity=55.9766763848396, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323452, Length=355, Percent_Identity=35.4929577464789, Blast_Score=194, Evalue=2e-50,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38465; Mature: 38334

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASNASSPATLSLARPDDMHLHLRDGEMLAAVLPHTARQFARAIVMPNLKPPVTTTAHA
CCCCCCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
QAYRDRILAALPAGMAFEPLMTLYLTDNTSPDEIRRARESGFVHGVKLYPAGATTNSDHG
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
VTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKVFIDRVMTPLRRDFPGLKVVF
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEHHCCHHHHHHHHHHHHHHCCCCHHHHH
EHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRV
HHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHCCCCEE
ALVEAATSGNPRFFLGTDSAPHARGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLE
EEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GFASFYGADFYGLPRSAETVTLRRETWELPREVLAGDTPVVPLRAGETLGWKLA
HHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
TASNASSPATLSLARPDDMHLHLRDGEMLAAVLPHTARQFARAIVMPNLKPPVTTTAHA
CCCCCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
QAYRDRILAALPAGMAFEPLMTLYLTDNTSPDEIRRARESGFVHGVKLYPAGATTNSDHG
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
VTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKVFIDRVMTPLRRDFPGLKVVF
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEHHCCHHHHHHHHHHHHHHCCCCHHHHH
EHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRV
HHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHCCCCEE
ALVEAATSGNPRFFLGTDSAPHARGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLE
EEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GFASFYGADFYGLPRSAETVTLRRETWELPREVLAGDTPVVPLRAGETLGWKLA
HHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA